2,200 件 ・ 関連度順
概要と使いどころ
Applies game theory to multi-agent coordination protocols with advisory claims, repeated interactions, daemon-mediated correlation, and deviation penalties. Use for Nash equilibrium checks, folk-theorem cooperation analysis, correlated-equilibrium routing, and price-of-anarchy audits in strategic agent systems. NOT for consumer pricing, card-game strategy, or general microeconomics outside agent coordination.
日本語の概要は準備中です。原文の説明を表示しています。
Frontend stack decisions, Cloudflare deployment patterns, component systems, and internal tools architecture. Use for framework selection, deployment strategy, design system bridging, shadcn setup. Activate on "frontend architecture", "tech stack", "Cloudflare Pages", "component library", "internal tools", "shadcn setup". NOT for writing CSS (use frontend-developer), design critique (use design-critic), or backend APIs.
日本語の概要は準備中です。原文の説明を表示しています。
Git branching strategies, conflict resolution, rebase workflows, monorepo patterns, and advanced operations like cherry-pick, bisect, and reflog recovery. Activate on "git", "branching strategy", "merge conflict", "rebase", "cherry-pick", "monorepo git", "git bisect", "git reflog", "squash commits". NOT for GitHub Actions CI/CD (use github-actions-pipeline-builder), GitHub API/webhooks, or PR review processes (use code-review-checklist).
日本語の概要は準備中です。原文の説明を表示しています。
Expert in Git workflows, conventions, and patterns for modern development teams and AI agents. Activate on: branching strategy, commit conventions, git hooks, pre-commit, husky, lint-staged, trunk-based development, git worktree, monorepo git, PR review workflow, conventional commits, git workflow. NOT for: CI/CD pipelines (use github-actions-pipeline-builder), repository hosting (use devops-automator), multi-agent orchestration (use multi-agent-coordination).
日本語の概要は準備中です。原文の説明を表示しています。
Diagnose and eliminate the GraphQL N+1 resolver explosion using Facebook DataLoader's per-request batching, plus the second-order defenses (persisted queries, depth limits, cost analysis). Use when a GraphQL query that returns N items in a list triggers N+1 database round trips, when designing nested resolvers that load associations, when a list query times out under load, or when you need to budget query cost before resolvers run. NOT for REST-style endpoint design (use api-versioning-strategy), generic database query optimization (use database-query-optimizer), or schema design (use graphql-server-architect).
日本語の概要は準備中です。原文の説明を表示しています。
Use for sensemaking, frame revision, anomaly handling, questioning strategy, and ambiguity diagnosis with the Data/Frame model before action is chosen. NOT for deterministic classification, settled execution planning, or situations where the frame is already stable.
日本語の概要は準備中です。原文の説明を表示しています。
Guides the practical path from 'we have no design system' or 'we have a mess' to a real, functional design system. Component inventory, design token extraction, headless UI adoption (Radix, React Aria, Headless UI), migration order of operations, and the assessment-to-rollout pipeline. Activate on 'design system from scratch', 'bootstrap design system', 'no design system', 'design system migration', 'headless UI adoption', 'component audit', 'design token extraction', 'design system strategy'. NOT for building specific components once a system exists (use design-system-creator), not for generating token files/configs (use design-system-generator).
日本語の概要は準備中です。原文の説明を表示しています。
Builds comprehensive design systems and design bibles with production-ready CSS. Expert in design tokens, component libraries, CSS architecture. Use for design system creation, token architecture, component documentation, style guide generation. Activate on "design system", "design tokens", "CSS architecture", "component library", "style guide", "design bible". NOT for typography deep-dives (use typography-expert), color theory mathematics (use color-theory-palette-harmony-expert), brand identity strategy (use web-design-expert), or actual UI implementation (use web-design-expert or native-app-designer).
日本語の概要は準備中です。原文の説明を表示しています。
Schema design, normalization decisions, indexing strategies, and migration safety for relational databases. Use when designing tables, choosing between normalize vs denormalize, selecting index types, planning zero-downtime migrations, or setting up connection pooling. Activate on "schema design", "normalization", "denormalization", "foreign key", "index strategy", "migration", "connection pooling", "composite key", "surrogate key", "soft delete", "polymorphic association". NOT for PostgreSQL-specific query tuning or EXPLAIN analysis (use postgresql-optimization), NoSQL or document database design, or cloud database provisioning.
日本語の概要は準備中です。原文の説明を表示しています。
Analyze bonded agent systems, escrow workflows, slashing rules, oracle trust, Sybil cost, and front-running risk in protocols where agents post bonds or stake reputation. Use for collateral sizing, griefing analysis, dispute design, and bonded-agent security reviews. NOT for smart contract auditing, DeFi tokenomics, blockchain consensus design, or trading strategy.
日本語の概要は準備中です。原文の説明を表示しています。
Builds, validates, schedules, and dynamically modifies DAG execution graphs. Decomposes problems into nodes with dependencies, performs topological sorting, detects cycles, resolves conflicts, and schedules wave-based parallel execution. Use when designing a DAG structure, validating dependencies, planning execution order, or modifying a DAG at runtime. Activate on "build DAG", "plan workflow", "DAG dependencies", "topological sort", "schedule execution", "modify DAG", "replan". NOT for executing DAGs (use dag-runtime), validating outputs (use dag-quality), or matching skills to nodes (use dag-skills-matcher).
日本語の概要は準備中です。原文の説明を表示しています。
Tracks cumulative LLM costs across DAG execution and makes real-time decisions to stay within budget. Downgrades models, skips optional nodes, or stops early when cost exceeds thresholds. Use when managing execution budgets, analyzing cost breakdowns, or optimizing model routing for cost. Activate on "cost budget", "too expensive", "reduce cost", "cost optimization", "model downgrade", "budget exceeded". NOT for LLM model selection logic (use llm-router), pricing comparisons across providers, or billing/invoicing.
日本語の概要は準備中です。原文の説明を表示しています。
CI/CD caching optimizer for dependency caching, Docker layer caching, and build speed improvements. Activate on: CI cache, build speed, dependency caching, Docker layer cache, turbo remote cache, GitHub Actions cache, pnpm store cache. NOT for: CI/CD pipeline creation (use github-actions-pipeline-builder), deployment strategy (use blue-green-deployment-orchestrator), Docker image building (use docker-multi-stage-optimizer).
日本語の概要は準備中です。原文の説明を表示しています。
Interprets GitHub Actions run status and logs, diagnoses CI failure patterns, and suggests targeted fixes. Handles dependency install failures, test timeouts, build OOM, flaky tests, and workflow misconfigurations. Activate on: 'CI failing', 'build broken', 'workflow error', 'GitHub Actions debug', 'flaky CI', 'pipeline timeout', 'CI red'. NOT for: writing new workflows from scratch (use github-actions-pipeline-builder), CI caching strategy (use ci-cache-optimizer), deployment orchestration (use devops-automator).
日本語の概要は準備中です。原文の説明を表示しています。
Design multi-tier caching architectures for web applications — cache-aside vs write-through vs write-behind, TTL design, cache invalidation, Redis patterns, CDN configuration, browser caching, and stampede prevention. Use when choosing a caching pattern, designing cache invalidation strategies, implementing Redis caching, configuring Cache-Control headers, or preventing cache stampedes. Activate on "cache invalidation", "cache-aside", "write-through", "TTL", "Redis cache", "CDN caching", "cache stampede", "stale data", "browser cache". NOT for database query caching within an ORM, memoization of pure functions, or CPU-level caching.
日本語の概要は準備中です。原文の説明を表示しています。
Redis caching patterns, cache-aside, write-through, TTL strategies, and invalidation. Activate on: caching, Redis, cache invalidation, cache-aside, write-through, TTL, CDN cache, stale-while-revalidate. NOT for: CDN/reverse proxy setup (use api-gateway-reverse-proxy-expert), database query optimization (use data-warehouse-optimizer).
日本語の概要は準備中です。原文の説明を表示しています。
Token bucket, sliding window, and Redis-based rate limiting for API protection. Activate on: rate limiting, throttling, token bucket, sliding window, API abuse, DDoS protection, quota management. NOT for: API gateway setup (use api-gateway-reverse-proxy-expert), caching (use cache-strategy-invalidation-expert).
日本語の概要は準備中です。原文の説明を表示しています。
Defines cell populations in flow and spectral cytometry through manual gates (rectangle, polygon, quadrant, boolean) and reproducible automated gating (openCyto gating templates, flowDensity data-driven thresholds, flowClust model-based gates), organized as a hierarchical GatingSet (flowWorkspace) and round-tripped with FlowJo via CytoML. Covers the canonical gate order (time -> debris -> singlets -> live -> lineage), FMO-vs-isotype boundary setting, gate-order dependence and recompute semantics, rare-event/MRD gating, and per-population statistics. Use when building a gating strategy, automating a manual FlowJo scheme across samples, choosing manual vs data-driven gates, or extracting population frequencies.
日本語の概要は準備中です。原文の説明を表示しています。
Calls m6A peaks from MeRIP-seq / m6A-seq paired IP-vs-input data using exomePeak2 (transcript-aware, GC-bias-corrected Poisson GLM), MeTPeak (HMM over sliding windows), MACS3/MACS2 with --nomodel --broad --keep-dup all (genome-wide broad alternative), and DRACH motif enrichment via HOMER or ggseqlogo as a sanity check (NOT a filter). Covers BED12 vs narrowPeak output, exonic vs intronic peak handling, multi-tool reconciliation (intersection vs union), the m6A-vs-m6Am ambiguity at 5'UTR peaks that antibody methods cannot resolve, and orthogonal validation (miCLIP/GLORI/m6A-SAC-seq/m6Anet). Use when calling peaks from paired IP/input genome BAMs, choosing exomePeak2 (transcript-aware default) vs MACS3 (broad genomic) vs MeTPeak (HMM-smoothed low-coverage), confirming DRACH enrichment as a sanity check on the peak set, reconciling differing peak sets across tools, validating MeRIP peaks against single-base methods, interpreting 5' peaks where m6Am contamination is possible, or recommending a consensus strategy.
日本語の概要は準備中です。原文の説明を表示しています。
Quality control for pooled CRISPR screens covering library representation, Gini index, log-skew, replicate Pearson and Spearman concordance, essentialome precision-recall AUC against CEGv2 (Hart 2017), Cas9 cut-toxicity diagnostics, copy-number amplicon detection (Aguirre 2016 / Munoz 2016), bottleneck propagation through plasmid pool, infection, selection, and endpoint stages, MOI verification, and DepMap-style screen-quality scoring. Use when assessing screen quality before hit calling, deciding whether to repeat or rescue a screen, diagnosing low-confidence hits, choosing between MAGeCK / BAGEL2 / Chronos based on quality grade, picking a normalization strategy from QC signatures, or evaluating whether an in-vivo screen retained adequate library complexity.
日本語の概要は準備中です。原文の説明を表示しています。
Designs and analyzes pooled prime-editor (PE) screens for installing precise genetic variants without bystander confounding. Covers pegRNA design with PRIDICT and PRIDICT2 for predicting per-pegRNA editing efficiency, pegRNA architecture (spacer + scaffold + PBS + RTT), PE2/PE3/PE3b/PEmax variants, MOSAIC in situ saturation mutagenesis, the PRIME pooled-screen methodology (Ren 2023; ~3,699 ClinVar variant screens), chromatin context as a major locus-level determinant of PE efficiency, scaffold-incorporation and indel byproduct quantification with CRISPResso2, and the cross-modal validation strategy of PE + base-editor screens for variant function. Use when designing a pegRNA library for variant installation, choosing between BE and PE for a specific edit, predicting pegRNA efficiency before library synthesis, analyzing PE screen output, distinguishing intended-edit from scaffold-incorporation, or scaling PE screens to thousands of variants.
日本語の概要は準備中です。原文の説明を表示しています。
Cross-method decision tree for calling hits in pooled CRISPR screens. Catalogs statistical models (MAGeCK RRA, MAGeCK MLE, BAGEL2, drugZ, JACKS, Chronos, CERES), experimental designs each is built for, failure modes outside design domain, reconciliation when methods disagree, multiple-testing and effect-size thresholds, the order of operations (count -> QC -> CN-correct -> hit-call -> validate), the second-best-sgRNA conservative rule, and consensus-hit strategy. Use when choosing among MAGeCK / BAGEL2 / drugZ / JACKS / Chronos for a given design, reconciling disagreement across two or three methods on the same screen, deciding whether to require consensus, gating downstream validation by hit-confidence tier, or interpreting unstable hit lists across reruns.
日本語の概要は準備中です。原文の説明を表示しています。
Implements multiplicity control for confirmatory clinical trials using graphical procedures (Bretz-Maurer-Hommel), gatekeeping (parallel, serial, mixed), Hochberg/Hommel/Holm with PRDS, and the closed-testing principle (Marcus-Peritz-Gabriel; Goeman 2021 admissibility). Covers FDA Multiple Endpoints Final Guidance (October 2022), graphical procedures via R gMCP, primary + key-secondary + subgroup hierarchies, and FWER vs FDR distinction. Use when designing the multiplicity strategy for confirmatory trials with multiple primary or key secondary endpoints.
日本語の概要は準備中です。原文の説明を表示しています。
Decides how to preprocess plasma cfDNA sequencing data so the recoverable signal survives - library-prep-aware fragment expectations (dsDNA vs ssDNA/adaptase prep), UMI/duplex consensus with fgbio (ExtractUmisFromBam, GroupReadsByUmi --strategy paired for duplex, CallMolecularConsensusReads vs CallDuplexConsensusReads, FilterConsensusReads min-reads "total s1 s2"), the align->group->consensus->RE-align ordering, and the cfDNA dedup trap where naive coordinate dedup collapses nucleosome-coincident independent molecules. Covers when single-strand consensus suffices vs when duplex is mandatory, the singleton/sensitivity tax at low input, and reading the insert-size histogram as a pre-analytical QC instrument. Use when processing plasma cfDNA reads before fragmentomics, ctDNA mutation calling, or tumor-fraction estimation.
日本語の概要は準備中です。原文の説明を表示しています。