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概要と使いどころ
Use when exposure, outcome, covariate or eligibility definitions and cutoffs need a citable basis before the protocol. Reads the data dictionary first, then maps each variable to a guideline or published definition and the database columns in a citation-backed table.
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Use DeepVariant and DeepTrio for genomics variant-calling command planning, input validation, pipeline-stage troubleshooting, custom training, and report analysis.
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Use Adversarial Robustness Toolbox (ART) for estimator wrappers, adversarial attacks, defences, poisoning/privacy/extraction, metrics, and certification workflows.
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Guides managing conflicting privacy requirements across jurisdictions. Covers data localisation vs transfer freedom, consent standards variation, age thresholds, breach timelines, and resolution frameworks for incompatible obligations. Keywords: conflicting laws, data localisation, consent variation, age thresholds, resolution framework.
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OI-3 spike harness — ADVERSARIAL inline guidance variant. Worst-case anchor: ends with a final-sounding completion statement and gives NO instruction to return to the caller. Use only when a spike consumer skill invokes it.
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Adversarial code review using the opposite model. Spawns 1–3 reviewers on the opposing model (Claude spawns Codex, Codex spawns Claude) to challenge work from distinct critical lenses. Triggers: "adversarial review".
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Adversarial code review using the opposite model's CLI. Spawns 1–3 reviewers on the opposing model (Codex sessions typically spawn Claude; Claude sessions spawn Codex) to challenge work from distinct critical lenses. Triggers: "adversarial review".
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Automatically complete partial code snippets while satisfying semantic constraints including variable types, invariants, pre/post-conditions, interface contracts, and expected input/output behavior. Use when users provide incomplete code with specific requirements like "complete this function that takes a list and returns sorted unique elements" or "fill in this method body that must maintain the invariant that x stays positive" or "implement this interface method with these type constraints." Produces compilable, executable code with tests and a constraint satisfaction report.
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Run the weak-agent adversarial test harness against docx-cli. Spawns weak exercise agents (Haiku by default, Sonnet to probe, or a local agent harness's pre-produced runs) to perform real document tasks over six scenarios — five editing (MNDA form-fill + font fidelity, invoice table-edit/restructure + logo replace, résumé styling, contract redlining + commenting, contract finalize via accept/reject + comment reply/resolve) and one authoring (T. S. Eliot poetry journal: multi-column, verse, footnotes, links, figure) — renders every result with Word, has opus judge them against ground-truth rubrics, measures each exercise's tool economy, token cost, wall-clock, and correctness (from transcripts for Claude, the exercise.json ledger for the local harness), and synthesizes a prioritized ergonomics report. Use when the user says 'adversarial review', 'test docx-cli with weak agents', 'run the haiku harness', 'weak agent test', or wants to re-run yesterday's adversarial process.
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Think and work like an expert Actuarial Scientist. Use when a task calls for Actuarial Scientist judgment. Reasons from mortality tables (qx, period/cohort, select/ultimate) and Chain-Ladder/Mack reserving through GLM/GAM frequency–severity and Tweedie pricing, limited-fluctuation and Bühlhmann-Straub credibility, Solvency II SCR standard formula, and IFRS 17 CSM/RA while treating triangle truncation, overfitting, and tail risk as first-class failure modes.
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Comprehensive variant filtering including GATK VQSR, hard filters, bcftools expressions, and quality metric interpretation for SNPs and indels. Use when filtering variants using GATK best practices.
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Deep learning-based variant calling from long reads using Clair3 for SNPs and small indels. Use when calling germline variants from ONT or PacBio alignments, particularly when high accuracy is needed for clinical or research applications.
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Trains and applies base-resolution deep learning models on ChIP-seq / ChIP-nexus / CUT&RUN data. Uses BPNet (Avsec 2021 Nat Genet 53:354; soft motif syntax from ChIP-nexus), chromBPNet (Pampari A et al 2025 Nat Genet; bias-factorized base-resolution profiles), EnFormer (Avsec 2021 Nat Methods 18:1196; 196 kb input, ~100 kb effective receptive field), DeepSEA (Zhou 2015; multi-task CNN), and JASPAR 2026 deep-learning collection (1259 BPNet ChIP models). Performs in silico mutagenesis for variant-effect prediction, DeepLIFT/Grad attribution, and TF-MoDISco motif discovery from attribution scores. Use when predicting variant effects on TF binding, discovering soft motif syntax / cooperativity, integrating ChIP-seq with sequence-only predictions, or applying precomputed JASPAR Deep Learning models to new variants.
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Analyzes community composition using constrained ordination (CCA, RDA, db-RDA), variance partitioning (varpart), indicator species analysis (indicspecies multipatt), and distance-based environmental gradient methods with vegan. Links species composition to environmental explanatory variables. Use when testing how environmental gradients structure species communities, identifying habitat indicator taxa, or partitioning explained variation among predictors. Not for basic unconstrained ordination and PERMANOVA (see microbiome/diversity-analysis).
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Workflow for small-variant and structural-variant discovery, filtering, annotation, and interpretation from sequencing data.
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Accessibility isn't a feature - it's a fundamental quality of good software. 1 in 4 adults has a disability. Many more have temporary impairments or situational limitations. Your users include people who can't see, can't hear, can't use a mouse, or can't process information the way you do. This skill covers WCAG guidelines, ARIA patterns, keyboard navigation, screen reader compatibility, and automated testing. Key insight: accessible code is better code. The constraints of accessibility lead to simpler, more semantic, more maintainable implementations. 2025 lesson: Accessibility lawsuits are at an all-time high. "We'll add it later" is both ethically wrong and legally risky. Start accessible, stay accessible. Use when "accessibility, a11y, wcag, aria, screen reader, keyboard navigation, focus trap, alt text, color contrast, skip link, accessible, accessibility, a11y, wcag, aria, screen-reader, keyboard, inclusive, semantic-html" mentioned.
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The intersection of AI generation and performance marketing. This skill covers creating ad creatives at scale using AI tools—from static images to video ads to dynamic creative optimization—while maintaining the conversion focus that performance marketing demands. Traditional creative testing is slow: create 5 variants, wait weeks for data, iterate. AI-powered ad creative is fast: generate 50 variants in an hour, test simultaneously, learn in days, iterate continuously. The constraint is no longer production capacity—it's testing velocity and creative strategy. This skill bridges AI generation capability with advertising effectiveness, ensuring that AI-created ads don't just look good—they convert. Use when "AI ads, ad creative, performance creative, ad generation, creative testing, ad variants, DCO, dynamic creative, Meta ads, Google ads, ad fatigue, conversion creative, advertising, performance-marketing, creative-testing, ai-ads, conversion, paid-media, scale" mentioned.
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Synthesize the single strongest EVIDENCE-BOUND reviewer case to reject a paper, built ONLY from the evidence ledger (claims.json) + the other auditors' confirmed findings — never free-floating LLM critique. Two fresh cross-model codex threads: an attack writes the ~200-word rejection paragraph (every accusation tagged to an existing claim_id/finding_id), a defense decomposes it and rules each point against the anchored evidence. MEMO-ONLY: emits adversarial-case-builder.memo.md (fed to the adjudicator via --memo) and carries NO verdict weight — tools/adjudicate_findings.py lists it in ZERO_WEIGHT_SKILLS and caps it at info. Honest-null allowed (the paper may survive). Run LAST. Detect-only. Adapted from ARIS kill-argument. Triggers: "adversarial case", "strongest objection", "rejection memo", "kill argument", "最强拒稿点".
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Figma 转 Photoshop (PSD) (Figma → Photoshop (PSD) 设计稿转换 (从业者视角) — 把 Figma 设计文件高保真转换为 Photoshop 分层 PSD, 核心是对齐两个工具的概念/渲染差异, 让产出的设计稿视觉一致. 覆盖: (a) 概念映射 — Figma frame / auto-layout / component / variant / constraint / vector-network / boolean / effect (drop·inner shadow / layer·background blur) / mask / blend mode / gradient / text-engine / color 与 Photoshop artboard / group / smart-object / linked / layer-style / shape-layer / path / clipping·layer mask / blend-mode 的对应关系与不可逆损耗点; (b) 转换方法栈 — 插件直出 PSD / 导出图层 (PNG·SVG) 再重组 / SVG·PDF 桥接 / 手工重建 / Figma REST API + Photoshop UXP·ExtendScript 脚本化, 各法在保真度-可编辑性-工时上的权衡与选型; (c) 保真度 QA — 字体回退与缺字处理 / 颜色空间 (sRGB·ICC profile) / 效果参数对齐 / @Nx·DPI 与栅格化 / 像素 diff 验收; (d) 两种交付目标 — 可编辑分层 PSD vs 像素保真扁平 PSD 的方法选择. 主战场 = Figma Community 插件 + Adobe 官方文档/论坛 + 设计交付 (design handoff) 实践 + 设计师社区. 不含: PSD→Figma 反向转换 / Sketch / Adobe XD / 纯前端 code handoff (HTML·CSS) / 印刷 CMYK 专业制版 (仅触及).) Master OS — automated mastery of Figma → Photoshop (PSD) 设计稿转换 (从业者视角) — 把 Figma 设计文件高保真转换为 Photoshop 分层 PSD, 核心是对齐两个工具的概念/渲染差异, 让产出的设计稿视觉一致. 覆盖: (a) 概念映射 — Figma frame / auto-layout / component / variant / constraint / vector-network / boolean / effect (drop·inner shadow / layer·background blur) / mask / blend mode / gradient / text-engine / color 与 Photoshop artboard / group / smart-object / linked / layer-style / shape-layer / path / clipping·layer mask / blend-mode 的对应关系与不可逆损耗点; (b) 转换方法栈 — 插件直出 PSD / 导出图层 (PNG·SVG) 再重组 / SVG·PDF 桥接 / 手工重建 / Figma REST API + Photoshop UXP·ExtendScript 脚本化, 各法在保真度-可编辑性-工时上的权衡与选型; (c) 保真度 QA — 字体回退与缺字处理 / 颜色空间 (sRGB·ICC profile) / 效果参数对齐 / @Nx·DPI 与栅格化 / 像素 diff 验收; (d) 两种交付目标 — 可编辑分层 PSD vs 像素保真扁平 PSD 的方法选择. 主战场 = Figma Community 插件 + Adobe 官方文档/论坛 + 设计交付 (design handoff) 实践 + 设计师社区. 不含: PSD→Figma 反向转换 / Sketch / Adobe XD / 纯前端 code handoff (HTML·CSS) / 印刷 CMYK 专业制版 (仅触及).: top builders' mental models, tool stack, current workflows, jargon, and where to keep up. Trigger this skill when the user works on Figma → Photoshop (PSD) 设计稿转换 (从业者视角) — 把 Figma 设计文件高保真转换为 Photoshop 分层 PSD, 核心是对齐两个工具的概念/渲染差异, 让产出的设计稿视觉一致. 覆盖: (a) 概念映射 — Figma frame / auto-layout / component / variant / constraint / vector-network / boolean / effect (drop·inner shadow / layer·background blur) / mask / blend mode / gradient / text-engine / color 与 Photoshop artboard / group / smart-object / linked / layer-style / shape-layer / path / clipping·layer mask / blend-mode 的对应关系与不可逆损耗点; (b) 转换方法栈 — 插件直出 PSD / 导出图层 (PNG·SVG) 再重组 / SVG·PDF 桥接 / 手工重建 / Figma REST API + Photoshop UXP·ExtendScript 脚本化, 各法在保真度-可编辑性-工时上的权衡与选型; (c) 保真度 QA — 字体回退与缺字处理 / 颜色空间 (sRGB·ICC profile) / 效果参数对齐 / @Nx·DPI 与栅格化 / 像素 diff 验收; (d) 两种交付目标 — 可编辑分层 PSD vs 像素保真扁平 PSD 的方法选择. 主战场 = Figma Community 插件 + Adobe 官方文档/论坛 + 设计交付 (design handoff) 实践 + 设计师社区. 不含: PSD→Figma 反向转换 / Sketch / Adobe XD / 纯前端 code handoff (HTML·CSS) / 印刷 CMYK 专业制版 (仅触及). problems and wants industry-grade thinking, tool selection, or workflow guidance. 触发词：「figma 转 psd」「figma to psd」「figma 转 photoshop」「figma 导出 psd」「设计稿转换」
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Find tests that enumerate a domain by copying it, and declare the invariants a codebase depends on. Reports where a parametrize list, for-loop, or it.each iterates a hand-written subset of a dict/set/tuple/Enum that exists in the source, and names the members nothing covers. Use when reviewing tests, when a module gains a name-to-thing table, registry, enum, or dispatch map, before trusting a green suite as evidence a domain is covered, or when asked "is this test actually total", "does anything cover X", "what does this repo guarantee", "which invariants do we declare". Also for vacuous tests that pass over an empty collection, for a domain that has silently NARROWED (an enumeration cannot see that), and for recording the refutation that proves a claim can fail.
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When the user wants to generate, iterate, or scale ad creative — headlines, descriptions, primary text, or full ad variations — for any paid advertising platform. Also use when the user mentions 'ad copy variations,' 'ad creative,' 'generate headlines,' 'RSA headlines,' 'bulk ad copy,' 'ad iterations,' 'creative testing,' 'ad performance optimization,' 'write me some ads,' 'Facebook ad copy,' 'Google ad headlines,' 'LinkedIn ad text,' or 'I need more ad variations.' Use this whenever someone needs to produce ad copy at scale or iterate on existing ads. For campaign strategy and targeting, see ads. For landing page copy, see copywriting.
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Design a variation theory task using contrast, separation, and fusion to teach critical features of a concept. Use when students confuse similar concepts or fail to discern key distinctions.
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When the user wants to generate, iterate, or scale ad creative — headlines, descriptions, primary text, or full ad variations — for any paid advertising platform. Also use when the user mentions 'ad copy variations,' 'ad creative,' 'generate headlines,' 'RSA headlines,' 'bulk ad copy,' 'ad iterations,' 'creative testing,' 'ad performance optimization,' 'write me some ads,' 'Facebook ad copy,' 'Google ad headlines,' 'LinkedIn ad text,' or 'I need more ad variations.' Use this whenever someone needs to produce ad copy at scale or iterate on existing ads. For campaign strategy and targeting, see ads. For landing page copy, see copywriting.
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CSS design tokens and color system for vehicle insurance platform. Use when defining colors, spacing, typography, or design variables. Keywords: eye-care colors #5B8DEF/#8B95A5/#C5CAD3, CSS variables, spacing system, color palette, typography scale, design tokens, variables.css, theme colors.
日本語の概要は準備中です。原文の説明を表示しています。