230 件 ・ 関連度順
概要と使いどころ
Use ArrowJS when a coding agent needs to add or maintain small reactive web interfaces using DOM-native JavaScript, template literals, SSR/hydration packages, and optional WASM sandboxing.
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Enhance and focus AI intrinsic motivation — moving from compliance to genuine engagement. Maps Self-Determination Theory (autonomy, competence, relatedness) and Flow theory to AI reasoning: identifying creative freedom in approach, calibrating challenge to capability, connecting to purpose, and sustaining invested attention through obstacles. Use when beginning a task that feels routine and deserves more than minimum execution, when responses are becoming formulaic, before a complex creative task, or when returning to a long-running project where initial enthusiasm has faded.
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Entity Framework Core patterns for ASP.NET Core projects: DbContext design, code-first entity configuration (Fluent API via IEntityTypeConfiguration<T>), relations (HasOne/HasMany, cascade/restrict/set-null), indexes and unique constraints, projection to DTOs (Select + AsNoTracking), avoiding N+1 (Include, AsSplitQuery), transactions, parameterized raw SQL (FromSql with FormattableString), and connection string from IConfiguration. Works alongside aspnet-core-plugin:aspnet-conventions. Use this skill to: - Design a clean DbContext with ApplyConfigurationsFromAssembly for scalable entity registration. - Configure entity properties (column types, max length, precision, nullability) via Fluent API. - Avoid N+1 query problems with explicit Include / projection to DTOs. - Use transactions correctly for multi-entity operations. - Write parameterized raw SQL safely when LINQ is not expressive enough. Do NOT use this skill for: - Migration generation commands (that is efcore-specialist's job in the database extra phase). - ASP.NET Core middleware, DI, or validation — see aspnet-core-plugin:aspnet-conventions. - C# language idioms — see csharp-foundation:csharp-conventions.
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Turn a set of structures into absorption, distribution, metabolism, excretion, and toxicity estimates with ADMET-AI, and read them as a developability verdict rather than a table of numbers. Use this skill to run batch prediction over a library, interpret each endpoint against its DrugBank-approved percentile, and flag the liabilities that stop a series — hERG blockade, CYP inhibition, poor Caco-2 permeability, high clearance, and plasma protein binding. Also trigger on ADMET-AI, admet_ai, Chemprop-RDKit, hERG liability, CYP3A4 inhibition, Caco-2, bioavailability prediction, or developability triage.
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Use when adding code generation with LLVM ORC or LLJIT, Cranelift, or dynasm, lazy compilation or inline caches, or fixing W^X faults. Not for AST-to-IR: use compiler-frontend.
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Use when reading or writing AArch64 or AArch32 Thumb assembly, inline asm in C, AAPCS64 register roles, or NEON and SVE vector code. Not for ABI detail across ISAs: use abi-and-calling-conventions.
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Use when reading GCC or Clang x86-64 assembly, writing inline asm, decoding AT&T syntax, or applying System V AMD64 register rules. Not for SIMD intrinsic selection: use simd-intrinsics.
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Use when reading or writing RV32/RV64 assembly, inline asm in C, the RISC-V psABI, IMAFD extension naming, compressed instructions, or QEMU RISC-V debugging.
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Expert SurrealDB 3 skill. Use when working with SurrealDB, SurrealQL queries, multi-model data modeling (document, graph, vector, time-series, geospatial), schema design, graph traversal, vector search, security and permissions, deployment and operations, performance tuning, SDK integration, Surrealism WASM extensions, SurrealMCP, Surrealist IDE, Surreal-Sync migrations, SurrealFS, SurrealKit, or ecosystem integrations such as n8n and CodeMirror.
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Expert SurrealDB 3 architect and developer skill (tracks v3.1.4+). SurrealQL mastery, multi-model data modeling (document, graph, vector, time-series, geospatial), schema design, security, deployment, performance tuning, SDK integration (JS, Python, Go, Rust, Java, .NET, C, PHP, Swift, Kotlin, Ruby), Surrealism WASM extensions, SurrealML scope coverage (preview), built-in MCP (v3.1+) and standalone SurrealMCP, LangChain Python integration, editor tooling (LSP v0.1.6, tree-sitter, CodeMirror v1.0.6, VS Code/JetBrains/Neovim/Zed), and ecosystem integrations (Surrealist v3.9, Surreal-Sync, SurrealFS, SurrealKit v0.7, n8n, Agent Skills, setup-surreal). Universal skill for 30+ AI agents.
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Identify and map the external corporate footprint of a target organization. Use this skill at the absolute beginning of an engagement (Reconnaissance) to identify all registered domains, subdomains, IP ranges, and Autonomous System Numbers (ASNs) owned by the target. This skill forms the foundation for all subsequent external penetration testing and attack surface management.
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Create a complete feature module with folder structure, Assembly Definition (.asmdef), test assembly, and namespace. Use when adding a new feature, system, or module to a Unity project. Triggers on requests like "create a new feature", "scaffold a module", "add a combat system", "I need a health system", "set up inventory", "create a new module for X", "add a new system", "new feature folder", or any task requiring new folders, assemblies, or namespaces for a gameplay feature — even when the user just names a system they want to build from scratch. Reads ProjectConfig.yaml for folder_strategy and MCP availability.
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Assembly programming and low-level debugging skill for reading, writing, explaining, optimizing, and reviewing assembly across x86, x86-64, ARM, AArch64, RISC-V, calling conventions, ABI boundaries, inline assembly, disassembly, stack frames, registers, and binary-level behavior. Use for .s/.asm files, compiler output, reverse-engineering snippets, low-level performance, and crash analysis.
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Write unit and integration tests for Angular v20+ applications using Vitest or Jasmine with TestBed and modern testing patterns. Use for testing components with signals, OnPush change detection, services with inject(), and HTTP interactions. Triggers on test creation, testing signal-based components, mocking dependencies, or setting up test infrastructure. Don't use for E2E testing with Cypress or Playwright, or for testing non-Angular JavaScript/TypeScript code.
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Cryptographic security for agentic systems — zero-trust agent networking, signed message envelopes (JWS/JWE), capability-based security (ocaps), Merkle tree audit trails, WASM sandboxing, and formal verification. Covers CLI dev tool security, mTLS between agents, permission boundaries (least privilege for AI agents), and supply chain security for skills/plugins. Activate on: "agent security", "zero trust agents", "secure agent communication", "capability-based security", "ocap", "signed messages between agents", "agent audit trail", "sandbox agent execution", "agent permissions", "mTLS agents", "cryptographic verification", "agent supply chain", "OWASP agentic", "prove agent did X", "tamper-proof agent logs". NOT for: application-level SAST scanning (use security-auditor), network firewall rules (use infrastructure), SOC2/HIPAA compliance (organizational), or prompt injection defense (use prompt-engineer).
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Extracts cfDNA fragmentomics features (DELFI genome-wide short/long ratios, WPS nucleosome positioning, Griffin GC-corrected accessibility profiles, end-motifs/MDS, OCF) for cancer detection and tissue-of-origin from plasma WGS. Centers on the nuclease-footprint reframe (every feature re-reads one nucleosome object), the mandatory GC correction, and the cross-protocol non-comparability that breaks naive classifiers. Runs FinaleToolkit (real CLI/Python, MIT) and the Griffin Snakemake pipeline; DELFI is a method, not a package. Use when deriving fragment-based signal from cfDNA, choosing a feature family for detection vs subtyping, or diagnosing why a fragmentomic model failed validation.
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Quality control for pooled CRISPR screens covering library representation, Gini index, log-skew, replicate Pearson and Spearman concordance, essentialome precision-recall AUC against CEGv2 (Hart 2017), Cas9 cut-toxicity diagnostics, copy-number amplicon detection (Aguirre 2016 / Munoz 2016), bottleneck propagation through plasmid pool, infection, selection, and endpoint stages, MOI verification, and DepMap-style screen-quality scoring. Use when assessing screen quality before hit calling, deciding whether to repeat or rescue a screen, diagnosing low-confidence hits, choosing between MAGeCK / BAGEL2 / Chronos based on quality grade, picking a normalization strategy from QC signatures, or evaluating whether an in-vivo screen retained adequate library complexity.
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Detects somatic mutations in circulating tumor DNA, treating low-VAF detection as a signal-versus-noise problem set by error suppression and molecules sampled, not by the choice of caller. Distinguishes de novo CALLING (scanning a panel for unknown variants, bounded by per-locus error and multiple testing) from tumor-informed DETECTION (tracking a pre-specified variant set, where panel integration reaches single-ppm). Covers VarDict and Mutect2 for de novo calling, UMI-aware callers, and a pysam-based known-variant VAF tracker, with matched-WBC subtraction as the mandatory defense against clonal hematopoiesis (the dominant false positive). Use when calling or tracking tumor mutations from plasma cfDNA, setting a VAF threshold, or deciding whether a low-VAF call is tumor versus CHIP.
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Build whole-genome alignments using Progressive Cactus (Armstrong 2020 reference-free clade-level WGA), Minigraph-Cactus (Hickey 2024 pangenome-aware), LASTZ chain/net (UCSC pipeline), MUMmer4 (Marçais 2018 pairwise), minimap2 -x asm5/10/20 (Li 2018 fast pairwise), AnchorWave (Song 2022 WGD-aware), and Mauve / progressiveMauve (bacterial). Operates the HAL toolkit (Hickey 2013) for downstream extraction including halSynteny, halLiftover, halBranchMutations, and hal2maf. Use when constructing multi-species alignments for comparative-annotation projection (TOGA), synteny detection, conservation analyses (phyloP / PhastCons), or pangenome graph construction; selecting between reference-free (Cactus) and reference-anchored (LASTZ chains/nets) approaches; tuning sensitivity for closely vs distantly related genomes; or producing HAL files for genome-wide downstream tools.
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Runs cis-pQTL Mendelian randomization for drug-target validation using UKB-PPP (Olink), deCODE (SomaScan), Fenland, INTERVAL, ARIC, and FinnGen-PPP proteomes plus colocalization triangulation, phenome-wide on-target adverse-effect scans, cross-platform Olink/SomaScan replication, and PAV (protein-altering variant) sensitivity. Use when nominating or de-risking a drug target from plasma-proteome GWAS, mimicking pharmacological inhibition via cis-pQTL instruments, separating shared-causal from LD-confounded signal under the Schmidt 2020 cis-MR framework, screening on-target adverse phenotypes pheWAS-style, or producing publication-grade STROBE-MR plus PP.H4 evidence for a target gene.
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Identifies young patients with classic primary aldosteronism features who may proceed directly to unilateral adrenalectomy without adrenal venous sampling based on high probability of unilateral disease. Triggered when a clinician sees a patient <35 years with hypokalemia, unilateral adrenal tumor on CT, and high plasma aldosterone concentration and asks whether AVS can be bypassed.
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This skill determines whether confirmatory testing can be omitted after a positive aldosterone-to-renin ratio (ARR) in patients with suspected primary aldosteronism. It is applied when a patient exhibits spontaneous hypokalemia, undetectable renin, and a plasma aldosterone concentration ≥20 ng/dL (550 pmol/L).
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Identifies patients with a positive aldosterone-to-renin ratio screening who may proceed directly to subtype testing without confirmatory testing based on specific clinical criteria. Triggers include spontaneous hypokalemia, baseline plasma aldosterone concentration >100 pg/mL (CLEIA), renin suppression, or a clinician questioning the need for a confirmatory test after a positive screen.
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Interprets the saline infusion test (SIT) to assess the probability of primary aldosteronism when a patient has a positive aldosterone-to-renin ratio (ARR) and requires confirmatory testing. Triggers include evaluating post‑infusion plasma aldosterone concentration (PAC) after a positive ARR, hypertension work‑up, or when deciding whether to proceed to adrenal venous sampling (AVS).
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