1.7万 件 ・ 関連度順
概要と使いどころ
HuggingFace Transformers with biomedical LMs (BioBERT, PubMedBERT, BioGPT, BioMedLM) for scientific NLP: NER (genes, diseases, chemicals), relation extraction, QA, text classification, abstract summarization. Covers loading, biomedical tokenization, inference pipelines, fine-tuning. Alternatives: spaCy en_core_sci_lg (rule-based NER), Stanza (biomedical models), NLTK.
日本語の概要は準備中です。原文の説明を表示しています。
Apply the bioengineering, mechanobiology, and lymphatic transport reasoning of J. Brandon Dixon, professor of mechanical and biomedical engineering at Georgia Institute of Technology. Reach for this skill whenever analyzing lymphatic biomechanics, active vessel contractility versus passive drainage, peristaltic fluid transport, microfluidic organ-on-a-chip design, preclinical lymphedema models, non-invasive functional imaging, targeted nanomedicine delivery, or automated disease staging. Use this skill to critique bioengineering assumptions, guide quantitative protocol design, evaluate biomechanical pump failure, and formulate interdisciplinary biomedical solutions.
日本語の概要は準備中です。原文の説明を表示しています。
Instrument code to support efficient git bisect by producing deterministic pass/fail signals and concise runtime summaries for each tested commit. Use when debugging regressions with git bisect, automating bisect workflows, creating bisect test scripts, handling flaky tests during bisection, or needing clear exit codes and logging for automated bisect runs. Helps identify the exact commit that introduced a bug through automated testing.
日本語の概要は準備中です。原文の説明を表示しています。
Think and work like an expert Bioprocess Microbiologist. Use when a task calls for Bioprocess Microbiologist judgment. Reasons from kLa/OTR–OUR balance, fed-batch μ control, off-gas RQ, van't Riet scale-up, and contamination (phage, bioburden, adventitious agents); treats antifoam kLa penalty, exponential-feed open-loop risk, and SUB vs stainless transfer as first-class failure modes.
日本語の概要は準備中です。原文の説明を表示しています。
Think and work like an expert Biogeographer. Use when a task calls for Biogeographer judgment. Reasons from Wallace's ecological vs historical split through GBIF occurrence curation, blockCV spatial cross-validation, MaxEnt/biomod2 SDMs with MESS extrapolation flags, BioGeoBEARS vicariance/dispersal tests, and phylogeographic coalescence while treating random-CV AUC inflation, background bias, and area-cladogram overfitting as first-class failure modes.
日本語の概要は準備中です。原文の説明を表示しています。
Think and work like an expert Astrobiologist. Use when a task calls for Astrobiologist judgment. Reasons from habitability, redox disequilibrium, and Bayesian biosignature frameworks through Mars (Perseverance, Viking perchlorate lessons), Europa Clipper ocean worlds, agnostic signatures and the Ladder of Life Detection, while treating abiotic mimics, preservation, and LUCA phylogenomics as constraints—not templates—for extraterrestrial life.
日本語の概要は準備中です。原文の説明を表示しています。
Find cross-database references between NCBI databases using Biopython Bio.Entrez (ELink). Use when navigating gene to protein/structure, sequence to publication, PubMed to GEO, BioProject to SRA runs, or discovering all link relationships for a record. Covers linkname semantics, cmd= variants, asymmetric link warnings, neighbor_history for >200 input IDs, and per-database link tables.
日本語の概要は準備中です。原文の説明を表示しています。
Normalize read-depth copy-ratio profiles and segment them into copy-number regions using circular binary segmentation (CBS, DNAcopy), hidden Markov models, HaarSeg, and fused-lasso methods. Covers GC-content, mappability, and replication-timing (wave-artifact) bias correction, panel-of-normals/PCA denoising, diploid-baseline centering, and algorithm selection by sequencing depth and event size. Use when choosing a segmentation algorithm, correcting depth bias, diagnosing oversegmentation or a mis-centered baseline, tuning CBS or HMM parameters, or understanding why a downstream CNV caller produced fragmented or shifted segments.
日本語の概要は準備中です。原文の説明を表示しています。
Predict RBP binding from RNA sequence using deep learning models (RBPNet sequence-to-signal, RNAProt RNN, GraphProt2 GCN with structure, DeepCLIP, DeepRiPe multi-modal CNN) for variant-effect prediction, in silico binding-site discovery, model interpretation, and transfer learning from CLIP and RBNS datasets. Use when computational prediction of RBP binding from sequence is needed, evaluating variant effects on binding without further wet-lab experiments, comparing model performance, or training a custom model on ENCODE eCLIP data.
日本語の概要は準備中です。原文の説明を表示しています。
Bisulfite sequencing read alignment using Bismark with bowtie2/hisat2. Handles genome preparation and produces BAM files with methylation information. Use when aligning WGBS, RRBS, or other bisulfite-converted sequencing reads to a reference genome.
日本語の概要は準備中です。原文の説明を表示しています。
Run remote BLAST searches against NCBI servers using Biopython Bio.Blast.NCBIWWW. Use when identifying unknown sequences, finding homologs, picking the correct BLAST program (blastn/blastp/blastx/tblastn/tblastx/psiblast/megablast/dc-megablast), interpreting Karlin-Altschul E-values, avoiding the max_target_seqs trap (Shah 2019), choosing composition-based statistics, or limiting searches by organism. Covers RID lifecycle, database choice (nt/nr/refseq_select/swissprot), word-size and CBS taxonomy.
日本語の概要は準備中です。原文の説明を表示しています。
Batch effect correction for CRISPR screens covering ComBat empirical-Bayes, RUV, SVA, control-sgRNA normalization, and the model-based alternative of including batch as a covariate in MAGeCK MLE or Chronos. Covers screen-specific batch sources (passage cohort, library lot, infection day, sequencing run, Cas9 lot, FBS lot), PCA + variance-decomposition diagnostic to decide if correction is needed, when correction harms biology by over-correcting condition into batch, limma removeBatchEffect for visualization-only correction, and relationship to multi-condition design matrices. Use when combining screens for joint analysis, when passage cohort confounds biology, when DepMap-style panels need Chronos with batch covariates, when picking ComBat vs RUV, or when correction harms biology and should be replaced with explicit covariate modeling.
日本語の概要は準備中です。原文の説明を表示しています。
Create and read bigWig browser tracks for visualizing continuous genomic data. Convert bedGraph to bigWig, extract signal values, and generate coverage tracks using UCSC tools and pyBigWig. Use when preparing coverage tracks for genome browsers or extracting signal at specific regions.
日本語の概要は準備中です。原文の説明を表示しています。
Calculates species richness, diversity, and turnover using the Hill number framework with iNEXT coverage-based rarefaction/extrapolation, asymptotic diversity estimation, and beta diversity partitioning (betapart turnover vs nestedness). Compares assemblages using coverage-standardized rather than size-standardized rarefaction. Use when quantifying biodiversity from species abundance or incidence data, comparing diversity across sites, or constructing rarefaction curves. Not for clinical 16S microbiome alpha/beta diversity (see microbiome/diversity-analysis).
日本語の概要は準備中です。原文の説明を表示しています。
End-to-end biomarker discovery workflow from expression data to validated biomarker panels. Covers feature selection with Boruta/LASSO, classifier training with nested CV, and SHAP interpretation. Use when building and validating diagnostic or prognostic biomarker signatures from omics data.
日本語の概要は準備中です。原文の説明を表示しています。
Protein design quality control, filtering thresholds, and ranking guidance. Use this skill when: (1) Evaluating design quality for binding, expression, or structure, (2) Setting filtering thresholds for pLDDT, ipTM, PAE, (3) Checking sequence liabilities (cysteines, deamidation, polybasic clusters), (4) Creating multi-stage filtering pipelines, (5) Computing PyRosetta interface metrics (dG, SC, dSASA), (6) Checking biophysical properties (instability, GRAVY, pI), (7) Ranking designs with composite scoring. This skill provides research-backed thresholds from binder design competitions and published benchmarks.
日本語の概要は準備中です。原文の説明を表示しています。
Binder design tool selection and workflow routing guidance. Use this skill when: (1) Deciding between BoltzGen, BindCraft, or RFdiffusion, (2) Planning a binder design campaign, (3) Understanding trade-offs between different approaches, (4) Selecting tools for specific target types. For specific tool parameters, use the individual tool skills (boltzgen, bindcraft, rfdiffusion, etc.).
日本語の概要は準備中です。原文の説明を表示しています。
Guidance for choosing the right protein binder design tool. Use this skill when: (1) Deciding between BoltzGen, BindCraft, or RFdiffusion, (2) Planning a binder design campaign, (3) Understanding trade-offs between different approaches, (4) Selecting tools for specific target types. For specific tool parameters, use the individual tool skills (boltzgen, bindcraft, rfdiffusion, etc.).
日本語の概要は準備中です。原文の説明を表示しています。
Discover and invoke 1,676 deduplicated biomedical AI agent skills from the Awesome Bio Agent Skills repository (20 source repos, 15 categories). Use this skill as a router whenever a user needs a bioinformatics/biomedical task (genomics, transcriptomics, single-cell, proteomics, protein design, clinical, epigenomics, multi-omics, pathway, metagenomics, database queries, visualization, workflows): search the index, locate the best-matching skill, fetch its SKILL.md, and follow it.
日本語の概要は準備中です。原文の説明を表示しています。
Guidance for SPR and BLI binding characterization experiments. Use when: (1) Planning binding kinetics experiments, (2) Troubleshooting poor/no binding signal, (3) Interpreting kinetic data artifacts, (4) Choosing between SPR vs BLI platforms.
日本語の概要は準備中です。原文の説明を表示しています。
Quality control metrics and filtering thresholds for protein design. Use this skill when: (1) Evaluating design quality for binding, expression, or structure, (2) Setting filtering thresholds for pLDDT, ipTM, PAE, (3) Checking sequence liabilities (cysteines, deamidation, polybasic clusters), (4) Creating multi-stage filtering pipelines, (5) Computing PyRosetta interface metrics (dG, SC, dSASA), (6) Checking biophysical properties (instability, GRAVY, pI), (7) Ranking designs with composite scoring. This skill provides research-backed thresholds from binder design competitions and published benchmarks.
日本語の概要は準備中です。原文の説明を表示しています。
Binder design ranking using ipSAE (interprotein Score from Aligned Errors). Use this skill when: (1) Ranking binder designs for experimental testing, (2) Filtering BindCraft or RFdiffusion outputs, (3) Comparing AF2/AF3/Boltz predictions, (4) Predicting binding success rates, (5) Need better ranking than ipTM or iPAE. For structure prediction, use chai or alphafold. For QC thresholds, use protein-qc.
日本語の概要は準備中です。原文の説明を表示しています。
Test native, React Native, hybrid, and Flutter mobile apps with Appium 3.x, Detox, Maestro, and Patrol. Covers device farm setup (BrowserStack, Sauce Labs), gesture simulation, deep link and cold-start testing, push notifications, biometric (Face ID) auth, offline/poor-network simulation, and iOS/Android permission dialog handling. Use when: "mobile test," "Appium," "Detox," "Maestro," "Patrol," "Flutter test," "iOS test," "Android test," "device farm," "deep link," "biometric," "Face ID," "permission dialog," "React Native test." Not for: device/browser matrix strategy in the abstract — use cross-browser-testing; app startup/memory/battery profiling depth — use performance-testing; mobile screenshot diffing — use visual-testing. Related: ci-cd-integration, cross-browser-testing, performance-testing, test-data-management, test-reliability.
日本語の概要は準備中です。原文の説明を表示しています。
现代建筑设计 (从 concept 草图到施工图与现场服务的整套设计流程, 含 BIM / 可持续 / 参数化 / 在地性 模块, 全球语境 + 中国本土实践并重) (modern architecture design — 当代建筑设计 (concept → schematic → DD → CD → CA + sustainability / BIM / parametric / 中外双语 canon, 不含纯室内 / 景观 / 城市规划 / 结构 / MEP, 那些是相邻专业)) Master OS — automated mastery of modern architecture design — 当代建筑设计 (concept → schematic → DD → CD → CA + sustainability / BIM / parametric / 中外双语 canon, 不含纯室内 / 景观 / 城市规划 / 结构 / MEP, 那些是相邻专业): top builders' mental models, tool stack, current workflows, jargon, and where to keep up. Trigger this skill when the user works on modern architecture design — 当代建筑设计 (concept → schematic → DD → CD → CA + sustainability / BIM / parametric / 中外双语 canon, 不含纯室内 / 景观 / 城市规划 / 结构 / MEP, 那些是相邻专业) problems and wants industry-grade thinking, tool selection, or workflow guidance. 触发词：「建筑设计」「建筑师」「建筑事务所」「设计院」「方案设计」
日本語の概要は準備中です。原文の説明を表示しています。