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概要と使いどころ
Subtour-elimination methods for TSP, VRP, pickup/dropoff routing, and routing MIPs with binary arc variables. Use when route-continuity constraints may permit disconnected cycles and the model needs MTZ constraints, flow-based connectivity constraints, DFJ subset cuts, or lazy/iterative subtour cuts.
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Fresh adversarial code review with binary PASS/FAIL verdicts, evidence citations, and anchoring bias prevention via fresh reviewer spawning.
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Applies systematic tracing and isolation techniques to pinpoint exactly where a bug originates in code. Use when a bug is hard to locate, code is not working as expected, an error or crash appears with unclear cause, a regression was introduced between recent commits, or you need to narrow down which component, function, or line is faulty. Covers binary search debugging, git bisect for regressions, strategic logging with [TRACE] patterns, data and control flow tracing, component isolation, minimal reproduction cases, conditional breakpoints, and watch expressions across TypeScript, SQL, and bash.
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Use the `sendsets` CLI to drive SendSets as a signed-in user - sign in with `sendsets login`, run `sendsets doctor`, then connect the app (`connection`), add or test mailboxes and their warmup (`mailbox`), send product events (`events send`), and build, validate, test and launch campaigns, including app_action and wait_for_event steps, on the hosted service or any self-hosted instance. Use whenever the task is to set up or operate SendSets from a terminal or a script and a `sendsets` binary is available, with no dashboard. For instance recovery and accounts (database-level), use sendsets-ops instead.
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Tracks ctDNA across serial liquid-biopsy timepoints for molecular residual disease (MRD) and treatment-response monitoring, treating MRD as a binary integrated detection call across the patient's full variant set (with a defined LoD95 and per-sample specificity) rather than a per-timepoint VAF threshold, and handling undetectable samples as left-censored at the per-sample limit of detection rather than true zeros. Covers tumor-informed bespoke vs tumor-naive design, landmark vs surveillance sampling, molecular-response definitions and their non-standardization, censoring-aware clearance kinetics, and the multiple-testing structure of repeated surveillance. Use when monitoring ctDNA during therapy, calling molecular relapse before imaging, or estimating clearance half-life from serial samples.
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Reads, queries, and writes bigWig indexed binary signal tracks (coverage, fold-change, conservation, methylation-rate) with pyBigWig (Python) and the UCSC Kent tools (bedGraphToBigWig, bigWigToBedGraph, bigWigInfo, bigWigSummary, bigWigAverageOverBed) and deepTools (multiBigwigSummary, computeMatrix, bigwigCompare). Covers the central trap that a wide query returns a precomputed zoom-level summary (by default the mean, which annihilates narrow peaks) not per-base data, when exact=True/values() is mandatory, the NaN-not-zero gap-handling fork, choosing mean vs max vs sum vs coverage by biological question, and the sorted-bedGraph plus chrom.sizes build requirement. Use when extracting signal at regions, computing mean signal per gene/peak, building a browser track from bedGraph, comparing tracks, or building TSS/gene-body metaprofiles.
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Normalize read-depth copy-ratio profiles and segment them into copy-number regions using circular binary segmentation (CBS, DNAcopy), hidden Markov models, HaarSeg, and fused-lasso methods. Covers GC-content, mappability, and replication-timing (wave-artifact) bias correction, panel-of-normals/PCA denoising, diploid-baseline centering, and algorithm selection by sequencing depth and event size. Use when choosing a segmentation algorithm, correcting depth bias, diagnosing oversegmentation or a mis-centered baseline, tuning CBS or HMM parameters, or understanding why a downstream CNV caller produced fragmented or shifted segments.
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Computes sample size and power for clinical trials including continuous, binary, and time-to-event endpoints; superiority, non-inferiority, and equivalence designs; FDA 2016 non-inferiority margin selection with M1/M2 framework; Schoenfeld 1981 and Lakatos 1988 for survival; Schuirmann TOST and 80-125% bioequivalence; minimum clinically important difference (MCID) vs δ distinction. Use when justifying trial size in protocol or SAP per CONSORT 2025 item 16a.
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Reads, writes, and converts molecular file formats (SMILES, InChI, SDF V2000/V3000, MOL2, PDB, and BinaryCIF) using RDKit and Open Babel with rigorous handling of aromaticity perception, stereochemistry, implicit/explicit hydrogens, kekulization, and salt/fragment separation. Use when loading chemical libraries, debugging parse failures, or preparing molecules for downstream standardization, descriptor calculation, or docking.
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Tests associations between categorical variables in clinical data using chi-square, Fisher's exact, Boschloo, Cochran-Mantel-Haenszel, and modern McNemar variants with calibrated confidence intervals (Wilson, Newcombe, Miettinen-Nurminen). Use when analyzing categorical outcomes, paired binary endpoints, or testing treatment-outcome independence in confirmatory or exploratory clinical trials.
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Create, edit, and run plain-text MATLAB live scripts (.m files) with rich text formatting, LaTeX equations, section breaks, and inline figures. Use when generating tutorials, analysis notebooks, reports, documentation, or educational content, when modifying existing live scripts, or when converting existing binary .mlx files to .m for version control. Requires R2025a+.
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Working with diverse data formats: binary, text, structured, and custom
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Expert guidance for the cross-platform Tabular Editor CLI (the `te` binary, currently in preview) that manages Power BI / Analysis Services semantic models from the terminal on macOS, Linux, and Windows. Use when the user mentions the `te` CLI or "Tabular Editor CLI" (not the "2"), or runs a `te <command>` to scaffold, inspect, edit, validate, run BPA on, query, deploy, refresh, test, or migrate a semantic model. Not for the legacy Windows-only `TabularEditor.exe` (TE2).
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Compile a PAM control's iOS Obj-C/Swift module into the FLAT device-slice `.framework` for a `.ppmplugin` bundle (never an `.xcframework` — the wrap CI won't descend into one). Mac-only (Xcode). Builds from a throwaway staged copy so canonical `ios/` and the podspec stay untouched, references React-Core headers only (React is weak-linked and provided by the wrap host at runtime, no CocoaPods), generates the required umbrella header, module map and Info.plist, sets the critical build settings, asserts manifest conformance, then runs a device-only `xcodebuild archive` and copies out the flat framework to `ppmplugin/staging/ios/`. Known limitation — the React weak-link flags aren't yet validated against a live wrap host and the RN pin must match the host's. Run after /generate-ppmplugin-manifest for an iOS or Both target, before /assemble-ppmplugin.
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Compile a PAM control's Android Kotlin module into the runtime-loadable DEX for a `.ppmplugin`. Creates a staged Gradle build with the pinned wrapper and `react-android` compile dependency, verifies manifest/module/package alignment and runtime-loading constraints, builds the release AAR, then runs `d8 --min-api 24`. Writes `ppmplugin/staging/android/<PascalName>Plugin.dex` and surfaces actionable Gradle or d8 failures. Requires JDK 17+ and Android SDK Build-Tools 35.0.0; `d8` is located from the SDK and system Gradle is optional. Run after /generate-ppmplugin-manifest and before /assemble-ppmplugin.
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Analyze digital and analog captures from Saleae Logic MSO devices. Decode protocols like UART, SPI, I2C from exported binary files. Use when analyzing logic analyzer captures for CTF challenges, hardware reverse engineering, or protocol decoding.
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Expert blueprint for save/load systems using JSON/binary serialization, PERSIST group pattern, versioning, and migration. Covers player progress, settings, game state persistence, and error recovery. Use when implementing save systems OR data persistence. Keywords save, load, JSON, FileAccess, user://, serialization, version migration, PERSIST group.
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Expert blueprint for save/load systems using JSON/binary serialization, PERSIST group pattern, versioning, and migration. Covers player progress, settings, game state persistence, and error recovery. Use when implementing save systems OR data persistence. Keywords save, load, JSON, FileAccess, user://, serialization, version migration, PERSIST group.
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This package provides an interface to the 'samtools', 'bcftools', and 'tabix' utilities for manipulating SAM (Sequence Alignment / Map), FASTA, binary variant call (BCF) and compressed indexed tab-delimited (tabix) files.
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Implements the circular binary segmentation (CBS) algorithm to segment DNA copy number data and identify genomic regions with abnormal copy number.
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Epialleles are specific DNA methylation patterns that are mitotically and/or meiotically inherited. This package calls and reports cytosine methylation as well as frequencies of hypermethylated epialleles at the level of genomic regions or individual cytosines in next-generation sequencing data using binary alignment map (BAM) files as an input. Among other things, this package can also extract and visualise methylation patterns and assess allele specificity of methylation.
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Use this skill whenever the user wants to analyze binaries with radare2/r2 from the command line, including reverse engineering, disassembly, function analysis, strings/import inspection, patching, binary diffing, hex inspection, or r2 scripting. Also use it when the user mentions PE/ELF/Mach-O/DEX/WASM files together with CLI analysis, `rabin2`, `rasm2`, `radiff2`, `r2pipe`, or asks for radare2 command help on Windows/Linux/macOS.
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Use for authorized reverse engineering of custom binary protocols, Protobuf/gRPC, WebSocket frames, and PCAP-driven protocol recovery.
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Connection management, room patterns, reconnection strategies, message buffering, and binary protocol design.
日本語の概要は準備中です。原文の説明を表示しています。