「depth」の検索結果

Audit and fix visual hierarchy, spacing, color, and depth in web UIs. Use when the user mentions "my UI looks off" (or amateur/unprofessional), "fix the design", "Tailwind styling", "color palette", "visual hierarchy", "design system", "spacing scale", or "component styling". Also trigger when building consistent design tokens, creating dark mode themes, improving data-visualization clarity, or polishing UI details before launch. Covers grayscale-first workflow, constrained design scales, shadows, and component styling. For typeface selection, see web-typography. For usability audits, see ux-heuristics.

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Validate at every layer data passes through to make bugs impossible

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Systematic debugging frameworks for finding and fixing bugs - includes root cause analysis, defense-in-depth validation, and verification protocols

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When the user wants to analyze their own app's actual performance data from App Store Connect — real downloads, revenue, IAP, subscriptions, trials, or country breakdowns synced via Appeeky Connect. Use when the user asks about "my downloads", "my revenue", "how is my app performing", "ASC data", "sales and trends", "my subscription numbers", "App Store Connect metrics", or wants to compare periods or top markets. For third-party app estimates, see app-analytics. For subscription analytics depth, see monetization-strategy.

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Use this skill when the user asks about Ni Haisha / 倪海厦 TCM course material, especially Shang Han Lun / 伤寒论, Jingui / 金匮要略, Zhongjing Xinfa / 仲景心法, clinical cases / 临床案例 / 倪师医案, Bagang Bianzheng / 八纲辨证, Fuyang Forum / 扶阳论坛, Yijinjing / 易筋经, Liang Dong dialogue / 梁冬对话倪师, Stanford lecture / 斯坦福大学演讲, Tianji / 天纪 / 易经 / 阳宅 / 紫微斗数, Huangdi Neijing / 黄帝内经, Shennong Bencao / 神农本草, acupuncture / 针灸, meridians, acupoints, acupuncture depth safety / 危险进针深度 / 气胸风险, six-channel pattern identification, symptom-to-formula routing, formula comparison, lesson review, board/PPT screenshot evidence, or course-derived study notes. This skill is for educational distillation and study support only, not medical diagnosis, prescriptions, dosage, individualized treatment, or self-administered acupuncture.

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Qianfan Deep Research Agent for complex research tasks. Combines information retrieval, multi-source analysis, content synthesis, and report generation. Use when user needs in-depth research, analysis reports, or comprehensive investigation on complex topics.

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Generates complete reference-grounded single-drug adverse-effect network-pharmacology research designs from a user-provided drug, adverse event, and desired evidence depth. Always use this skill when a user wants to design, plan, or upgrade a conventional network-pharmacology study centered on one fixed drug and one fixed adverse-effect endpoint, using drug-target prediction, adverse-event target collection, overlap analysis, PPI hub prioritization, enrichment interpretation, molecular docking, and optional orthogonal transcriptomic or literature validation. Covers five study patterns (canonical hub-first, cardiotoxicity or electrophysiology-oriented, immune-inflammatory adverse effect, organ-toxicity pathway context, translational validation) and always outputs four workload configs (Lite / Standard / Advanced / Publication+) with a recommended primary plan, dependency/evidence map, step-by-step workflow, figure plan, validation strategy, minimal executable version, publication upgrade path, verified-reference pack, and self-critical risk review.

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Generates complete reference-grounded single-drug adverse-effect network-pharmacology research designs from a user-provided drug, adverse event, and desired evidence depth. Always use this skill when a user wants to design, plan, or upgrade a conventional network-pharmacology study centered on one fixed drug and one fixed adverse-effect endpoint, using drug-target prediction, adverse-event target collection, overlap analysis, PPI hub prioritization, enrichment interpretation, molecular docking, and optional orthogonal transcriptomic or literature validation. Covers five study patterns (canonical hub-first, cardiotoxicity or electrophysiology-oriented, immune-inflammatory adverse effect, organ-toxicity pathway context, translational validation) and always outputs four workload configs (Lite / Standard / Advanced / Publication+) with a recommended primary plan, dependency/evidence map, step-by-step workflow, figure plan, validation strategy, minimal executable version, publication upgrade path, verified-reference pack, and self-critical risk review.

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Ranks papers by evidence family, methodological quality tier, validation depth, and claim discipline; assigns anchor, context-setting, mechanistic support, or caution citation roles; prevents prestige-based or design-label-based ranking errors.

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Identifies translationally meaningful paths for bioinformatics findings by mapping omics or computational discoveries to diagnosis, stratification, prognosis, treatment-response, monitoring, or target-nomination use cases, while auditing bridge evidence, assayability, and validation burden. Use this skill when a user wants to know whether a bioinformatics finding can be framed as a stronger translational topic without overclaiming clinical relevance. Always separate statistical signal from translational value, and never imply clinical utility, targetability, or validation depth without explicit evidence support.

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Structured code quality assessment with Conventional Comments format, scaled review depth, and soft-gating verdicts preserving user autonomy.

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Read and process GLM output files. Use when you need to extract temperature data from NetCDF output, convert depth coordinates, or calculate RMSE against observations.

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An overview of the core model API of SeisBench, a Python framework for training and applying machine learning algorithms to seismic data. It is useful for annotating waveforms using pretrained SOTA ML models, for tasks like phase picking, earthquake detection, waveform denoising and depth estimation. For any waveform, you can manipulate it into an obspy stream object and it will work seamlessly with seisbench models.

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Build a dense, data-heavy screen - an analytics console or a trading terminal - with real charts drawn from tokens: candlestick, volume, depth, stacked area, waterfall, scatter, correlation matrix, donut, gauge, sparklines, heatmaps and order books. Use when the request is a dashboard, terminal, monitoring view, data console, or any screen whose job is to show many numbers at once. Covers the layout sequence, the SVG geometry, the accessibility contract per chart type, and the contrast traps that only appear in dark mode.

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Review code changes from multiple perspectives with context bootstrap, depth-tier rigor, and structured findings output.

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Generate a tailored code review checklist for any pull request based on the language, type of change, and risk level. Use when asked to review code, check a PR, review a pull request, or generate a code review checklist. Produces a focused checklist with language-specific checks, risk-level-appropriate depth, and a clear approve/request-changes recommendation.

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Explain what a piece of code does in plain English, at the depth the reader needs. Use when asked to explain code, walk through a function, understand an unfamiliar snippet, or onboard to a file. Produces a one-line summary, a step-by-step walkthrough, the non-obvious parts called out, and any bugs or smells spotted along the way.

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Detects focal chromatin loops (point interactions / corner-dots) in balanced Hi-C and Micro-C contact maps and aggregates/validates a loop set. Covers de-novo calling with cooltools dots (HiCCUPS-style 4-background local enrichment with lambda-chunked FDR), chromosight (template-correlation), and Mustache (scale-space blob detection); aggregate peak analysis (APA) via cooltools pileup for confirmation; the depth/resolution prerequisite (de-novo needs ~5-10kb resolution = hundreds of millions to billions of valid pairs); consensus across callers and convergent-CTCF support as validation; and differential loops via union anchors plus chromosight quantify. Use when calling chromatin loops or dots from a cooler, deciding whether a map is deep enough to call de-novo vs running APA on known CTCF/cohesin anchors, building an aggregate peak pileup, comparing loops across conditions, or validating loop calls. For HiChIP/PLAC-seq/PCHi-C protein-anchored data use FitHiChIP/MAPS, not dots.

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Compares Hi-C contact maps between conditions across the right scale -- differential bin-pair contacts (multiHiCcompare, diffHic), differential A/B compartments (dcHiC), differential TAD boundaries (delta insulation), and differential loops (diffloop, DiffHiChIP) -- with distance-stratified between-sample normalization, replicate-aware NB-GLM FDR, HiCRep SCC reproducibility gating, and CNV correction for cancer/aneuploid samples. Use when comparing Hi-C between treatment and control, finding differential contacts/compartments/boundaries/loops, normalizing two maps of unequal depth, choosing a replicate-aware test, gating replicates with SCC, or correcting copy-number artifacts before a tumor-vs-normal comparison.

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Assembles a genome de novo from Illumina short reads with SPAdes (isolate/careful/sc/meta/plasmid/rna modes), MEGAHIT (low-memory, huge datasets), Unicycler (bacterial finishing/hybrid), MaSuRCA (large hybrid), ABySS (Bloom-filter), and Platanus (heterozygous diploids), using multi-k de Bruijn graphs. Covers the repeat-resolution limit, why N50 plateaus at the genome not the depth, GenomeScope2 k-mer profiling first, the heterozygosity/haplotig trap, error-correction erasing rare alleles, GC dropout, and NG50/auN/BUSCO reporting. Use when assembling a bacterial isolate, fungal, small-eukaryotic, single-cell, or metagenome genome from Illumina reads, or when deciding whether short reads can even produce the assembly being asked for.

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Treats a ctDNA assay as a molecule-counting experiment at the Poisson edge and builds its analytical-validation case the measurement-science way. Covers the genome-equivalent currency (~330 haploid copies/ng), the lambda = input_GE x VAF sampling ceiling (lambda>=3 for ~95% detection), the error-suppression ladder (raw NGS ~1e-3 -> single-strand UMI ~1e-4/1e-5 -> duplex <1e-7), the CLSI EP17 LoB/LoD/LoD95/LoQ framework, the per-locus-vs-panel-integrated LoD distinction that lets bespoke MRD reach ppm, contrived/SEQC2 reference standards, and honest LoD reporting conditioned on input mass + consensus depth + replicate detection rate. Use when stating or trusting a sensitivity claim, designing a dilution-series validation, deciding how many genome equivalents are needed at a target VAF, choosing a single-locus vs panel-integrated LoD, or auditing a "detects 0.1% VAF" claim.

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Infer integer allele-specific copy number, tumor purity, and ploidy from tumor sequencing by jointly modeling read depth (logR) and B-allele frequency (BAF) with ASCAT, Sequenza, FACETS, PURPLE, and PureCN (tumor-only). Covers the purity-ploidy identifiability problem, the diploid-baseline (dipLogR) anchor, major/minor copy number, loss of heterozygosity, sunrise/contour fit diagnostics, and reconciliation of conflicting fits. Use when tumor analysis needs absolute copy number rather than relative log2, when estimating purity and ploidy, calling LOH or copy-neutral LOH, resolving whole-genome doubling, running tumor-only allele-specific calling, or choosing among ASCAT, Sequenza, FACETS, and PureCN.

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Visualize copy number profiles, segments, allele-specific tracks, and cohort patterns from CNVkit, GATK, ASCAT, FACETS, Sequenza, and other callers. Covers genome-wide and per-chromosome log2 scatter plots, B-allele-frequency/minor-allele-fraction tracks, ideograms, cohort heatmaps, circos views, and caller-native plots. Use when creating publication CNV figures, choosing which plot answers a given question, diagnosing a wrong diploid baseline visually, displaying loss of heterozygosity, or deciding what depth-only plots cannot reveal.

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Resolve the architecture of focal oncogene amplifications — extrachromosomal DNA (ecDNA), breakage-fusion-bridge (BFB) cycles, homogeneously staining regions (HSR), and linear amplification — from whole-genome sequencing with AmpliconArchitect, the AmpliconSuite pipeline, and AmpliconClassifier. Covers copy-number seed selection, breakpoint-graph reconstruction, balanced-flow optimization, ecDNA classification, and the limits of depth-only amplification calls. Use when a focal amplification needs structural characterization, when distinguishing ecDNA from chromosomal amplification, suspecting ecDNA-driven oncogene amplification or therapy resistance, or selecting copy-number seeds for amplicon reconstruction.

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