「filter」の検索結果

Analyzes single-cell pooled CRISPR screens (Perturb-seq, CROP-seq, Perturb-CITE-seq, ECCITE-seq, multiome) where each cell carries an sgRNA and a scRNA-seq / surface-protein / chromatin readout. Covers experimental design (direct-capture Perturb-seq Dixit 2016 vs CROP-seq 3'UTR-barcoded Datlinger 2017 vs ECCITE-seq vs Multiome), MOI for sgRNA assignment, escaper-cell filtering (Mixscape, Papalexi 2021), SCEPTRE NB GLM + permutation for low-MOI (Barry 2024 Genome Biol 25:124), the Pertpy framework, factor decomposition, genome-scale Perturb-seq (Replogle 2022 Cell, 2.5M cells), and per-perturbation single-cell DE. Use when running a single-cell CRISPR screen, choosing direct-capture vs CROP-seq architecture, filtering escaper cells, performing single-cell DE, integrating Perturb-seq with pathway analysis, scaling to GW CRISPRi via Replogle protocol, or analyzing multi-omics screens.

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Align preprocessed CLIP-seq reads (eCLIP, iCLIP, iCLIP2, PAR-CLIP) to genome with STAR or bowtie2 using crosslink-preserving parameters, choosing between unique-mapper-only and multi-mapper-aware alignment for repeat-binding RBPs, deciding STAR vs HISAT2 memory trade-offs, and applying ENCODE-compatible filters. Use when turning preprocessed CLIP FASTQ into a deduplicated, MAPQ-filtered BAM ready for peak calling or crosslink-site detection.

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Annotate copy number variant segments with overlapping genes, dosage-sensitivity scores, cancer driver databases, population frequencies, and clinical-variant content. Covers bedtools/pybedtools interval intersection, AnnotSV comprehensive annotation and ranking, ClinGen haploinsufficiency/triplosensitivity scoring, gnomAD-SV/DGV frequency filtering, COSMIC Cancer Gene Census, and ClinVar overlap. Use when interpreting which genes a CNV affects, distinguishing the driver gene of a focal event from passengers, filtering against population CNVs, separating whole-gene from partial-gene overlap, or preparing CNVs for clinical classification.

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Call copy number variants with the GATK best-practices workflows — the somatic CNV pipeline (CollectReadCounts, DenoiseReadCounts with tangent normalization, ModelSegments, CallCopyRatioSegments) and the germline GATK-gCNV pipeline (DetermineGermlineContigPloidy, GermlineCNVCaller cohort/case mode, PostprocessGermlineCNVCalls). Covers panel-of-normals construction, AnnotateIntervals/FilterIntervals, allelic-count integration, and QS-based filtering. Use when integrating CNV calling into a GATK variant pipeline, calling rare germline CNVs from an exome cohort, deciding between the somatic and germline GATK workflows, or diagnosing why tangent normalization removed a real event or why gCNV output has low precision.

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Searches molecular libraries for substructure matches using SMARTS patterns with explicit handling of recursive SMARTS, ring membership, aromaticity dialect, vector binding, atom map indices, and reactive/PAINS/REOS/Brenk filter catalogs. Use when filtering compounds by pharmacophore features, functional groups, scaffold matches, or screening for assay-interference / structural alerts.

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Predicts ADMET properties using ADMETlab 3.0 (119 platform features, including 77 prediction models with modeled-endpoint uncertainty), ADMET-AI, DeepChem MolNet, and chemprop D-MPNN with explicit handling of OECD QSAR principles, applicability domain assessment, calibration, hERG/CYP/AMES endpoints, and PAINS / Lipinski / Ro5 / Veber / BBB druglikeness filters. Use when filtering compounds for drug-likeness, prioritizing leads by predicted safety, or building an in-house ADMET QSAR model.

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Filter alignments by flags, mapping quality, and regions using samtools view and pysam. Use when extracting specific reads, removing low-quality alignments, or subsetting to target regions.

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Generate read-only MongoDB queries (find) or aggregation pipelines using natural language, with collection schema context and sample documents. Use this skill whenever the user asks to write, create, or generate MongoDB queries, wants to filter/query/aggregate data in MongoDB, asks "how do I query...", needs help with query syntax, or discusses finding/filtering/grouping MongoDB documents. Also use for translating SQL-like requests to MongoDB syntax. Does NOT handle Atlas Search ($search operator), vector/semantic search ($vectorSearch operator), fuzzy matching, autocomplete indexes, or relevance scoring - use search-and-ai for those. Does NOT analyze or optimize existing queries - use mongodb-query-optimizer for that. Does NOT handle aggregation pipelines that involve write operations. Requires MongoDB MCP server.

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Model a Phase-Locked Loop (PLL) IC from its datasheet or system specs using Mixed-Signal Blockset. Without this skill, agents universally select the wrong solver and produce non-functional PLL models — 100% of unguided attempts fail. Covers Integer-N, Fractional-N, Dual Modulus architectures, loop filter design, lock time optimization, VCO phase noise configuration, and msbPllArchitectures/msbPllFoundation block assembly. Use when: PLL modeling, frequency synthesizer design, phase noise simulation, lock time analysis, charge pump design, loop filter tuning, datasheet-to-model, Mixed-Signal Blockset PLL, msbPllArchitectures.

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Spiral inductors, interdigital capacitors, baluns, resonators, phase shifters for impedance matching, DC blocking, and bias tees. TRIGGER: user asks to design or create a spiral inductor, interdigital capacitor, balun, resonator, phase shifter, or other passive RF component. Invoke BEFORE writing code — class names and property patterns are non-obvious. SKIP: filter design (use matlab-design-pcb-filter), coupler/splitter design (use matlab-design-pcb-coupler), transmission line design (use matlab-design-pcb-transmission-line), EM analysis (use matlab-analyze-em), material setup only (use matlab-manage-pcb-material).

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RF Toolbox and RF Blockset in MATLAB -- S-parameter I/O, network conversions (S/Z/Y/ABCD/T/H/G, mixed-mode), cascade/de-embedding, rfbudget analysis, circuit composition, matching networks, amplifier stability, mixer spurs, rational fitting, SI channels, baseband processing, Circuit Envelope simulation. Trigger: sparameters, Touchstone, .s2p, .s4p, rfplot, smithplot, rfparam, rfwrite, zparameters, yparameters, abcdparameters, s2sdd, cascadesparams, deembedsparams, rfbudget, noise figure, OIP3, IIP3, amplifier, modulator, nport, rffilter, attenuator, seriesRLC, shuntRLC, lcladder, txline, circuit, setports, clone, matchingnetwork, stabilityk, stabilitymu, powergain, gammams, gammaml, mixerIMT, OpenIF, rational, rationalfit, stepresp, txlineWRLGC, rf.Amplifier, rf.Mixer, rf.Filter, rf.Sparameter, rfsystem, RF Blockset.

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Perform time-frequency analysis in MATLAB using CWT, STFT, synchrosqueezing, reassignment, wavelet coherence, cross spectrogram, EMD/VMD, multiresolution analysis, and time-frequency filtering. Triggers on: time-frequency, spectrogram, scalogram, cwt, stft, istft, fsst, wsst, wcoherence, xspectrogram, modwt, modwtmra, modwpt, emd, vmd, hht, tffilt, dgt, gabor, instantaneous frequency, synchrosqueezing, reassignment, ridge extraction, wavelet coherence, cross spectrum, mode decomposition, signal decomposition, time-frequency filtering.

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Run MATLAB test suites and analyze results, including test filtering, parallel execution, result diagnostics, code coverage collection, gap analysis, and CI/CD with buildtool. Use when running tests, filtering test suites, analyzing test failures, checking, collecting, or analyzing coverage, justifying uncovered code, or configuring CI pipelines. Do NOT use for writing, generating, or structuring tests. Do NOT use for Simulink coverage or Simulink testing workflows.

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Connect MATLAB to Databricks via Spark (Databricks Connect) or JDBC (Database Toolbox). Use when setting up the MATLAB Interface for Databricks, configuring authentication (OauthU2M, OauthM2M, PAT), creating Spark sessions with getDatabricksSession(), reading Unity Catalog tables with server-side filtering, creating JDBC connections with databricks.JDBCConnection or StandaloneJDBCConnection, connecting to SQL Warehouses, selecting JDBC drivers (Simba/OSS), or writing data back to Databricks. Triggers on: Databricks Connect, Spark from MATLAB, getDatabricksSession, .databrickscfg, databricks.JDBCConnection, StandaloneJDBCConnection, SQLWarehouse, Databricks JDBC, Databricks cluster, large table server-side filtering.

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Perform advanced search on CNKI with field filters like author, title, journal, date range, source category (SCI/EI/CSSCI/北大核心). Use when user needs precise filtered search beyond simple keywords.

日本語の概要は準備中です。原文の説明を表示しています。

Some basic functions for filtering genes.

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Turns one customer case study into the tightest list of companies that would read that case study and see themselves. Decomposes WHY the case-study company resonates into concrete attributes, translates those attributes into database filters, intersects them with a lookalike anchor, then widens with a model judge. Triggers on "find more companies like our best customer", "who would our case study land with", "lookalikes of X", "build a list around this case study", "companies like our happiest client", "expand this list, it is too small". Outputs a filter set plus one merge field naming which case study to cite.

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Expand a hard-to-build niche list from ~10 known-good seed companies into a full qualified TAM. Seed fingerprinting (how do good-fit companies ACTUALLY show up in the company database's filters) → lookalike generation (Prospeo company_lookalike, Exa findSimilar, Parallel.ai entity search) → filter mining with a precision/volume scorecard → wide pull with auto-sharding → cheap-AI qualification → live-website verification → client transparency report. Use when a vertical list feels "too small" (medical groups, hedge funds, Medicare brokerages), when known good-fit companies don't show up in keyword searches, or when someone says "expand this list", "the TAM should be bigger", "find more companies like these".

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Rewrites scene descriptions using professional cinematography language, structures prompts with a six-slot formula (camera + subject + action + setting + style + lighting), and diagnoses content filter rejections via a preflight linter. Use whenever the user asks for a Seedance 2.0 / Seedance Pro prompt, describes a scene for Seedance generation, mentions Seedance, reports a Seedance generation failure or flagged prompt, or is burning credits on Seedance regenerations.

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Performs quality control on single-cell RNA-seq data (.h5ad or .h5 files) using scverse best practices with MAD-based filtering and comprehensive visualizations. Use when users request QC analysis, filtering low-quality cells, assessing data quality, or following scverse/scanpy best practices for single-cell analysis.

日本語の概要は準備中です。原文の説明を表示しています。

Implement Global Exception Filters and standard error formats in NestJS. Use when implementing global exception filters or standardizing error responses in NestJS.

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Enforce "No Exploit, No Report" policy with PoC construction standards, false-positive filtering, and evidence collection per vulnerability class across backend, frontend, and mobile. Use when validating security findings, constructing exploit proofs, filtering false positives, or writing pentest findings.

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Identify a .NET project's test platform, framework, command mode, and SDK-style vs classic project system. Use only for "which test platform/framework?", "VSTest or MTP?", or "what runner does this project use?", including bridge settings, UseVSTest opt-outs, and incompatible or conflicting VSTest/MTP configuration. Resolves global.json, project, packages.config, Directory.Build.props, and Directory.Packages.props precedence for MSTest/xUnit/NUnit/TUnit. DO NOT USE when the user asks to run/filter tests or for commands, flags, TRX/dumps, or test-command/filter errors; use run-tests directly. Do not route hot-reload or migration requests here as the entry skill; mtp-hot-reload may use this skill internally for platform detection.

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Set up or recover MTP hot reload for a long-lived console-host edit/re-run loop in a Microsoft Testing Platform project. Use for explicit MTP console requests such as "enable hot reload", "dotnet run to rerun on edit", or unsupported/rude edits. Covers setup, run/watch, restarts, filters, and the VSTest no-mutation fallback. For one-time runs, exact commands, filter errors, TRX/dumps, or merely a failing test, use run-tests. Do not use when Test Explorer or an IDE should rerun tests without an MTP console host. Excludes editor integration, CI, and writing/debugging tests.

日本語の概要は準備中です。原文の説明を表示しています。