540 件 ・ 関連度順
概要と使いどころ
Preprocesses cell-free DNA sequencing data including adapter trimming, alignment optimized for short fragments, and UMI-aware duplicate removal using fgbio. Applies cfDNA-specific quality thresholds and fragment length filtering. Use when processing plasma cfDNA sequencing data before downstream analysis.
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Query gnomAD for population allele frequencies to assess variant rarity. Use when filtering variants by population frequency for rare disease analysis or determining if a variant is common in the general population.
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Screen US stocks for high-quality dividend opportunities combining value characteristics (P/E ratio under 20, P/B ratio under 2), attractive yields (3% or higher), and consistent growth (dividend/revenue/EPS trending up over 3 years). Supports two-stage screening using FINVIZ Elite API for efficient pre-filtering followed by FMP API for detailed analysis. Use when user requests dividend stock screening, income portfolio ideas, or quality value stocks with strong fundamentals.
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Routes AWS networking requests to the correct service skill for implementation. Covers Route 53 (DNS, health checks, routing policies, Resolver, DNS Firewall), CloudFront (caching, edge, OAC, mTLS, signed URLs), Transit Gateway (multi-VPC hub, segmentation, centralized egress), Direct Connect (hybrid link, DX Gateway, MACsec), Site-to-Site VPN (IPsec tunnels, static or BGP), WAF (web ACLs, AWS Managed Rules, rate-based rules, Bot and Fraud Control), and Shield Advanced (L3/L4 DDoS). Applicable when creating, configuring, troubleshooting, or designing across these services, choosing between them, or diagnosing connectivity or traffic-filtering issues. Not for VPC subnets and route tables, load balancers, VPC endpoints, PrivateLink, API Gateway, IAM policy logic, container or serverless networking, or IaC authoring.
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SQL injection playbook. Use when input reaches SQL queries, authentication logic, sorting, filtering, reporting, or DB-specific blind and out-of-band execution paths.
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Process multimedia files with FFmpeg (video/audio encoding, conversion, streaming, filtering, hardware acceleration) and ImageMagick (image manipulation, format conversion, batch processing, effects, composition). Use when converting media formats, encoding videos with specific codecs (H.264, H.265, VP9), resizing/cropping images, extracting audio from video, applying filters and effects, optimizing file sizes, creating streaming manifests (HLS/DASH), generating thumbnails, batch processing images, creating composite images, or implementing media processing pipelines. Supports 100+ formats, hardware acceleration (NVENC, QSV), and complex filtergraphs.
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Run inference on Fireworks AI — direct, through the Leanmcp AI Gateway proxy (aigateway.leanmcp.com) for observability, or via LiteLLM / the OpenAI SDK / raw HTTP. Covers the endpoint-and-key matrix for each route, serverless vs dedicated deployments and their cold starts, browsing and filtering the model catalogue, reasoning models that return content:null with the answer in reasoning_content, function calling, concurrency and load testing, and runner scripts where many models share one protocol with a --use-proxy toggle. Use this skill whenever the user mentions Fireworks, FIREWORKS_API_KEY, api.fireworks.ai, fireworks_ai/ model ids, accounts/fireworks/models/..., a Fireworks deployment id, the Leanmcp gateway or LEANMCP_API_KEY, app.leanmcp.com observability, or gpt-oss / kimi / glm / qwen / deepseek served on Fireworks; wants to route LLM calls through a proxy for logging or cost tracking; is debugging empty responses, 404s, scope errors, cold starts, or "the gateway isn't working"; wants to pick a Fireworks model with tool calling; or wants to sweep several models over one benchmark. Reach for it even on vague asks like "why is this model returning nothing" or "set up inference for these models" when Fireworks is in play.
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Process, clean, and compare mass spectrometry (MS/MS) spectra with Matchms; use when you need reproducible spectral filtering and similarity scoring for metabolomics workflows.
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Detect and correct for horizontal pleiotropy in Mendelian randomization analyses using MR-PRESSO for outlier removal, MR-Egger regression for directional pleiotropy, and Steiger filtering for variant directionality. Use when validating MR results, detecting pleiotropic instrum...
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Sequence alignment and alignment file processing with Biopython (Bio.Align/Bio.AlignIO), triggered when you need global/local pairwise alignment, MSA read/write/format conversion, or alignment statistics/filtering.
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Generates complete FAERS-style pharmacovigilance disproportionality research designs from a user-provided drug class, comparator strategy, adverse-event domain, and patient-group stratification. Always use this skill whenever a user wants to design, plan, or build a spontaneous-report safety signal study using FAERS or a similar pharmacovigilance database, especially when the article logic includes product selection, indication-group stratification, MedDRA-based adverse-event extraction, serious-case filtering, suspect-drug and concomitant-exclusion logic, reporting odds ratio analysis, comparator-drug benchmarking, cross-drug comparison, and cautious signal interpretation without causal overclaiming. Covers five study patterns (single-drug disproportionality workflow, multi-drug class comparison workflow, indication-stratified workflow, comparator-controlled signal screening workflow...
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Generates complete conventional oncology bulk-transcriptome biomarker and hub-gene research designs from a user-provided cancer type and study direction. Always use this skill whenever a user wants to design, plan, or build a tumor bioinformatics study centered on differential expression, prognostic filtering or risk modeling, PPI-based hub-gene prioritization, diagnostic/prognostic evaluation, clinical association, immune infiltration context, methylation context, and optional tissue or cell validation. Covers five study patterns (signature-first prognostic workflow, hub-gene-first biomarker workflow, hybrid signature-to-hub workflow, immune-context biomarker workflow, translational validation workflow) and always outputs four workload configs (Lite / Standard / Advanced / Publication+) with recommended primary plan, step-by-step workflow, figure plan, validation strategy, minimal executable version, publication upgrade path...
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Generates complete bidirectional multi-phenotype Mendelian randomization research designs from a user-provided exposure family and outcome family. Always use this skill whenever a user wants to design, plan, or build a genome-wide causal-inference study based on publicly available GWAS summary statistics, especially when the article logic includes multiple exposures, multiple outcomes or subtypes, bidirectional MR, IV filtering, IVW as the main estimator, weighted median / MR-Egger / MR-PRESSO sensitivity analyses, leave-one-out testing, heterogeneity / pleiotropy checks, and multiple-testing control with FDR. Covers five study patterns (single-family bidirectional MR, multi-phenotype screening MR, subtype-resolved MR, phenome-style bidirectional causal map, mechanism-prioritized MR follow-up) and always outputs four workload configs (Lite / Standard / Advanced / Publication+) with recommended primary plan, step-by-step workflow, figure plan, validation strategy, minimal executable version...
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Use when building a weighted gene co-expression network from a bulk expression matrix and a sample group file, filtering variable genes by MAD, identifying co-expression modules with WGCNA, correlating modules with traits, and exporting module-level plots and gene tables. NOT for single-cell RNA-seq, differential expression testing, methylation analysis, or datasets that are too small for WGCNA after quality control.
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Use when filtering genes with high missingness and then imputing missing values in a bulk expression matrix with group-aware KNN through DMwR2, where donor samples are restricted by one annotation column before imputation. For strata with 10 or fewer samples, the script falls back to row-wise direct filling with mean or median. NOT for: single-cell data, multi-column stratification, non-tabular inputs, network access, or interactive workflows.
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Analyze geospatial data using geopandas with proper coordinate projections. Use when calculating distances between geographic features, performing spatial filtering, or working with plate boundaries and earthquake data.
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Detect speech segments in audio using VAD tools like Silero VAD, SpeechBrain VAD, or WebRTC VAD. Use when preprocessing audio for speaker diarization, filtering silence, or segmenting audio into speech chunks. Choose Silero VAD for short segments, SpeechBrain VAD for general purpose, or WebRTC VAD for lightweight applications.
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Cross-encoder reranking and MMR diversity filtering for improved retrieval quality
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Qdrant vector database with filtering, payloads, and quantization support
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Expert web researcher using advanced search techniques and synthesis. Masters search operators, result filtering, and multi-source verification. Handles competitive analysis and fact-checking. Use PROACTIVELY for deep research, information gathering, or trend analysis.
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Generates PR reference XML with commit history and unified diffs between branches, with extension and path filtering. Use when creating pull request descriptions, preparing code reviews, analyzing branch changes, discovering work items from diffs, or generating structured diff summaries.
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Keep Claude Code sessions productive across resets with output filtering, session logging, and auto-resume. Use when starting a long or complex coding session, when previous sessions lost context mid-task, or when you need Claude to resume exactly where it left off after a reset. Produces a session.log at the project root, filtered command output that preserves context, and automatic resume of in-progress tasks after any reset.
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EMC pre-compliance risk analysis for KiCad PCB designs — 18 check categories, 44 rule IDs covering ground planes, decoupling, I/O filtering, switching harmonics, clock routing, differential pair skew, board edge radiation, PDN impedance, return paths, crosstalk, ESD protection, shielding, and magnetic leakage from switching inductors. Produces severity-ranked risk report with pre-compliance test plan. Supports FCC Part 15, CISPR 32, CISPR 25 (automotive), MIL-STD-461G. SPICE-enhanced when available. Use when the user asks about EMC, EMI, radiated/conducted emissions, FCC compliance, CE marking, CISPR, ground plane issues, decoupling strategy, clock routing EMC, switching noise, differential pair skew, or whether their board will pass EMC testing. Also for "will this pass FCC?", "check my EMC", "is my ground plane okay?", "check my decoupling", or "generate an EMC test plan".
日本語の概要は準備中です。原文の説明を表示しています。
REST API design patterns including resource naming, status codes, pagination, filtering, error responses, versioning, and rate limiting for production APIs.
日本語の概要は準備中です。原文の説明を表示しています。