632 件 ・ 関連度順
概要と使いどころ
AI DevKit · Test-driven development — write a failing test before writing production code. Use when implementing new functionality, adding behavior, or fixing bugs during active development.
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Upgrade an existing website or app to premium quality without breaking functionality — audit the current design, identify generic/AI tells, then apply taste and system rules surgically. Use when the user wants to improve, modernize, polish, or "make better" an existing UI/codebase.
日本語の概要は準備中です。原文の説明を表示しています。
Read-only PRD-to-work-item hierarchy planning. Use to turn a PRD into a validated Azure DevOps, GitHub, or Jira handoff.
日本語の概要は準備中です。原文の説明を表示しています。
Help users navigate the path from junior product manager to executive leadership by focusing on ownership, cross-functional influence, and intentional career design.
日本語の概要は準備中です。原文の説明を表示しています。
Help users design high-performing product and engineering organizations by choosing the right reporting models, team sizes, and cross-functional partnerships. It focuses on reducing friction and maximizing ownership through structural clarity.
日本語の概要は準備中です。原文の説明を表示しています。
Help users build functional product prototypes from natural language or visual mocks using AI coding tools. This skill enables product leaders to bypass engineering bottlenecks and validate ideas through hands-on building.
日本語の概要は準備中です。原文の説明を表示しています。
Use when deciding whether a materials result clears Advanced Materials' advance-and-broad-impact gate, or whether it belongs in Advanced Functional Materials, Advanced Science, Small, or Advanced Materials Interfaces. Diagnoses venue fit; does not write or characterize the material.
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Use when packaging ACM CCS artifacts for the artifact-evaluation committee and the ACM badges — Artifacts Available, Artifacts Evaluated Functional, Artifacts Evaluated Reusable, and Results Reproduced — covering what security evaluators inspect, how to make attacks and defenses turnkey, and how to justify withheld artifacts.
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Write modern, high-performance C# code using records, pattern matching, value objects, async/await, Span<T>/Memory<T>, and best-practice API design patterns. Emphasizes functional-style programming with C# 12+ features.
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Assign cell types from marker expression in IMC/MIBI data using clustering (PhenoGraph/FlowSOM/Leiden/Pixie), marker-based probabilistic classifiers (Astir), or image-context CNNs (CellSighter), covering the double-positive segmentation artifact, lineage-vs-state markers, the two spillover types, and why a "cell type" in imaging is conditioned on a segmentation guess. Use when phenotyping segmented IMC cells, choosing clustering vs classification, diagnosing implausible double-positive populations, separating lineage from functional markers, or transferring labels across a cohort.
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Quantifies biodiversity from species abundance/incidence tables using Hill numbers (iNEXT) with coverage-based rarefaction-extrapolation (Chao & Jost 2012), asymptotic richness via Chao1/ACE/jackknife as a lower bound, Baselga turnover/nestedness partition with the Podani alternative as sensitivity check, mandatory Hellinger transformation before ordination (Legendre & Gallagher 2001), Faith PD and SES_MPD/SES_MNTD with explicit null-model choice, and Maire 2015 functional-diversity dimensionality optimization. Use when comparing diversity across sites with unequal sampling effort, picking the right richness estimator for singleton-heavy amplicon data, partitioning beta diversity into turnover vs nestedness, reporting Hill-number effective species counts rather than raw entropies, computing SES_MPD with explicit null-model justification, or deciding whether to apply standard metrics to compositional amplicon data. Not for clinical 16S microbiome diversity (see microbiome/diversity-analysis).
日本語の概要は準備中です。原文の説明を表示しています。
Query protein-protein and gene interaction databases (STRING, BioGRID, IntAct, SIGNOR, Reactome, HuRI, HuMAP, OmniPath, ConsensusPathDB, DIP). Use when building PPI networks, choosing between physical vs functional vs genetic interactions, signed/directed vs undirected, high-throughput vs curated, picking confidence thresholds, aggregating across resources, or navigating license constraints. Encodes the database decision matrix, STRING v12 channel semantics, OmniPath as meta-database, SIGNOR for signed signaling, and per-resource rate limits.
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Model gene-family birth-death dynamics across a species tree using CAFE5 (Mendes et al 2020 Bioinformatics 36:5516 gamma-distributed rate categories), CAFE5-error (annotation-error-aware), Count (Csurös 2010 ancestral state reconstruction), BadiRate (Librado 2012 likelihood + parsimony), DupliPHY-Family, and ALE/AleRax (for per-family DTL; see [[gene-tree-species-tree-reconciliation]]). Test lineage-specific gene-family expansions and contractions, distinguish biological dynamics from annotation artifacts, account for assembly fragmentation, identify functional enrichment in expanded / contracted families. Use when correlating gene-family changes with phenotype evolution, ranking lineages by adaptive gene-family-rate shifts, post-WGD dosage-balance analysis, or building Birth-death models from OrthoFinder presence/absence matrices.
日本語の概要は準備中です。原文の説明を表示しています。
Infer orthologous genes and gene families across species using OrthoFinder3 (HOG-based phylogenetic orthology), SonicParanoid2, Broccoli, ProteinOrtho, OMA / FastOMA hierarchical orthologous groups, eggNOG-mapper, JustOrthologs, and TOGA whole-genome-alignment orthology. Use when building single-copy ortholog sets for phylogenomics, classifying co-orthologs and in/out-paralogs after gene duplication, propagating functional annotation via orthology with awareness of the ortholog conjecture, distinguishing speciation from duplication via gene-tree species-tree reconciliation, computing Quest-for-Orthologs benchmark performance, or running synteny-aware ortholog detection in WGD-affected lineages.
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Analyzes base-editing screens for variant function. Covers library design (Hanna 2021 ClinVar-scale CBE screen benchmarked on BRCA1/2, Cuella-Martin 2021 DDR saturation), CBE vs ABE chemistry choice (BE3/BE4 vs ABE7.10/ABE8.20/ABE8e), editing-window math (positions 4-8 from PAM-distal end; 4-7 for ABE7.10), bystander-edit quantification and the variant-call ambiguity it creates, sgRNA-efficiency filtering before hit calling, indel byproduct interpretation, the substitution-vs-indel diagnostic, variant annotation against ClinVar / COSMIC, and the Broad be-validation-pipeline. Use when designing a BE variant screen, choosing CBE vs ABE for a specific edit, interpreting bystander-confounded hits, distinguishing functional signal from indel artifact, integrating CRISPResso2 output with screen scoring, or deciding BE vs PE for SNV installation.
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Searches molecular libraries for substructure matches using SMARTS patterns with explicit handling of recursive SMARTS, ring membership, aromaticity dialect, vector binding, atom map indices, and reactive/PAINS/REOS/Brenk filter catalogs. Use when filtering compounds by pharmacophore features, functional groups, scaffold matches, or screening for assay-interference / structural alerts.
日本語の概要は準備中です。原文の説明を表示しています。
Resolves GWAS associations to candidate causal variants and credible sets via SuSiE, susie_rss, FINEMAP, CAVIAR, DAP-G, PAINTOR, PolyFun, SuSiEx, MultiSuSiE, and FOCUS. Use when narrowing a GWAS lead SNP to a 95 percent credible set, choosing between in-sample and reference LD, calibrating non-sparse loci with SuSiE-inf or FINEMAP-inf, integrating functional priors via PolyFun, fine-mapping across ancestries with SuSiEx, diagnosing LD mismatch via estimate_s_rss and kriging_rss, handling HLA or long-range LD, or feeding credible sets into coloc.susie for colocalization.
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Analyzes differential transcript usage (DTU) and isoform switches with functional consequence prediction (NMD via 50nt rule, ORF disruption, protein domain loss/gain, signal peptide changes, IDR alterations, coding-potential shifts). Tools include IsoformSwitchAnalyzeR v2 (auto-selects satuRn for >5 reps else DEXSeq), the manual DRIMSeq -> DEXSeq/satuRn -> stageR DTU pipeline, and fishpond/swish for inferential-uncertainty-aware DTE. Distinguishes DTU from DGE and DTE; integrates external annotators (CPC2, Pfam, SignalP, IUPred2A or DeepTMHMM). Use when investigating how splicing differences alter protein function or trigger NMD-mediated degradation.
日本語の概要は準備中です。原文の説明を表示しています。
Guides MongoDB users through implementing and optimizing Atlas Search (full-text), Vector Search (semantic), and Hybrid Search solutions. Use this skill when users need to build search functionality for text-based queries (autocomplete, fuzzy matching, faceted search), semantic similarity (embeddings, RAG applications), or combined approaches. Also use when users need text containment, substring matching ('contains', 'includes', 'appears in'), case-insensitive or multi-field text search, or filtering across many fields with variable combinations. Provides workflows for selecting the right search type, creating indexes, constructing queries, and optimizing performance using the MongoDB MCP server.
日本語の概要は準備中です。原文の説明を表示しています。
Deploy and manage the ELK Stack (Elasticsearch, Logstash, Kibana) for log aggregation and analysis. Configure log pipelines, create visualizations, and implement log-based monitoring. Use when centralizing logs, implementing search functionality, or building log analytics platforms.
日本語の概要は準備中です。原文の説明を表示しています。
Model a Phase-Locked Loop (PLL) IC from its datasheet or system specs using Mixed-Signal Blockset. Without this skill, agents universally select the wrong solver and produce non-functional PLL models — 100% of unguided attempts fail. Covers Integer-N, Fractional-N, Dual Modulus architectures, loop filter design, lock time optimization, VCO phase noise configuration, and msbPllArchitectures/msbPllFoundation block assembly. Use when: PLL modeling, frequency synthesizer design, phase noise simulation, lock time analysis, charge pump design, loop filter tuning, datasheet-to-model, Mixed-Signal Blockset PLL, msbPllArchitectures.
日本語の概要は準備中です。原文の説明を表示しています。
Translate NI-DAQmx C function signatures into correct calldaqlib MATLAB calls. Use when the user mentions calldaqlib, any DAQmx* C function name (DAQmxCfgSampClkTiming, DAQmxExportSignal, DAQmxSetStartTrigRetriggerable, DAQmxGetSampClkRate, etc.), or needs NI-DAQmx functionality not exposed by the daq object. Covers: projection rules (taskHandle implicit, output pointers become return values, buffer-size args, enum-as-string), multi-task semantics, start() clobber, device-level empty-daq workaround, dictionary returns, string getter placeholder, array getter placeholder. Trigger contexts: low-level DAQ, escape hatch, retriggerable acquisition, shared timebase, export signal, connect terminals, external sample clock, trigger configuration, NI driver, C function translation.
日本語の概要は準備中です。原文の説明を表示しています。
Implement a feature safely end-to-end in this repository. Use when adding or changing functionality across backend, frontend, or MCP with required verification and documentation updates.
日本語の概要は準備中です。原文の説明を表示しています。
Simplifies and refines code for clarity, consistency, and maintainability while preserving all functionality. Use when asked to "simplify code", "clean up code", "refactor for clarity", "improve readability", or review recently modified code for elegance. Focuses on project-specific best practices.
日本語の概要は準備中です。原文の説明を表示しています。