「osm」の検索結果

Annotate copy number variant segments with overlapping genes, dosage-sensitivity scores, cancer driver databases, population frequencies, and clinical-variant content. Covers bedtools/pybedtools interval intersection, AnnotSV comprehensive annotation and ranking, ClinGen haploinsufficiency/triplosensitivity scoring, gnomAD-SV/DGV frequency filtering, COSMIC Cancer Gene Census, and ClinVar overlap. Use when interpreting which genes a CNV affects, distinguishing the driver gene of a focal event from passengers, filtering against population CNVs, separating whole-gene from partial-gene overlap, or preparing CNVs for clinical classification.

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Identify recurrent and driver copy number alterations across a tumor cohort with GISTIC2 (G-score, Ziggurat deconstruction, focal vs broad/arm-level analysis, q-values from permutation) and quantify copy-number signatures with the Steele 2022 COSMIC framework and the Drews 2022 CINSignatures framework. Covers driver-gene localization from recurrence peaks, distinguishing focal drivers from arm-level passengers, and the caller-sensitivity caveats of copy-number signatures. Use when finding recurrently amplified or deleted regions in a cohort, localizing driver genes, separating focal from broad events, running GISTIC2, or extracting copy-number mutational signatures.

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Extracts and assigns COSMIC v3.4 mutational signatures (86 SBS / 11 DBS / 18 ID / 21 CN / 16 SV) from somatic VCFs using SigProfilerSuite, MutationalPatterns, MuSiCal mvNMF, SigNet, or HRDetect. Use when characterizing DNA-damage etiology (BRCA1/2 HRD, MMR-D, POLE, APOBEC3A, UV, tobacco, aflatoxin, 5-FU/SBS17b, platinum, colibactin SBS88), routing PARP inhibitor decisions, or auditing de novo extraction vs refit choice for cohort size.

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Queries myvariant.info BioThings aggregator for ClinVar, gnomAD, dbSNP, dbNSFP, COSMIC, CADD, and CIViC annotations in batched, version-tracked requests. Use when annotating variant lists from multiple databases simultaneously without managing per-source APIs, and when reproducibility-grade analyses require recording source data versions via _meta.

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This skill should be used when user asks to "query Azure resources", "list storage accounts", "manage Key Vault secrets", "work with Cosmos DB", "check AKS clusters", "use Azure MCP", or interact with any Azure service.

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Provision Azure SQL Database and Cosmos DB. Configure security, backups, and replication. Use when deploying managed databases on Azure.

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Convert Lanelet2 maps (.osm) to RoadRunner HD Map (.rrhd) format using MATLAB. Use when converting Lanelet2 maps into RoadRunner Scene Builder, building driving scenes from open-source map data, or transforming road network definitions for simulation.

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A slow drifting starfield — a calm cosmic backdrop. A bold, canvas-based effect from Open Design's html-ppt fx pack — for slides and launch videos. Guards prefers-reduced-motion (does not start). One per screen; on web use sparingly.

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Anime/illustration text-to-image (ANIMA 1.0, ~2B Cosmos DiT). Use for anime, manga, illustrated characters; accepts Danbooru tags + natural language; runs/trains on <6GB VRAM; includes anime inpainting via Anima-LLLite ControlNet

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Maps intelligence for local SEO — geo-grid rank tracking, GBP profile auditing via API, review intelligence across Google/Tripadvisor/Trustpilot, cross-platform NAP verification (Google/Bing/Apple/OSM), competitor radius mapping, and LocalBusiness schema generation from API data. Three-tier capability: free (Overpass + Geoapify), DataForSEO (full intelligence), DataForSEO + Google (maximum coverage). Use when user says "maps", "geo-grid", "rank tracking", "GBP audit", "review velocity", "competitor radius", "maps analysis", "local rank tracking", "Share of Local Voice", or "SoLV".

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Expert knowledge for Azure Synapse Analytics development including troubleshooting, best practices, decision making, architecture & design patterns, limits & quotas, security, configuration, integrations & coding patterns, and deployment. Use when designing Synapse workspaces, SQL/dedicated pools, serverless SQL, Spark pools, or Synapse Link for Cosmos DB, and other Azure Synapse Analytics related development tasks. Not for Azure Data Factory (use azure-data-factory), Azure Data Explorer (use azure-data-explorer), Azure Databricks (use azure-databricks), Azure HDInsight (use azure-hdinsight).

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Expert knowledge for Azure Stream Analytics development including troubleshooting, best practices, decision making, architecture & design patterns, limits & quotas, security, configuration, integrations & coding patterns, and deployment. Use when building ASA jobs with Event Hubs/Kafka, Cosmos/SQL outputs, ML/UDF queries, autoscale, or IoT Edge clusters, and other Azure Stream Analytics related development tasks. Not for Azure Synapse Analytics (use azure-synapse-analytics), Azure Data Factory (use azure-data-factory), Azure Event Hubs (use azure-event-hubs), Azure Functions (use azure-functions).

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Expert knowledge for Azure IoT Hub development including troubleshooting, best practices, decision making, architecture & design patterns, limits & quotas, security, configuration, integrations & coding patterns, and deployment. Use when configuring IoT Hub/DPS routing, device twins, MQTT/AMQP clients, Device Update, or Cosmos DB event storage, and other Azure IoT Hub related development tasks. Not for Azure IoT (use azure-iot), Azure IoT Central (use azure-iot-central), Azure IoT Edge (use azure-iot-edge), Azure IoT Operations (use azure-iot-operations).

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Expert knowledge for Azure Copilot development including troubleshooting, decision making, architecture & design patterns, security, configuration, and integrations & coding patterns. Use when sizing VMs, generating Bicep/Terraform, configuring Cosmos DB chat storage, or designing Azure networks, and other Azure Copilot related development tasks. Not for Azure Portal (use azure-portal), Azure Machine Learning (use azure-machine-learning), Azure DevOps (use azure-devops), Microsoft Foundry (use microsoft-foundry).

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Expert knowledge for Azure Confidential Ledger development including troubleshooting, decision making, security, integrations & coding patterns, and deployment. Use when configuring ACL auth/attestation, integrating with Blob/Cosmos, using MST payloads, or deploying via ARM/Terraform, and other Azure Confidential Ledger related development tasks. Not for Azure Confidential Computing (use azure-confidential-computing), Azure Key Vault (use azure-key-vault), Azure Dedicated HSM (use azure-dedicated-hsm), Azure Payment Hsm (use azure-payment-hsm).

日本語の概要は準備中です。原文の説明を表示しています。

Azure Functions, Cosmos DB modeling, Service Bus patterns, Bicep templates

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Migrate a .NET 10 project or solution to .NET 11 and resolve all breaking changes. This is a MIGRATION skill — use it when upgrading from .NET 10 to .NET 11, NOT for writing new programs. USE FOR: upgrading TargetFramework from net10.0 to net11.0, fixing build errors after updating the .NET 11 SDK, resolving source-breaking and behavioral changes in .NET 11 runtime, C# 15 compiler, and EF Core 11, adapting to updated minimum hardware requirements (x86-64-v2, Arm64 LSE), and updating CI/CD pipelines and Dockerfiles for .NET 11. DO NOT USE FOR: .NET Framework migrations, upgrading from .NET 9 or earlier, greenfield .NET 11 projects, or cosmetic modernization unrelated to the upgrade. NOTE: .NET 11 is in preview. Covers breaking changes through Preview 3.

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Migrate a .NET 9 project or solution to .NET 10 and resolve all breaking changes. USE FOR: upgrading TargetFramework from net9.0 to net10.0, fixing build errors after updating the .NET 10 SDK, resolving source and behavioral changes in .NET 10 / C# 14 / ASP.NET Core 10 / EF Core 10, updating Dockerfiles for Debian-to-Ubuntu base images, resolving obsoletion warnings (SYSLIB0058-SYSLIB0062), adapting to SDK/NuGet changes (NU1510, PrunePackageReference), migrating System.Linq.Async to built-in AsyncEnumerable, fixing OpenApi v2 API changes, cryptography renames, and C# 14 compiler changes (field keyword, extension keyword, span overloads). DO NOT USE FOR: .NET Framework migrations, upgrading from .NET 8 or earlier (use migrate-dotnet8-to-dotnet9 first), greenfield .NET 10 projects, or cosmetic modernization. LOADS REFERENCES: csharp-compiler, core-libraries, sdk-msbuild (always); aspnet-core, efcore, cryptography, extensions-hosting, serialization-networking, winforms-wpf, containers-interop (selective).

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CLI/Python toolkit for rapid bioinformatics queries. Preferred for quick BLAST searches. Access to 20+ databases: gene info (Ensembl/UniProt), AlphaFold, ARCHS4, Enrichr, OpenTargets, COSMIC, genome downloads. For advanced BLAST/batch processing, use biopython. For multi-database integration, use bioservices.

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Unified CLI/Python interface to 20+ genomic databases. Gene lookups (Ensembl search/info/seq), BLAST/BLAT, AlphaFold, Enrichr enrichment, OpenTargets disease/drug, CELLxGENE single-cell, cBioPortal/COSMIC cancer, ARCHS4 expression. Spans genomics, proteomics, disease. For batch/advanced BLAST use biopython; for multi-DB Python SDK use bioservices.

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Query the ClinPGx (formerly PharmGKB) REST API plus the CPIC PostgREST companion API for pharmacogenomic clinical annotations, CPIC/DPWG dosing guidelines, gene-drug pairs, variant-drug associations, FDA/EMA drug labels, and PGx pathways. Two-host architecture: api.clinpgx.org for annotation records, api.cpicpgx.org for genotype→recommendation lookups. No auth. For germline pathogenicity use clinvar-database; for somatic cancer PGx use cosmic-database or opentargets-database; for drug bioactivity use chembl-database-bioactivity.

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Core Python library for astronomy/astrophysics: units with dimensional analysis, celestial coordinate transforms (ICRS/Galactic/AltAz/FK5), FITS I/O, tables (FITS/HDF5/VOTable/CSV), cosmology (Planck18, distance/age), precise time (UTC/TAI/TT/TDB, Julian, barycentric), WCS pixel-world mapping, model fitting. For general tables use pandas/polars; for radio interferometry use CASA.

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Use Astropy core for astronomy units, coordinates, times, tables, FITS/WCS files, modeling, statistics, visualization, cosmology, configuration, and public CLIs.

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Route BlenderGIS add-on tasks for georeferencing, vector and OSM data, raster/DEM basemaps, terrain analysis, and geocamera rendering in Blender.

日本語の概要は準備中です。原文の説明を表示しています。