2,230 件 ・ 関連度順
概要と使いどころ
"Solve the newsvendor problem for single-period ordering decisions under uncertain demand. Use this skill when the user needs to determine optimal order quantity for perishable goods, seasonal products, or one-time purchase decisions — even if they say 'how much to order for this season', 'perishable inventory', or 'single-period ordering'.".
日本語の概要は準備中です。原文の説明を表示しています。
Expands one indicator into the full scope of an incident: pivoting across data sources to find related hosts, accounts, and infrastructure, building a timeline, and bounding what is and is not affected. Activates for requests to scope an incident, pivot from a single IOC, or determine the blast radius of a detection.
日本語の概要は準備中です。原文の説明を表示しています。
Diagnose and fix slow pyfixest regression GRIDS (many feols/fepois calls run sequentially) that stay slow despite demeaner_backend="cupy64" and an idle GPU. Use when: (1) a script looping dozens of pf.feols models on a 100k+ row panel takes ~1 min/model, (2) process inspection shows ~1-1.5 cores busy and nvidia-smi shows ~0% GPU utilization with a resident cupy context, (3) planning any worker prompt that will run a model grid (robustness variants x FE structures x domains). Root cause: per-model CPU-side single-threaded fixed costs (formulaic model-matrix build, interaction construction, singleton detection, cluster vcov) dominate wall time; GPU demeaning is a small slice. Fix: shard the model grid across OS processes and/or use pyfixest multiple-estimation syntax; mandate this IN THE WORKER PROMPT.
日本語の概要は準備中です。原文の説明を表示しています。
Conduct rigorous cross-study meta-analysis of scRNA-seq data from ENCODE, integrating multiple single-cell transcriptomic datasets for a tissue/cell type. Use when the user wants to answer "what cell types exist in my tissue and what genes define them?" by combining scRNA-seq data across donors, labs, and platforms. Follows the Mawla et al. 2019 framework for assessing cross-study reproducibility, TIN-based quality filtering, and detection-limit-aware interpretation. Handles batch correction (Harmony/Seurat), dropout awareness, cross-contamination artifacts, and platform-specific biases. Use this skill for ANY scRNA-seq integration task, cross-dataset comparison, cell atlas construction, or reproducibility assessment involving ENCODE single-cell data.
日本語の概要は準備中です。原文の説明を表示しています。
Deep single-page SEO analysis covering on-page elements, content quality, technical meta tags, schema, images, and performance. Enhanced with live Ahrefs (page authority, referring domains) and GSC (search performance, top keywords) data when MCPs are available. Use when user says "analyze this page", "check page SEO", or provides a single URL for review.
日本語の概要は準備中です。原文の説明を表示しています。
Guidance for Tauri v2 single-instance behavior and second-launch argument handling.
日本語の概要は準備中です。原文の説明を表示しています。
Guidance on non-obvious runtime behaviors of Salesforce standard objects — polymorphic lookups, lead conversion field loss, PersonAccount dual-nature, CaseComment trigger isolation, and Activity date fields. Also covers which trigger actually fires for a person account, the either/or Event duration contract, the Closed status category behind Task.CompletedDateTime, the 3-record merge cap and its single delete + single update trigger events, and the CaseComment post-insert write lock. Trigger keywords: person account trigger not firing, Contact trigger person account, Event required field EndDateTime, DurationInMinutes, CompletedDateTime null, merge MasterRecordId, CaseComment cannot be edited, IsNotificationSelected null, lead conversion triggers disabled. NOT for the Activity object model — use admin/activity-and-task-patterns. NOT for writing TYPEOF queries — use apex/apex-polymorphic-soql.
日本語の概要は準備中です。原文の説明を表示しています。
Configure related lists on Salesforce records — column choice on Page Layouts (max 10 fields per related list), sort field selection, the Spring '24 Enhanced Related Lists component (which adds filtering, mass actions, and 10-row inline display), the choice between Related Lists / Related Lists - Single / Related List - Quick Links in Lightning App Builder, per-record-type related-list assignments, and the View All / pagination UX. NOT for FSL WorkOrderMilestone-on-Work-Order layout (use admin/fsl-sla-configuration-requirements), NOT for the Lightning page performance Related List - Single vs Full tradeoff in isolation (use admin/lightning-page-performance-tuning), NOT for Industries Timeline-as-related-list (use admin/health-cloud-timeline), NOT for offline-priming related-list caps (use admin/fsl-mobile-app-setup).
日本語の概要は準備中です。原文の説明を表示しています。
Use when planning, sequencing, or troubleshooting an org-wide migration from Salesforce Classic to Lightning Experience. Covers the LEX Transition Assistant Readiness Check, asset triage matrix (Visualforce, JavaScript buttons, page layouts, Knowledge, email templates, list views, AppExchange), pilot/wave rollout sequencing, end-user adoption telemetry, and cutover criteria. Triggers: 'lightning experience transition', 'classic to lightning migration plan', 'LEX readiness check', 'why are some users still on Classic', 'turning on Lightning for everyone'. NOT for individual asset migrations like a single VF page (use lwc/visualforce-to-lwc-migration), a single JavaScript button (use admin/custom-button-to-action-migration), or Knowledge article migration (use admin/knowledge-classic-to-lightning) — this skill orchestrates the program. NOT for Lightning App Builder page design (use admin/lightning-app-builder-advanced).
日本語の概要は準備中です。原文の説明を表示しています。
Integrate PocketBase as a Go library using the github.com/castle-x/goutils/pocketbase (gopb) package to build single-binary full-stack applications. Use when building Go applications that need user authentication, embedding PocketBase into Go binary, registering custom API routes, managing default users, serving embedded SPA frontend, or deploying single-binary applications. NOT for using PocketBase as a standalone separate process.
日本語の概要は準備中です。原文の説明を表示しています。
Pre-ticket Fibonacci sizing for a paste-mode batch of user stories. Default mode is advisory-only (writes a Story Sizing Report). Opt-in `--auto-create` delegates ticket creation to mk:jira-issue + mk:jira-collaborate with mandatory dry-run + single batch confirmation gate. NOT for single-ticket estimation (mk:jira-estimator); NOT for sprint capacity (mk:planning-engine).
日本語の概要は準備中です。原文の説明を表示しています。
Profiles RNA-binding protein targets without antibody or UV crosslinking using STAMP (APOBEC1-RBP fusion, C-to-U editing), scSTAMP (single-cell), TRIBE/HyperTRIBE (ADAR-RBP, A-to-I editing), DART-seq (APOBEC1-YTH for m6A), or Bullseye/SAILOR edit-site detection pipelines. Use when antibody is unavailable or specificity is doubtful, when single-cell RBP profiling is needed (scSTAMP), or when in vivo RBP profiling without UV is preferred.
日本語の概要は準備中です。原文の説明を表示しています。
Designs and analyzes combinatorial CRISPR screens covering paired-Cas9 (Big Papi, Najm 2018), enhanced AsCas12a multiplex (enCas12a, DeWeirdt 2021), in4mer 4-guide-array Cas12a (Esmaeili Anvar N et al 2024 Nat Commun 15:3577) and the Inzolia paralog-pair library, paralog-buffering detection (Dede 2020 Genome Biol; Thompson 2021 Nat Commun 12:1302), genetic-interaction (GI) scoring as observed_double_LFC minus expected_additive_double_LFC, synthetic-lethal and synthetic-rescue interaction interpretation, the half-of-essentiality buffered by paralogs phenomenon, multiplex screen statistical analysis with MAGeCK MLE interaction terms, and the relationship to single-cell combinatorial Perturb-seq. Use when designing a paralog or pathway-pair screen, choosing between paired-Cas9 (Big Papi) and Cas12a multiplex (Inzolia), interpreting genetic interaction scores, identifying synthetic-lethal targets for drug development, or scaling beyond single-gene CRISPR screens.
日本語の概要は準備中です。原文の説明を表示しています。
Detect single-nucleotide crosslink (CL) sites in CLIP-seq data using truncation patterns (iCLIP/eCLIP CITS), crosslink-induced mutations (HITS-CLIP CIMS deletions, PAR-CLIP T-to-C), or HMM/kernel-density methods (PureCLIP, PARalyzer, CTK). Use when single-nucleotide resolution is required for motif registration (mCross), allele-specific binding (BEAPR), variant-effect prediction, or comparing crosslink chemistry across CLIP variants.
日本語の概要は準備中です。原文の説明を表示しています。
Decides how to preprocess plasma cfDNA sequencing data so the recoverable signal survives - library-prep-aware fragment expectations (dsDNA vs ssDNA/adaptase prep), UMI/duplex consensus with fgbio (ExtractUmisFromBam, GroupReadsByUmi --strategy paired for duplex, CallMolecularConsensusReads vs CallDuplexConsensusReads, FilterConsensusReads min-reads "total s1 s2"), the align->group->consensus->RE-align ordering, and the cfDNA dedup trap where naive coordinate dedup collapses nucleosome-coincident independent molecules. Covers when single-strand consensus suffices vs when duplex is mandatory, the singleton/sensitivity tax at low input, and reading the insert-size histogram as a pre-analytical QC instrument. Use when processing plasma cfDNA reads before fragmentomics, ctDNA mutation calling, or tumor-fraction estimation.
日本語の概要は準備中です。原文の説明を表示しています。
Treats a ctDNA assay as a molecule-counting experiment at the Poisson edge and builds its analytical-validation case the measurement-science way. Covers the genome-equivalent currency (~330 haploid copies/ng), the lambda = input_GE x VAF sampling ceiling (lambda>=3 for ~95% detection), the error-suppression ladder (raw NGS ~1e-3 -> single-strand UMI ~1e-4/1e-5 -> duplex <1e-7), the CLSI EP17 LoB/LoD/LoD95/LoQ framework, the per-locus-vs-panel-integrated LoD distinction that lets bespoke MRD reach ppm, contrived/SEQC2 reference standards, and honest LoD reporting conditioned on input mass + consensus depth + replicate detection rate. Use when stating or trusting a sensitivity claim, designing a dilution-series validation, deciding how many genome equivalents are needed at a target VAF, choosing a single-locus vs panel-integrated LoD, or auditing a "detects 0.1% VAF" claim.
日本語の概要は準備中です。原文の説明を表示しています。
Process and analyze single-cell ATAC-seq data with Signac, ArchR, SnapATAC2, or Cell Ranger ATAC. Use when handling 10X scATAC or 10X Multiome (paired RNA+ATAC) data, performing per-cell QC, choosing between ArchR/Signac/SnapATAC2 ecosystems, building per-cluster consensus peaksets, integrating with paired scRNA-seq, doublet detection (AMULET vs ArchR vs scDblFinder), or running pseudobulk differential accessibility per cluster.
日本語の概要は準備中です。原文の説明を表示しています。
Expert-level biophysics covering single molecule techniques, membrane biophysics, protein mechanics, motor proteins, ion channels, and biological imaging methods.
日本語の概要は準備中です。原文の説明を表示しています。
Load this skill when writing, reviewing, or interpreting behavioral accessibility automation — tests that manipulate a rendered page (resizing the viewport, pressing real keys, capturing and comparing screenshots) rather than only inspecting static markup or a single computed accessibility tree. Covers Reflow risk (SC 1.4.10) and Focus Visible risk (SC 2.4.7) checks. Absolutely always report indicator results separately from confirmed failures. Under no circumstances treat a clean behavioral scan as WCAG conformance, or collapse `cantTell`/test-error/indicator outcomes into a single pass/fail signal.
日本語の概要は準備中です。原文の説明を表示しています。
MUST USE when the user needs current, online, or web-derived information — news, latest releases, vendor docs, real-world examples, recent changes, or anything not in the model's training set. LLM-neutral skill that exposes a unified web search CLI behind a single command. Runs single or multi-provider in parallel, saves raw + normalized JSON to a temp directory, prints the path so callers can pipe through rg / jq / grep. Zero-config out of the box. Works identically on macOS, Linux, WSL, Git Bash for Windows, and any environment with Python 3.8+. Triggers: 'search the web', 'look up online', 'google this', 'find current information', 'latest news', 'recent docs', 'check the internet', 'web search', 'browser search', 'research this', 'what is the latest', 'who is X', 'find examples of', 'is there documentation for', 'how do people solve', 'web-search', 'web_search'.
日本語の概要は準備中です。原文の説明を表示しています。
Explain a topic like I'm a 5 year old, as a single HTML artifact built from big pictures and very few words. Use this whenever the user asks for a dead-simple explanation of how something works, says "ELI5", "explain like I'm five", "簡単に説明して", "図で説明して", "初心者向けに", "素人にもわかるように", wants to explain a concept to a non-technical manager, customer, or family member, or asks for a visual explainer — even if they don't say "ELI5" explicitly.
Typosquat and malicious-package detection across installed dependencies (or a single prospective addition) — cross-checks AI-malware family intelligence, package-name similarity to known popular packages, low maintainer-health signals. Use when auditing a freshly-onboarded repo, vetting a single suspicious package, gating CI on supply-chain risk, or investigating an incident.
日本語の概要は準備中です。原文の説明を表示しています。
METAINFORMANT rules for directory scripts/singlecell. Use when editing, adding tests, or reviewing code under this path. Read the linked AGENTS.md first; use uv only, write outputs to output/, real implementations.
日本語の概要は準備中です。原文の説明を表示しています。
METAINFORMANT rules for directory docs/singlecell. Use when editing, adding tests, or reviewing code under this path. Read the linked AGENTS.md first; use uv only, write outputs to output/, real implementations.
日本語の概要は準備中です。原文の説明を表示しています。