「cer」の検索結果

Azure Event Hubs SDK for Python streaming. Use for high-throughput event ingestion, producers, consumers, and checkpointing.

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Integracao completa com Amazon Alexa para criar skills de voz inteligentes, transformar Alexa em assistente com Claude como cerebro (projeto Auri) e integrar com AWS ecosystem (Lambda, DynamoDB, Polly, Transcribe, Lex, Smart Home).

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Geracao de imagens humanizadas via Google AI Studio (Gemini). Fotos realistas estilo influencer ou educacional com iluminacao natural e imperfeicoes sutis.

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Use when the user wants the existing codebase analyzed for planning — 'mapear o código', 'analisar o projeto', 'atualizar o contexto', 'map codebase' — or when a planning skill reports a missing or stale map. Runs a deterministic read-only evidence scan and writes codebase.md plus the architecture, conventions, testing and concerns context documents under .planning/feat/. Do NOT use for code review (feat-review), architecture decisions, or writing the project instructions file (feat-setup).

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Configuração e diagnóstico de Nginx — reverse proxy, TLS, HTTP/2, HTTP/3, cache, compressão, rate limit e load balancing. Use quando o usuário disser "nginx", "reverse proxy", "502", "504", "certificado", "SSL", "TLS", "rate limit", "cache", "upstream".

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Diagnóstico e operação de Kubernetes — pods, deployments, ingress, HPA, PVC, StorageClass, NetworkPolicy, Secrets, Helm, ArgoCD, cert-manager. Use quando o usuário disser "kubernetes", "k8s", "pod", "deployment", "ingress", "CrashLoopBackOff", "não sobe", "escalar", "helm", "argocd". Leitura livre; apply, scale, delete passam pelo portão.

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Make a GTK4/libadwaita app accessible — accessible labels and roles, tooltips on icon-only buttons, keyboard navigation, contrast, and testing with Orca/Accerciser. Use when fixing a11y issues or running the accessibility category of a HIG audit.

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Chief Security Officer mode. Infrastructure-first security audit: secrets archaeology, dependency supply chain, CI/CD pipeline security, LLM/AI security, skill supply chain scanning, plus OWASP Top 10, STRIDE threat modeling, and active verification. Two modes: daily (zero-noise, 8/10 confidence gate) and comprehensive (monthly deep scan, 2/10 bar). Trend tracking across audit runs. Use when: "security audit", "threat model", "pentest review", "OWASP", "CSO review". (gstack) Voice triggers (speech-to-text aliases): "see-so", "see so", "security review", "security check", "vulnerability scan", "run security".

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Orchestrates end-to-end replication workflows spanning multiple concerns: new environment setup, production incident response, and performance optimization for AEM 6.5 LTS.

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Create any visual design using Adobe Express templates — including flyers, posters, banners, social media posts (Instagram stories, Facebook posts, LinkedIn graphics), business cards, invitations, greeting cards, resumes, cover letters, brochures, newsletters, certificates, presentations, YouTube thumbnails, email headers, logos, menus, labels, and more. Use this skill whenever the user wants to make, design, create, or build any visual — even if they just say "make me a flyer", "design a poster", "I need something for Instagram", "create an event invite", "make a business card", or any similar request. Also handles requests to find or browse templates, edit text/copy, change background colors, or animate a design. Access: 🔐 Signed-In required | Gen AI: ❌

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Scan an AEM Edge Delivery Services page for WCAG 2.1 AA accessibility violations and generate specific fixes. Identifies missing alt text, heading hierarchy issues, link text problems, color contrast concerns, and EDS-specific accessibility patterns. Use when fixing accessibility issues, preparing for compliance audits, or remediating WCAG violations.

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Break a plan, spec, or PRD into independently-grabbable issues on the project issue tracker using tracer-bullet vertical slices. Use when user wants to convert a plan into issues, create implementation tickets, or break down work into issues.

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Think through the consequences of consequences — not just what happens immediately, but what happens next, and next after that, across time. Load when a decision looks obviously good or obviously bad on initial read, when the user is optimising for a short-term outcome that might create a long-term problem, when unintended consequences are a concern, or when deep-thinking diagnoses a second-order frame. Triggers on "what are the downstream effects", "what happens after that", "unintended consequences", "think ahead on this", "long-term vs short-term", or "what comes after that". Based on Howard Marks second-level thinking and Farnam Street mental models. Most powerful for decisions with delayed consequences or systemic effects.

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Improves the quality of images, especially screenshots, by enhancing resolution, sharpness, and clarity. Perfect for preparing images for presentations, documentation, or social media posts.

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Azure Key Vault SDK for Python. Use for secrets, keys, and certificates management with secure storage.

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Azure Event Hubs SDK for Python streaming. Use for high-throughput event ingestion, producers, consumers, and checkpointing.

日本語の概要は準備中です。原文の説明を表示しています。

Geracao de imagens humanizadas via Google AI Studio (Gemini). Fotos realistas estilo influencer ou educacional com iluminacao natural e imperfeicoes sutis.

日本語の概要は準備中です。原文の説明を表示しています。

Integracao completa com Amazon Alexa para criar skills de voz inteligentes, transformar Alexa em assistente com Claude como cerebro (projeto Auri) e integrar com AWS ecosystem (Lambda, DynamoDB, Polly, Transcribe, Lex, Smart Home).

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Identify tumor neoantigens from somatic variants with pVACtools (pVACseq/pVACfuse/pVACbind/pVACvector/pVACview) for personalized cancer vaccines and checkpoint biomarkers. Encodes the field's hard truth that binding prediction is the easy, near-solved part and single-digit-percent PPV lives downstream — so it centers clonality/CCF, HLA LOH (the silent invalidator), expression, proximal-variant phasing, agretopicity/foreignness quality, and the predicted->presented->immunogenic validation tiers. Use when nominating vaccine targets, ranking neoantigens, or building a tumor-to-candidate pipeline. Binding details in mhc-binding-prediction; ranking in immunogenicity-scoring.

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Designs cytosine (CBE, C-to-T) and adenine (ABE, A-to-G) base-editor guides by positioning the target base at the activity-peak of the editing window (protospacer positions ~5-7, PAM-distal numbering), minimizing bystander edits for product purity, reading dinucleotide context (APOBEC1 TC favored / GC disfavored), and selecting the editor variant (BE4max, ABEmax, ABE8e, YE1/SECURE, TadCBE, CGBE, SpG/SpRY-BE). Covers knockout by premature stop (CRISPR-STOP/iSTOP) and splice-site disruption, the three off-target classes (Cas-dependent, Cas-independent DNA, RNA), outcome prediction (BE-Hive/DeepBE), and the base-vs-prime-vs-HDR decision. Use when installing a transition mutation without a double-strand break, knocking out a gene without indels, or choosing CBE vs ABE. Generic guide scoring, prime editing, and HDR donors are separate skills.

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Designs and ranks guide RNAs (sgRNAs) for CRISPR-Cas9/Cas12a gene knockout by scanning a target for PAM sites (NGG SpCas9, NNGRRT SaCas9, TTTV Cas12a, NG SpCas9-NG, near-PAMless SpRY), enumerating candidate spacers, applying hard filters (Pol-III TTTT terminator, 5' G, GC), ranking on-target activity with the context-appropriate model (Rule Set 2/Azimuth for U6/lentiviral, CRISPRscan for T7/embryo, DeepHF for high-fidelity variants, DeepCpf1 for Cas12a), and predicting the indel/frameshift outcome (Bae out-of-frame score, inDelphi, FORECasT, Lindel). Use when selecting sgRNAs to knock out a gene, choosing a nuclease/PAM for a constrained locus, picking which exon to target, or shortlisting guides before an off-target check. Off-target specificity, base/prime editing, and HDR donors are separate skills.

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Designs donor/repair templates for precise CRISPR knock-ins -- choosing the format (ssODN, long-ssDNA/Easi-CRISPR, dsDNA/plasmid, AAV6), sizing homology arms, placing the cut within ~10 bp of the edit, and adding a mandatory codon-checked blocking (PAM/seed) mutation so the edited allele is not re-cut. Frames the HDR-vs-NHEJ-vs-MMEJ pathway competition, the MMEJ (PITCh) and homology-independent (HITI/HMEJ) alternatives for post-mitotic cells, ssODN strand/asymmetry choice, phosphorothioate end-protection, and ranked HDR enhancers. Use when designing a donor for a point mutation, epitope/fluorophore tag, allele replacement, or knock-in, or when HDR efficiency is low. Guide design and base/prime editing are separate skills.

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Tests whether two genomic interval sets overlap (colocalize) more than expected by chance using a permutation test against a structured-genome null model. Covers bedtools fisher (analytic 2x2 screen), bedtools shuffle + jaccard permutation, GAT (isochore/GC-conditioned simulation with FDR), regioneR (flexible permutation, randomizeRegions vs circularRandomizeRegions, localZScore), LOLA (universe-relative Fisher against a region database), and GREAT/rGREAT (regulatory-domain binomial + hypergeometric for ontology-from-regions). Stresses the universe/background choice, matched background, blacklist exclusion, and multiple-testing control. Use when asking whether peaks/regions are enriched at enhancers/TFBS/features, scoring region-set colocalization or region-set enrichment, comparing CNV/SV concordance, or turning an overlap count into a defensible p-value.

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Performs proximity operations on genomic intervals with bedtools (closest, window, flank, slop) and pybedtools - nearest-feature queries with signed/strand-aware distance, fixed-radius window searches, strand-aware promoter construction, and interval extension. Covers the closest -d/-D a/b/ref/-t/-k/-io/-iu/-id flags, the -D ref strand sign-flip, silent chromosome-end clipping in slop/flank, -t all tie double-counting, and the critical distinction between a geometry answer (nearest TSS) and a biology answer (which gene an element regulates). Use when assigning peaks or variants to genes, defining promoters from a gene model, building distance-to-TSS distributions, finding features within a window, or extending intervals - and when deciding whether nearest-gene is a fair prior (GWAS locus) or a trap (distal enhancer).

日本語の概要は準備中です。原文の説明を表示しています。