「validate」の検索結果

Orchestrator for the experimentation skill suite — turn assumptions and product questions into rigorous, well-instrumented experiments and decision-grade readouts. Routes through backlog → spec → runbook → readout based on user need and existing artefacts. Platform-agnostic with PostHog as the primary binding. Load when the user asks to design an experiment, A/B test something, set up an experiment, run a holdout, test a hypothesis, decide what to test next, read out experiment results, analyse a test, or says "should we A/B test this", "experiment on the landing page", "is this lift real", "ship or kill this test", "what should we test next", "build an experiment backlog", "test the pricing page", "validate this with an experiment".

日本語の概要は準備中です。原文の説明を表示しています。

Harden an application against common security risks — validate inputs at boundaries, least-privilege access, safe secrets handling, dependency hygiene, and secure defaults. Load when shipping user-facing code, adding auth/session flows, handling untrusted data, exposing APIs, or the user asks for "security hardening", "OWASP hardening", "secure this feature". Not for skill-library security gates (use secure-skill family).

日本語の概要は準備中です。原文の説明を表示しています。

Gracefully retire a skill that is redundant, superseded, or no longer earning its place in the context window. Load when improve-skills finds a skill scoring 0-5/14 AND research confirms the domain is now handled natively by current models, when two skills have overlapping triggers and one subsumes the other, when the user asks to remove a skill, retire a skill, delete a skill, or clean up redundant skills, or when validate-skills flags a skill as a duplicate trigger risk. Handles removal cleanly: updates all callers, removes from AGENTS.md, updates README, and archives rather than deletes so the skill can be recovered if needed.

日本語の概要は準備中です。原文の説明を表示しています。

Prisma ORM CLI commands reference covering init, generate, migrate, db, dev, complete, studio, validate, format, debug, and mcp. Use for ORM/database CLI workflows, not the Prisma Platform CLI. Triggers on "prisma init", "prisma generate", "prisma migrate", "prisma db", "prisma complete", "prisma studio", "prisma mcp".

日本語の概要は準備中です。原文の説明を表示しています。

Verify a code change end-to-end in the current worktree: identify what changed, run the relevant tests, get the app running, drive a browser over the affected areas, and report a verdict with screenshots. Generic across project types (Laravel/Herd, Node/bun, frontend, CLI, library). Use when the user wants to verify/QA/smoke-test a change, check that a PR or branch works, validate uncommitted work, or says "/flow", "verify this change", "does this PR work", "test and click through this". Optional target: PR number/URL, branch/ref, or worktree path; default is the current working changes.

日本語の概要は準備中です。原文の説明を表示しています。

Build, validate, and troubleshoot deep links for Codex, Cursor, VS Code, Visual Studio, and similar tools. Use when users ask for clickable links (especially in Slack) that open threads, files, folders, or app settings.

日本語の概要は準備中です。原文の説明を表示しています。

Use before creative or constructive work (features, architecture, behavior). Transforms vague ideas into validated designs through disciplined reasoning and collaboration.

日本語の概要は準備中です。原文の説明を表示しています。

Validates animation durations, enforces typography scale, checks component accessibility, and prevents layout anti-patterns in Tailwind CSS projects. Use when building UI components, reviewing CSS utilities, styling React views, or enforcing design consistency.

日本語の概要は準備中です。原文の説明を表示しています。

Detects focal chromatin loops (point interactions / corner-dots) in balanced Hi-C and Micro-C contact maps and aggregates/validates a loop set. Covers de-novo calling with cooltools dots (HiCCUPS-style 4-background local enrichment with lambda-chunked FDR), chromosight (template-correlation), and Mustache (scale-space blob detection); aggregate peak analysis (APA) via cooltools pileup for confirmation; the depth/resolution prerequisite (de-novo needs ~5-10kb resolution = hundreds of millions to billions of valid pairs); consensus across callers and convergent-CTCF support as validation; and differential loops via union anchors plus chromosight quantify. Use when calling chromatin loops or dots from a cooler, deciding whether a map is deep enough to call de-novo vs running APA on known CTCF/cohesin anchors, building an aggregate peak pileup, comparing loops across conditions, or validating loop calls. For HiChIP/PLAC-seq/PCHi-C protein-anchored data use FitHiChIP/MAPS, not dots.

日本語の概要は準備中です。原文の説明を表示しています。

Nominates and assesses CRISPR off-target sites genome-wide. Enumerates candidate sites by mismatch and bulge tolerance with Cas-OFFinder/CRISPRitz, ranks them with the published CFD score (SpCas9-only, relative ranker) or MIT/CRISTA/energy models, runs variant-aware screening against gnomAD/individual genomes (CRISPRme), and frames the empirical genome-wide discovery assays (GUIDE-seq, CIRCLE-seq, CHANGE-seq, DISCOVER-seq, Digenome-seq) and high-fidelity nuclease choice (HiFi Cas9, Sniper-Cas9, eSpCas9, SpCas9-HF1). Use when assessing guide RNA specificity, choosing among candidate guides, screening a therapeutic guide against population variation, or planning empirical off-target validation. Distinguishes predicted vs detected vs validated. On-target activity scoring and deaminase (Cas-independent) base/prime-editor off-targets are separate skills.

日本語の概要は準備中です。原文の説明を表示しています。

Download large datasets from NCBI efficiently using EPost, history server, batching, rate limiting, and retry logic. Use when bulk-fetching tens of thousands of sequences, pulling all results of a large ESearch, designing reproducible pipelines, comparing E-utilities to NCBI Datasets v2 CLI, or implementing checksum-validated downloads. Encodes WebEnv TTL (~8h), EPost 200-ID limit, retmax caps, parallelization design, and integrity verification.

日本語の概要は準備中です。原文の説明を表示しています。

Cross-method decision tree for calling hits in pooled CRISPR screens. Catalogs statistical models (MAGeCK RRA, MAGeCK MLE, BAGEL2, drugZ, JACKS, Chronos, CERES), experimental designs each is built for, failure modes outside design domain, reconciliation when methods disagree, multiple-testing and effect-size thresholds, the order of operations (count -> QC -> CN-correct -> hit-call -> validate), the second-best-sgRNA conservative rule, and consensus-hit strategy. Use when choosing among MAGeCK / BAGEL2 / drugZ / JACKS / Chronos for a given design, reconciling disagreement across two or three methods on the same screen, deciding whether to require consensus, gating downstream validation by hit-confidence tier, or interpreting unstable hit lists across reruns.

日本語の概要は準備中です。原文の説明を表示しています。

Constructs and validates polygenic risk scores using LDpred2-auto, SBayesRC, MegaPRS, PRS-CS, PROSPER, MUSSEL, BridgePRS, JointPRS, PRSmix, or PGS Catalog Calculator with ancestry-aware reference panels (HapMap3, UKB-LD), Pejaver-style calibration, and PRS-RS reporting standards. Use when computing PRS for cohorts, applying Whiffin-style absolute-risk transformation, assessing cross-ancestry portability (Martin 2017 / Ding 2023 continuous ancestry), or auditing PRS manuscripts against the 22-item PRS-RS reviewer checklist.

日本語の概要は準備中です。原文の説明を表示しています。

Normalizes ChIP-seq data using exogenous spike-in (ChIP-Rx with Drosophila chromatin per Orlando 2014 / Egan 2016; E. coli carryover for CUT&RUN/CUT&Tag). Distinguishes RRPM from Rx-Input scaling, integrates with DiffBind / DESeq2 / edgeR / csaw via sizeFactors and DiffBind library-size vectors, and applies the Patel et al 2024 *Nat Biotechnol* review's failure-mode framework to validate that normalization is correctly applied at the read level (not peak counts). Use when global signal shifts are expected (HDACi, BETi, EZH2i, dosage, target knockdown), when ChIPseqSpikeInFree detects post-hoc shifts, or when validating internal-control regions before publication.

日本語の概要は準備中です。原文の説明を表示しています。

Validates docked / generated protein-ligand poses using PoseBusters physical-validity tests, strain energy quantification, geometric checks (planarity, vdW overlap, bond/angle distortion), and pose-energy reasonableness. Filters AI-docking outputs (DiffDock, EquiBind, NeuralPLexer) where ~50% of poses fail physical-validity tests. Use when QC-ing docking results, comparing classical vs ML docking outputs, or filtering pose lists before SAR analysis.

日本語の概要は準備中です。原文の説明を表示しています。

Reads, validates, and prepares CDISC SDTM and ADaM clinical trial data for analysis. Covers SDTM domain joins (DM, AE, EX, VS, LB, DS), ADaM architecture (ADSL, BDS, OCCDS, ADTTE) with traceability, treatment-emergent AE conventions, baseline derivation, SUPPQUAL/NSV handling, Define-XML 2.1, and Pinnacle 21 / CORE validation. Use when working with clinical trial datasets in CDISC SDTM/ADaM format, preparing analysis-ready data, or validating for regulatory submission.

日本語の概要は準備中です。原文の説明を表示しています。

Audit required bioinformatics command-line tools against Lmod or Environment Modules on Linux HPC clusters, resolve executable and version requirements, and reproducibly deploy missing software through a site-approved EasyBuild, Spack, Bioconda/micromamba, Apptainer, binary, or source-build workflow. Use when Codex must inspect module availability, diagnose a missing or wrong-version bioinformatics tool, install scientific software on Slurm/PBS clusters, publish or validate modulefiles, or produce an auditable and rollback-ready cluster software deployment.

日本語の概要は準備中です。原文の説明を表示しています。

Validate alignment quality with insert size distribution, proper pairing rates, GC bias, strand balance, and other post-alignment metrics. Use when verifying alignment data quality before variant calling or quantification.

日本語の概要は準備中です。原文の説明を表示しています。

Validate one Coval judge against independent human labels, with grouped development/test separation, class-specific errors and uncertainty. Use for trust claims or calibration; without real labels, prepare review rather than inventing ground truth.

日本語の概要は準備中です。原文の説明を表示しています。

Hreflang and international SEO audit, validation, and generation. Detects common mistakes, validates language/region codes, and generates correct hreflang implementations. Use when user says "hreflang", "i18n SEO", "international SEO", "multi-language", "multi-region", or "language tags".

日本語の概要は準備中です。原文の説明を表示しています。

Analyze existing XML sitemaps or generate new ones with industry templates. Validates format, URLs, and structure. Use when user says "sitemap", "generate sitemap", "sitemap issues", or "XML sitemap".

日本語の概要は準備中です。原文の説明を表示しています。

Detect, validate, and generate Schema.org structured data. JSON-LD format preferred. Use when user says "schema", "structured data", "rich results", "JSON-LD", or "markup".

日本語の概要は準備中です。原文の説明を表示しています。

One-click contribution flow for Open Design (nexu-io/open-design) — even for non-coders. Pick one of four cards (ship a Skill or Design System you made with OD; translate docs; fix a typo / write a blog; report a bug), the agent validates and opens a PR (or issue) for you. Trigger words contribute to open design, ship my OD skill, ship my OD design system, translate OD docs, report an OD bug, od-contribute.

日本語の概要は準備中です。原文の説明を表示しています。

Parse and validate project specifications. Use when loading YAML/JSON specs, validating spec structure, extracting requirements, or converting between spec formats.

日本語の概要は準備中です。原文の説明を表示しています。