「domain」の検索結果

TypeScript and test style conventions for the testmex monorepo. Use when writing or reviewing TypeScript types, interfaces, core domain models, or tests in this repository.

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Auto-detect project tech stack and generate stack-specific references for domain skills

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Coordinate multiple agents for a complex multi-domain project using PM planning, parallel agent spawning, and QA review

日本語の概要は準備中です。原文の説明を表示しています。

Initialize project harness — AGENTS.md as table of contents, ARCHITECTURE.md as domain map, structured docs/ knowledge base

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Launches a CARLA RPC server a carla.Client can connect to, working out for itself what you pointed it at — a downloaded/extracted release, a package cooked inside a checkout, or a source checkout run through the UE4 editor — headless or windowed, and shuts it down cleanly. ROS2=1 starts it with the native ROS 2 interface active (--ros2, --rmw=fastdds/cyclonedds/zenoh, --ros-domain-id). Use when the user asks to "run/start the CARLA server", "boot CARLA headless", "launch CARLA with a window", "run the CARLA I downloaded", "start CARLA with ROS2 enabled", or "serve a packaged CARLA build".

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Provide comprehensive techniques for attacking Microsoft Active Directory environments. Covers reconnaissance, credential harvesting, Kerberos attacks, lateral movement, privilege escalation, and domain dominance for red team operations and penetration testing.

日本語の概要は準備中です。原文の説明を表示しています。

Generates Policy pattern for PHP 8.5. Creates encapsulated business rules for authorization, validation, and domain constraints. Includes unit tests.

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Raccourcir des URLs via is.gd ou v.gd. Use when: l'utilisateur demande de raccourcir une URL, créer un lien court, ou simplifier une URL longue. NOT for: URLs nécessitant une authentification, liens personnalisés avec domaine propre, analytics avancés.

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Scaffolds a complete .NET solution following Clean Architecture principles with proper layer separation (API, Application, Domain, Infrastructure). Creates project structure, dependency injection setup, and cross-cutting concerns configuration.

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Compile the Unity project and report errors/warnings. Use after C# edits or when a full Domain Reload compile is needed.

日本語の概要は準備中です。原文の説明を表示しています。

Tests whether two genomic interval sets overlap (colocalize) more than expected by chance using a permutation test against a structured-genome null model. Covers bedtools fisher (analytic 2x2 screen), bedtools shuffle + jaccard permutation, GAT (isochore/GC-conditioned simulation with FDR), regioneR (flexible permutation, randomizeRegions vs circularRandomizeRegions, localZScore), LOLA (universe-relative Fisher against a region database), and GREAT/rGREAT (regulatory-domain binomial + hypergeometric for ontology-from-regions). Stresses the universe/background choice, matched background, blacklist exclusion, and multiple-testing control. Use when asking whether peaks/regions are enriched at enhancers/TFBS/features, scoring region-set colocalization or region-set enrichment, comparing CNV/SV concordance, or turning an overlap count into a defensible p-value.

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Identifies non-coding RNAs (tRNA, rRNA, snoRNA, snRNA, riboswitches, sRNAs) using Infernal covariance-model search against Rfam, tRNAscan-SE 2.0 for tRNA, barrnap for rRNA, and ARAGORN for tmRNA, plus the small-RNA-seq boundary for miRNA and the transcript-assembly boundary for lncRNA. Covers the structure-conserved-not-sequence-conserved principle (why BLAST fails), GA-threshold and clan-competition correctness, tRNAscan-SE domain modes and pseudogene flags, rDNA copy-number collapse, and why homology annotation is a recall floor. Use when performing genome-wide ncRNA annotation, choosing the right tool for an RNA class, or interpreting ncRNA counts.

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Cross-method decision tree for calling hits in pooled CRISPR screens. Catalogs statistical models (MAGeCK RRA, MAGeCK MLE, BAGEL2, drugZ, JACKS, Chronos, CERES), experimental designs each is built for, failure modes outside design domain, reconciliation when methods disagree, multiple-testing and effect-size thresholds, the order of operations (count -> QC -> CN-correct -> hit-call -> validate), the second-best-sgRNA conservative rule, and consensus-hit strategy. Use when choosing among MAGeCK / BAGEL2 / drugZ / JACKS / Chronos for a given design, reconciling disagreement across two or three methods on the same screen, deciding whether to require consensus, gating downstream validation by hit-confidence tier, or interpreting unstable hit lists across reruns.

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Builds QSAR / QSPR models using chemprop D-MPNN, MolFormer, Uni-Mol, ChemBERTa, random forest baselines, and Gaussian processes with explicit handling of OECD 5 principles, applicability domain (kNN, leverage, conformal prediction, Mahalanobis), scaffold-balanced splits, ensemble uncertainty, calibration (Platt, isotonic), feature importance (SHAP, atomic attribution), and prospective validation. Use when building target-specific predictive models from in-house bioassay data, ADMET endpoints, or selectivity profiles.

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Reads, validates, and prepares CDISC SDTM and ADaM clinical trial data for analysis. Covers SDTM domain joins (DM, AE, EX, VS, LB, DS), ADaM architecture (ADSL, BDS, OCCDS, ADTTE) with traceability, treatment-emergent AE conventions, baseline derivation, SUPPQUAL/NSV handling, Define-XML 2.1, and Pinnacle 21 / CORE validation. Use when working with clinical trial datasets in CDISC SDTM/ADaM format, preparing analysis-ready data, or validating for regulatory submission.

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Identifies super-enhancers from H3K27ac, MED1, or BRD4 ChIP-seq using ROSE, ROSE2, LILY, HOMER -style super, and ENCODE dELS cross-referencing. Handles peak stitching parameters, ranking choices, hockey-stick inflection, marker choice (H3K27ac vs MED1/BRD4), and cross-condition comparison with spike-in normalization. Constructs core regulatory circuitry (Saint-Andre 2016) from SE-encoded TFs. Use when identifying cell-identity / cancer-associated regulatory domains, comparing super-enhancers between conditions, identifying master transcription factor networks, or predicting BET-inhibitor responsiveness.

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Predicts ADMET properties using ADMETlab 3.0 (119 endpoints with uncertainty), ADMET-AI, DeepChem MolNet, and chemprop D-MPNN with explicit handling of OECD QSAR principles, applicability domain assessment, calibration, hERG/CYP/AMES gold-standard endpoints, and PAINS / Lipinski / Ro5 / Veber / BBB druglikeness filters. Use when filtering compounds for drug-likeness, prioritizing leads by predicted safety, or building an in-house ADMET QSAR model.

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Analyzes differential transcript usage (DTU) and isoform switches with functional consequence prediction (NMD via 50nt rule, ORF disruption, protein domain loss/gain, signal peptide changes, IDR alterations, coding-potential shifts). Tools include IsoformSwitchAnalyzeR v2 (auto-selects satuRn for >5 reps else DEXSeq), the manual DRIMSeq -> DEXSeq/satuRn -> stageR DTU pipeline, and fishpond/swish for inferential-uncertainty-aware DTE. Distinguishes DTU from DGE and DTE; integrates external annotators (CPC2, Pfam, SignalP, IUPred2A or DeepTMHMM). Use when investigating how splicing differences alter protein function or trigger NMD-mediated degradation.

日本語の概要は準備中です。原文の説明を表示しています。

Run the authorized defensive security workflow — domain security-* skills, authorization gate, risk-based routing, hardening, and review.

日本語の概要は準備中です。原文の説明を表示しています。

Design and coordinate multi-agent systems where specialized agents work together to solve complex problems. Covers agent communication, task delegation, workflow orchestration, and result aggregation. Use when building coordinated agent teams, complex workflows, or systems requiring specialized expertise across domains.

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Provides and generates complete CRUD workflows for Spring Boot 3 services. Creates feature-focused architecture with Spring Data JPA aggregates, repositories, DTOs, controllers, and REST APIs. Validates domain invariants and transaction boundaries. Use when modeling Java backend services, REST API endpoints, database operations, web service patterns, or JPA entities for Spring Boot applications.

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Provides expert knowledge for building Django 5+ projects with UV as the package manager, domain-driven app structure, ruff for linting, and pytest-django for testing.

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Master proven backend architecture patterns including Clean Architecture, Hexagonal Architecture, and Domain-Driven Design to build maintainable, testable, and scalable systems.

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Provide comprehensive techniques for attacking Microsoft Active Directory enprojectnments. Covers reconnaissance, credential harvesting, Kerberos attacks, lateral movement, privilege escalation, and domain dominance for red team operations and penetration testing.

日本語の概要は準備中です。原文の説明を表示しています。