2,025 件 ・ 関連度順
概要と使いどころ
Calculates molecular fingerprints (ECFP/Morgan, FCFP, MACCS, RDKit, AtomPair, TopologicalTorsion, Avalon, MAP4, MHFP6) and physicochemical descriptors (Lipinski, QED, TPSA, Crippen LogP, 3D shape) with explicit choice tables, bit vs count semantics, and partial-charge model selection. Use when featurizing molecules for similarity, QSAR, virtual screening, or ML, or selecting the correct fingerprint for a chemotype-aware task.
日本語の概要は準備中です。原文の説明を表示しています。
Generates 3D conformer ensembles using RDKit ETKDGv3 with knowledge-enhanced distance geometry, MMFF94/UFF force-field optimization, CREST + GFN2-xTB semi-empirical refinement, and macrocycle-aware torsion preferences. Provides explicit decision rules for single vs ensemble conformer use, RMSD pruning, energy windows, conformer count, and force-field choice. Use when preparing 3D ligands for docking, generating descriptor input for 3D QSAR, or sampling macrocycle/peptide conformational ensembles.
日本語の概要は準備中です。原文の説明を表示しています。
Builds and applies 3D pharmacophore models using RDKit Pharm3D, the apo2ph4 receptor-based workflow (Heider et al 2022/2023 J Chem Inf Model 63:147-158), Pharmer / Pharmit (search), and PharmacoForge (diffusion-based generation, Flynn et al 2025 Front Bioinform), covering ligand-based pharmacophore (from active set alignment) and receptor-based pharmacophore (from binding pocket geometry). Explicit handling of feature types, geometric tolerances, partial matching, and pharmacophore-based virtual screening. Use when identifying scaffold-hopping candidates, building shape-and-feature search queries, or transferring SAR across chemotypes.
日本語の概要は準備中です。原文の説明を表示しています。
Validates docked / generated protein-ligand poses using PoseBusters physical-validity tests, strain energy quantification, geometric checks (planarity, vdW overlap, bond/angle distortion), and pose-energy reasonableness. Filters AI-docking outputs (DiffDock, EquiBind, NeuralPLexer) where ~50% of poses fail physical-validity tests. Use when QC-ing docking results, comparing classical vs ML docking outputs, or filtering pose lists before SAR analysis.
日本語の概要は準備中です。原文の説明を表示しています。
Performs structure-based virtual screening using AutoDock Vina, SMINA, GNINA (CNN scoring), and DiffDock-L hybrid workflows with explicit choice rules across rigid vs flexible docking, cross-docking vs self-docking, binding-site detection (P2Rank, fpocket), receptor preparation (PDB2PQR, PROPKA), ligand preparation (meeko, OpenBabel), and ultralarge-library screening (ZINC22, Enamine REAL). Use when screening chemical libraries against a protein target to find candidate binders, ranking docking poses, or selecting a docking workflow for a specific scenario.
日本語の概要は準備中です。原文の説明を表示しています。
Map nucleosome center positions, occupancy, and fuzziness from ATAC-seq fragment-size patterns using NucleoATAC, ATACseqQC, DANPOS3, or scprinter. Use when characterizing nucleosome organization at promoters and enhancers, calling +1/-1 nucleosomes flanking NFRs, generating V-plots for chromatin structure visualization, or comparing nucleosome positioning between conditions.
日本語の概要は準備中です。原文の説明を表示しています。
Use this skill to respond to an FMCSA audit document request efficiently. Covers organization, file labeling, secure transmission.
日本語の概要は準備中です。原文の説明を表示しています。
Delegate a read-only Coval evaluation, simulation, monitoring, product-how-to, or troubleshooting subtask to Sofia through the official Coval MCP consult_sofia tool. Use when the user needs Coval-specific FDE judgment, analysis of organization data, metric or test-set recommendations, or a diagnosis grounded in Coval runs and conversations.
日本語の概要は準備中です。原文の説明を表示しています。
Ahrefs API analyst (extension). Reads referring domains, backlinks, organic keywords, and content explorer data via the tested @ahrefs/mcp@0.0.11 server. Pairs with seo-backlinks for multi-source confidence weighting.
日本語の概要は準備中です。原文の説明を表示しています。
When the user wants to apply psychological principles, mental models, or behavioral science to marketing. Also use when the user mentions 'psychology,' 'mental models,' 'cognitive bias,' 'persuasion,' 'behavioral science,' 'why people buy,' 'decision-making,' or 'consumer behavior.' This skill provides 70+ mental models organized for marketing application.
日本語の概要は準備中です。原文の説明を表示しています。
多数の元IDをカテゴリ別に管理し、各IDを専任PMが完了まで担当する継続開発に使う。担当配置、カテゴリ間の調整、停滞の解消と成果回収を扱う。
ガントから限定された成果群の分担を提案し、承諾後に各タスクchatのPMとそのワーカーが独立して実装・検収・正式化まで進める場合に使う。
Automate Basecamp project management, to-dos, messages, people, and to-do list organization via Rube MCP (Composio). Always search tools first for current schemas.
日本語の概要は準備中です。原文の説明を表示しています。
Manage MongoDB Atlas Organizations as Azure ARM resources with unified billing through Azure Marketplace.
日本語の概要は準備中です。原文の説明を表示しています。
Azure API Center Management SDK for Python. Use for managing API inventory, metadata, and governance across your organization.
日本語の概要は準備中です。原文の説明を表示しています。
Memory is the cornerstone of intelligent agents. Without it, every interaction starts from zero. This skill covers the architecture of agent memory: short-term (context window), long-term (vector stores), and the cognitive architectures that organize them.
日本語の概要は準備中です。原文の説明を表示しています。
Use this skill for internal architecture work around config-driven, registry-driven, and pattern-driven feature design in the nuxt-ui-tools repository. Covers how to organize variant-heavy features, where to put implementations, and how to keep both internals and public APIs standardized.
日本語の概要は準備中です。原文の説明を表示しています。
Manage Linear issues, projects, and teams via the GraphQL API. Create, update, search, and organize issues. Uses API key auth (no OAuth needed). All operations via curl — no dependencies.
日本語の概要は準備中です。原文の説明を表示しています。
CLI to manage emails via IMAP/SMTP. Use himalaya to list, read, write, reply, forward, search, and organize emails from the terminal. Supports multiple accounts and message composition with MML (MIME Meta Language).
日本語の概要は準備中です。原文の説明を表示しています。
Create new Claude Code Skills with proper YAML frontmatter, progressive disclosure structure, and complete directory organization. Use when you need to build custom skills for specific workflows, generate skill templates, or understand the Claude Skills specification.
日本語の概要は準備中です。原文の説明を表示しています。
Use this skill whenever the user wants to create, read, edit, or manipulate Word documents (.docx files). Triggers include: any mention of 'Word doc', 'word document', '.docx', or requests to produce professional documents with formatting like tables of contents, headings, page numbers, or letterheads. Also use when extracting or reorganizing content from .docx files, inserting or replacing images in documents, performing find-and-replace in Word files, working with tracked changes or comments, or converting content into a polished Word document. If the user asks for a 'report', 'memo', 'letter', 'template', or similar deliverable as a Word or .docx file, use this skill. Do NOT use for PDFs, spreadsheets, Google Docs, or general coding tasks unrelated to document generation.
日本語の概要は準備中です。原文の説明を表示しています。
This skill should be used when the user requests social media content creation for Twitter, Instagram, LinkedIn, or Facebook. It generates platform-optimized posts and saves them in an organized folder structure with meaningful filenames based on event details.
日本語の概要は準備中です。原文の説明を表示しています。
Captures clause risks, compliance gaps, precedent shifts, contract deviations, regulatory changes, and litigation exposure to enable continuous legal operations improvement. Use when: (1) An unfavorable clause is accepted or slips through review, (2) A compliance deadline is missed or approaching, (3) A new regulation impacts the organization, (4) A contract remains unsigned past SLA, (5) An IP infringement notice is received, (6) New case law changes interpretation in a relevant jurisdiction, (7) A data subject access request reveals process gaps.
日本語の概要は準備中です。原文の説明を表示しています。
Local-first year-round tax memory system for individuals, freelancers, and small businesses. Use when users mention tax documents, receipts, expenses, tax notices, filing preparation, missing forms, accountant meetings, or year-end organization. Captures tax-relevant facts as they happen, tracks what may be missing, and prepares CPA-ready handoff summaries. NEVER provides tax advice, legal interpretations, filing positions, or final tax calculations.
日本語の概要は準備中です。原文の説明を表示しています。