「wind」の検索結果

Quantifies CRISPR editing outcomes with CRISPResso2 (Clement 2019 Nat Biotechnol) across Cas9-nuclease (indels, HDR), CBE and ABE base editors (target conversion + bystander), and prime editor (pegRNA-templated) modes. Covers single-amplicon (CRISPResso), multi-sample batch (CRISPRessoBatch), pooled-amplicon (CRISPRessoPooled), WGS off-target (CRISPRessoWGS), and sample-comparison (CRISPRessoCompare) workflows; quantification-window math that controls what is called edited; substitution-vs-indel diagnostic to distinguish BE from Cas9 contamination; MMEJ deletion pattern interpretation; allele-frequency tables; and failure modes from amplicon misalignment or contamination. Use when quantifying editing from amplicon sequencing, choosing CRISPResso mode by design, distinguishing intended edits from bystanders and indel byproducts, debugging low-alignment runs, or generating publication-grade editing reports.

日本語の概要は準備中です。原文の説明を表示しています。

Call protein-RNA binding sites from CLIP-seq BAM with CLIPper, PureCLIP, Skipper, Piranha, omniCLIP, CTK, CLAM, or Paraclu. Use when choosing between coverage-based, HMM-based, beta-binomial window-based, and crosslink-site-based peak callers; applying ENCODE eCLIP thresholds (log2 IP/SMInput >= 3, -log10 p >= 3); deciding when SMInput is mandatory; or reconciling peak-set discordance between callers for the same RBP.

日本語の概要は準備中です。原文の説明を表示しています。

Performs alchemical free-energy calculations including relative binding free energy (RBFE / FEP+) and absolute binding free energy (ABFE) via OpenFE, FEP+, GROMACS, AMBER pmemd, and OpenMM with explicit lambda window scheduling, soft-core potentials, REST2 enhanced sampling, MBAR/BAR analysis, and cycle closure validation. Compares ML alternatives (Boltz-2 affinity, DeepDock). Use when ranking analogs by binding affinity beyond docking accuracy, performing prospective lead optimization, or validating SAR predictions.

日本語の概要は準備中です。原文の説明を表示しています。

Generates 3D conformer ensembles using RDKit ETKDGv3 with knowledge-enhanced distance geometry, MMFF94/UFF force-field optimization, CREST + GFN2-xTB semi-empirical refinement, and macrocycle-aware torsion preferences. Provides explicit decision rules for single vs ensemble conformer use, RMSD pruning, energy windows, conformer count, and force-field choice. Use when preparing 3D ligands for docking, generating descriptor input for 3D QSAR, or sampling macrocycle/peptide conformational ensembles.

日本語の概要は準備中です。原文の説明を表示しています。

Identifies differentially bound ChIP-seq regions between conditions using DiffBind, csaw (sliding windows), DESeq2/edgeR/PyDESeq2 on count matrices, NormR (control-aware), or MAnorm2. Distinguishes three distinct normalization problems (composition bias, trended bias, global shifts) and matches each to its appropriate fix including spike-in scaling. Use when comparing ChIP-seq binding between experimental conditions, choosing normalization for global vs local changes, integrating spike-in data, or reconciling DiffBind/DESeq2 disagreement.

日本語の概要は準備中です。原文の説明を表示しています。

Annotates ChIP-seq peaks to genomic features, nearest genes, ENCODE candidate cis-regulatory elements (cCREs), and regulatory domains. Uses ChIPseeker (R), HOMER annotatePeaks.pl (CLI), pyranges (Python), GREAT/rGREAT (regulatory domain gene-set enrichment), ChIP-Enrich (locus-length-adjusted), ENCODE SCREEN cCRE classification (PLS/pELS/dELS/CTCF-only/DNase-H3K4me3), and ENCODE-rE2G for cell-type-specific enhancer-gene linking. Handles nearest-TSS vs host-gene ambiguity, promoter window definition, and feature priority. Use when assigning genomic context to peaks, linking enhancer peaks to target genes, classifying peaks against ENCODE cCRE registry, or running gene-set enrichment on peak-associated genes.

日本語の概要は準備中です。原文の説明を表示しています。

Predicts whether a DNA variant alters mRNA splicing using sequence-based deep-learning tools — SpliceAI (10kb context dilated CNN, clinical default), Pangolin (multi-tissue), MMSplice (modular per-region CNN with calibrated ΔPSI), SpliceTransformer/TrASPr (tissue-aware transformers), SpliceVault (empirical 300K-RNA lookup of likely mis-splicing outcomes), CADD-Splice (composite score). Applies the ClinGen SVI 2023 framework for ACMG/AMP variant interpretation (PVS1, PP3, BP4 evidence codes), HGVS splicing nomenclature (c.123+1G>A, c.123-3T>G, r.spl?), extended-window scoring for deep-intronic pseudoexons, tissue-specific predictions, branchpoint variant detection (BPHunter, LaBranchoR), and splice-switching ASO design. Use when interpreting splice impact of clinical variants, prioritizing VUS, identifying deep-intronic pathogenic variants, or designing ASOs.

日本語の概要は準備中です。原文の説明を表示しています。

Identify differentially accessible chromatin regions across conditions using DiffBind, csaw, DESeq2, or edgeR. Use when comparing ATAC-seq accessibility between treatment groups, choosing between consensus-peak vs sliding-window approaches, picking the correct normalization (full library vs reads-in-peaks), correcting batch with SVA/RUVseq, or interpreting log2FC and FDR thresholds in a chromatin context.

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Use this skill when the user asks about Hours of Service (HOS) rules under 49 CFR 395 — the 11-hour driving limit, 14-hour on-duty window, 60/70 hour rule, 30-minute break, 10-hour off-duty reset, 34-hour restart, sleeper berth provisions, split sleeper berth, short-haul exemption (150-air-mile), agricultural exemption, adverse driving conditions, ELD malfunction handling, personal conveyance, yard moves, or anything related to driver duty status. Cite specific 49 CFR 395 subsection. If the question involves a non-standard operation (passenger carrier, oilfield, agricultural, military), confirm which set of rules applies.

日本語の概要は準備中です。原文の説明を表示しています。

Use this skill when a driver needs to extend the 14-hour duty window using the 16-hour exception under § 395.1(o). Covers eligibility, frequency limits (once per 7 days), return-to-terminal requirement, and documentation.

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Use this skill to file your IFTA quarterly fuel tax return. Covers filing windows, calculation, payment, and refund situations.

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Use this skill to understand how current a driver's employment application must remain in the DQF. Covers update triggers, when to require re-application, and 3-year retention.

日本語の概要は準備中です。原文の説明を表示しています。

Use this skill when the user asks about trucking dispatch software — McLeod, TMW (Trimble), Tailwind, Truckbase, AscendTMS — vs load boards — DAT, Truckstop, 123Loadboard, Convoy, Uber Freight. Covers the workflow (find load, book, dispatch, run, settle), how dispatch software integrates with ELDs + accounting + customer EDI, and what small fleets vs larger fleets typically use.

日本語の概要は準備中です。原文の説明を表示しています。

Printing and PDF export for AI response blocks and messages via @ai-matrx/print. Use when adding a print button or BlockPrinter to a render block, wiring PrintOptionsDialog/usePrintOptions, captureBlockElement, or useDomCapturePrint, or when a print window shows no images or a print fails silently.

日本語の概要は準備中です。原文の説明を表示しています。

next/dynamic code splitting and build-graph cost; first stop for build failures. Use before lazy-loading or deferring a heavy component, adding a dynamic import, React.lazy, or ssr: false; on 'window is not defined' or a hydration mismatch; shrinking the bundle; or on 'build failed', OOM, SIGKILL, a slower build, or 'Collecting page data'.

日本語の概要は準備中です。原文の説明を表示しています。

The matrx-frontend side of the matrx-extend Chrome extension bridge. Use when adding or changing a FRONTEND_RPC action handler, a window-panels deep-link the extension opens, a headless API route it calls, or debugging a silent chrome.runtime.sendMessage or Broadcast round-trip. NOT for code in matrx-extend, matrx-local, or aidream (each has its own connect-* skill).

日本語の概要は準備中です。原文の説明を表示しています。

Disclosing a surface's existing fixed AI jobs in the shell's top Agents menu. Use when a page, panel, overlay, or window already runs a mandate behind a button, assist, automatic action, or mode; when the agent-disclosure guard names a file; or during a surface check.

日本語の概要は準備中です。原文の説明を表示しています。

Find and identify the CCSGameRules__sm_mapGcBanInformation global variable in CS2 binary using IDA Pro MCP. Use this skill when reverse engineering CS2 server.dll or libserver.so to locate the GC ban information map structure by decompiling CCSPlayerController_ResourceDataThink's sub-function (Linux) or searching for the "Notification about user penalty" string (Windows).

日本語の概要は準備中です。原文の説明を表示しています。

Apple Human Interface Guidelines for Mac. Use when building macOS apps with SwiftUI or AppKit, implementing menu bars, toolbars, window management, or keyboard shortcuts. Triggers on tasks involving Mac UI, desktop apps, or Mac Catalyst.

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Use when the user explicitly asks for a desktop or system screenshot (full screen, specific app or window, or a pixel region), or when tool-specific capture capabilities are unavailable and an OS-level capture is needed.

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Enables Claude Code to collaborate with OpenAI Codex CLI on Windows. Use this skill when the user wants to get a second opinion from Codex, compare approaches between Claude and Codex, or leverage both AI assistants for collaborative problem-solving. This skill supports both non-interactive mode (automatic response retrieval) and interactive mode (visual pane splitting with tmux).

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Gives coding agents temporal awareness by reading the session transcript the host already writes, so the agent stops guessing about time and stops repeating commands that just failed. Activates whenever an agent reasons about recency, elapsed time, retry windows, deploy cooldowns, memory or file staleness, idle detection, or any "when / how long ago / how long did that take" question. Required for autonomous, parallel, or long-running agents.

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Use psamvault MCP server: credential vault, browser login, API key injection, .env secret protection. MCP tools keep secrets out of the agent's context window.

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[72] CLOSE. Save and restore session context between conversations. Use when ending a session to preserve progress, or starting a new session to restore context. Triggers on "save session", "end session", "preserve context", "handoff", "continue from last time", or when context window is running low.

日本語の概要は準備中です。原文の説明を表示しています。