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R generic interface to Hi-C contact matrices in `.(m)cool`, `.hic` or HiC-Pro derived formats, as well as other Hi-C processed file formats. Contact matrices can be partially parsed using a random access method, allowing a memory-efficient representation of Hi-C data in R. The `HiCExperiment` class stores the Hi-C contacts parsed from local contact matrix files. `HiCExperiment` instances can be further investigated in R using the `HiContacts` analysis package.

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In recent years a wealth of biological data has become available in public data repositories. Easy access to these valuable data resources and firm integration with data analysis is needed for comprehensive bioinformatics data analysis. bio

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This package provides a client for the Bioconductor ExperimentHub web resource. ExperimentHub provides a central location where curated data from experiments, publications or training courses can be accessed. Each resource has associated me

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Universal LaTeX document skill: create, compile, and convert any document to professional PDF with PNG previews. Supports resumes, reports, cover letters, invoices, academic papers, theses/dissertations, academic CVs, presentations (Beamer), scientific posters, formal letters, exams/quizzes, books, cheat sheets, reference cards, exam formula sheets, fillable PDF forms (hyperref form fields), conditional content (etoolbox toggles), mail merge from CSV/JSON (Jinja2 templates), version diffing (latexdiff), charts (pgfplots + matplotlib), tables (booktabs + CSV import), images (TikZ), Mermaid diagrams, AI-generated images, watermarks, landscape pages, bibliography/citations (BibTeX/biblatex), multi-language/CJK (auto XeLaTeX), algorithms/pseudocode, colored boxes (tcolorbox), SI units (siunitx), Pandoc format conversion (Markdown/DOCX/HTML ↔ LaTeX), and PDF-to-LaTeX conversion of handwritten or printed documents (math, business, legal, general). Compile script supports pdflatex, xelatex, lualatex with auto-detection, latexmk backend, texfot log filtering, PDF/A output, and verbosity control (--verbose/--quiet). Empirically optimized scaling: single agent 1-10 pages, split 11-20, batch-7 pipeline 21+. Use when user asks to: (1) create a resume/CV/cover letter, (2) write a LaTeX document, (3) create PDF with tables/charts/images, (4) compile a .tex file, (5) make a report/invoice/presentation, (6) anything involving LaTeX or pdflatex, (7) convert/OCR a PDF to LaTeX, (8) convert handwritten notes, (9) create charts/graphs/diagrams, (10) create slides, (11) write a thesis or dissertation, (12) create an academic CV, (13) create a poster, (14) create an exam/quiz, (15) create a book, (16) convert between document formats (Markdown, DOCX, HTML to/from LaTeX), (17) generate Mermaid diagrams for LaTeX, (18) create a formal business letter, (19) create a cheat sheet or reference card, (20) create an exam formula sheet or crib sheet, (21) condense lecture notes/PDFs into a cheat sheet, (22) create a fillable PDF form with text fields/checkboxes/dropdowns, (23) create a document with conditional content/toggles (show/hide sections), (24) generate batch/mail-merge documents from CSV/JSON data, (25) create a version diff PDF (latexdiff) highlighting changes between documents, (26) create a homework or assignment submission with problems and solutions, (27) create a lab report with data tables, graphs, and error analysis, (28) encrypt or password-protect a PDF, (29) merge multiple PDFs into one, (30) optimize/compress a PDF for web or email, (31) lint or check a LaTeX document for common issues, (32) count words in a LaTeX document, (33) analyze document statistics (figures, tables, citations), (34) fetch BibTeX from a DOI, (35) convert a Graphviz .dot file to PDF/PNG, (36) convert a PlantUML .puml file to PDF/PNG, (37) create a one-pager/fact sheet/executive summary, (38) create a datasheet or product specification sheet, (39) extract pages from a PDF (page ranges, odd/even), (40) check LaTeX package availability before compiling, (41) analyze citations and cross-reference with .bib files, (42) debug LaTeX compilation errors, (43) make a document accessible (PDF/A, tagged PDF), (44) create lecture notes or course handouts, (45) fill an existing PDF form (fillable fields or non-fillable with annotations), (46) extract text or tables from a PDF (pdfplumber, pypdf), (47) OCR a scanned PDF to text (pytesseract), (48) create a PDF programmatically with reportlab (Canvas, Platypus), (49) rotate or crop PDF pages (pypdf), (50) add a watermark to an existing PDF, (51) extract metadata from a PDF (title, author, subject).

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Expert knowledge for Azure Resource Manager development including troubleshooting, best practices, decision making, architecture & design patterns, limits & quotas, security, configuration, integrations & coding patterns, and deployment. Use when authoring Bicep/ARM templates, using CLI/SDK/REST, deploying stacks/registries, or securing with Key Vault/RBAC, and other Azure Resource Manager related development tasks. Not for Azure Policy (use azure-policy), Azure Resource Graph (use azure-resource-graph), Azure Portal (use azure-portal), Azure Role-based access control (use azure-rbac).

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Expert knowledge for Azure Portal development including troubleshooting, security, and configuration. Use when managing portal RBAC sharing, Intune/Entra mobile access, dashboard JSON, portal policies, or HAR diagnostics, and other Azure Portal related development tasks. Not for Azure Cloud Shell (use azure-cloud-shell), Azure Resource Manager (use azure-resource-manager), Azure Monitor (use azure-monitor), Azure Security (use azure-security).

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Expert knowledge for Azure Payment Hsm development including troubleshooting, best practices, decision making, architecture & design patterns, security, and configuration. Use when configuring Payment HSM VNets/peering, FastPath, payShield Manager access, SKUs, HA/DR topologies, or traffic routing, and other Azure Payment Hsm related development tasks. Not for Azure Cloud Hsm (use azure-cloud-hsm), Azure Dedicated HSM (use azure-dedicated-hsm), Azure Key Vault (use azure-key-vault), Azure Security (use azure-security).

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Expert knowledge for Azure Managed Applications development including limits & quotas, security, configuration, and deployment. Use when designing createUiDefinition UIs, JIT access, managed identities, StorageAccountSelector, or Bicep-based catalog publishing, and other Azure Managed Applications related development tasks. Not for Azure Blueprints (use azure-blueprints), Azure Resource Manager (use azure-resource-manager), Azure Lighthouse (use azure-lighthouse), Azure Partner Solutions (use azure-partner-solutions).

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Expert knowledge for Azure Policy development including troubleshooting, best practices, decision making, architecture & design patterns, security, configuration, integrations & coding patterns, and deployment. Use when authoring JSON policies, deploying via ARM/Bicep/Terraform, enforcing security baselines, automating with Gatekeeper, or running policy-as-code in CI/CD, and other Azure Policy related development tasks. Not for Azure Blueprints (use azure-blueprints), Azure Role-based access control (use azure-rbac), Azure Resource Manager (use azure-resource-manager), Azure Security (use azure-security).

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Expert knowledge for Azure Network Function Manager development including security, and configuration. Use when setting up NF Manager prerequisites, resource groups, managed identities, role assignments, or secure NF access, and other Azure Network Function Manager related development tasks. Not for Azure Firewall Manager (use azure-firewall-manager), Azure Virtual Network Manager (use azure-virtual-network-manager), Azure Virtual Network (use azure-virtual-network), Azure Virtual WAN (use azure-virtual-wan).

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Expert knowledge for Microsoft Planetary Computer Pro development including troubleshooting, decision making, limits & quotas, security, configuration, integrations & coding patterns, and deployment. Use when using GeoCatalog/STAC APIs, configuring collections/tiles, securing access, integrating QGIS/ArcGIS, or troubleshooting ingestion, and other Microsoft Planetary Computer Pro related development tasks. Not for Azure Maps (use azure-maps), Azure Open Datasets (use azure-open-datasets), Azure Data Explorer (use azure-data-explorer).

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Expert knowledge for Azure HPC Cache development including troubleshooting, best practices, decision making, architecture & design patterns, limits & quotas, security, configuration, integrations & coding patterns, and deployment. Use when configuring HPC Cache namespaces, NFS/Blob targets, client access, data ingest scripts, or cache failover, and other Azure HPC Cache related development tasks. Not for Azure Managed Lustre (use azure-managed-lustre), Azure NetApp Files (use azure-netapp-files), Azure Batch (use azure-batch), Azure Virtual Machines (use azure-virtual-machines).

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Expert knowledge for Azure Dev Box development including troubleshooting, best practices, decision making, limits & quotas, security, configuration, integrations & coding patterns, and deployment. Use when designing Dev Box images, configuring pools/catalogs, securing access (RBAC/SSO), managing quotas, or fixing connectivity, and other Azure Dev Box related development tasks. Not for Azure DevTest Labs (use azure-devtest-labs), Azure Virtual Machines (use azure-virtual-machines), Azure Virtual Desktop (use azure-virtual-desktop).

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Expert knowledge for Azure Digital Twins development including troubleshooting, best practices, decision making, architecture & design patterns, limits & quotas, security, configuration, integrations & coding patterns, and deployment. Use when modeling DTDL graphs, integrating IoT Hub/ADx, configuring endpoints/routes, securing access, or tuning query units, and other Azure Digital Twins related development tasks. Not for Azure IoT Hub (use azure-iot-hub), Azure IoT Central (use azure-iot-central), Azure IoT Operations (use azure-iot-operations).

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Expert knowledge for Azure CycleCloud development including troubleshooting, best practices, decision making, architecture & design patterns, security, configuration, integrations & coding patterns, and deployment. Use when automating CycleCloud via API/CLI/SDK, configuring Slurm clusters, tuning HB/HC VMs, or securing access, and other Azure CycleCloud related development tasks. Not for Azure Batch (use azure-batch), Azure HDInsight (use azure-hdinsight), Azure Databricks (use azure-databricks), Azure Kubernetes Service (AKS) (use azure-kubernetes-service).

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Expert knowledge for Azure Bastion development including best practices, decision making, architecture & design patterns, limits & quotas, security, configuration, and integrations & coding patterns. Use when configuring Bastion for AKS private clusters, VM scale sets, Entra ID auth, hub/spoke VNets, or IP-based cross-VNet access, and other Azure Bastion related development tasks. Not for Azure Virtual Network (use azure-virtual-network), Azure Virtual Network Manager (use azure-virtual-network-manager), Azure VPN Gateway (use azure-vpn-gateway), Azure Firewall (use azure-firewall).

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Expert knowledge for Azure Cloud Shell development including troubleshooting, limits & quotas, and security. Use when handling Cloud Shell storage mounts, session limits, file persistence, private VNet access, or RBAC setup, and other Azure Cloud Shell related development tasks. Not for Azure Portal (use azure-portal), Azure Virtual Machines (use azure-virtual-machines), Azure Virtual Desktop (use azure-virtual-desktop), Azure DevOps (use azure-devops).

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Expert knowledge for Azure Active Directory B2C development including troubleshooting, best practices, decision making, architecture & design patterns, limits & quotas, security, configuration, integrations & coding patterns, and deployment. Use when building B2C user flows/custom policies, configuring IdPs/MFA, securing APIs, automating CI/CD, or monitoring with Sentinel, and other Azure Active Directory B2C related development tasks. Not for Azure Role-based access control (use azure-rbac), Azure Information Protection (use azure-information-protection), Azure Security (use azure-security), Azure Sentinel (use azure-sentinel).

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Expert knowledge for Azure Advisor development including best practices, decision making, limits & quotas, security, configuration, and integrations & coding patterns. Use when configuring Advisor alerts/digests, managing rec states, using workbooks, Resource Graph, or RBAC for access, and other Azure Advisor related development tasks. Not for Cost Management (use azure-cost-management), Azure Monitor (use azure-monitor), Azure Policy (use azure-policy), Azure Security (use azure-security).

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Access a Base Account via the Base MCP server (mcp.base.org) - wallet, portfolio, sending, swapping, signing, x402 payments, batched calls, and transaction history.

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Amazon Brand Analytics interpretation and strategic insights for Brand Registry owners. Decode Search Frequency Rank (SFR) data, analyze Market Basket patterns, interpret Item Comparison reports, and extract demographic insights to optimize product strategy and advertising spend. Works with Brand Analytics data from all Amazon marketplaces. Requires Brand Registry access. Use when: (1) analyzing Search Frequency Rank data for keyword opportunities, (2) interpreting Market Basket data for cross-sell and bundling, (3) understanding Item Comparison competitive positioning, (4) extracting customer demographic insights, (5) optimizing product portfolio based on customer behavior, (6) building data-driven advertising strategies.

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Brand Registry enrollment guide — eligibility, application, benefits, A+ Content access, brand protection tools

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Catch the accessibility failures that ship in almost every AI-built UI. Use after building any interactive component.

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用火山引擎 Podcast AI 模型生成中文双人对话播客。当用户要把文章、报告、话题文本转成播客音频、生成对话式音频内容时使用，需要环境具备火山引擎 APP_ID 和 ACCESS_KEY。支持 mp3/ogg_opus/pcm/aac、语速调节、自定义音色、断点续传。不用于：单人朗读式 TTS（用普通语音合成）、英文播客（模型主要优化中文）、播客文稿本身的撰写（先用写作类 skill 产出文本再来）。

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