「clo」の検索結果

Bulk mode — maximum development speed by spending tokens aggressively on massive parallel sub-agents and multi-agent workflows, while the orchestrator context stays lean (pairs with /slim). Invoking /bulk is the user's explicit opt-in to Workflow/ultracode-style orchestration for this session. Use when the user types /bulk, asks for "爆速", "並列で大量に", "ultracode", "多エージェント", or hands over a big task where wall-clock speed matters more than token cost.

Performs proximity operations on genomic intervals with bedtools (closest, window, flank, slop) and pybedtools - nearest-feature queries with signed/strand-aware distance, fixed-radius window searches, strand-aware promoter construction, and interval extension. Covers the closest -d/-D a/b/ref/-t/-k/-io/-iu/-id flags, the -D ref strand sign-flip, silent chromosome-end clipping in slop/flank, -t all tie double-counting, and the critical distinction between a geometry answer (nearest TSS) and a biology answer (which gene an element regulates). Use when assigning peaks or variants to genes, defining promoters from a gene model, building distance-to-TSS distributions, finding features within a window, or extending intervals - and when deciding whether nearest-gene is a fair prior (GWAS locus) or a trap (distal enhancer).

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Stores and operates on sparse expression matrices for single-cell and large bulk RNA-seq, covering dgCMatrix/dgRMatrix/dgTMatrix when-each-is-fast, the dgCMatrix (CSC, R) <-> CSR (Python) implicit transpose, AnnData (cells-rows) <-> SingleCellExperiment (cells-cols) orientation flip, HDF5/h5ad vs Zarr cloud-native shift, HDF5SummarizedExperiment + DelayedArray for out-of-memory bulk, scanpy backed mode for large h5ad, the ~10-15% density crossover where dense beats sparse, 10X format proliferation (MTX vs CellRanger H5 vs h5ad), the dense-conversion memory blow-up, and Dask + Zarr for consortium-scale matrices. Use when choosing sparse format, working with single-cell-sized matrices, importing/exporting 10X, debugging R/Python interop transposes, processing matrices too large for RAM, or building cloud-native pipelines.

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Download raw sequencing reads from NCBI SRA using sra-tools (prefetch, fasterq-dump, vdb-validate) or the ENA mirror. Use when pulling FASTQ for SRR/ERR/DRR accessions, deciding between SRA-direct, ENA mirror, or AWS/GCP cloud mirror (STRIDES), handling --include-technical for 10x and other single-cell records, validating with MD5/vdb-validate, navigating SRR/SRX/SRS/SRP/PRJNA hierarchy, or finding accessions via pysradb. Encodes SRA cloud-egress economics, the fasterq-dump uncompressed-scratch trap, and the --max-size default that silently truncates large prefetches.

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Designs and analyzes in vivo CRISPR screens in animal tumor models, organoids, and immune-cell adoptive transfers. Covers bottleneck math (250x cells/sgRNA requires ~25M cells implanted; impossible for most syngeneic models, forcing focused libraries), focused library design (Manguso 2017 Nature 547:413 immune screen; Chen 2015 tumor screens), CRISPR-StAR intrinsic-control screening (Uijttewaal 2025 Nat Biotechnol 43:1848), clonal-dynamics-limited detection, tumor-explant DNA recovery, syngeneic vs xenograft vs PDX considerations, and the relationship to downstream MAGeCK / drugZ analysis. Use when designing in vivo CRISPR screens for tumor / immune / metastasis biology, choosing focused vs genome-wide for animal models, addressing bottleneck-induced clonal collapse, picking the syngeneic / xenograft / PDX model, integrating in vivo with in vitro results, or applying CRISPR-StAR for animal experiments.

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Designs pooled sgRNA libraries for CRISPR knockout, interference (CRISPRi), activation (CRISPRa), Cas12a multiplex, base-editor, and prime-editor screens. Covers on-target scoring (Rule Set 2, Azimuth, DeepSpCas9, CRISPRon), off-target scoring (CFD, MIT), TSS-relative positioning for CRISPRi/a (Horlbeck, Dolcetto, Calabrese), PAM-variant chemistries, control-guide composition, oligo cloning architecture, and library QC. Use when choosing a genome-wide library (GeCKOv2 vs Avana vs Brunello vs TKOv3 vs Inzolia), designing a focused or paralog-focused custom library, picking CRISPRi vs CRISPRa TSS windows, deciding control-guide proportions, or diagnosing library skew and dropout in a freshly cloned pool.

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Harden IAM, storage, keys, and org policies in cloud accounts you administer. Focus on identity, logging, and public-exposure controls.

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CodexとDevinがMCPまたはCLIで直接対話し、調査・実装・レビュー・修正を進める。Devinとの対話的な開発を依頼されたときに使い、質問への回答と成果の確認を往復しながら、許可されたPR作成・採用まで進める。Cloudでは公式MCP、手元のファイルや環境ではDevin CLIを使う。Devinの画面操作を指定された場合はdevin-browser-prを使う。

Systematically evaluate weak, stale, or low-conviction theses for upgrade, monitoring, or closure. Use when user says "prune", "kill list", "clean up theses", "what should I close", or "reduce portfolio".

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Reserved and on-demand GPU cloud instances for ML training and inference. Use when you need dedicated GPU instances with simple SSH access, persistent filesystems, or high-performance multi-node clusters for large-scale training.

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Design and create AEM Workflow models on AEM as a Cloud Service. Use when creating workflow models via the Workflow Model Editor or content package XML, defining step types (PROCESS, PARTICIPANT, DYNAMIC_PARTICIPANT, OR_SPLIT, AND_SPLIT), configuring step properties, declaring workflow variables, and deploying models through the Cloud Manager pipeline.

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Optimize performance of the Adobe Dispatcher Apache HTTP Server module and related HTTPD configuration for AEMaaCS cloud workflows only, with cloud-specific baseline and runtime verification.

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Publish, deactivate, and delete AEM content programmatically via the Cloud Service Replication API (com.day.cq.replication). Covers single-path and bulk activation, preview-tier targeting with AgentFilter, synchronous/async options, ReplicationStatus checks, permission validation, workflow process steps, and replication event handling. Use when the user needs to publish pages, activate or deactivate content, check replication status, build workflow steps that replicate content, listen to replication events, query batch publication state, or work with Replicator, ReplicationOptions, or ReplicationStatusProvider in AEM Cloud Service.

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Triage AEM Workflow issues on AEM as a Cloud Service by classifying symptoms, gathering the right logs and metrics, and mapping to runbooks or Splunk searches. Use when the user asks for workflow activity/errors on a Cloud Service host, needs to classify a Jira ticket, or wants to know what to collect for workflow debugging.

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Provide advisory guidance for the Adobe Dispatcher Apache HTTP Server module and related HTTPD configuration in AEMaaCS cloud workflows only, with public-doc citations and cloud-specific MCP verification plans. Use for conceptual questions such as `statfileslevel`, filter rules, URL decomposition, cache invalidation behavior, rewrite behavior, and security headers.

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Debug AEM Workflow issues on AEM as a Cloud Service — stuck workflows, failed steps, missing Inbox tasks, launcher failures, stale instances, thread pool exhaustion, queue backlogs, purge failures, and permissions errors. Use when the user reports workflow problems on Cloud Service, asks why a workflow is stuck or failed, needs step-by-step troubleshooting, or provides thread dumps, configuration status output, or Sling Job console output for analysis.

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Perform security audits for the Adobe Dispatcher Apache HTTP Server module and Apache HTTPD in AEMaaCS cloud workflows only, with cloud-specific hardening verification.

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Single entry point for all AEM as a Cloud Service Workflow skills. Covers workflow model design, custom process step and participant chooser development, launcher configuration, workflow triggering, and production support including debugging stuck/failed workflows, triaging incidents with Cloud Manager logs, thread pool analysis, and Sling Job diagnostics for the Granite Workflow Engine.

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Automate Cloudpress tasks via Rube MCP (Composio). Always search tools first for current schemas.

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Automate Cloudflare tasks via Rube MCP (Composio). Always search tools first for current schemas.

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Automate Cloudlayer tasks via Rube MCP (Composio). Always search tools first for current schemas.

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Automate Cloudflare Browser Rendering tasks via Rube MCP (Composio). Always search tools first for current schemas.

日本語の概要は準備中です。原文の説明を表示しています。

Automate Cloudinary media management including folder organization, upload presets, asset lookup, transformations, and usage monitoring through natural language commands

日本語の概要は準備中です。原文の説明を表示しています。

Automate Cloudflare API tasks via Rube MCP (Composio). Always search tools first for current schemas.

日本語の概要は準備中です。原文の説明を表示しています。