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概要と使いどころ
Use when you need to understand or set expectations for the Academy of Management Journal (AMJ) editorial and peer-review process — desk review, the developmental multi-round R&R culture, and reading a decision letter. Explains the process and how to read decisions; it does not draft the response letter (amj-rebuttal).
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Use when working with the Associate Editor and Editor of an Academy of Management Annals (Annals) review — scope alignment after a proposal is invited, what review-article referees evaluate, and revision expectations. Plans the interaction; it does not run the portal preflight (amann-submission) or draft the response letter (amann-revision).
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Use when organizing AAAI supplementary material, including the technical appendix, multimedia appendix, and code/data ZIPs, while respecting that AAAI supplements are due with the paper, treated as immutable after submission, must stay double-blind, and should never hide main-paper-critical evidence from reviewers who skim the appendix.
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Analyze a creator, influencer, founder, competitor, or brand social account to explain its positioning, content pillars, winning posts, hooks, formats, series, calls to action, and audience response. Use when the user wants to understand why an account works and what patterns to test without copying it.
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Find posts that materially outperform an account's normal baseline and explain the hook, topic, format, timing, and audience response patterns worth testing.
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Aggregate customer feedback from multiple sources — support tickets, NPS comments, Slack messages, G2 reviews, call transcripts, survey responses — into a unified VoC report with theme clustering, sentiment analysis, trend detection, and actionable recommendations for product, marketing, and CS teams. Chains review-site-scraper for public review data.
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Triages all inbound leads from a given period — demo requests, free trial signups, content downloads, webinar registrations, chatbot conversations. Classifies by urgency, qualifies against ICP, enriches with context, and produces a prioritized action queue with recommended response for each lead. Tool-agnostic — works with any CRM, form tool, or lead source.
日本語の概要は準備中です。原文の説明を表示しています。
Test and document API endpoints - validate responses, check status, generate examples
日本語の概要は準備中です。原文の説明を表示しています。
Monitor website uptime - check availability, response times, and status
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Take raw customer inputs — interview transcripts, survey responses, Slack quotes, support tickets, review excerpts — and generate a structured case study draft with problem/solution/result narrative, pull-quotes, metric callouts, and multi-format outputs (full case study, one-pager, social proof snippet, sales deck slide). Pure reasoning skill. Use when a product marketing team has customer signal but no time to write the story.
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Render a punchy ~12s vertical (9:16) music-only direct-response OFFER ad as a 4-beat kinetic-typography film — HEADLINE slam → real PRODUCT drop → CLAIM/proof → CTA pill — from one config of copy slots, a real product photo, a brand palette, fonts, bpm, and beat split. DETERMINISTIC + FREE (a bundled Remotion project; springs + interpolate, no AI-gen for visuals). Backgrounds are engine gradient divs off the palette, props are inline SVG, the ONLY composited bitmap is the REAL product photo (objectFit:contain, never stretched), and ALL headline/claim/CTA/URL/wordmark text is typeset in the engine — never AI-rendered (the format's credibility guard). A driver binds the config to Remotion input props, renders the 9:16 master, and derives a 1:1 center-crop with ffmpeg. Two gating checks run before render (claim verbs must match the product's physical format; the claim beat needs an edge-entry mechanism prop). Use for the motion-graphics-offer-ad format.
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Use Verify for snapshot testing in .NET. Approve API surfaces, HTTP responses, rendered emails, and serialized outputs. Detect unintended changes through human-reviewed baseline files.
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Build responsive email templates using MJML markup language. Compiles to cross-client HTML that works in Outlook, Gmail, and Apple Mail. Includes template renderer, layout patterns, and variable substitution.
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Nominates and assesses CRISPR off-target sites genome-wide. Enumerates candidate sites by mismatch and bulge tolerance with Cas-OFFinder/CRISPRitz, ranks them with the published CFD score (SpCas9-only, relative ranker) or MIT/CRISTA/energy models, runs variant-aware screening against gnomAD/individual genomes (CRISPRme), and frames the empirical genome-wide discovery assays (GUIDE-seq, CIRCLE-seq, CHANGE-seq, DISCOVER-seq, Digenome-seq) and high-fidelity nuclease choice (HiFi Cas9, Sniper-Cas9, eSpCas9, SpCas9-HF1). Use when assessing guide RNA specificity, choosing among candidate guides, screening a therapeutic guide against population variation, or planning empirical off-target validation. Distinguishes predicted vs detected vs validated. On-target activity scoring and deaminase (Cas-independent) base/prime-editor off-targets are separate skills.
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Treats a ctDNA assay as a molecule-counting experiment at the Poisson edge and builds its analytical-validation case the measurement-science way. Covers the genome-equivalent currency (~330 haploid copies/ng), the lambda = input_GE x VAF sampling ceiling (lambda>=3 for ~95% detection), the error-suppression ladder (raw NGS ~1e-3 -> single-strand UMI ~1e-4/1e-5 -> duplex <1e-7), the CLSI EP17 LoB/LoD/LoD95/LoQ framework, the per-locus-vs-panel-integrated LoD distinction that lets bespoke MRD reach ppm, contrived/SEQC2 reference standards, and honest LoD reporting conditioned on input mass + consensus depth + replicate detection rate. Use when stating or trusting a sensitivity claim, designing a dilution-series validation, deciding how many genome equivalents are needed at a target VAF, choosing a single-locus vs panel-integrated LoD, or auditing a "detects 0.1% VAF" claim.
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Rank and prioritize neoantigen/epitope candidates by likely T-cell response using NeoFox feature annotation, PRIME2.0, BigMHC-IM, the Łuksza/Balachandran fitness model (agretopicity + foreignness), and pVACtools tiering. Encodes the field's hard truths that immunogenicity is the least-solved layer (dedicated scores ~AUROC 0.6-0.7, modest PPV), that scores are valid only for RANKING within one patient (never absolute go/no-go or cross-patient), that DAI has anchor-inflation and WT-denominator traps, and that stacking weak correlated scores into one number is a red flag. Use when ordering a candidate list for a vaccine. Binding lives in mhc-binding-prediction; calling in neoantigen-prediction.
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Simulate transcription factor perturbation effects on cell state in silico with CellOracle and Dynamo, and predict transcriptional responses to genetic perturbations with GEARS, scGen, and CPA. Covers the direction-not-magnitude principle, local-linear validity, the GRN/velocity error it inherits, baseline discipline (mean and additive baselines), and the validation gap. Use when predicting TF knockout or overexpression effects, ranking driver TFs for fate transitions, or planning perturbation experiments. For GRN construction see multiomics-grn; for experimental Perturb-seq see single-cell/perturb-seq.
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Assigns pathogen lineages (SARS-CoV-2 Pangolin UShER mode; Nextclade clade + QC; pango-designation alias resolution) and tracks variant frequencies over time using Nextstrain (Augur + Auspice), wastewater deconvolution (Freyja, COJAC, alcov, lineagespot), lineage-fitness modelling (multinomial logistic), and recombinant detection (3SEQ, RDP4, Bolotie). Covers Pangolin pangolin-data and Nextclade dataset version pinning (mandatory; lineage-defining mutations change with dataset), Freyja barcode forward-only date constraint, ARTIC primer scheme churn (V3/V4/V4.1/V5.3.2/Midnight) with dropout regions, and recombinant X-prefix designation lag. Use when assigning Pango lineages and Nextclade clades to viral consensus sequences, building Nextstrain Augur surveillance pipelines, deconvolving wastewater into lineage frequencies with Freyja, tracking lineage frequencies over time, handling ARTIC primer dropouts, or running surveillance for SARS-CoV-2/influenza/Mpox/RSV/H5N1/measles.
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Search NCBI databases using Biopython Bio.Entrez (ESearch, EInfo, EGQuery, ESpell). Use when finding records by keyword, building reproducible field-qualified queries, navigating the Entrez Query Translator, exploiting the history server for large result sets, handling retmax caps, or interpreting weekly index lag. Covers PubMed, Nucleotide, Protein, Gene, SRA, GEO, Assembly, Taxonomy, ClinVar, dbSNP.
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Bulk-query Ensembl BioMart (and other BioMart instances) for cross-database ID mapping, gene/transcript/exon coordinates, and ortholog tables. Use when batch-converting Ensembl IDs to other namespaces (HGNC, RefSeq, UniProt, Entrez), pulling gene coordinate tables for thousands of genes, building ortholog wide-tables across species, or replacing slow Ensembl REST loops with one-shot bulk export. Encodes BioMart's XML query format, R biomaRt vs Python pybiomart trade-off, mart-vs-dataset hierarchy, and the URL endpoint that's BioMart-specific (separate from rest.ensembl.org).
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Build Sankey, alluvial, river, and CONSORT-style flow diagrams to visualize cohort transitions, cell-state changes, or pipeline filtering using ggalluvial, networkD3, plotly, and consort. Use when showing how entities move between categories across timepoints (cell states, drug response classes, patient flow through a trial) or filtering pipelines (variants filtered through QC stages).
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Detect syntenic blocks and structural rearrangements between genomes using MCScanX (Wang 2012), JCVI/MCScan (Tang 2008 Python), GENESPACE (Lovell 2022) for orthology-anchored riparian visualization, SyRI for structural variation, AnchorWave for sequence-level synteny, i-ADHoRe 3.0 for highly diverged species, SynNet for synteny networks, and ntSynt for multi-genome macrosynteny. Use when identifying collinear gene blocks across species, distinguishing macrosynteny from microsynteny, detecting inversions/translocations/duplications, anchoring orthology in WGD lineages, producing publication riparian plots, computing synteny block age via Ks (cross-references whole-genome-duplication), or running synteny-aware ortholog inference in polyploids.
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Identifies super-enhancers from H3K27ac, MED1, or BRD4 ChIP-seq using ROSE, ROSE2, LILY, HOMER -style super, and ENCODE dELS cross-referencing. Handles peak stitching parameters, ranking choices, hockey-stick inflection, marker choice (H3K27ac vs MED1/BRD4), and cross-condition comparison with spike-in normalization. Constructs core regulatory circuitry (Saint-Andre 2016) from SE-encoded TFs. Use when identifying cell-identity / cancer-associated regulatory domains, comparing super-enhancers between conditions, identifying master transcription factor networks, or predicting BET-inhibitor responsiveness.
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Performs 3D shape-based similarity searching using ROCS (OpenEye), USRCAT (ultra-fast), Open3DAlign (RDKit), ESPSim (electrostatic), and ShaEP with explicit handling of Tanimoto-Combo (shape + color), shape vs ECFP4 complementarity, conformer-ensemble searching, alignment optimization, and scaffold hopping. Use when searching for shape-mimicking compounds with different scaffolds, identifying bioisosteric replacements, prospective scaffold hopping, or expanding hit series beyond 2D similarity.
日本語の概要は準備中です。原文の説明を表示しています。