「aria」の検索結果

Guide actuarial analysis for insurance pricing. TRIGGERS - Use when user needs help with actuarial-analysis related tasks.

日本語の概要は準備中です。原文の説明を表示しています。

Generates design variants of existing Stitch screens using the native variant API. Explore alternative layouts, color schemes, fonts, or content with configurable creativity levels.

日本語の概要は準備中です。原文の説明を表示しています。

5つの異なるUIデザインバリエーションを並列エージェントチームで生成し、Pencil(.pen)で比較するスキル。 各バリエーションに デザイナー + レビュアー + コピーライター の3人チーム（計15エージェント）。 デザイナーが直接 Pencil に構築するため、5画面が同時並行で出来上がる。 固定プリセットは使わず、現在のアプリのコードベース・ドメイン・ペルソナ・トンマナ・競合を分析し、 そのアプリに最適な5つのスタイル方向を毎回ゼロから生成する。 Use when: UIのバリエーションを比較したい、複数のデザイン案を出したい、 デザインの方向性を探りたい、A/Bテスト用のデザインが欲しい。 Triggers: "UIバリエーション", "デザイン比較", "デザイン案", "5案出して", "バリエーション", "デザインパターン", "UI variations", "design alternatives", "複数案", "A/Bテスト", "デザイン探索", "スタイル比較"

Evolve an existing agent definition by refining its persona in-place or creating an advanced variant. Covers assessing the current agent against best practices, gathering evolution requirements, choosing scope (refinement vs. variant), applying changes to skills, tools, capabilities, and limitations, updating version metadata, and synchronizing the registry and cross-references. Use when an agent's skills list is outdated, user feedback reveals capability gaps, tool requirements have changed, an advanced variant is needed alongside the original, or the agent's scope needs sharpening after real-world use.

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Evolve an existing skill by refining its content in-place or creating an advanced variant. Covers assessing the current skill, gathering evolution requirements, choosing scope (refinement vs. variant), applying changes, updating version metadata, and synchronizing the registry and cross-references. Use when a skill's procedure steps are outdated, user feedback reveals gaps, a skill needs a complexity upgrade, an advanced variant is needed alongside the original, or related skills are added and cross-references are stale.

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Fix silent incorrect results in RFDB Datalog queries that share a variable between two edge atoms on opposite ends (e.g. self-join patterns like `edge(M, C, "T1"), edge(C, M, "T2")`). Use when: (1) a Datalog rule returns rows that look structurally wrong (e.g. a self-loop rule reports hits but pinning M to each reported id refutes the edge existence), (2) Cypher `MATCH (m)-[:R1]->(c)-[:R2]->(m)` returns the same bogus rows (engine-level bug, not Datalog-specific), (3) results change when you bind one variable explicitly vs. leave it free. Root cause: hash- join fast path in `eval_edge_hash_join` / `eval_incoming_hash_join` unconditionally rebinds the non-key Term::Var without checking whether the variable is already bound in the current row.

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Guide actuarial analysis for insurance pricing. TRIGGERS - Use when user needs help with actuarial-analysis related tasks.

日本語の概要は準備中です。原文の説明を表示しています。

Guide basic actuarial analysis for rate setting. TRIGGERS - Use when user needs help with actuarial-analysis-guide related tasks.

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"Analyze and mitigate the bullwhip effect where demand variability amplifies upstream in supply chains. Use this skill when the user needs to diagnose order variability amplification, quantify the bullwhip ratio, or implement dampening strategies — even if they say 'why are our orders so volatile', 'supply chain variability', or 'demand amplification problem'.".

日本語の概要は準備中です。原文の説明を表示しています。

Run a seven-agent adversarial pipeline against a resume and cover letter before submission. Produces channel-conditional verdicts anchored to the realistic applicant pool, separates materials quality from submission expected value, and ends with a contrarian pass that can overturn the verdict.

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Query the Ensembl REST API for regulatory feature annotations, variant effect prediction (VEP), coordinate liftover, gene lookups, and cross-references. Use when the user needs to annotate variants with VEP (consequence, CADD, REVEL, SpliceAI), check Ensembl Regulatory Build overlap for ENCODE regions, convert coordinates between GRCh37 and GRCh38, resolve gene IDs (Ensembl ↔ symbol ↔ RefSeq), look up gene phenotype associations, or cross-reference ENCODE targets with Ensembl annotations. Also use when the user mentions Ensembl, VEP, variant effect predictor, liftover, assembly conversion, regulatory build, gene lookup, or cross-references between databases.

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Use ENCODE functional genomics data for disease mechanism research. Use when the user wants to connect GWAS variants to regulatory elements, annotate disease-associated loci with functional data, identify therapeutic targets from epigenomic data, build disease regulatory models, cross-reference with clinical trials and drug databases, or conduct any disease-focused, pathology-driven, or clinical variant interpretation workflow. Covers the full pipeline from disease-tissue mapping through GWAS variant annotation, heritability enrichment, cancer epigenomics, drug target identification, and clinical trial cross-referencing. Integrates ENCODE with Open Targets, PubMed, ClinicalTrials.gov, and bioRxiv.

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Guide for integrating NHGRI-EBI GWAS Catalog associations with ENCODE regulatory data. Use when users need to find GWAS variants in ENCODE peaks, connect regulatory elements to disease associations, or prioritize functional variants using ENCODE annotations. Trigger on: GWAS, genome-wide association, SNP association, trait association, GWAS Catalog, disease association, risk variant, lead SNP, LD proxy.

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Write paid ad copy for LinkedIn, Google, Meta, and YouTube. Produces multiple variants per platform, each targeting a different Eugene Schwartz awareness level and Cialdini persuasion principle. Use when the user asks for ad copy, ad variants, "write LinkedIn ads", Google ads, Meta ads, paid social copy, ad headlines, or wants creative for a paid campaign. Reads brand voice, ICP, and positioning from knowledge/. For organic social posts, see linkedin-post or social-calendar. For the landing page the ad points at, see landing-page-writer. For testing variants, see ab-copy-writer.

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Configuring or troubleshooting Salesforce CPQ Advanced Approvals: SBAA__ApprovalRule__c, SBAA__ApprovalVariable__c for cross-line aggregation, SBAA__ApprovalChain__c for ordered approver sequences, escalation timeouts, Smart Approvals for re-quote skip logic, and the managed package's permission sets. Trigger keywords: CPQ Advanced Approvals, SBAA approval rule, approval variable, approval chain, discount approval, line-level approval, Smart Approvals, requote approval. NOT for standard non-CPQ Salesforce approval processes - use admin/approval-processes. NOT for CPQ price rules and discount schedules - use admin/cpq-pricing-rules.

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Use when configuring or troubleshooting the B2B/B2C Commerce product catalog — ProductCatalog, ProductCategory, ProductCategoryProduct, WebStoreCatalog, CommerceEntitlementPolicy, product attributes, and product variants. Trigger keywords: product catalog, product category, commerce catalog, entitlement policy, product variants, product attributes, catalog visibility. NOT for taxonomy, attribute strategy or category navigation design — use admin/commerce-catalog-strategy. NOT for search ranking, facets or index rebuilds — use apex/commerce-search-customization. NOT for CPQ catalogs.

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Multi-pass structural code review with adversarial analysis, scope-aware dispatch, adversarial persona passes, and forced-finding protocol. Supports input modes: branch diff (default), PR number (#123), commit hash, pending changes (--pending). Use when asked to "review this PR", "code review", "pre-landing review", "check my diff", or "review #123". Proactively suggest when the user is about to merge or land code changes. NOT for behavioral verification against a running build (see mk:evaluate); NOT for post-implementation simplification (see mk:simplify).

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Call germline SNPs and indels with GATK HaplotypeCaller and the GVCF joint-genotyping workflow. Covers the local-reassembly + PairHMM mechanism (why HC beats pileup callers on indels), the -ERC GVCF reference-confidence model and <NON_REF> allele, BQSR-vs-DRAGSTR and --dragen-mode error modeling, allele-specific (AS_) annotations, and edge cases (ploidy, Mutect2 mitochondria mode, sex chromosomes/PAR, contamination gating). Use when deciding whether to use HaplotypeCaller vs a pileup or DRAGEN caller, whether BQSR still earns its place, whether to call per-sample GVCFs for a cohort, or how to handle non-diploid, mitochondrial, sex-chromosome, or contaminated samples. Not for post-calling filtering depth (see variant-calling/filtering-best-practices) or cohort joint-genotyping scaling (see variant-calling/joint-calling).

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Designs genomics experiments so technical nuisance variation (batch, lane, plate, flow cell, operator, reagent lot, processing day) is balanced against the biological variable of interest and therefore estimable rather than confounded, using constrained sample-to-batch assignment (designit, OSAT), the confounder/mediator/collider distinction, and the principle that no post-hoc correction recovers a fully confounded design. Covers detecting hidden batches with surrogate variable analysis, a decision table for downstream correction (ComBat-seq, RUVSeq, SVA) whose execution is deferred to differential-expression/batch-correction, and reproducibility metadata. Use when assigning samples to sequencing batches/lanes/plates, avoiding batch-condition confounding, deciding whether a design is salvageable by correction, choosing a correction method, or estimating the number of hidden batches. For the experimental unit, randomization, and blocking concepts see experimental-design/randomization-blocking.

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Aligns sample metadata with count matrices and constructs design matrices for downstream DE, handling the alphabetical-reference-level trap (relevel BEFORE DESeq), LRT reduced-model rules, the interaction-term resultsNames trap, continuous-covariate scaling and splines, repeated measures via duplicateCorrelation or dream, high-cardinality categorical pseudo-singular designs, sample swap detection via XIST/RPS4Y1 expression and somalier/NGSCheckMate genotypes, SABV (sex-as-biological-variable) mandate, Simpson's-paradox collapsing of technical replicates, and the `~ 0 + group` parameterization for clean contrasts. Use when building a design matrix, troubleshooting reversed fold-change direction, encoding paired or repeated-measures designs, detecting sample swaps, deciding sex-as-covariate, or aggregating technical replicates.

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Analyzes species-environment relationships with constrained ordination (CCA, RDA, db-RDA), variance partitioning, indicator species (indicspecies IndVal.g group-equalized), PERMANOVA paired MANDATORILY with PERMDISP (Anderson & Walsh 2013; dispersion confounds centroid tests), Joint Species Distribution Models (HMSC, sjSDM, gjam) with explicit rejection of "residual covariance equals biotic interaction", phylogenetic community ecology (SES_MPD/MNTD), trait-environment via RLQ + fourth-corner with corrected modeltype=6 (Dray 2014), bipartite network metrics (NODF, modularity) with curveball null (Strona 2014), and Mantel-test replacements (dbRDA, GDM) for spatial data. Use when testing how environmental gradients structure communities, identifying habitat indicator taxa, partitioning variance among predictors, deciding whether PERMANOVA significance is location vs dispersion, picking among HMSC/sjSDM/gjam, or replacing Mantel tests for landscape data.

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Detects somatic mutations in circulating tumor DNA, treating low-VAF detection as a signal-versus-noise problem set by error suppression and molecules sampled, not by the choice of caller. Distinguishes de novo CALLING (scanning a panel for unknown variants, bounded by per-locus error and multiple testing) from tumor-informed DETECTION (tracking a pre-specified variant set, where panel integration reaches single-ppm). Covers VarDict and Mutect2 for de novo calling, UMI-aware callers, and a pysam-based known-variant VAF tracker, with matched-WBC subtraction as the mandatory defense against clonal hematopoiesis (the dominant false positive). Use when calling or tracking tumor mutations from plasma cfDNA, setting a VAF threshold, or deciding whether a low-VAF call is tumor versus CHIP.

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Detect syntenic blocks and structural rearrangements between genomes using MCScanX (Wang 2012), JCVI/MCScan (Tang 2008 Python), GENESPACE (Lovell 2022) for orthology-anchored riparian visualization, SyRI for structural variation, AnchorWave for sequence-level synteny, i-ADHoRe 3.0 for highly diverged species, SynNet for synteny networks, and ntSynt for multi-genome macrosynteny. Use when identifying collinear gene blocks across species, distinguishing macrosynteny from microsynteny, detecting inversions/translocations/duplications, anchoring orthology in WGD lineages, producing publication riparian plots, computing synteny block age via Ks (cross-references whole-genome-duplication), or running synteny-aware ortholog inference in polyploids.

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Trains and applies base-resolution deep learning models on ChIP-seq / ChIP-nexus / CUT&RUN data. Uses BPNet (Avsec 2021 Nat Genet 53:354; soft motif syntax from ChIP-nexus), chromBPNet (Pampari A et al 2024 bioRxiv; bias-factorized base-resolution profiles), EnFormer (Avsec 2021 Nat Methods 18:1196; 196 kb input, ~100 kb effective receptive field), DeepSEA (Zhou 2015; multi-task CNN), and JASPAR 2026 deep-learning collection (1259 BPNet ChIP models). Performs in silico mutagenesis for variant-effect prediction, DeepLIFT/Grad attribution, and TF-MoDISco motif discovery from attribution scores. Use when predicting variant effects on TF binding, discovering soft motif syntax / cooperativity, integrating ChIP-seq with sequence-only predictions, or applying precomputed JASPAR Deep Learning models to new variants.

日本語の概要は準備中です。原文の説明を表示しています。