677 件 ・ 関連度順
概要と使いどころ
Use when defining ambiguous or high-complexity new features, product behavior, UI/component design, architecture choices, contract changes, or when grilling/pressure-testing a plan or design. Routine small requests stay on the fast path.
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Tear down a competitor's repo or product into a feature inventory and adoption choices. Use when: comparing us to another tool or asking what to steal.
日本語の概要は準備中です。原文の説明を表示しています。
Use when deciding how to correctly download/install a Bethesda mod per the author's instructions — triggers "how do I install", "FOMOD choices", "which file to download", "author说明", "install instructions", "which variant", "按作者说明安装", "这个mod怎么装". NOT for deciding whether to include the mod (use evaluating-bgs-mods), load order editing (writing-bgs-load-order), record conflicts (xedit-conflict-audit), archive operations (using-bgs-archive), Papyrus work (using-bgs-papyrus), or translation/export tasks (using-bgs-translator).
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INVOKE THIS SKILL when routing a LangGraph agent with a decision model (TypeSafe Jev, SemIf) instead of an LLM, or when auditing an existing agent for LLM calls that only produce a routing decision. Covers langchain-typesafe Noul/Choice/Score, reading answers correctly, threshold design, and LangSmith Gateway wiring.
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Use when you need to understand how American Anthropologist (AA) evaluates a manuscript — editorial screening, anonymous peer review under an ethics of care, the four-field editorial board, decision categories, and how section choice shapes the path. Sets expectations and shapes the paper to survive review; it does not contact editors.
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Use when the headline result of an American Economic Journal: Macroeconomics (AEJ: Macro) manuscript must be shown stable across specification, sample, identification, and tuning choices. Builds the robustness program a macro referee will demand; it does not establish the primary identification or model (use aejmac-identification / aejmac-theory-model first).
日本語の概要は準備中です。原文の説明を表示しています。
Use when an American Economic Journal: Applied Economics (AEJ: Applied) manuscript's headline estimate must be shown to survive specification, sample, and inference choices before submission or in an R&R. Builds the robustness suite a sophisticated referee expects; it does not establish the primary identification (aeja-identification) or format the exhibits (aeja-tables-figures).
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Use when auditing an ACM MM (ACM Multimedia) submission for OpenReview readiness — thematic-area choice, the 6-8 page ACM sigconf budget, references-only overflow, double-blind anonymity versus the single-blind Reproducibility/Open-Source/Dataset tracks, supplementary media, dual submission, desk-reject triggers, and last-week sequencing.
日本語の概要は準備中です。原文の説明を表示しています。
Use when planning the end-to-end ACM MM (ACM Multimedia) campaign calendar — from thematic-area scoping and track choice, through the April OpenReview abstract/paper/supplement chain, the June anonymous rebuttal, the July decision, the August camera-ready, and the November presentation in Rio, with the right skill invoked at each stage.
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Use when deciding whether a project fits ACL versus EMNLP, NAACL, EACL, TACL, Computational Linguistics, COLM, or an ML venue, covering contribution typing for NLP work, long-versus-short paper choice, the annual theme track, Findings-tier expectations, and sharpening the computational-linguistics framing before writing starts.
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Use when systematically gathering, coding, and synthesizing a management/organization literature for an Academy of Management Annals (Annals) review — the search-and-coverage methodology and the choice of narrative vs. systematic vs. bibliometric integration. Builds the corpus and synthesis notes; it does not impose the organizing spine (amann-organizing-framework) or write prose.
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Use when auditing an AAMAS main-track submission for OpenReview readiness, the 8-page-plus-references limit, the full-paper versus 2-page extended-abstract choice, double-blind anonymity, the supplementary zip cap, track fit across the AAAI/JAAMAS/Blue Sky tracks, dual-submission rules, and desk-reject triggers before upload.
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Create stunning, animation-rich HTML presentations from scratch or by converting PowerPoint files. Use when the user wants to build a presentation, convert a PPT/PPTX to web, or create slides for a talk/pitch. Helps non-designers discover their aesthetic through visual exploration rather than abstract choices.
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Full video production sequence with script review, actual ingredient choices, controlled generation, editing, evidence-based quality review, polish, captions and delivery. A host binding supplies project storage, authentic approvals, provider access and billing.
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Assemble a 3D-CGI app sizzle — nano-banana CGI plates (blank-glow floating phone + a CGI studio with rim-light + placeholder burst shapes; studio look and phone finish come from the recipe choices) plus PIL compositing of the REAL App Store screenshots onto the bezel + burst-out overlays, driven by Kling 3.0 i2v steady-float per beat with a per-beat Ken-Burns FFmpeg push-in fallback when Kling garbles the UI, then VO/music mix (sidechain duck, loudnorm) + 1.15x speed + anti-AI grain finalize. The on-screen UI, any faces in it, and the wordmark are ALWAYS real assets composited via PIL — never AI-rendered. The paid steps (plates, i2v clips, VO, music) are separate capabilities; this ships the config + PIPELINE + FREE assembly and the recipe orchestrates the spend. Use for the cgi-app-sizzle video format.
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Assemble the FREE steps of the flat-vector-explainer video format — a flat-illustration host character (who, where, tone, voice and music come from the recipe choices) walks a countable N-step product routine, one step per beat, and Remotion composites every chip/numeral/tagline/slate/CTA as an animated DOM overlay ON TOP of the Kling i2v character clips (text is NEVER baked into a keyframe — i2v warps type), the closing 'N products' grid is a PIL composite of the REAL product photos (not AI), full-sentence VO drives word-by-word burned captions over a VO-forward music bed, and the ~50s animated silent master is re-cut to a 30s deliverable FROM the animated master (never a static intermediate). Documentation-grade — ships config.example.json + PIPELINE.md + a README of the free assembly; the paid gen steps (keyframes, Kling i2v, VO, music) are separate capabilities the recipe orchestrates. Use for the flat-vector-explainer format.
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Plans and builds end-to-end Fabric data platforms on the Bronze, Silver, and Gold medallion pattern: ingestion to analytics, PySpark and Delta layers, pipeline orchestration, per-layer Spark tuning, Materialized Lake View versus notebook choices for Silver and Gold, and Direct Lake handoff. Use for layered architecture design, planning and recommendations. For questions over an existing Power BI report use fabriciq.
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Building or editing Simulink (.slx) models that stream signals in frames using DSP System Toolbox — audio, vibration, radar, comms. Use when the prompt names a Simulink block (Discrete FIR Filter, Buffer, Unbuffer, Rate Transition, Downsample, Upsample, Sample-Rate Converter, FIR Decimation, Time Scope, Spectrum Analyzer, From Multimedia File) or an action (frame-based processing, InputProcessing, buffering, overlap, windowing, STFT, short-time Fourier, decimate, downsample, upsample, resample, multirate, anti-aliasing, tunable filter). Prevents silent numerical errors from sample-vs-frame mismatch, wrong block choice, or missing anti-aliasing.
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Tests whether two genomic interval sets overlap (colocalize) more than expected by chance using a permutation test against a structured-genome null model. Covers bedtools fisher (analytic 2x2 screen), bedtools shuffle + jaccard permutation, GAT (isochore/GC-conditioned simulation with FDR), regioneR (flexible permutation, randomizeRegions vs circularRandomizeRegions, localZScore), LOLA (universe-relative Fisher against a region database), and GREAT/rGREAT (regulatory-domain binomial + hypergeometric for ontology-from-regions). Stresses the universe/background choice, matched background, blacklist exclusion, and multiple-testing control. Use when asking whether peaks/regions are enriched at enhancers/TFBS/features, scoring region-set colocalization or region-set enrichment, comparing CNV/SV concordance, or turning an overlap count into a defensible p-value.
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Renders Hi-C contact matrices honestly and reproducibly with matplotlib, cooltools, HiCExplorer, pyGenomeTracks, FAN-C, CoolBox, and plotgardener. Covers the raw/ICE-balanced/observed-over-expected transform choice, LogNorm vs symmetric-diverging colormaps with vmax/percentile clipping, resolution-to-feature matching (compartments 100-500kb, TADs 10-40kb, loops 5-10kb), square vs rotated-triangle track-stacking, NaN/white-stripe handling, virtual 4C, APA/saddle/on-diagonal pileups, two-condition side-by-side and log2-ratio maps, and interactive (HiGlass) vs scripted-static publication figures. Use when plotting a contact matrix, choosing a normalization or color scale, building a multi-track Hi-C figure, making a virtual 4C profile, piling up loops/boundaries, or comparing two conditions.
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Nominates and assesses CRISPR off-target sites genome-wide. Enumerates candidate sites by mismatch and bulge tolerance with Cas-OFFinder/CRISPRitz, ranks them with the published CFD score (SpCas9-only, relative ranker) or MIT/CRISTA/energy models, runs variant-aware screening against gnomAD/individual genomes (CRISPRme), and frames the empirical genome-wide discovery assays (GUIDE-seq, CIRCLE-seq, CHANGE-seq, DISCOVER-seq, Digenome-seq) and high-fidelity nuclease choice (HiFi Cas9, Sniper-Cas9, eSpCas9, SpCas9-HF1). Use when assessing guide RNA specificity, choosing among candidate guides, screening a therapeutic guide against population variation, or planning empirical off-target validation. Distinguishes predicted vs detected vs validated. On-target activity scoring and deaminase (Cas-independent) base/prime-editor off-targets are separate skills.
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Detects somatic mutations in circulating tumor DNA, treating low-VAF detection as a signal-versus-noise problem set by error suppression and molecules sampled, not by the choice of caller. Distinguishes de novo CALLING (scanning a panel for unknown variants, bounded by per-locus error and multiple testing) from tumor-informed DETECTION (tracking a pre-specified variant set, where panel integration reaches single-ppm). Covers VarDict and Mutect2 for de novo calling, UMI-aware callers, and a pysam-based known-variant VAF tracker, with matched-WBC subtraction as the mandatory defense against clonal hematopoiesis (the dominant false positive). Use when calling or tracking tumor mutations from plasma cfDNA, setting a VAF threshold, or deciding whether a low-VAF call is tumor versus CHIP.
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Designs donor/repair templates for precise CRISPR knock-ins -- choosing the format (ssODN, long-ssDNA/Easi-CRISPR, dsDNA/plasmid, AAV6), sizing homology arms, placing the cut within ~10 bp of the edit, and adding a mandatory codon-checked blocking (PAM/seed) mutation so the edited allele is not re-cut. Frames the HDR-vs-NHEJ-vs-MMEJ pathway competition, the MMEJ (PITCh) and homology-independent (HITI/HMEJ) alternatives for post-mitotic cells, ssODN strand/asymmetry choice, phosphorothioate end-protection, and ranked HDR enhancers. Use when designing a donor for a point mutation, epitope/fluorophore tag, allele replacement, or knock-in, or when HDR efficiency is low. Guide design and base/prime editing are separate skills.
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Turns Hi-C/Micro-C FASTQ into a deduplicated, filtered .pairs file with pairtools and decides whether the library worked. Covers the bwa mem -SP5M / bwa-mem2 / chromap --preset hic alignment idiom (mates mapped as independent single-end reads), pairtools parse vs parse2 and the walks-policy choice (5unique pairwise vs all for Pore-C/Micro-C concatemers), pair-type classification (keep UU and rescued UC), dedup (PCR vs optical/by-tile), select by pair_type/MAPQ/distance, restriction-fragment handling (restrict, Arima dual-enzyme, Micro-C/DNase fragment-free), and allele-specific phasing (pairtools phase to two coolers). The library-QC decision uses % long-range cis as the one-number quality metric, trans as the noise floor, orientation balance as fragment-map-free dangling-end/self-circle QC, and % duplicates as a complexity proxy. Use when processing Hi-C/Micro-C/Omni-C reads into pairs, judging library quality, handling multi-enzyme or restriction-agnostic protocols, or generating allele-specific contacts.
日本語の概要は準備中です。原文の説明を表示しています。