「classification」の検索結果

Classify constitutional (germline) copy number variants for clinical reporting using the 2019 ACMG/ClinGen technical standards points-based framework, with ClassifyCNV and AnnotSV for semi-automated scoring. Covers the separate copy-number-loss and copy-number-gain rubrics, the five-tier classification, ClinGen haploinsufficiency/triplosensitivity and dosage-sensitive regions, de novo and segregation evidence, and population-frequency benign evidence. Use when assigning pathogenic/likely-pathogenic/VUS/likely-benign/benign to a constitutional CNV, scoring a CNV against ACMG/ClinGen criteria, or distinguishing the automatable evidence from the case-specific evidence requiring manual input.

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Project gene annotations across genomes using TOGA (Kirilenko 2023 whole-genome-alignment chain-based projection with intactness classification), CESAR 2.0 (Sharma, Schwede & Hiller 2017 codon-aware exon projection), LiftOff (Shumate & Salzberg 2021 reference-based annotation transfer), Liftover (UCSC), GeMoMa (Keilwagen 2019 evidence-based projection), and Comparative Annotation Toolkit (CAT). Use when transferring annotations from a well-annotated reference to query genome(s), classifying gene-loss vs gene-intact across many genomes at scale, building Zoonomia-style comparative annotations across hundreds of mammals or birds (Kirilenko 2023), detecting pseudogenization, projecting alternative isoforms, or selecting between WGA-anchored (TOGA) vs ortholog-based (LiftOff) annotation transfer strategies.

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Annotates ChIP-seq peaks to genomic features, nearest genes, ENCODE candidate cis-regulatory elements (cCREs), and regulatory domains. Uses ChIPseeker (R), HOMER annotatePeaks.pl (CLI), pyranges (Python), GREAT/rGREAT (regulatory domain gene-set enrichment), ChIP-Enrich (locus-length-adjusted), ENCODE SCREEN cCRE classification (PLS/pELS/dELS/CA-CTCF/CA-H3K4me3), and ENCODE-rE2G for cell-type-specific enhancer-gene linking. Handles nearest-TSS vs host-gene ambiguity, promoter window definition, and feature priority. Use when assigning genomic context to peaks, linking enhancer peaks to target genes, classifying peaks against ENCODE cCRE registry, or running gene-set enrichment on peak-associated genes.

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Queries ClinVar for variant pathogenicity classifications, ClinGen VCEP curations, and somatic-vs-germline interpretations via REST API, weekly VCF, or bulk XML. Use when determining clinical significance, triangulating conflicting interpretations, or aggregating evidence against the ACMG/AMP framework with ClinGen SVI specifications.

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Applies ACMG/AMP 2015 framework with ClinGen SVI specifications, Tavtigian 2018/2020 Bayesian point system, Abou Tayoun 2018 PVS1 decision tree, Pejaver 2022 and Bergquist 2025 calibrated PP3/BP4 thresholds for REVEL/BayesDel/AlphaMissense, Brnich 2020 PS3/BS3 OddsPath, Walker 2023 SpliceAI splicing framework, and AMP/ASCO/CAP 2017 tumor tiers. Use when classifying germline variants P / LP / VUS / LB / B, applying VCEP-specific CSpec rules, computing Whiffin BS1, or assigning cancer Tier I-IV per Li 2017.

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Analyzes alternative splicing from PacBio Iso-Seq (HiFi, Kinnex/MAS-Iso-seq) and Oxford Nanopore (direct cDNA, direct RNA, R10.4.1+) long-read RNA-seq with full-isoform resolution. Tools include FLAIR (correct/collapse/quantify/diffSplice for PacBio + ONT), IsoQuant (de-novo or annotation-guided isoform discovery 2024 SOTA), Bambu (annotation-aware Bayesian discovery + quantification with Novel Discovery Rate), SQANTI3 (isoform classification: FSM/ISM/NIC/NNC + artifact flags), rMATS-long (event calling on long-read isoforms), and minimap2 (-ax splice:hq for HiFi; -ax splice -k14 for ONT cDNA; add -uf only for direct RNA or stranded cDNA preps). Solves microexon detection, recursive splicing, complex multi-exon isoforms, and DTU without transcript-quantification uncertainty. Use when short-read AS limitations (anchor length, complex isoforms, microexons, recursive splicing, transcript ambiguity) demand full-isoform resolution.

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This skill should be used when user asks to "improve my mAP", "why is my model overfitting", "my training is diverging", "read my results.csv", "interpret my training curves", "my AP50 is good but AP50-95 is bad", "my recall is low", "how do I pick learning rate", "which augmentations should I use", "should I use a bigger model", "tune hyperparameters", or asks how to train YOLO26 for detection, instance or semantic segmentation, pose, OBB, classification, or depth.

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Generate driving scenes, scenarios, road surfaces, and 3D content from scenariobuilder.* sensor data (GPS, camera, lidar, actor tracks) using Scenario Builder for Automated Driving Toolbox. BUILD, EXPORT, or AUGMENT a virtual scenario/scene/map: ego or actor trajectories, trajectory smoothing, OpenCRG road-surface extraction, 3D asset generation, static-object placement, point-cloud georeferencing + elevation, lane-based ego localization, sensor-fusion tracking, scenario-event extraction (cut-ins, hard brakes, near-misses, ADAS disengagements), or export to RoadRunner, drivingScenario, OpenDRIVE, OpenCRG, OpenSCENARIO, or Unreal Engine. Also: log-to-scenario, scenario harvesting, accident/near-miss reconstruction, SOTIF (ISO 21448) and ISO 26262 scenario coverage, USGS-aerial-lidar augmentation, traffic-sign placement, vision-based vehicle classification for actor assets. NOT for raw-data import or multi-sensor sync/crop/offset/timestamp normalization — route those to matlab-import-driving-data.

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Work with hyperspectral and multispectral images in MATLAB. Covers reading/writing (ENVI, NITF, TIFF, Sentinel-2, Landsat, ASTER), ECOSTRESS spectral libraries, processing (calibration, atmospheric correction, denoising, sharpening, dimensionality reduction, endmember extraction, unmixing, target/anomaly detection, spectral indices, segmentation), labeling (Spectral Image Labeler app, ground truth objects, automation algorithms), and deep learning (pixel classification CNNs, unmixing autoencoders, transfer learning). Use when reading, writing, processing, analyzing, classifying, labeling, or applying deep learning to hyperspectral or multispectral images.

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Use when engineering or selecting the best features for single-response classification or regression in MATLAB, whatever the data's modality — for non-tabular data it routes extraction to a domain skill, then selects, assesses, and delivers on the resulting table. Not for multi-response problems, model training, or raw data acquisition.

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Interpret and explain a trained tabular machine-learning model (classification or regression) in MATLAB. Find which predictors, features, or columns matter most; explain why the model made a specific prediction, including diagnosing predictions it got wrong; show how a predictor affects the output; and compare how the model behaves across cohorts or subgroups. Uses model-agnostic techniques and model-native measures, and works on custom models (such as a dlnetwork) through a prediction function handle. Use for model interpretability, explainability, and feature-importance questions on tabular data, not for training, tuning, feature selection, deploying models, or models trained on image, text, signal, or other non-tabular data.

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Generate the post-EXECUTE closeout packet for a plan or phase. Includes archive-readiness classification, drift signal scoring, commit checkpoint recommendation, and move-on next-state recommendation.

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Extract full paper details from a CNKI paper page including title, authors, affiliations, abstract, keywords, fund, classification. Use when the user needs detailed information about a specific paper.

日本語の概要は準備中です。原文の説明を表示しています。

California Consumer Privacy Act (CCPA) and California Privacy Rights Act (CPRA) compliance advisor — business threshold analysis, consumer rights fulfillment (access, delete, correct, opt-out of sale/sharing, limit SPI, ADMT opt-out), privacy notice drafting, service provider vs. contractor vs. third-party classification, sensitive personal information (SPI) handling, data minimization, opt-out mechanisms (including GPC), cybersecurity audits and risk assessments (live since Jan 1, 2026), ADMT obligations (effective 2026, deadline Jan 1, 2027), CPPA enforcement (Disney $2.75M, PlayOn $1.1M, Ford $375K), penalty exposure, GDPR comparison, and gap assessments for businesses operating in or targeting California residents.

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Expert EU Cyber Resilience Act (CRA) advisor for Regulation (EU) 2024/2847 — mandatory cybersecurity and vulnerability handling requirements for all products with digital elements (PDEs) sold in the EU. Use this skill for gap analysis, product classification (Default / Class I / Class II), conformity assessment route selection, CE marking, SBOM requirements, vulnerability and incident reporting to ENISA/CSIRTs, support period obligations, and manufacturer/importer/distributor duties. Trigger for EU CRA, Cyber Resilience Act, PDE compliance, Annex I requirements, SBOM EU, CE marking cybersecurity, or connected product security EU.

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Expert DORA (Regulation (EU) 2022/2554 — Digital Operational Resilience Act) compliance advisor for EU financial entities. Use this skill whenever a user asks about DORA compliance, ICT risk management frameworks, ICT incident classification or reporting, threat-led penetration testing (TLPT), ICT third-party risk management, Register of Information, contractual provisions with ICT providers, ICT concentration risk, oversight of critical ICT third-party service providers (CTPPs), or any DORA RTS/ITS obligation. Also trigger for: "DORA gap analysis", "DORA readiness", "Art. 6 ICT risk framework", "Art. 17 incident reporting", "Art. 26 TLPT", "Art. 28 third-party policy", "Art. 30 contractual provisions", "Register of Information CIR 2024/2956", "critical TPSP designation", "DORA vs NIS2", "DORA simplified framework", or EBA/ESMA/EIOPA digital resilience guidance.

日本語の概要は準備中です。原文の説明を表示しています。

EU NIS2 Directive (Directive (EU) 2022/2555) compliance advisor for essential and important entities: entity classification, Art. 21 risk management measures, Art. 23 incident reporting timelines (24h/72h/1 month), Art. 20 governance obligations, supply chain security (Art. 21(2)(d); coordinated risk assessments Art. 22), gap assessments, policy drafting, ISO 27001 alignment, and penalty exposure analysis. Also covers Commission Implementing Regulation (EU) 2024/2690, the technical/methodological sub-requirements for Art. 21(2) and the significant-incident thresholds binding on DNS/cloud/data-centre/MSP/MSSP/trust-service and other digital entities. Use for NIS2 readiness, transposition questions, ENISA technical implementation guidance, significant-incident thresholds, supervisory differences between essential and important entities, and cross-border coordination.

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Expert Australian Information Security Manual (ISM) advisor for government entities and their supply chains. Use for ISM control selection, gap analysis, system authorisation, IRAP assessment preparation, security documentation, and ASD compliance. Triggers on: ISM controls, ASD compliance, IRAP assessment, PROTECTED system scoping, Essential Eight vs ISM, system authorisation, NC/OS/ PROTECTED/SECRET/TOP SECRET classification markings, security objectives, ISM guidelines or chapters, control applicability markings, cybersecurity documentation for Australian government, the June 2026 ISM update, ISM AI application controls (ISM-2112/2113/2114), and any question about the ASD Information Security Manual framework or Australian government cybersecurity obligations.

日本語の概要は準備中です。原文の説明を表示しています。

ISO 13485 internal audit expertise for medical device QMS. Use for audit planning and execution, nonconformity classification, CAPA verification, external audit preparation, or audit program management.

日本語の概要は準備中です。原文の説明を表示しています。

DORA (EU 2022/2554) digital operational resilience compliance for financial entities, covering all 5 pillars. Use for DORA readiness assessments, ICT risk management, incident classification, and third-party ICT oversight.

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Rapid NDA screening with GREEN/YELLOW/RED classification. 10-point checklist for incoming NDAs. Use when triaging NDAs, screening non-disclosure agreements, or routing NDAs for approval.

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Production incident response. Use when handling incidents, classifying severity, reconstructing timelines, writing postmortems, generating comms templates, or building response playbooks with severity scoring and RCA frameworks.

日本語の概要は準備中です。原文の説明を表示しています。

EU NIS2 Directive (Directive (EU) 2022/2555) compliance advisor for essential and important entities: entity classification, Art. 21 risk management measures, Art. 23 incident reporting timelines (24h/72h/1 month), Art. 20 governance obligations, supply chain security (Art. 21(2)(d); coordinated risk assessments Art. 22), gap assessments, policy drafting, ISO 27001 alignment, and penalty exposure analysis. Also covers Commission Implementing Regulation (EU) 2024/2690, the technical/methodological sub-requirements for Art. 21(2) and the significant-incident thresholds binding on DNS/cloud/data-centre/MSP/MSSP/trust-service and other digital entities. Use for NIS2 readiness, transposition questions, ENISA technical implementation guidance, significant-incident thresholds, supervisory differences between essential and important entities, and cross-border coordination.

日本語の概要は準備中です。原文の説明を表示しています。

NIS2 Compliance Navigator — scope classification, Art. 21 gap analysis (0-4 maturity scoring), and compliance roadmap under EU Directive 2022/2555 with deep German BSIG-neu coverage and profiles for Italy, France, Netherlands, Austria, Spain. Use when: (1) User mentions "NIS2", "NIS-2", "BSIG", "BSIG-neu", "NIS2UmsuCG", "Cyberbeveiligingswet", "Loi Résilience", "NISG", "decreto legislativo 138", (2) User asks if their organization falls under NIS2 or needs a cybersecurity compliance assessment, (3) User mentions essential/important entities, Annex I/II, BSI registration, § 30 BSIG, incident reporting, management body liability, supply chain security, (4) User wants a NIS2 gap analysis, readiness assessment, or compliance roadmap, (5) User asks about NIS2 fines, enforcement, or Nachweispflicht, (6) User asks about NIS2 in any EU Member State.

日本語の概要は準備中です。原文の説明を表示しています。