「did」の検索結果

Rank and prioritize neoantigen/epitope candidates by likely T-cell response using NeoFox feature annotation, PRIME2.0, BigMHC-IM, the Łuksza/Balachandran fitness model (agretopicity + foreignness), and pVACtools tiering. Encodes the field's hard truths that immunogenicity is the least-solved layer (dedicated scores ~AUROC 0.6-0.7, modest PPV), that scores are valid only for RANKING within one patient (never absolute go/no-go or cross-patient), that DAI has anchor-inflation and WT-denominator traps, and that stacking weak correlated scores into one number is a red flag. Use when ordering a candidate list for a vaccine. Binding lives in mhc-binding-prediction; calling in neoantigen-prediction.

日本語の概要は準備中です。原文の説明を表示しています。

Maps GWAS-implicated loci to candidate effector (causal) genes by integrating variant-to-gene (V2G) features via Open Targets L2G (Mountjoy 2021), MAGMA gene-based association (de Leeuw 2015), FUMA SNP2GENE, cS2G combined SNP-to-gene scores (Gazal 2022), Polygenic Priority Scores (PoPS, Weeks 2023), FLAMES, INQUISIT, DEPICT, and enhancer-gene predictors (ABC, ENCODE-rE2G). Use when narrowing a GWAS lead locus to a candidate causal gene, picking between proximity, eQTL-based, and similarity-based prioritizers, integrating multi-evidence streams (fine-mapping, colocalization, ABC enhancer-gene, distance, chromatin), reconciling discordant L2G vs PoPS calls, prioritizing tissue-specific eQTL evidence, or triangulating across at least three independent lines of evidence for a publication-grade effector-gene nomination.

日本語の概要は準備中です。原文の説明を表示しています。

Harvest every `ponytail:` comment in the codebase into a debt ledger, so the deliberate shortcuts and deferrals ponytail leaves behind get tracked instead of rotting into "later means never". Use when the user says "ponytail debt", "/ponytail-debt", "what did ponytail defer", "list the shortcuts", "ponytail ledger", or "what did we mark to do later". One-shot report, changes nothing.

日本語の概要は準備中です。原文の説明を表示しています。

Sanguo event review loop with LangGraph Studio visualization. Use for: 三國事件審核、generic event candidates、battle candidates、event review MCQ、accepted/rejected events、promote events、LangGraph Studio、human-in-the-loop、事件候選可視化、chunk -> extract -> validate -> review -> publish。

日本語の概要は準備中です。原文の説明を表示しています。

Generate 5–10 business idea candidates from a blank page or a founder's domain context — using pain mining, jobs-to-be-done, trend × capability mapping, constraint relaxation, adjacency search, and founder-market-fit prompts. Each candidate is a structured idea card (segment, JTBD, current alternative, why-now, distribution wedge, monetisation, "feels like"). Load when the user asks to generate business ideas, brainstorm startup ideas, find ideas to work on, says "what business should I start", "give me startup ideas", "I don't know what to build", "ideate ventures", "blank-page idea generation", "find me a startup idea", "explore business opportunities". Sub-skill of `venture-exploration`. Hard-bans "Uber for X" / "AI for X" with no specific JTBD, "everyone" segments, and idea cards missing any of the 7 required fields. Does NOT design or evaluate ideas generated — for that use `idea-evaluation`.

日本語の概要は準備中です。原文の説明を表示しています。

Analyse experiment results, run validity checks (SRM, exposure parity, data integrity, novelty/primacy), interpret causally, make a ship/iterate/kill decision against the pre-declared rule, and append to cumulative learnings. Forces honest readouts — strips significance claims from underpowered or peek-violating tests; never lets directional results masquerade as causal wins. Load when results exist, or when the user says "read out this experiment", "analyse the test", "did the test win", "interpret the results", "what did we learn", "ship or kill", or when the experimentation orchestrator routes here.

日本語の概要は準備中です。原文の説明を表示しています。

Predict peptide-MHC class I binding and natural presentation with MHCflurry, NetMHCpan-4.1, and MixMHCpred to nominate candidate CD8 T-cell epitopes. Covers the binding-affinity (BA) vs eluted-ligand (EL/presentation) distinction, why %Rank beats raw nM for cross-allele work, the MS abundance bias that misranks low-expression neoantigens, allele-coverage inequity, and length bias. Use when scanning a protein or peptide set for class I epitopes, scoring neoantigen candidates, or choosing a binding predictor. For CD4/HLA class II see mhc-class-ii-prediction.

日本語の概要は準備中です。原文の説明を表示しています。

Nominates and assesses CRISPR off-target sites genome-wide. Enumerates candidate sites by mismatch and bulge tolerance with Cas-OFFinder/CRISPRitz, ranks them with the published CFD score (SpCas9-only, relative ranker) or MIT/CRISTA/energy models, runs variant-aware screening against gnomAD/individual genomes (CRISPRme), and frames the empirical genome-wide discovery assays (GUIDE-seq, CIRCLE-seq, CHANGE-seq, DISCOVER-seq, Digenome-seq) and high-fidelity nuclease choice (HiFi Cas9, Sniper-Cas9, eSpCas9, SpCas9-HF1). Use when assessing guide RNA specificity, choosing among candidate guides, screening a therapeutic guide against population variation, or planning empirical off-target validation. Distinguishes predicted vs detected vs validated. On-target activity scoring and deaminase (Cas-independent) base/prime-editor off-targets are separate skills.

日本語の概要は準備中です。原文の説明を表示しています。

Rank and prioritize neoantigen/epitope candidates by likely T-cell response using NeoFox feature annotation, PRIME2.0, BigMHC-IM, the Łuksza/Balachandran fitness model (agretopicity + foreignness), and pVACtools tiering. Encodes the field's hard truths that immunogenicity is the least-solved layer (dedicated scores ~AUROC 0.6-0.7, modest PPV), that scores are valid only for RANKING within one patient (never absolute go/no-go or cross-patient), that DAI has anchor-inflation and WT-denominator traps, and that stacking weak correlated scores into one number is a red flag. Use when ordering a candidate list for a vaccine. Binding lives in mhc-binding-prediction; calling in neoantigen-prediction.

日本語の概要は準備中です。原文の説明を表示しています。

Maps GWAS-implicated loci to candidate effector (causal) genes by integrating variant-to-gene (V2G) features via Open Targets L2G (Mountjoy 2021), MAGMA gene-based association (de Leeuw 2015), FUMA SNP2GENE, cS2G combined SNP-to-gene scores (Gazal 2022), Polygenic Priority Scores (PoPS, Weeks 2023), FLAMES, INQUISIT, DEPICT, and enhancer-gene predictors (ABC, ENCODE-rE2G). Use when narrowing a GWAS lead locus to a candidate causal gene, picking between proximity, eQTL-based, and similarity-based prioritizers, integrating multi-evidence streams (fine-mapping, colocalization, ABC enhancer-gene, distance, chromatin), reconciling discordant L2G vs PoPS calls, prioritizing tissue-specific eQTL evidence, or triangulating across at least three independent lines of evidence for a publication-grade effector-gene nomination.

日本語の概要は準備中です。原文の説明を表示しています。

Search claude-mem's persistent cross-session memory database. Use when user asks "did we already solve this?", "how did we do X last time?", or needs work from previous sessions.

日本語の概要は準備中です。原文の説明を表示しています。

Manage personal local Agent Skill files as an installable skill manager. Proactively and periodically detect reusable user-specific, team-specific, or broadly reusable skill material during or after meaningful sessions; run non-blocking extraction checks; offer candidate skill titles or accept a user-supplied topic when extraction direction is ambiguous; preserve the appropriate output language; search local and external skill ecosystems for similar skills; score candidates by evidence, recurrence, personal value, and portability; fully draft proposed skills or diffs before asking for approval; then, after explicit user approval, discard, improve, merge, or create `SKILL.md` folders.

日本語の概要は準備中です。原文の説明を表示しています。

Diagnose why a social post performed — "analyze this post", "why did this post flop", "why did this post do well", "what should I change". Scores hook strength, clarity, tension and call to action.

日本語の概要は準備中です。原文の説明を表示しています。

Parses complex problems into candidate DAG (Directed Acyclic Graph) execution structures. Decomposes tasks into nodes with dependencies and identifies candidate parallelization opportunities. Activate on 'build dag', 'create workflow graph', 'decompose task', 'execution graph', 'task graph'. NOT for simple linear tasks or when an existing DAG structure is provided.

日本語の概要は準備中です。原文の説明を表示しています。

OpenClawのリリース候補に対するCIを実行・監視し、実際のプロバイダー接続やインストール・更新を検証して、失敗の原因と結果を整理するスキルです。

• OpenClawのリリース候補を検証したいとき
• 失敗したCIジョブの調査と再実行
• プロバイダーの認証と推論利用を確認

OpenClawのリリース情報を確認し、Discord向けの告知文を作成します。版ごとの更新手順や利用者に試してほしい点を整理し、投稿にも対応します。

• beta版の告知文を作りたいとき
• stable版の更新方法を案内したいとき
• 利用者向けのテスト項目の整理

現在のブランチの変更差分だけを点検し、冗長なコメントや不要な防御処理、型の強引な変換、周囲と合わない書き方を、動作を変えずレビュー前に整理するスキル。

• AI生成コードの冗長コメント整理
• 不要な防御処理や型変換の点検
• 変更箇所を周囲の書き方にそろえる

GitHubのIssueを条件で絞り込み、修正・テスト・PR作成をバックグラウンドのエージェントに任せます。重複作業の回避やレビュー指摘への対応も扱います。

• ラベルや担当者で課題を選びたいとき
• 複数の課題の修正PRを作りたいとき
• 作成したPRのレビュー対応

superpowersの作業記録を読み、作業の重複や計画逸脱、時間・トークン消費などを調べます。ファイルの行番号を根拠に、経緯を報告書へまとめるスキルです。

• 作業の重複や計画逸脱を調べたいとき
• セッションの時間や消費量の確認
• スキルが使われたか確認したいとき

直前の説明が分かりにくかったときに、背景を補って説明し直します。簡略化された技術英語の規格とプロジェクトの用語集に沿い、話の流れを伝え直すスキルです。

• 直前の説明を分かりやすく聞き直したいとき
• 話の流れを理解するための背景説明
• プロジェクトの共通用語での説明

コードの構造を調べ、理解やテストを難しくしている箇所の改善案を図入りHTMLレポートにまとめます。候補を選んだ後は、制約や設計判断を対話で掘り下げます。

• 変更が多い領域の設計を見直したいとき
• リファクタリング案を図で比較
• テストしやすいモジュール設計を検討

新しいスキルを作る前に、ローカル環境やマーケット、GitHub、ウェブから既存候補を探し、用途との一致度や安全性を確認して再利用・拡張・新規作成の判断を助けます。

• 作業に合うスキルを探したいとき
• 新規作成前に重複を確認したいとき
• 拡張する既存スキルの候補選び

ユーザーや状況に合う上位候補を選ぶ推薦・ランキング処理を、候補取得から採点、選択、記録までの6段階で設計し、動くコードのひな形にするスキル。

• 個人向けコンテンツ配信の設計
• 検索やRAGの結果を並べ替えたいとき
• タスクの優先順位付け

Laravel向けパッケージを機能や対応バージョンで探し、更新状況、健全性の評価、提供元の指標を確認します。導入前に候補の互換性や保守状況を見比べるスキルです。

• 認証や権限管理のパッケージを探したいとき
• 管理画面向けパッケージの検索
• パッケージの保守状況を確認したいとき