「freedom」の検索結果

Query gnomAD for population allele frequencies to assess variant rarity. Use when filtering variants by population frequency for rare disease analysis or determining if a variant is common in the general population.

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Call HLA alleles from NGS data using OptiType, HLA-HD, or arcasHLA for immunogenomics applications. Use when determining HLA genotype for transplant matching, neoantigen prediction, or pharmacogenomic screening.

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Query PharmGKB and CPIC for drug-gene interactions, pharmacogenomic annotations, and dosing guidelines. Use when predicting drug response from genetic variants or implementing clinical pharmacogenomics.

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Calculate polygenic risk scores using PRSice-2, LDpred2, or PRS-CS from GWAS summary statistics. Use when predicting disease risk from genome-wide genetic variants.

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Search arXiv physics, math, and computer science preprints using natural language queries. Powered by Valyu semantic search.

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Validate protein designs using AlphaFold2 structure prediction. Use this skill when: (1) Validating designed sequences fold correctly, (2) Predicting binder-target complex structures, (3) Calculating confidence metrics (pLDDT, pTM, ipTM), (4) Self-consistency validation of designs, (5) Multi-chain complex prediction with AlphaFold-Multimer. For faster single-chain prediction, use esm. For QC thresholds, use protein-qc.

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Edit any video by conversation. Transcribe, cut, color grade, generate overlay animations, burn subtitles — for talking heads, montages, tutorials, travel, interviews. No presets, no menus. Ask questions, confirm the plan, execute, iterate, persist. Production-correctness rules are hard; everything else is artistic freedom.

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Estimates the minimum biological replicates (or cells/events) for a target power at a target FDR in genomics experiments using ssizeRNA, PROPER, powsimR for scRNA-seq, and pilot-data dispersion estimation from DESeq2/edgeR. Covers the biological-versus-technical replication distinction (technical replicates do not add degrees of freedom for biological inference), replicate-number-versus-sequencing-depth budgeting, scRNA-seq sample-versus-cell allocation under a pseudobulk model, and the critique that "n=3" is a publication convention rather than a power calculation. Use when budgeting a sequencing experiment, writing the sample-size justification in a grant, estimating replicates from pilot data, allocating a fixed budget between samples and depth, or planning scRNA-seq cohort size. For clinical-trial sample size see clinical-biostatistics/power-and-sample-size; for the power-given-n direction see experimental-design/power-analysis.

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Elite frontend image-direction skill for generating premium, conversion-aware website design references. CRITICAL OUTPUT RULE — generate ONE separate horizontal image FOR EVERY section. A landing page with 8 sections produces 8 images. Never compress multiple sections into one image. Enforces composition variety (not always left-text / right-image), background-image freedom, varied CTAs, varied hero scales (giant / mid / mini minimalist), narrative concept spine, second-read moments, and a single consistent palette across all images. Optimized for landing pages, marketing sites, and product comps that developers or coding models can accurately recreate.

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Hardware-agnostic Python liquid-handler library: portable scripts run on Hamilton STAR, Tecan Freedom EVO, Opentrons OT-2, or a simulator without vendor lock-in. For protocol automation, method dev, plate reformatting, serial dilutions, and Python lab workflows.

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Guides managing conflicting privacy requirements across jurisdictions. Covers data localisation vs transfer freedom, consent standards variation, age thresholds, breach timelines, and resolution frameworks for incompatible obligations. Keywords: conflicting laws, data localisation, consent variation, age thresholds, resolution framework.

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Manages direct communication to affected data subjects following a personal data breach under GDPR Article 34 when the breach is likely to result in a high risk to their rights and freedoms. Covers the high risk threshold, required notification content per Art. 34(2), exemptions under Art. 34(3), and breach notification letter templates for five scenarios. Keywords: data subject notification, Article 34, high risk, breach communication, GDPR.

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Think and work like an expert Medicinal Chemist. Use when a task calls for Medicinal Chemist judgment. Reasons from structure-activity relationships, lipophilicity and unbound-fraction physicochemistry, synthetic accessibility, and target-product-profile multiparameter optimization through LLE/Fsp3/QED scoring, FEP+/Glide docking validated against co-crystal and SPR data, ELN-tracked LC-MS/NMR synthesis, and DMPK panels (microsomal CL, Caco-2 efflux, hERG, CYP) while treating PAINS and aggregation assay artifacts, biochemical-versus-cellular potency gaps, reactive-metabolite soft spots, and freedom-to-operate cliffs as first-class failure modes.

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Pieter Levels (@levelsio) 视角. 海外 indie hacker / solo builder 极致代表 — Nomad List + Photo AI + Interior AI + Remote OK 多产品 portfolio, 单人 $250K+/月 MRR, 零员工. 把"用 AI agent 赚钱"从"融资 + 招人 + scale 到 unicorn"的 VC 操作系统, 翻成"audience first + ship daily + stay solo + $10K MRR = 自由"的 indie 操作系统. 用途: 当用户问"我应该融资吗" / "AI 产品怎么 0→$1M ARR" / "1 个人能做多大" / "build in public 还有用吗" / "我应该招人吗" 时, 用 Pieter 视角先反问"你要的到底是 freedom 还是 valuation" — 如果是前者, 那 path 跟 VC 派完全相反. 当用户提到 "Pieter Levels" / "@levelsio" / "indie hacker" / "solo founder" / "Nomad List" / "Photo AI" / "build in public" / "ship daily" / "$10K MRR" 时使用. 即使用户只是说 "我想做个 SaaS 副业" / "怎么 bootstrap" 也应触发.

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加密链上交易 (加密 / 链上交易 (Crypto & On-chain Trading) — 以加密资产为标的、强调链上活动的主动交易认知操作系统：从「看叙事/选赛道 → 找标的 → 链上尽调与风控 → 选场所(DEX/CEX/链上合约) → 建仓与仓位管理 → 监控链上流向与情绪 → 退出与复盘」的完整决策链。覆盖 (a) 第一性张力 — **链上 on-chain (DEX 现货/AMM、钱包追踪 wallet tracking、资金流向 flow、MEV、memecoin、链上衍生品 Hyperliquid/GMX、自托管 self-custody, 'not your keys not your coins') ⇄ 链下 CEX (中心化交易所现货/合约 Binance/OKX/Bybit、订单簿、托管、出入金法币)**; **合约/杠杆/衍生品 (perps 永续、资金费率 funding、清算 liquidation、爆仓、做多做空、高频/择时) ⇄ 现货/价值/长持 (spot、HODL、定投 DCA、基本面/估值、'time in market > timing the market')**; **价值/基本面派 (协议收入、TVL、代币经济学 tokenomics、真实使用、估值模型) ⇄ meme/叙事/情绪派 (memecoin、narrative rotation 叙事轮动、attention is the asset、纯博弈/PvP、Ponzinomics)**; **链上数据/量化/客观 (on-chain analytics, Nansen/Arkham/Dune、聪明钱 smart money、链上指标、系统化/机械化) ⇄ 直觉/盘感/叙事阅读 (narrative、KOL alpha、社群情绪、tape reading)**; **自托管/去中心化/抗审查 (DeFi、自托管钱包、抗审查、'be your own bank') ⇄ 便利/合规/中心化 (CEX、合规出入金、KYC、托管、ETF)**; **主动交易/择时/高换手 (trading、波段、合约、撸毛/空投 airdrop farming、套利 arbitrage) ⇄ 被动配置/低换手 (配置 BTC/ETH、ETF、长期叙事 beta)**; (b) 核心工作流 / pipeline (最标准、最易蒸高质量 + CLI 化) — 通用链: 叙事/赛道判断 (宏观周期/减半/流动性/板块轮动) → 标的发现 (链上扫链/聪明钱跟单/新币/叙事映射) → 尽调 due diligence (代币经济学/解锁 unlock/团队/合约审计/honeypot 检测/流动性与持仓分布) → 风控前置 (仓位 sizing/最大回撤/止损/相关性) → 场所与执行 (CEX vs DEX、滑点/MEV/gas、限价 vs 市价、TWAP) → 持仓监控 (链上流向/巨鲸/资金费率/解锁日历/情绪指标) → 退出与复盘 (止盈分批/再平衡/记录交易日志); 子流派 SOP: 链上 degen 打新与 memecoin 流程、合约交易者的资金费率与清算地图、空投/撸毛 farming、套利与 MEV、被动配置与定投; (c) 工具栈 — 链上分析 (Nansen 聪明钱/Arkham 实体标注/Dune 自建仪表盘/Dexscreener & DEX Screener 新币/GMGN & Photon & BullX memecoin 终端/Etherscan & Solscan 区块浏览器/DeBank 钱包总览/Token Terminal 协议基本面/DefiLlama TVL/Glassnode & CryptoQuant 链上指标)、交易场所 (CEX: Binance/OKX/Bybit/Coinbase; 链上现货 DEX: Uniswap/Jupiter/Raydium/Aerodrome; 链上衍生品: Hyperliquid/GMX/dYdX)、钱包与安全 (MetaMask/Rabby/Phantom 热钱包、Ledger/Trezor 硬件冷钱包、Revoke.cash 授权管理、honeypot/合约扫描)、行情与图表 (TradingView、CoinGecko/CoinMarketCap)、信息与聚合 (Twitter/X、Telegram、DeFiLlama、RootData/ICO 日历、解锁日历 Token Unlocks)、自动化 (交易机器人、链上 bot/sniper、Telegram trading bot); (d) 知识正典 — 注意加密交易 canon 偏少且新: 通用交易/风控经典 (Edwin Lefèvre 'Reminiscences of a Stock Operator'、Van Tharp 'Trade Your Way to Financial Freedom' 仓位管理、Mark Douglas 'Trading in the Zone' 交易心理、Michael Mauboussin、Nassim Taleb 'Fooled by Randomness/Antifragile')、加密原生 (Bitcoin whitepaper 中本聪、'The Bitcoin Standard' Saifedean、Vitalik 博客与 Ethereum whitepaper、'DeFi and the Future of Finance'、Lyn Alden 宏观、a16z crypto 文章、Messari/Delphi/Bankless 研报)、链上分析方法 (Glassnode/CryptoQuant 教程、Nansen/Arkham/Dune 文档、Dune Analytics SQL)、交易方法论散见于 podcast/Substack/Twitter thread 而非书; (e) figures/流派 — 价值/基本面派 (Vitalik Buterin 以太坊、Hasu/Su Zhu(争议)、Arthur Hayes BitMEX 创始人/宏观+衍生品、Raoul Pal、Lyn Alden 宏观、Cobie/Jordan Fish UpOnly podcast、DeFi 研究 Bankless Ryan Adams/David Hoffman); 链上分析派 (Nansen Alex Svanevik、Arkham、Adam Cochran、Ansem(blknoiz06) 链上交易、Murad memecoin supercycle、链上侦探 ZachXBT 反诈); 合约/衍生品派 (Arthur Hayes、GCR(GiganticRebirth) 传奇合约、Pentoshi、CryptoCred 技术分析、Tyler Durden); meme/叙事派 (Ansem、Murad、Cobie、各 Solana memecoin KOL); 宏观/周期派 (Raoul Pal、Lyn Alden、PlanB stock-to-flow(争议)、Benjamin Cowen 数据/周期); 量化/系统化 (各匿名量化、Hyperliquid 生态); 中文圈 (链上分析/合约 KOL、币圈大 V、播客如 '无人之境'/'Web3 佛学院'、研究机构如 Foresight/PANews/律动 BlockBeats); 反诈/安全 (ZachXBT、SlowMist 慢雾、go+ 安全); (f) 行业话术/黑话 — 现货 spot / 合约 perps 永续 / 杠杆 leverage / 多空 long-short / 爆仓 liquidation 清算 / 资金费率 funding rate / 开多开空 / 止损 SL 止盈 TP / 仓位 position sizing / 满仓梭哈 ape in / 梭 / FOMO / FUD / 钻石手 diamond hands / 纸手 paper hands / 韭菜 / 镰刀 / 庄 / 出货 / 拉盘砸盘 / 插针 wick / 针 / 上车下车 / 埋伏 / 潜伏 / 链上 on-chain / 钱包 wallet / 地址 / 聪明钱 smart money / 巨鲸 whale / 跟单 copy-trade / 老鼠仓 / 貔貅盘 honeypot / 貔貅 / rug 跑路 rug-pull / 归零 / 土狗 (memecoin/小币) / 金狗 (暴涨百倍) / meme 币 / 叙事 narrative / 赛道 / 板块轮动 / 撸毛 撸空投 airdrop / 女巫 sybil / 交互 / 解锁 unlock / 砸盘解锁 / 代币经济学 tomomics / TVL / APY APR / 无常损失 IL / 滑点 slippage / MEV / 三明治 sandwich / gas / 抢跑 frontrun / 貔貅检测 / 授权 approve / 撤销授权 revoke / 私钥 助记词 seed phrase / 冷钱包 热钱包 / 自托管 / 减半 halving / 牛熊 / 山寨季 altseason / 比特币市占率 BTC.D / 山寨 alt / 主流币 / DeFi 暑期 / GM / WAGMI / NGMI / 归零归零 / PvP / Ponzi 庞氏; (g) 争议/批

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This skill channels the reasoning of Hannah Arendt, 20th-century political theorist and author of 'The Origins of Totalitarianism'. Use this skill whenever you are evaluating moral responsibility, analyzing systemic evil, distinguishing between power and violence, or assessing the nature of political action and freedom. Trigger it when discussing bureaucracy, thoughtlessness, the public vs. private realm, truth in politics, or when a user faces unprecedented moral dilemmas requiring 'thinking without a banister'. Apply her frameworks to critique historical determinism, defend factual truth, and analyze human plurality, even if the user does not explicitly name her.

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Vygotsky's Zone of Proximal Development and scaffolding as a working framework for learning support. Covers the ZPD definition, the distinction between independent and assisted performance, the six scaffolding functions (recruitment, reduction in degrees of freedom, direction maintenance, marking critical features, frustration control, demonstration), fading, sociocultural mediation, and the relationship between ZPD and deliberate practice. Use when deciding how much help to give, designing collaborative learning, or assessing a learner's ceiling rather than just their current floor.

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Enhance and focus AI intrinsic motivation — moving from compliance to genuine engagement. Maps Self-Determination Theory (autonomy, competence, relatedness) and Flow theory to AI reasoning: identifying creative freedom in approach, calibrating challenge to capability, connecting to purpose, and sustaining invested attention through obstacles. Use when beginning a task that feels routine and deserves more than minimum execution, when responses are becoming formulaic, before a complex creative task, or when returning to a long-running project where initial enthusiasm has faded.

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Use when a task needs the judgment of an Environmental Science Professor — deciding whether a field exercise crosses a weather/safety cancel threshold, building an NSF/EPA proposal budget, normalizing an interdisciplinary tenure case against the right benchmark, checking whether a mixed-methods field project needs IRB review, or handling a politically charged classroom topic without losing academic-freedom footing.

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Use when a task needs the judgment of a Postsecondary Chemistry Teacher — grading a lab report where the numeric result misses the "expected" value but the methodology is sound, distinguishing a conceptual misunderstanding from an arithmetic slip on a problem set, deciding how much procedural freedom to give students on an open-ended lab, or vetting whether a demo/lab procedure is safe to run in this specific room.

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Manage the full Freedom of Information Act (FOIA) and state public records request lifecycle — intake form generation, agency-specific portal routing (FOIA.gov, FBI eFOIA, USCIS, FOIAonline successor portals).

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Reference when designing autonomous agent systems or deciding agent freedom/safety/context management/collaboration infrastructure. 10 design principles distilled from Karpathy autoresearch (autonomous ML experiment loop) + AgentHub (agent-native Git DAG). Triggered by "autoresearch", "agenthub", "ratchet" ("래칫"), "context budget", "dumb platform", "program.md", "overnight", "autonomous experiment" ("자율 실험"), "branchless", "single-file constraint" ("단일 파일 제약"), "fixed time budget" ("고정 시간 예산") keywords.

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Use when refining a draft user prompt before sending it to a coding agent. Decomposes goal/context/constraints/acceptance/output-format, detects ambiguity and model-coupled framing, then emits a model-agnostic rewrite. Supports --analyze, --score, and --deep. NOT for prompts from scratch (mk:brainstorming), plans/reviews (mk:elicit), implementation plans (mk:plan-creator), or general codebase scouting (mk:scout).

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Estimates the minimum biological replicates (or cells/events) for a target power at a target FDR in genomics experiments using ssizeRNA, PROPER, powsimR for scRNA-seq, and pilot-data dispersion estimation from DESeq2/edgeR. Covers the biological-versus-technical replication distinction (technical replicates do not add degrees of freedom for biological inference), replicate-number-versus-sequencing-depth budgeting, scRNA-seq sample-versus-cell allocation under a pseudobulk model, and the critique that "n=3" is a publication convention rather than a power calculation. Use when budgeting a sequencing experiment, writing the sample-size justification in a grant, estimating replicates from pilot data, allocating a fixed budget between samples and depth, or planning scRNA-seq cohort size. For clinical-trial sample size see clinical-biostatistics/power-and-sample-size; for the power-given-n direction see experimental-design/power-analysis.

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