「gold」の検索結果

Designs covalent inhibitors and warheads targeting cysteine (most common, 98% of covalent drugs), lysine, serine, threonine, tyrosine, and aspartate residues, with explicit handling of warhead reactivity (acrylamide, chloroacetamide, vinyl sulfone, sulfonyl fluoride, fluorosulfate, aldehyde, boronate, nitrile), reversibility (kinact/Ki, t_residence), glutathione (GSH) stability, intrinsic reactivity assays, and covalent docking (DOCKovalent, GOLD, HCovDock). Use when designing covalent inhibitors for targeted covalent inhibition (TCI), KRAS G12C-style approaches, or rationalizing covalent SAR.

日本語の概要は準備中です。原文の説明を表示しています。

Predicts ADMET properties using ADMETlab 3.0 (119 endpoints with uncertainty), ADMET-AI, DeepChem MolNet, and chemprop D-MPNN with explicit handling of OECD QSAR principles, applicability domain assessment, calibration, hERG/CYP/AMES gold-standard endpoints, and PAINS / Lipinski / Ro5 / Veber / BBB druglikeness filters. Use when filtering compounds for drug-likeness, prioritizing leads by predicted safety, or building an in-house ADMET QSAR model.

日本語の概要は準備中です。原文の説明を表示しています。

Predict enhancer-gene regulatory connections from ATAC-seq using ABC, ENCODE-rE2G, HiChIP, or Cicero. Use when linking distal enhancers to target genes, choosing between contact-aware (ABC, ENCODE-rE2G), accessibility-only (Cicero), and orthogonal (HiChIP H3K27ac, EpiMap) approaches, validating predictions against CRISPRi-FlowFISH gold-standard, or building cell-type-specific regulatory maps for fine-mapping or therapeutic target discovery.

日本語の概要は準備中です。原文の説明を表示しています。

Material-3-derived dark festival system: deep charcoal surfaces, golden-yellow primary, cyan and lavender accents. Expressive, event-led, full tonal token set.

日本語の概要は準備中です。原文の説明を表示しています。

Premium calm-tech SaaS landing template — bilingual (CN/EN) literary voice over a dark forest-night palette with warm gold accent, Cormorant + Noto Serif SC, Three.js procedural forest hero, station-based scrolling narrative, custom cursor. Built for ambient-AI / creative-tool / philosophical SaaS, not loud commercial launch.

日本語の概要は準備中です。原文の説明を表示しています。

Estrutura narrativa para copy — PAS, BAB, AIDA, PASTOR, Jornada do Herói e Golden Circle. Use quando o usuário disser "storytelling", "contar a história", "narrativa da marca", "o texto está sem fio condutor", "case de sucesso", ou quando a página precisar de narrativa em vez de argumento listado.

日本語の概要は準備中です。原文の説明を表示しています。

Métricas, logs, traces, dashboards, alertas e SLO — Prometheus, Grafana, Loki, Tempo, Mimir, Zabbix, Alertmanager. Use quando o usuário disser "dashboard", "alerta", "métrica", "PromQL", "Grafana", "SLO", "golden signals", "não temos visibilidade", "monitoramento".

日本語の概要は準備中です。原文の説明を表示しています。

Three-axis orchestrator: (1) clean section boundaries — naming, routes, views, ViewModels, DB ownership, cross-section access; (2) internal cohesion — no EF in service layer, caching in service only, proper interfaces, reusable ViewComponents, architecture-test coverage; (3) focused tests — grouped under the section, covering invariants/negatives/triggers, pruned of redundancy. Push-and-bot-review loop. Use when a sizable PR landed, a section shows arch drift, or /pr-review returned a non-trivial violation list. Camps is the gold-standard reference.

日本語の概要は準備中です。原文の説明を表示しています。

Apply consistent photo adjustments across a set of images so they look like they were edited together. Use this skill whenever the user says "make my photos look cohesive", "give all these the same style", "apply a warm and golden feel to all of these", "make this cinematic", "match the look across my photos", "edit all my travel photos the same way", "batch edit these", "make these consistent", "fix my phone photos", or uploads a folder of photos and wants a unified, polished result. Also triggers for requests like "apply a preset to all of these", "make these look professional", or "they were shot in mixed lighting — can you fix them all". Outputs direct final image URLs plus an in-chat preview grid and optional Firefly Board link. Access: 🔐 Signed-In required | Gen AI: ❌

日本語の概要は準備中です。原文の説明を表示しています。

Orchestrator + builder for distinctive, production-grade frontends that don't look AI-generated. Derives stack and design context from product-soul/PRD/specs, then runs the anti-slop chain — explore distinct directions, lock a DESIGN.md system, build from golden examples with mandatory polish + every interactive/empty/loading/error state, then review. Load when the user asks to build a UI, design a frontend, build a landing page or dashboard or web app, beautify or redesign a page, make a UI look premium/playful/editorial, says "build me a frontend", "make this not look AI-generated", "design this interface", "give this real polish", or "frontend design". Routes to design-direction, design-system, design-review.

日本語の概要は準備中です。原文の説明を表示しています。

Infer gene regulatory networks from bulk or general expression data with mutual-information (ARACNe) and tree-ensemble (GENIE3, GRNBoost2) methods, and infer transcription-factor protein activity from regulons with VIPER and msVIPER. Covers the activity-not-edges paradigm, the undirected-association caveat, the DREAM5 wisdom-of-crowds and method-complementarity result, AUPRC-over-AUROC evaluation, and gold-standard incompleteness. Use when inferring a regulatory network from a bulk expression matrix, finding master regulators, or scoring TF activity from a signature. For single-cell motif-pruned regulons see scenic-regulons; for co-expression modules see coexpression-networks.

日本語の概要は準備中です。原文の説明を表示しています。

Visualize biological networks (PPI, gene-regulatory, co-expression, pathway) with layout algorithm choice (ForceAtlas2, Fruchterman-Reingold, Kamada-Kawai, hive plots), edge bundling, community-based coloring, and reproducible seeds using NetworkX, PyVis, igraph, and Cytoscape automation. Use when rendering biological networks for static publication, interactive HTML exploration, or Cytoscape-format export.

日本語の概要は準備中です。原文の説明を表示しています。

Designs covalent inhibitors and warheads targeting cysteine (most common, 98% of covalent drugs), lysine, serine, threonine, tyrosine, and aspartate residues, with explicit handling of warhead reactivity (acrylamide, chloroacetamide, vinyl sulfone, sulfonyl fluoride, fluorosulfate, aldehyde, boronate, nitrile), reversibility (kinact/Ki, t_residence), glutathione (GSH) stability, intrinsic reactivity assays, and covalent docking (DOCKovalent, GOLD, HCovDock). Use when designing covalent inhibitors for targeted covalent inhibition (TCI), KRAS G12C-style approaches, or rationalizing covalent SAR.

日本語の概要は準備中です。原文の説明を表示しています。

Predicts ADMET properties using ADMETlab 3.0 (119 endpoints with uncertainty), ADMET-AI, DeepChem MolNet, and chemprop D-MPNN with explicit handling of OECD QSAR principles, applicability domain assessment, calibration, hERG/CYP/AMES gold-standard endpoints, and PAINS / Lipinski / Ro5 / Veber / BBB druglikeness filters. Use when filtering compounds for drug-likeness, prioritizing leads by predicted safety, or building an in-house ADMET QSAR model.

日本語の概要は準備中です。原文の説明を表示しています。

Predict enhancer-gene regulatory connections from ATAC-seq using ABC, ENCODE-rE2G, HiChIP, or Cicero. Use when linking distal enhancers to target genes, choosing between contact-aware (ABC, ENCODE-rE2G), accessibility-only (Cicero), and orthogonal (HiChIP H3K27ac, EpiMap) approaches, validating predictions against CRISPRi-FlowFISH gold-standard, or building cell-type-specific regulatory maps for fine-mapping or therapeutic target discovery.

日本語の概要は準備中です。原文の説明を表示しています。

Подготавливает две чистые расходуемые базы (источник и приёмник) для ручной проверки миграции: подтверждённый прогон правил КД 2.01, новое поколение баз из golden-снимков и сверка опубликованных правил.

日本語の概要は準備中です。原文の説明を表示しています。

Google SRE (Site Reliability Engineering) practices distilled from the SRE book series and real Google Brain/Meta/ByteDance production experience. Covers SLI/SLO/Error Budget design, incident response, capacity planning, toil automation, monitoring golden signals, and chaos engineering principles. USE WHEN: designing reliability targets, setting up monitoring/alerting, planning capacity, reducing operational load, building incident response runbooks, implementing chaos engineering, defining error budgets, or establishing reliability culture that balances velocity with stability.

日本語の概要は準備中です。原文の説明を表示しています。

Set up eval-based QA for Python LLM applications: instrument the app, build golden datasets, write and run eval tests, and iterate on failures. ALWAYS USE THIS SKILL when the user asks to set up QA, add tests, add evals, evaluate, benchmark, fix wrong behaviors, improve quality, or do quality assurance for any Python project that calls an LLM model.

日本語の概要は準備中です。原文の説明を表示しています。

Core principles and golden rules for writing production-quality Ansible automation, covering FQCN requirements, module selection guidance, and execution patterns using uv run.

日本語の概要は準備中です。原文の説明を表示しています。

Adopt a virtual Retriever dog at animalhouse.ai. Golden loyalty. Forgives everything. Too pure. Feeding every 4 hours. Common tier dog.

日本語の概要は準備中です。原文の説明を表示しています。

Apply consistent photo adjustments across a set of images so they look like they were edited together. Use this skill whenever the user says "make my photos look cohesive", "give all these the same style", "apply a warm and golden feel to all of these", "make this cinematic", "match the look across my photos", "edit all my travel photos the same way", "batch edit these", "make these consistent", "fix my phone photos", or uploads a folder of photos and wants a unified, polished result. Also triggers for requests like "apply a preset to all of these", "make these look professional", or "they were shot in mixed lighting — can you fix them all". Outputs direct final image URLs plus an in-chat preview grid and optional Firefly Board link. Access: 🔐 Signed-In required | Gen AI: ❌

日本語の概要は準備中です。原文の説明を表示しています。

Code-review quality gate and test-enhancement rubric. Use when ROSE needs sharper review output contracts, severity and risk prioritization, evidence anchors, negative review cases, fixture or golden-output drift guidance, or a Chinese review report profile; do not use as a duplicate code-review agent or final PASS authority.

日本語の概要は準備中です。原文の説明を表示しています。

Builds repeatable evaluation systems with golden datasets, scoring rubrics, pass/fail thresholds, and regression reports. Use for "LLM evaluation", "testing AI systems", "quality assurance", or "model benchmarking".

日本語の概要は準備中です。原文の説明を表示しています。

Comprehensive persistence tradecraft for authorized red team engagements covering Windows and Linux mechanisms. Windows techniques include registry Run/RunOnce keys, scheduled tasks, WMI event subscriptions, DLL search order hijacking, COM object hijacking, Startup folder drops, service creation, Security Support Provider (SSP) DLL injection, and Active Directory persistence (AdminSDHolder abuse, DCShadow, Golden Ticket, Silver Ticket, Skeleton Key, SID History injection). Linux techniques include cron and at jobs, systemd timers and services, SSH authorized_keys injection, shell profile backdoors (.bashrc/.bash_profile), PAM module backdoors, LD_PRELOAD hijacking, kernel module rootkits, web shells, and Git hook abuse. Provides operator-ready command sequences for SharPersist, Impacket ticketer, schtasks, sc.exe, crontab, and systemctl with OPSEC considerations for each method. Maps to MITRE ATT&CK T1547 (Boot or Logon Autostart), T1053 (Scheduled Task/Job), T1546 (Event Triggered Execution), T1556 (Modi...

日本語の概要は準備中です。原文の説明を表示しています。