「ema」の検索結果

Designs cytosine (CBE, C-to-T) and adenine (ABE, A-to-G) base-editor guides by positioning the target base at the activity-peak of the editing window (protospacer positions ~5-7, PAM-distal numbering), minimizing bystander edits for product purity, reading dinucleotide context (APOBEC1 TC favored / GC disfavored), and selecting the editor variant (BE4max, ABEmax, ABE8e, YE1/SECURE, TadCBE, CGBE, SpG/SpRY-BE). Covers knockout by premature stop (CRISPR-STOP/iSTOP) and splice-site disruption, the three off-target classes (Cas-dependent, Cas-independent DNA, RNA), outcome prediction (BE-Hive/DeepBE), and the base-vs-prime-vs-HDR decision. Use when installing a transition mutation without a double-strand break, knocking out a gene without indels, or choosing CBE vs ABE. Generic guide scoring, prime editing, and HDR donors are separate skills.

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Query UniProt's REST API (post-2022 endpoint at rest.uniprot.org) for protein sequences, annotations, GO terms, cross-references, ID mappings, and proteomes. Use when fetching UniProtKB entries, navigating the JSON schema, choosing between UniProtKB/UniRef/UniParc/Proteomes resources, deciding stream vs search endpoint for batch retrieval, running ID-mapping jobs with the async pattern, handling isoform suffixes, or filtering reviewed Swiss-Prot vs auto-annotated TrEMBL. Encodes the legacy URL migration (2022), the new JSON schema layout, and bulk-pull patterns.

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Resolves GWAS associations to candidate causal variants and credible sets via SuSiE, susie_rss, FINEMAP, CAVIAR, DAP-G, PAINTOR, PolyFun, SuSiEx, MultiSuSiE, and FOCUS. Use when narrowing a GWAS lead SNP to a 95 percent credible set, choosing between in-sample and reference LD, calibrating non-sparse loci with SuSiE-inf or FINEMAP-inf, integrating functional priors via PolyFun, fine-mapping across ancestries with SuSiEx, diagnosing LD mismatch via estimate_s_rss and kriging_rss, handling HLA or long-range LD, or feeding credible sets into coloc.susie for colocalization.

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End-to-end form handling with react-hook-form, Zod schemas, validation patterns, error messaging, field arrays, and multi-step wizards. Use for complex forms, validation architecture, autosave, field dependencies. Activate on "form validation", "react-hook-form", "Zod", "form error", "multi-step form", "wizard". NOT for simple HTML forms, backend validation only, or non-React frameworks.

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Manage database schema with Drizzle ORM and SQLite migrations. Use when adding tables, modifying columns, creating indexes, or running migrations. Activates for database schema changes, migration generation, and Drizzle query patterns.

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Schema design, normalization decisions, indexing strategies, and migration safety for relational databases. Use when designing tables, choosing between normalize vs denormalize, selecting index types, planning zero-downtime migrations, or setting up connection pooling. Activate on "schema design", "normalization", "denormalization", "foreign key", "index strategy", "migration", "connection pooling", "composite key", "surrogate key", "soft delete", "polymorphic association". NOT for PostgreSQL-specific query tuning or EXPLAIN analysis (use postgresql-optimization), NoSQL or document database design, or cloud database provisioning.

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Safe database migration manager for zero-downtime DDL changes and rollback plans. Activate on: database migration, schema change, DDL, rollback plan, zero-downtime migration, Prisma migrate, Drizzle kit, Flyway, column rename, table alter. NOT for: query optimization (use database-optimizer), ORM modeling (use data-pipeline-engineer), backup/restore (use devops-automator).

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Runs an iterative, conversational product-discovery process with a founder/stakeholder: structured interview, live low-fi wireframing, a linked feature/page node-graph built up as you go, a founder-confirmed lock-in checkpoint, then a generated PRD, a Mermaid-rendered sitemap, and a mockup with a full design system (palette, typography, dark mode). Use when building or operating an AI product-discovery chatbot, or when running founder/stakeholder discovery by hand and you need the structure (interview script, node-graph schema, PRD template, design-system handoff order). NOT for implementing the spec'd product once locked — hand off to feature-specific skills (ideal-web-app-builder, tailwind-v4-expert, color-theory-palette-harmony-expert, typography-expert, dark-mode-design-expert) for that. NOT for one-shot PRD generation without an interview loop — if the founder already has a written spec, this process is unnecessary overhead.

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Semantic image-text matching with CLIP and alternatives. Use for image search, zero-shot classification, similarity matching. NOT for counting objects, fine-grained classification (celebrities, car models), spatial reasoning, or compositional queries. Activate on "CLIP", "embeddings", "image similarity", "semantic search", "zero-shot classification", "image-text matching".

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Treat tokens as a coding swarm's cost-of-goods-sold and legibility engine while accounting for finite subscription allowance when per-call price is unknown. Covers provider windows, remaining-usage evidence, burn forecasts, preemptive checkpoint/model switching, per-agent budgets, compaction, shared digests, context degradation, and spend metering. Activate on: "token budget", "context budget", "compaction strategy", "briefing as compression", "context rot", "summarization collapse", "COGS for agents", "subscription usage remaining", "five-hour or weekly limit", "burn forecast", "model switch before limit", or "/context-economics-for-agent-swarms". NOT for: memory architecture (use always-on-agent-architecture), single-prompt wording (use prompt-engineer), mechanism-design proofs (use nisan-et-al-2007-algorithmic-game-theory), physical containment (use sandboxed-adversarial-test-harness), or production rebodiment and fencing (use agent-resurrection-and-body-continuity).

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Expert API designer for REST, GraphQL, gRPC architectures. Activate on: API design, REST API, GraphQL schema, gRPC service, OpenAPI, Swagger, API versioning, endpoint design, rate limiting, OAuth flow. NOT for: database schema (use data-pipeline-engineer), frontend consumption (use web-design-expert), deployment (use devops-automator).

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API migration strategies, deprecation workflows, and header/URL/content versioning. Activate on: API versioning, backward compatibility, deprecation, breaking change, API migration, v1 v2, sunset header. NOT for: schema evolution in data (use schema-evolution-manager), gateway routing (use api-gateway-reverse-proxy-expert).

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Choosing and operating an HTTP API versioning strategy that doesn't break clients — Stripe's date-based pinned versions, the Deprecation/Sunset header pair (RFC 9745 + RFC 8594), URI vs header vs media-type approaches, and the version-transformer pattern. Grounded in Stripe's published architecture and IETF RFCs. NOT for GraphQL schema evolution, gRPC/Protobuf wire compatibility, database schema migrations, or library/SDK semver.

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Use when building content-heavy sites with Astro, deciding between SSG/SSR/hybrid, choosing client directives (idle/visible/load/media), structuring content collections with type-safe schemas, integrating React/Vue/Solid/Svelte components in the same project, or migrating from Next.js for marketing/docs. Triggers: client:idle vs client:load tradeoffs, content collections schema with zod, image optimization via @astrojs/image, view transitions, server islands, MDX layouts. NOT for SPA-style apps that need full interactivity (use Next/Remix), Astro internals/plugin authoring, or non-content sites where islands provide no benefit.

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Design and build beautiful, accessible graphical interfaces — web, desktop (Electron/Tauri), and native (iOS/macOS/Android). Use for visual hierarchy and layout, color and theming (light/dark, semantic tokens, WCAG contrast), typography systems, motion and micro-interactions, accessibility, component systems and design tokens, responsive/adaptive layout, and platform-native idioms. The GUI counterpart to beautiful-cli-design. NOT for terminal/CLI output (use beautiful-cli-design) or API/data schemas.

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Design a normalized, machine-readable "work receipt" that answers what changed, why, by whom, and with what validation, for any AI-coding-agent task regardless of backend (Claude Code, Codex, Cursor, Aider, CI, or homegrown). Use when defining a receipt schema, normalizing heterogeneous agent logs into one evidence shape, gating PR merges on artifact-backed proof, or designing an OSS maintainer's fast-reject/fast-merge workflow. NOT for validating a DAG node's output against its own schema (use output-contract-enforcer), continuous runtime monitoring of a live coordination daemon (use runtime-verification-for-agents), or general Port Daddy claims/notes/salvage mechanics (use port-daddy-agent-skill).

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SERP-based semantic topic clustering for content architecture planning. Groups keywords by actual Google SERP overlap (not text similarity), designs hub-and-spoke content clusters with internal link matrices, and generates interactive visualizations. Optionally executes content creation if claude-blog is installed. Use when user says "topic cluster", "content cluster", "semantic clustering", "pillar page", "hub and spoke", "content architecture", "keyword grouping", or "cluster plan".

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E-commerce SEO analysis: Google Shopping visibility, Amazon marketplace intelligence, product schema validation, competitor pricing analysis, and marketplace keyword gaps. Combines on-page product SEO with marketplace data from DataForSEO Merchant API. Use when user says "ecommerce SEO", "product SEO", "Google Shopping", "marketplace SEO", "product schema", "Amazon SEO", "product listings", "shopping ads", or "merchant SEO".

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AI image generation for SEO assets: OG/social preview images, blog hero images, schema images, product photography, infographics. Powered by Gemini via nanobanana-mcp. Requires banana extension installed. Use when user says "generate image", "OG image", "social preview", "hero image", "blog image", "product photo", "infographic", "seo image", "create visual", "image-gen", "favicon", "schema image", "pinterest pin", "generate visual", "banner", or "thumbnail".

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Retiring a dead table by moving it to the deprecated schema and clearing every reference in both repos. Use when asked to deprecate or retire a table, when a table is no longer used, or to take a table offline without dropping it. NOT for relocating a still-used table (use db-move-table-schema).

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Bringing an existing table onto the platform base standard. Use when asked to canonicalize, retrofit, or 'Wave 3' a table, run apply_rls or an org backfill, retire a bespoke *_versions table, or move it onto platform comments/associations/permissions. NOT for a schema move (use db-move-table-schema).

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Locate CCSPlayerInventory::m_pSOCache in CS2 server.dll / libserver.so via IDA Pro MCP and emit a fresh, minimal-unique signature or offset for the WeaponPaints gamedata entry "CCSPlayerInventory::m_pSOCache" (symbol CCSPlayerInventory_m_pSOCache). This is a STRUCT MEMBER OFFSET (schema netvar). Resolve the CCSPlayerInventory class layout via the schema system; m_pSOCache is the CGCClientSharedObjectCache pointer member. Cross-check: CCSPlayerInventory methods load this pointer and pass it to CGCClientSharedObjectCache methods (the GetItemInLoadout shortlist is a strong caller-side witness). Trigger: CCSPlayerInventory_m_pSOCache, CCSPlayerInventory::m_pSOCache

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Locate CCSPlayerController_InventoryServices::m_pInventory in CS2 server.dll / libserver.so via IDA Pro MCP and emit a fresh, minimal-unique signature or offset for the WeaponPaints gamedata entry "CCSPlayerController_InventoryServices::m_pInventory" (symbol CCSPlayerController_InventoryServices_m_pInventory). This is a STRUCT MEMBER OFFSET (schema netvar), not a function. Resolve the CCSPlayerController_InventoryServices class layout via the schema/network system; m_pInventory is an 8-byte pointer member early in the class (must stay 8-aligned). Cross-check: functions of the class dereference this->m_pInventory shortly after entry. Trigger: CCSPlayerController_InventoryServices_m_pInventory, CCSPlayerController_InventoryServices::m_pInventory

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Locate CBaseEntity::m_iTeamNum in CS2 server.dll / libserver.so via IDA Pro MCP and emit a fresh, minimal-unique signature or offset for the local gamedata entry "CBaseEntity::m_iTeamNum" (symbol CBaseEntity_m_iTeamNum). This is a STRUCT MEMBER OFFSET (schema netvar), not a function. Resolve the CBaseEntity class layout via the schema/network system; the member must satisfy natural alignment. Cross-check with functions that dereference the member. Trigger: CBaseEntity_m_iTeamNum, CBaseEntity::m_iTeamNum

日本語の概要は準備中です。原文の説明を表示しています。