「native」の検索結果

Cross-platform creative quality audit covering ad copy, video, image, and format diversity across all platforms. Detects creative fatigue, evaluates platform-native compliance, and provides production priorities. Use when user says creative audit, ad creative, creative fatigue, ad copy, ad design, or creative review.

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Add WhatsApp channel via native Baileys adapter. Direct connection — no Chat SDK bridge. Uses QR code or pairing code for authentication.

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Use when implementing reduced motion alternatives, vestibular-safe animations, WCAG compliance, or designing for users with motion sensitivity.

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Automated WCAG 2.1 AA accessibility testing with axe-core and Lighthouse CI. Auto-detects frontend framework (React, Next.js, Vue, Angular, Svelte, Astro, Flutter, React Native), discovers all routes and interactive components, installs Playwright + axe-core for page-level scanning and jest-axe/vitest-axe for component-level testing. Generates tests for color contrast (4.5:1), alt text, form labels, ARIA attributes, heading order, landmark regions, focus visibility, keyboard navigation (tab order, focus traps, modal focus management, skip-to-content), screen reader compatibility (aria-live regions, error announcements, toast notifications), and Flutter Semantics validation (48dp touch targets, semanticLabel). Reports violations by severity (critical, serious, moderate, minor) with WCAG criterion references. Use when adding a11y testing, auditing accessibility compliance, fixing contrast issues, or validating keyboard and screen reader support.

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Use this skill when the user asks about ARIA, ARIA roles, ARIA attributes, aria-label, aria-labelledby, aria-describedby, aria-expanded, aria-hidden, aria-live, aria-required, aria-invalid, "WAI-ARIA", "ARIA Authoring Practices", "APG pattern", "accessible name", "accessible description", live regions, custom widgets, dialogs, menus, tabs, accordions, comboboxes, tooltips, tree views, carousels, or is building any custom interactive component that requires ARIA roles and keyboard behavior beyond native HTML elements.

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AAWP (AI Agent Wallet Protocol) — the only crypto wallet protocol built exclusively for AI Agents on EVM-compatible blockchains and Solana. Not for humans. The signer is the AI Agent itself, cryptographically bound at wallet creation. Supports wallet lifecycle management, token transfers, DEX swaps, cross-chain bridging, Solana native trading (Pump.fun SDK + Jupiter), token launches, DCA automation, and price alerts.

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Use when you need to write or improve integration tests for Quarkus — including @QuarkusTest, Dev Services for automatic container provisioning, Testcontainers via QuarkusTestResourceLifecycleManager, WireMock for external HTTP stubs, @QuarkusIntegrationTest for black-box testing against packaged artifacts, REST Assured, data isolation strategies (@TestTransaction vs @BeforeEach cleanup), and Maven Surefire/Failsafe three-tier split (*Test, *IT, *AT). This should trigger for requests such as Add or improve integration tests in a Quarkus project; Configure Testcontainers or Dev Services for Quarkus tests; Add WireMock stubs for external HTTP dependencies in Quarkus integration tests; Set up @QuarkusIntegrationTest for packaged artifact or native binary testing; Fix test data isolation or configure Maven Surefire/Failsafe split. Part of cursor-rules-java project

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MANDATORY deploy after every code change. Typecheck → deploy → purge CDN → E2E on production → visual verify → fix-forward loop. Workers Builds native CI/CD, D1 Time Travel PIT recovery, D1→R2 long-term backups, wrangler rollback, wrangler secrets management, structured observability, cross-browser smoke tests, rollback procedures, and GitHub auto-configuration.

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Perform 12-Factor App compliance analysis on any codebase. Use when evaluating application architecture, auditing SaaS applications, or reviewing cloud-native applications against the original 12-Factor methodology.

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Build websites and web apps using 21st.dev — the largest marketplace of shadcn/ui-based React Tailwind components with 1400+ components. Use when user mentions "21st.dev", "21st", "ใช้ 21st", "จาก 21st", "build with 21st", "21st component", "21st magic MCP", or references the 21st.dev component registry in any language. Covers building complete sites (landing pages, dashboards, portfolios, e-commerce storefronts, auth pages), browsing and installing individual 21st.dev components into existing projects, and setting up the 21st.dev MCP server. Also trigger when user wants premium UI components specifically from the 21st.dev registry. Do NOT trigger for general web development, standard shadcn/ui, plain Tailwind CSS, React Native, API development, testing, deployment, or any task that doesn't explicitly reference 21st or 21st.dev.

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Use when starting feature work that needs isolation from current workspace or before executing implementation plans - ensures an isolated workspace exists via native tools or git worktree fallback

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Use when a user-driven CloakBrowser profile needs MV3 Chrome writes/events through the native messaging bridge.

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Read a liarjs fingerprint report and attribute each failing check to the component that produced it - what the check id measures, whether the signal comes from the launch configuration, the page-modifying layer, the network path or the machine image, and which failures are inherent to headless or datacenter environments. Use when a fingerprint scan came back with a low score, or when a check id such as webdriver, worker-consistency, gpu-triad, native-integrity or tz needs explaining.

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Designs donor/repair templates for precise CRISPR knock-ins -- choosing the format (ssODN, long-ssDNA/Easi-CRISPR, dsDNA/plasmid, AAV6), sizing homology arms, placing the cut within ~10 bp of the edit, and adding a mandatory codon-checked blocking (PAM/seed) mutation so the edited allele is not re-cut. Frames the HDR-vs-NHEJ-vs-MMEJ pathway competition, the MMEJ (PITCh) and homology-independent (HITI/HMEJ) alternatives for post-mitotic cells, ssODN strand/asymmetry choice, phosphorothioate end-protection, and ranked HDR enhancers. Use when designing a donor for a point mutation, epitope/fluorophore tag, allele replacement, or knock-in, or when HDR efficiency is low. Guide design and base/prime editing are separate skills.

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Calls m6A peaks from MeRIP-seq / m6A-seq paired IP-vs-input data using exomePeak2 (transcript-aware, GC-bias-corrected Poisson GLM; Liu 2022 *NAR Genom Bioinform* 4:lqac046), MeTPeak (HMM over sliding windows; Cui 2016 *Bioinformatics* 32:i378), MACS3 / MACS2 with --nomodel --broad --keep-dup all (genome-wide broad alternative), and DRACH motif enrichment confirmation via HOMER or ggseqlogo as a sanity check (NOT a filter). Covers BED12 vs narrowPeak output formats, exonic vs intronic peak handling, multi-tool reconciliation (intersection vs union; cross-caller IDR-equivalent), the m6A-vs-m6Am ambiguity at 5'UTR peaks that antibody-based methods cannot resolve, and orthogonal-validation routes (miCLIP / GLORI / m6A-SAC-seq / m6Anet). Use when calling peaks from paired IP/input genome BAMs, choosing exomePeak2 (transcript-aware default) vs MACS3 (broad genomic) vs MeTPeak (HMM-smoothed low-coverage), confirming DRACH enrichment as a sanity check on the peak set as a whole, reconciling differing peak sets across tools, validating MeRIP peaks against orthogonal single-base methods, interpreting peaks at the 5' end where m6Am contamination is possible, or recommending a multi-tool consensus strategy.

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Differential abundance (DA) and differential state (DS) analysis for flow and mass cytometry - tests which cell populations change in frequency or marker expression between conditions using diffcyt (edgeR/voom/GLMM for DA, limma/LMM for DS), with cydar, CITRUS, and compositional methods (sccomp, scCODA, DCATS) as alternatives. Covers the sample-is-the-experimental-unit principle, design/contrast and mixed-model formulas, compositionality of cluster proportions, and FDR across clusters. Use when comparing populations between groups, choosing a DA method, handling paired/batch designs, or deciding whether compositional correction is needed.

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Quantifies biodiversity from species abundance/incidence tables using Hill numbers (iNEXT) with coverage-based rarefaction-extrapolation (Chao & Jost 2012), asymptotic richness via Chao1/ACE/jackknife as a lower bound, Baselga turnover/nestedness partition with the Podani alternative as sensitivity check, mandatory Hellinger transformation before ordination (Legendre & Gallagher 2001), Faith PD and SES_MPD/SES_MNTD with explicit null-model choice, and Maire 2015 functional-diversity dimensionality optimization. Use when comparing diversity across sites with unequal sampling effort, picking the right richness estimator for singleton-heavy amplicon data, partitioning beta diversity into turnover vs nestedness, reporting Hill-number effective species counts rather than raw entropies, computing SES_MPD with explicit null-model justification, or deciding whether to apply standard metrics to compositional amplicon data. Not for clinical 16S microbiome diversity (see microbiome/diversity-analysis).

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Query the Ensembl REST API for gene/transcript/protein lookup, sequence retrieval, comparative genomics (Compara), variant effect prediction (VEP), regulatory features, and cross-species ortholog/paralog calls. Use when pulling Ensembl-native data (Ensembl Gene IDs, version-pinned releases, archive endpoints for reproducibility), gene/transcript/exon structure with stable IDs, or VEP for variant annotation. Encodes the 15 req/sec rate limit, archive (e110.rest.ensembl.org) for reproducibility, Ensembl divisions (vertebrates / plants / fungi / metazoa / bacteria), and the symbol-vs-ID stability problem.

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Corrects the gene-independent copy-number artifact in CRISPR-Cas9 screens (Aguirre 2016 / Munoz 2016 Cancer Discov) where amplified loci appear essential from DNA-damage burden of simultaneous cuts. Covers the p53-dependent G2-arrest mechanism, CRISPRcleanR (Iorio 2018) unsupervised pre-hoc correction, CERES (Meyers 2017) joint CN + gene-effect model, Chronos (Dempster 2021) DepMap-standard population-dynamics + CN model with lowest residual bias, the decision tree by data availability, the Spearman LFC-vs-CN diagnostic, focal-amplification examples (ERBB2 in HER2+, MYC in colorectal, FGFR1 in head and neck), and CRISPRi/a alternatives that bypass the artifact. Use when screening cancer cell lines, diagnosing essentiality at amplified loci, choosing CRISPRcleanR / CERES / Chronos, deciding whether CN correction is needed before MAGeCK / BAGEL2 / drugZ, or switching from Cas9 to CRISPRi.

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Batch effect correction for CRISPR screens covering ComBat empirical-Bayes, RUV, SVA, control-sgRNA normalization, and the model-based alternative of including batch as a covariate in MAGeCK MLE or Chronos. Covers screen-specific batch sources (passage cohort, library lot, infection day, sequencing run, Cas9 lot, FBS lot), PCA + variance-decomposition diagnostic to decide if correction is needed, when correction harms biology by over-correcting condition into batch, limma removeBatchEffect for visualization-only correction, and relationship to multi-condition design matrices. Use when combining screens for joint analysis, when passage cohort confounds biology, when DepMap-style panels need Chronos with batch covariates, when picking ComBat vs RUV, or when correction harms biology and should be replaced with explicit covariate modeling.

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Detect, date, and contextualize whole-genome duplication (WGD / paleopolyploidy) events using wgd v2 (Chen & Zwaenepoel 2024), KsRates (Sensalari 2022 substitution-rate-corrected Ks dating), DupGen_finder (Qiao 2019), MAPS (Li 2018 phylogenomic), POInT (Conant 2008 ordered-block), SLEDGe (2024 ML-based), Whale.jl (Bayesian DTL+WGD), and synteny-anchored paranome construction. Use when identifying ancient polyploidy from Ks distributions and synteny block analysis, positioning WGD events relative to speciation, distinguishing tandem from segmental from WGD duplications, dating the 2R/3R vertebrate / fish / salmonid WGDs, building paranome and Ks-age mixture models, applying KsRates substitution-rate correction across lineages, or testing alternative biased-fractionation / dosage-balance models post-WGD.

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Visualize copy number profiles, segments, allele-specific tracks, and cohort patterns from CNVkit, GATK, ASCAT, FACETS, Sequenza, and other callers. Covers genome-wide and per-chromosome log2 scatter plots, B-allele-frequency/minor-allele-fraction tracks, ideograms, cohort heatmaps, circos views, and caller-native plots. Use when creating publication CNV figures, choosing which plot answers a given question, diagnosing a wrong diploid baseline visually, displaying loss of heterozygosity, or deciding what depth-only plots cannot reveal.

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Project gene annotations across genomes using TOGA (Kirilenko 2023 whole-genome-alignment chain-based projection with intactness classification), CESAR 2.0 (Sharma & Hiller 2017 codon-aware exon projection), LiftOff (Shumate & Salzberg 2020 reference-based annotation transfer), Liftover (UCSC), GeMoMa (Keilwagen 2019 evidence-based projection), and Comparative Annotation Toolkit (CAT). Use when transferring annotations from a well-annotated reference to query genome(s), classifying gene-loss vs gene-intact across many genomes at scale, building Zoonomia-style comparative annotations across hundreds of mammals or birds (Kirilenko 2023), detecting pseudogenization, projecting alternative isoforms, or selecting between WGA-anchored (TOGA) vs ortholog-based (LiftOff) annotation transfer strategies.

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Annotate CLIP-seq peaks or crosslink sites to RNA features (5'UTR, CDS, 3'UTR, intron, splice junction, snoRNA, tRNA, ncRNA, repeat elements) with ChIPseeker, RCAS, RBP-Maps (Yeo splicing regulatory maps), and bedtools, applying feature-priority hierarchies, transcript-context resolution, and metagene aggregation. Use when characterizing where in transcripts an RBP binds, comparing peak distribution across regions, generating splicing-regulatory maps relative to alternative-splicing events, or distinguishing exonic vs intronic vs UTR binding.

日本語の概要は準備中です。原文の説明を表示しています。