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Normalize read-depth copy-ratio profiles and segment them into copy-number regions using circular binary segmentation (CBS, DNAcopy), hidden Markov models, HaarSeg, and fused-lasso methods. Covers GC-content, mappability, and replication-timing (wave-artifact) bias correction, panel-of-normals/PCA denoising, diploid-baseline centering, and algorithm selection by sequencing depth and event size. Use when choosing a segmentation algorithm, correcting depth bias, diagnosing oversegmentation or a mis-centered baseline, tuning CBS or HMM parameters, or understanding why a downstream CNV caller produced fragmented or shifted segments.

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Analyzes alternative splicing at single-cell resolution. The first decision is library chemistry — 10X 3' is fundamentally limited (RT primes from poly-A, R2 falls in 3' UTR, <0.1 junction read per cell per AS event). Plate-based full-length methods (Smart-seq3, FLASH-seq, VASA-seq, STORM-seq) and single-cell long-read (MAS-Iso-seq, scISOr-Seq2) are the chemistries that give per-cell isoform structure. Tools include MARVEL (R, Smart-seq integrated), BRIE2 (Bayesian PSI with regulatory features and ELBO_gain test), scQuint (junction-cluster, plate-based; not for 10X), SpliZ (annotation-free Z-score), Psix (graph-smoothness regulated AS), and Sierra (alternative polyadenylation, often confused with AS). Use when analyzing isoform usage in scRNA-seq, identifying cell-type-specific splicing, or determining whether scRNA-seq chemistry supports splicing analysis at all.

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Use this skill when the user asks about FMCSA investigation types — Focused Investigation vs Comprehensive Review vs Compliance Review (CR) vs Investigation, when each is triggered, scope differences, on-site vs off-site, and how to prepare for each. Cite 49 CFR 385 Subpart C + D.

日本語の概要は準備中です。原文の説明を表示しています。

Use this skill when the user asks about DOT audits, FMCSA compliance reviews, new entrant safety audits (NESA), focused investigations, what auditors actually ask for, audit document checklists, common audit failures, the audit ratings (Satisfactory / Conditional / Unsatisfactory), or how to prepare for an upcoming audit. Cite 49 CFR 385.

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Analyze development-set disagreements between human annotations and one Coval text LLM judge, then propose a focused prompt revision. Use coval-calibrate-metric for independent trust measurements.

日本語の概要は準備中です。原文の説明を表示しています。

Splits one big Claude task or automation into a set of focused AI Matrx agents that work on the person's own AI Matrx tables, then builds and test-runs each one. Use when the person says "split my task into agents", "turn my automation into AI Matrx agents", "make agents for my work", or after their data has moved into AI Matrx.

日本語の概要は準備中です。原文の説明を表示しています。

Collapsing every copy of one kind of thing (tables, UIs, utilities, hooks, APIs, renderers) into a single canonical one. Use when asked to unify, merge, converge, or 'make one X used everywhere', or before migrating callers onto a new canonical piece. NOT for docs (use docs).

日本語の概要は準備中です。原文の説明を表示しています。

Recipe for building one focused UI section out for every consumer. Use when asked to 'make this section canonical', 'productize this widget', give it 'the full treatment', or set it up 'like the SEO metadata system', or when building a new analyzer, preview, or calculator section.

日本語の概要は準備中です。原文の説明を表示しています。

Printing and PDF export for AI response blocks and messages via @ai-matrx/print. Use when adding a print button or BlockPrinter to a render block, wiring PrintOptionsDialog/usePrintOptions, captureBlockElement, or useDomCapturePrint, or when a print window shows no images or a print fails silently.

日本語の概要は準備中です。原文の説明を表示しています。

Relocating a live, still-used table to another Postgres schema with every reference intact. Use when asked to move or rehome a table into a schema, or to pull a table out of public into a domain schema. NOT for retiring a table (use db-deprecate-table).

日本語の概要は準備中です。原文の説明を表示しています。

The one association system (platform.associations) and schema-qualified table refs. Use when touching an M2M junction table, an associate_*/attach_*/tag_* RPC, FK columns used as tags, a 'things attached to X' list or card, or a PGRST205 / 42703 table-not-found on a bare .from().

日本語の概要は準備中です。原文の説明を表示しています。

Admin debug system wiring for the floating AdminIndicator's live debug data and Copy Full Context. Use when adding debug visibility to a route or feature, wiring useDebugContext or the debug panel, capturing console errors, or enabling the copy-context workflow for a page.

日本語の概要は準備中です。原文の説明を表示しています。

Find and identify the CBasePlayerPawn::CommitSuicide virtual function's vtable slot in the CS2 server binary using IDA Pro MCP. Use this skill when reverse engineering server.dll or libserver.so to locate the self-inflicted-death handler (used by the "kill"/bot_kill console commands and related gameplay code) by RTTI-walking CBasePlayerPawn's primary vtable and reading its known slot index directly, then confirming the body matches CommitSuicide(bool bExplode, bool bForce) semantics. Trigger: CBasePlayerPawn_CommitSuicide

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Find and identify the CGameSceneNode::GetSkeletonInstance virtual function's vtable slot, plus the CBaseAnimGraph::m_skeletonInstance and CSkeletonInstance::m_animationController struct member offsets, in the CS2 server binary using IDA Pro MCP. Use this skill when reverse engineering server.dll or libserver.so to locate the scene-node accessor that returns a node's CSkeletonInstance* (or null if the node isn't a skinned model), and the two related struct-member offsets used by CounterStrikeSharp's animation-graph memory patches. Trigger: CBaseAnimGraph_m_skeletonInstance, CGameSceneNode_GetSkeletonInstance, CSkeletonInstance_m_animationController

日本語の概要は準備中です。原文の説明を表示しています。

Guide for creating effective skills. This skill should be used when users want to create a new skill (or update an existing skill) that extends Claude's capabilities with specialized knowledge, workflows, or tool integrations.

日本語の概要は準備中です。原文の説明を表示しています。

Strip designs to their essence by removing unnecessary complexity. Great design is simple, powerful, and clean. Use when the user asks to simplify, declutter, reduce noise, remove elements, or make a UI cleaner and more focused.

日本語の概要は準備中です。原文の説明を表示しています。

Production error → triaged, root-caused, repaired, and certified (tsc + rehearsal + reproduce-then-gone) fix PR for a human to merge — then confirm the error stops recurring. Never auto-merges.

日本語の概要は準備中です。原文の説明を表示しています。

Prove a Convex feature works — seed, drive as multiple mocked users via convex-test, assert behavior including the negative authz cases (wrong user refused, data-scope enforced).

日本語の概要は準備中です。原文の説明を表示しています。

This skill should be used when agents generate placeholder tokens like "pseudo-", "mock-", "temporary", "TODO", "demo-", or similar incompleteness markers. Detects substitution patterns in agent OUTPUT and triggers mandatory user interview instead of accepting incomplete work. Activates automatically on any output containing forbidden tokens.

日本語の概要は準備中です。原文の説明を表示しています。

[61] VALIDATE. Comprehensive code quality check combining ESLint, TypeScript compilation, and unused code detection. Runs full lint suite with detailed error reporting and fix suggestions. Use before commits, after major changes, or when ensuring code quality standards.

日本語の概要は準備中です。原文の説明を表示しています。

Adds comprehensive accessibility testing to CI/CD pipelines using axe-core Playwright integration or pa11y-ci. Automatically generates markdown reports for pull requests showing WCAG violations with severity levels, affected elements, and remediation guidance. This skill should be used when implementing accessibility CI checks, adding a11y tests to pipelines, generating accessibility reports, enforcing WCAG compliance, automating accessibility scans, or setting up PR accessibility gates. Trigger terms include a11y ci, accessibility pipeline, wcag ci, axe-core ci, pa11y ci, accessibility reports, a11y automation, accessibility gate, compliance check.

日本語の概要は準備中です。原文の説明を表示しています。

Executive coaching skill that helps you plan your 2026 using research-backed process goals. Guides you through discovery questions, creates outcome goals, converts them to daily behaviors, and sets up accountability systems. Use when you want to plan your year, set goals, or need a coach to help you stay focused.

日本語の概要は準備中です。原文の説明を表示しています。

Protocol-based dependency injection for testable Swift code — mock file system, network, and external APIs using focused protocols and Swift Testing.

日本語の概要は準備中です。原文の説明を表示しています。

This skill should be used when the user asks to "model agent mental states", "implement BDI architecture", "create belief-desire-intention models", "transform RDF to beliefs", "build cognitive agent", or mentions BDI ontology, mental state modeling, rational agency, or neuro-symbolic AI integration.

日本語の概要は準備中です。原文の説明を表示しています。