「net」の検索結果

Implement minimal network events and component state with authority, conversion, dirtying, and regression coverage.

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When the user wants help with pricing decisions, packaging, or monetization strategy. Also use when the user mentions 'pricing,' 'pricing tiers,' 'freemium,' 'free trial,' 'packaging,' 'price increase,' 'value metric,' 'Van Westendorp,' 'willingness to pay,' or 'monetization.' This skill covers pricing research, tier structure, and packaging strategy.

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親イシュー配下のサブイシュー（孫以下の全子孫を含む）を依存順を保ちつつ worktree で並列に自動実装・push 前 review・PR 作成・CI 監視・マージ可能状態化まで一括自動化。 「イシューツリーを並列実装」「配下のサブイシューをまとめて実装」「ツリー全体を並列で実装して」「イシュー階層を自動開発」で使用。 per-issue 計画立案（Plan: セッション継承モデル）→実装（Implement: sonnet）の分業。push 前 review（Review 通過後にのみ push・PR 作成して CI を 1 回だけ起動）。 外部チェック構成は args の externalChecks で明示（{"app", "context"} の組で宣言。[] で「なし」を確定して不要待機なし・未指定なら自動マージ停止・slug のみの旧形式は自動マージ fail-closed）。 自動 squash merge は autoMerge: true + externalChecks 明示（全 App の信頼済み context 宣言込み）の opt-in で実行（merge-exec の自己取得再検証 + サーバー側 branch protection 実測が前提。既定 false はマージ可能状態で停止し人間がマージ。サーバー側 workflow サンプル（upstream の docs/implement-issue-tree/auto-merge-sample.yml 参照）+ branch protection への委譲も可）。並列度（parallel）と依存（dependsOn）で実行順を制御。 Phase 単位で厳密に直列化したい場合は phaseGate: true（opt-in。ルート直下の子〔Phase 親〕を sub-issues リスト順に直列化し、前 Phase の全子孫が merged/closed になるまで次 Phase 配下に着手しない。既定 false は現行の post-order 優先度のみ）。 着手できる件数・blocked になる件数を事前に知りたい場合は dryRun: true（何も書かずに見積りだけ返す）。 単一イシューの実装は implement-issue、PR レビューは implement-review-pr を参照。

Upstash サーバーレスデータプラットフォーム (マネージド SaaS の JS SDK)。 @upstash/redis (REST, pipelining, transactions, JSON, Redis Search, VECTOR/Array/Functions コマンド)、 @upstash/ratelimit (Fixed/Sliding Window, Token Bucket, blockUntilReady)、 QStash (publishJSON, schedules, queues, URL Groups, flow-control, DLQ)、 @upstash/vector (upsert, query, ANN, namespace, hybrid/sparse index, embedding models, reranking)、 @upstash/workflow (serve, durable execution, context.run/sleep/call/invoke, waitForEvent, parallel steps, agents)、 Upstash Search (@upstash/search, search, upsert, fetch, range, filtering, reranking, algorithm)、 @upstash/box (サンドボックス, filesystem, git, CDP, browser, network policy, snapshots, custom harness)、 upstash CLI。Rust 製 fandhe-db とは別。

Windows アプリ開発 (Win32 / WPF / WinForms 相互運用) の相互運用・近代化。 Win32 API (CreateWindowExW, WNDPROC, メッセージループ), COM (IUnknown, CoCreateInstance, ComPtr), CsWin32, windows-rs, C++/WinRT (winrt::com_ptr, IAsyncOperation, IDL, ABI 相互運用), C#/WinRT (cswinrt, ComWrappers, AOT/trimming, WindowNative), XAML Islands (DesktopWindowXamlSource, DesktopChildSiteBridge, WindowsXamlManager), HwndHost, HwndSource, WindowsFormsHost, ElementHost, UWP から Windows App SDK / WinUI 3 への移行 (namespace mapping, AppWindow, DispatcherQueue, .NET Upgrade Assistant)、 移行判断 (upgrade / modernize / migrate)、WinForms → WinUI 3 パターン対応、GitHub Copilot upgrade。

Windows アプリ開発 (Windows App SDK / WinRT) の OS 統合 API リファレンス。 DeviceInformation, DeviceWatcher, センサー (Accelerometer, Gyrometer, Pedometer, Compass, OrientationSensor, ActivitySensor), Bluetooth LE, USB, Serial, HID, Battery, HttpClient, StreamSocket, WebSocket, BackgroundDownloader/Uploader, NetworkInformation, PointerInput, KeyboardInput, IME/TextInput, FocusManager, DragAndDrop, ResourceLoader (多言語化・地域化), Calendar, DateTimeFormatter, CurrencyFormatter, PasswordVault, OAuth2Manager, Web Account Manager (WAM) / MSAL, WebAuthenticationBroker, WindowsHello/Passkeys, Age signals, CryptographicBuffer, Clipboard, DataTransferManager, Launcher, ProtocolActivation, JumpList, TaskbarManager, SecondaryTile, StartupTask, Smart App Control, Phone Link。

NVIDIA Sync デスクトップアプリ。DGX Spark, DGX Station, SSH Linux ホストのリモート接続管理。mDNS 自動検出, 手動 IP, SSH config インポート, Tailscale, 自動ネットワーク切替。 Cluster Assistant, ConnectX-7 クラスタトポロジ, netplan 検証。 Resource Monitor (CPU / GPU / memory), release notes。 VS Code, VS Code Insiders, Cursor, NVIDIA AI Workbench 起動, カスタムアプリ, ポートフォワード, SSH トンネル。

TanStack Start (TanStack Router ベースのフルスタック React フレームワーク、 @tanstack/react-start) の API リファレンス。Next.js とは別フレームワーク。 createServerFn (validator / handler), createMiddleware, server routes, createServerOnlyFn / createIsomorphicFn、SSR / selective SSR / SPA mode / static prerendering / ISR、streaming、hydration、server entry / client entry、 TanStack Query 連携 (setupRouterSsrQueryIntegration)、RC → stable 移行、 hosting (Cloudflare Workers / Netlify / Vercel / Node / Bun / Docker)、 production checklist、authentication / session、Tailwind、SEO、 environment variables。ルーティングは tanstack-router スキルを参照。

OpenAI API (developers.openai.com) の Responses API リファレンス。 text generation, embeddings, gpt-6-astra / gpt-6.1-sol / gpt-6-luna, structured outputs, streaming, function calling, programmatic / async tool calling, conversation state, prompt caching, prompt cache diagnostics, reasoning (configuration_update), background mode, compaction, multi-agent, WebSocket mode (mid-turn steering, stream_id), webhooks, error codes, rate limits, Realtime server controls, 公式 SDK (Python / JS / .NET / Java / Go / Ruby), openai CLI, Chat Completions / Assistants 移行, deprecations。

Inngest イベント駆動 Durable Execution リファレンス。バックグラウンドジョブ、長時間ワークフロー。 createFunction, step.run, step.sleep, step.waitForEvent, step.waitForSignal, step.invoke, step.sendEvent, step.sleepUntil, step.fetch, step.ai.infer, step.ai.wrap, step.metadata, inngest.send, serve, connect, checkpointing, Inngest CLI。 concurrency, throttle, debounce, rate-limit, batching, priority, idempotency, singleton, multi-tenancy フロー制御。 Realtime（channels, topics, publish, subscribe, subscription tokens, useRealtime）、 Agent Evals（scoring, group.experiment）、MCP（Dev Server / Cloud）。 デプロイ先 Next.js, Express, Hono, Cloudflare Workers, Vercel, Netlify, DigitalOcean, Render。

CadQuery (Python 製 3D CAD スクリプティングライブラリ) リファレンス。 Workplane API (lineTo / extrude / revolve / sweep / loft / fillet / chamfer / shell)、 Sketch API、Assemblies (Constraint solver)、Free Function API (hollow / prism / draft / offset2D, History)、 Selectors、Shape / Vertex / Edge / Wire / Face / Shell / Solid、 Import / Export (STEP / DXF / STL / glTF / SVG)、Visualization (VTK, cadquery.fig 非ブロッキング, Jupyter)、CQGI。

Claude API (platform.claude.com) のモデル・SDK。 model ID・選択基準、Fable・Mythos 5.1 / Opus・Sonnet・Haiku 5.5 移行・破壊的変更、 コスト最適化 (effort / caching / batch / advisor)、pricing、deprecation、用語集。 公式 SDK 7 言語 (Python / TypeScript / Java / Go / Ruby / C# / PHP)、 Claude API 用 CLI `ant` (Claude Code CLI とは別。quickstart / authentication / scripting、`ant apply` resources as code、Managed Agents session 接続)、 middleware、OpenAI SDK 互換、Apple Foundation Models。

Claude Code (code.claude.com) の権限・セキュリティ・企業管理リファレンス。 permissions (allow / ask / deny), permission modes, auto mode (classifier billing), sandboxing, sandbox environments, sandboxed Bash, zero data retention, data usage, HIPAA, managed settings (MDM / plist / registry), server-managed settings, managedMcpServers, allowedProviders, admin setup, authentication (SSO), network config, corporate launcher, OpenTelemetry monitoring, analytics, costs, large codebases, communications kit / champion kit。

NVIDIA DGX Spark User Guide リファレンス。GB10 Grace Blackwell Superchip 仕様、 first-boot / UEFI、ConnectX-7 Networking (旧 Spark Stacking)、複数 Spark 接続、 NVIDIA Sync Cluster Assistant、DGX OS / NGC / container runtime、 Release Notes (DGX OS 7.5.0)、known issues、PXE / cloud-init、fleet 運用、 apt / fwupdmgr、recovery、PSIRT、 NVIDIA Developer Forums 由来 troubleshooting、 build.nvidia.com/spark playbook (vLLM / vLLM cluster / TensorRT-LLM / Ollama / ComfyUI / NIM / NeMo / VLM fine-tuning / NVIDIA PAIR / NCCL)、Tailscale、VS Code。

Harden network architecture, segmentation, TLS, and allowlists for systems you operate. Defensive design and review only.

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Infer or annotate TCR antigen specificity by unsupervised clustering (TCRdist/tcrdist3, GLIPH2, clusTCR, GIANA) and database lookup (VDJdb, IEDB, McPAS-TCR), and rank candidates with supervised predictors (ERGO-II, NetTCR-2.x, pMTnet) under explicit caveats. Encodes the central truth that general TCR-epitope prediction for UNSEEN epitopes essentially does not work (collapses to near-random; IMMREP22, Grazioli 2022) because labeled data is dominated by a few immunodominant epitopes and there is no true negative set — so clustering for discovery is the honest task and de-novo binding needs wet-lab validation. Use when annotating TCR specificity or grouping a repertoire. Epitope/MHC context lives in mhc-binding-prediction.

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Simulate transcription factor perturbation effects on cell state in silico with CellOracle and Dynamo, and predict transcriptional responses to genetic perturbations with GEARS, scGen, and CPA. Covers the direction-not-magnitude principle, local-linear validity, the GRN/velocity error it inherits, baseline discipline (mean and additive baselines), and the validation gap. Use when predicting TF knockout or overexpression effects, ranking driver TFs for fate transitions, or planning perturbation experiments. For GRN construction see multiomics-grn; for experimental Perturb-seq see single-cell/perturb-seq.

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Analyzes species-environment relationships with constrained ordination (CCA, RDA, db-RDA), variance partitioning, indicator species (indicspecies IndVal.g group-equalized), PERMANOVA paired MANDATORILY with PERMDISP (Anderson & Walsh 2013; dispersion confounds centroid tests), Joint Species Distribution Models (HMSC, sjSDM, gjam) with explicit rejection of "residual covariance equals biotic interaction", phylogenetic community ecology (SES_MPD/MNTD), trait-environment via RLQ + fourth-corner with corrected modeltype=6 (Dray 2014), bipartite network metrics (NODF, modularity) with curveball null (Strona 2014), and Mantel-test replacements (dbRDA, GDM) for spatial data. Use when testing how environmental gradients structure communities, identifying habitat indicator taxa, partitioning variance among predictors, deciding whether PERMANOVA significance is location vs dispersion, picking among HMSC/sjSDM/gjam, or replacing Mantel tests for landscape data.

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Query protein-protein and gene interaction databases (STRING, BioGRID, IntAct, SIGNOR, Reactome, HuRI, HuMAP, OmniPath, ConsensusPathDB, DIP). Use when building PPI networks, choosing between physical vs functional vs genetic interactions, signed/directed vs undirected, high-throughput vs curated, picking confidence thresholds, aggregating across resources, or navigating license constraints. Encodes the database decision matrix, STRING v12 channel semantics, OmniPath as meta-database, SIGNOR for signed signaling, and per-resource rate limits.

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Designs and analyzes combinatorial CRISPR screens covering paired-Cas9 (Big Papi, Najm 2018), enhanced AsCas12a multiplex (enCas12a, DeWeirdt 2021), in4mer 4-guide-array Cas12a (Esmaeili Anvar N et al 2024 Nat Commun 15:3577) and the Inzolia paralog-pair library, paralog-buffering detection (Dede 2020 Genome Biol; Thompson 2021 Cell Reports 36:109597), genetic-interaction (GI) scoring as observed_double_LFC minus expected_additive_double_LFC, synthetic-lethal and synthetic-rescue interaction interpretation, the half-of-essentiality buffered by paralogs phenomenon, multiplex screen statistical analysis with MAGeCK MLE interaction terms, and the relationship to single-cell combinatorial Perturb-seq. Use when designing a paralog or pathway-pair screen, choosing between paired-Cas9 (Big Papi) and Cas12a multiplex (Inzolia), interpreting genetic interaction scores, identifying synthetic-lethal targets for drug development, or scaling beyond single-gene CRISPR screens.

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Build whole-genome alignments using Progressive Cactus (Armstrong 2020 reference-free clade-level WGA), Minigraph-Cactus (Hickey 2024 pangenome-aware), LASTZ chain/net (UCSC pipeline), MUMmer4 (Marçais 2018 pairwise), minimap2 -x asm5/10/20 (Li 2018 fast pairwise), AnchorWave (Song 2022 WGD-aware), and Mauve / progressiveMauve (bacterial). Operates the HAL toolkit (Hickey 2013) for downstream extraction including halSynteny, halLiftover, halBranchMutations, and hal2maf. Use when constructing multi-species alignments for comparative-annotation projection (TOGA), synteny detection, conservation analyses (phyloP / PhastCons), or pangenome graph construction; selecting between reference-free (Cactus) and reference-anchored (LASTZ chains/nets) approaches; tuning sensitivity for closely vs distantly related genomes; or producing HAL files for genome-wide downstream tools.

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Detect syntenic blocks and structural rearrangements between genomes using MCScanX (Wang 2012), JCVI/MCScan (Tang 2008 Python), GENESPACE (Lovell 2022) for orthology-anchored riparian visualization, SyRI for structural variation, AnchorWave for sequence-level synteny, i-ADHoRe 3.0 for highly diverged species, SynNet for synteny networks, and ntSynt for multi-genome macrosynteny. Use when identifying collinear gene blocks across species, distinguishing macrosynteny from microsynteny, detecting inversions/translocations/duplications, anchoring orthology in WGD lineages, producing publication riparian plots, computing synteny block age via Ks (cross-references whole-genome-duplication), or running synteny-aware ortholog inference in polyploids.

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Detect horizontal gene transfer (HGT / LGT) using compositional methods (GC%, codon usage, tetranucleotide z-scores via SIGI-HMM, AlienHunter, IslandViewer 4, IslandPath-DIMOB), phylogenetic-incongruence methods (AvP, HGTphyloDetect, ALE / GeneRax / AleRax reconciliation, RANGER-DTL), and BLAST-distribution methods (HGTector v2, DarkHorse, Alien Index). Use when screening prokaryote genomes for genomic islands and HGT events, distinguishing HGT from incomplete lineage sorting / differential gene loss / hybridization, mapping donor lineages via phylogenetic placement, separating eukaryotic HGT from contamination, ruling out gBGC as a false signal, or quantifying DTL rates with ALE/GeneRax on bacterial trees.

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Estimate SNP heritability and partition it across functional annotations, cell types, and loci from GWAS summary statistics or individual-level genotypes. Implements LDSC, stratified LDSC with the baseline-LD model, Finucane 2018 cell-type prioritization, LDAK SumHer, HDL, HESS local heritability, BOLT-REML, GCTA-GREML, graphREML, and Popcorn cross-population genetic correlation. Use when computing total h2_SNP from summary stats, partitioning heritability across functional categories, prioritizing trait-relevant tissues or cell types from ENCODE/Roadmap chromatin marks, reconciling LDSC vs LDAK enrichment estimates, computing local heritability with HESS, estimating genetic correlation between traits, or producing publication-grade enrichment with calibrated sensitivity to model assumptions.

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