3,617 件 ・ 関連度順
概要と使いどころ
ESM2 protein language model for embeddings and sequence scoring. Use this skill when: (1) Computing pseudo-log-likelihood (PLL) scores, (2) Getting protein embeddings for clustering, (3) Filtering designs by sequence plausibility, (4) Zero-shot variant effect prediction, (5) Analyzing sequence-function relationships. For structure prediction, use chai or boltz. For QC thresholds, use protein-qc.
日本語の概要は準備中です。原文の説明を表示しています。
Workflow for Hi-C and related 3D genomics analyses including compartments, loops, TADs, differential contacts, and visualization.
日本語の概要は準備中です。原文の説明を表示しています。
Structure prediction using Chai-1, a foundation model for molecular structure. Use this skill when: (1) Predicting protein-protein complex structures, (2) Validating designed binders, (3) Predicting protein-ligand complexes, (4) Using the Chai API for high-throughput prediction, (5) Need an alternative to AlphaFold2. For QC thresholds, use protein-qc. For AlphaFold2 prediction, use alphafold. For ESM-based analysis, use esm.
日本語の概要は準備中です。原文の説明を表示しています。
Binder design ranking using ipSAE (interprotein Score from Aligned Errors). Use this skill when: (1) Ranking binder designs for experimental testing, (2) Filtering BindCraft or RFdiffusion outputs, (3) Comparing AF2/AF3/Boltz predictions, (4) Predicting binding success rates, (5) Need better ranking than ipTM or iPAE. For structure prediction, use chai or alphafold. For QC thresholds, use protein-qc.
日本語の概要は準備中です。原文の説明を表示しています。
Workflow for predictive modeling, biomarker discovery, survival modeling, and explainability over omics-derived features.
日本語の概要は準備中です。原文の説明を表示しています。
Workflow for nanopore or PacBio long-read QC, alignment, polishing, methylation-aware analysis, and structural variant discovery.
日本語の概要は準備中です。原文の説明を表示しています。
Discover and invoke 1,676 deduplicated biomedical AI agent skills from the Awesome Bio Agent Skills repository (20 source repos, 15 categories). Use this skill as a router whenever a user needs a bioinformatics/biomedical task (genomics, transcriptomics, single-cell, proteomics, protein design, clinical, epigenomics, multi-omics, pathway, metagenomics, database queries, visualization, workflows): search the index, locate the best-matching skill, fetch its SKILL.md, and follow it.
日本語の概要は準備中です。原文の説明を表示しています。
Boltz-1 / Boltz-2 structure prediction for proteins, complexes, and ligand-aware validation. Use this skill when: (1) Predicting protein complex structures, (2) Validating designed binders, (3) Need open-source alternative to AF2, (4) Predicting protein-ligand complexes, (5) Using local GPU resources. For QC thresholds, use protein-design-qc. For AlphaFold2 prediction, use alphafold2-multimer. For Chai prediction, use chai1-structure-prediction.
日本語の概要は準備中です。原文の説明を表示しています。
Chai-1 structure prediction for protein complexes and design validation. Use this skill when: (1) Predicting protein-protein complex structures, (2) Validating designed binders, (3) Predicting protein-ligand complexes, (4) Using the Chai API for high-throughput prediction, (5) Need an alternative to AlphaFold2. For QC thresholds, use protein-design-qc. For AlphaFold2 prediction, use alphafold2-multimer. For ESM-based analysis, use esm2-sequence-scoring.
日本語の概要は準備中です。原文の説明を表示しています。
Workflow for regulatory network inference, regulon scoring, perturbation-aware comparison, and network visualization.
日本語の概要は準備中です。原文の説明を表示しています。
Workflow for ligand-receptor communication inference in single-cell or spatial data with sender-receiver summaries and cautious interpretation.
日本語の概要は準備中です。原文の説明を表示しています。
Workflow for untargeted or targeted metabolomics including preprocessing, normalization, annotation, statistics, and pathway mapping.
日本語の概要は準備中です。原文の説明を表示しています。
Binder design tool selection and workflow routing guidance. Use this skill when: (1) Deciding between BoltzGen, BindCraft, or RFdiffusion, (2) Planning a binder design campaign, (3) Understanding trade-offs between different approaches, (4) Selecting tools for specific target types. For specific tool parameters, use the individual tool skills (boltzgen, bindcraft, rfdiffusion, etc.).
日本語の概要は準備中です。原文の説明を表示しています。
Binder design campaign planning, monitoring, and troubleshooting. Use this skill when: (1) Planning a complete binder design campaign, (2) Converting high-level goals into runnable pipelines, (3) Assessing campaign health and pass rates, (4) Diagnosing why designs are failing QC, (5) Estimating time, cost, and expected yields, (6) Selecting between design tools for a specific target. This skill orchestrates the other protein design tools. For individual tool parameters, use the specific tool skills.
日本語の概要は準備中です。原文の説明を表示しています。
Fetch and analyze protein structures from RCSB PDB. Use this skill when: (1) Need to download a structure by PDB ID, (2) Search for similar structures, (3) Prepare target for binder design, (4) Extract specific chains or domains, (5) Get structure metadata. For sequence lookup, use uniprot. For binder design workflow, use binder-design.
日本語の概要は準備中です。原文の説明を表示しています。
Workflow for orthology, synteny, ancestral reconstruction, and evolutionary comparison across genomes.
日本語の概要は準備中です。原文の説明を表示しています。
Workflow for fine-mapping, colocalization, mediation, pleiotropy analysis, and Mendelian randomization.
日本語の概要は準備中です。原文の説明を表示しています。
Validate protein designs using AlphaFold2 structure prediction. Use this skill when: (1) Validating designed sequences fold correctly, (2) Predicting binder-target complex structures, (3) Calculating confidence metrics (pLDDT, pTM, ipTM), (4) Self-consistency validation of designs, (5) Multi-chain complex prediction with AlphaFold-Multimer. For faster single-chain prediction, use esm. For QC thresholds, use protein-qc.
日本語の概要は準備中です。原文の説明を表示しています。
Guidance for cell-free protein synthesis (CFPS) optimization. Use when: (1) Planning CFPS experiments, (2) Troubleshooting low yield or aggregation, (3) Optimizing DNA template design for CFPS, (4) Expressing difficult proteins (disulfide-rich, toxic, membrane).
日本語の概要は準備中です。原文の説明を表示しています。
End-to-end protein design pipeline guide across preparation, generation, validation, and filtering. Use this skill when: (1) Starting a new protein design project, (2) Need step-by-step workflow guidance, (3) Understanding the full design pipeline, (4) Planning compute resources and timelines, (5) Integrating multiple design tools. For tool selection, use binder-design-tool-selection. For QC thresholds, use protein-design-qc.
日本語の概要は準備中です。原文の説明を表示しています。
Workflow for copy-number estimation, segmentation, annotation, and visualization in sequencing-based assays.
日本語の概要は準備中です。原文の説明を表示しています。
Workflow for read alignment, sorting, indexing, mapping statistics, and downstream-ready alignment artifacts.
日本語の概要は準備中です。原文の説明を表示しています。
Workflow for event-level and isoform-level splicing analysis with sashimi-ready outputs and splice QC.
日本語の概要は準備中です。原文の説明を表示しています。
Workflow for RNA modification analysis such as m6A peak calling, differential modification, and transcript-level visualization.
日本語の概要は準備中です。原文の説明を表示しています。