「validation」の検索結果

Designs and validates quantitative targeted metabolomics assays (MRM/SRM on triple-quadrupole, PRM on high-resolution instruments) to report absolute concentrations. Covers the internal-standard strategy (external cal -> global IS -> standard addition -> stable-isotope-labeled IS), weighted calibration judged by back-calculated %RE not R-squared, ion-ratio quantifier/qualifier confirmation, matrix-effect/recovery characterization, and ICH M10 method validation. Use when quantifying a closed panel of known metabolites with units, building or validating an LC-MS/MS assay, choosing an IS or calibration weighting, or judging whether a reported concentration is trustworthy. For untargeted feature detection see metabolomics/xcms-preprocessing; for group statistics see metabolomics/statistical-analysis; for flux/MID/tracing see metabolomics/isotope-tracing.

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Performs alchemical free-energy calculations including relative binding free energy (RBFE / FEP+) and absolute binding free energy (ABFE) via OpenFE, FEP+, GROMACS, AMBER pmemd, and OpenMM with explicit lambda window scheduling, soft-core potentials, REST2 enhanced sampling, MBAR/BAR analysis, and cycle closure validation. Compares ML alternatives (Boltz-2 affinity, DeepDock). Use when ranking analogs by binding affinity beyond docking accuracy, performing prospective lead optimization, or validating SAR predictions.

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Performs retrosynthetic planning using AiZynthFinder (MCTS, template-based), Chemformer (template-free transformer), ASKCOS, and emerging RetroSynFormer with explicit handling of route scoring, building-block availability (eMolecules, Enamine, Mcule), forward prediction validation (Molecular Transformer), and disconnection-aware multi-objective search (MO-MCTS). Use when assessing synthetic feasibility of generated or selected molecules, planning multi-step syntheses, building synthesis-aware design pipelines, or screening libraries for retro-route feasibility.

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Enumerates virtual chemical libraries via reaction SMARTS transformations using RDKit and Reaction templates, with explicit handling of atom mapping, template extraction (RDKit reaction mining), product validation, RECAP/BRICS fragmentation, R-group decomposition, matched molecular pair analysis (MMPA), and Free-Wilson analysis. Use when generating combinatorial libraries from building blocks, enumerating analog series, deriving structure-activity rules, or extracting transformations from reaction data.

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Decision-grade statistical analysis for metabolomics intensity tables. Covers transformation and scaling (Pareto vs unit-variance as a hidden hypothesis), unsupervised structure (PCA/HCA for QC), permutation-validated PLS-DA/OPLS-DA (R2 vs Q2, double CV, VIP as heuristic), univariate testing (Welch/Mann-Whitney/ANOVA/LMM with covariate adjustment), and dependence-aware multiple testing. Use when testing which metabolites differ, building or validating a discriminant model, choosing a scaling, or correcting many correlated tests. For sample-wise normalization/drift correction see metabolomics/normalization-qc; for ML classifiers and selection-inside-CV leakage see machine-learning/biomarker-discovery and machine-learning/model-validation; for pathway interpretation see metabolomics/pathway-mapping; for design/power/multiplicity regime see experimental-design/multiple-testing.

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Builds QSAR / QSPR models using chemprop D-MPNN, MolFormer, Uni-Mol, ChemBERTa, random forest baselines, and Gaussian processes with explicit handling of OECD 5 principles, applicability domain (kNN, leverage, conformal prediction, Mahalanobis), scaffold-balanced splits, ensemble uncertainty, calibration (Platt, isotonic), feature importance (SHAP, atomic attribution), and prospective validation. Use when building target-specific predictive models from in-house bioassay data, ADMET endpoints, or selectivity profiles.

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Use when implementing a medium or large coding project from a written spec, plan, or product goal where drift, skipped validation, PR correctness, or multi-block delivery risk matter.

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Configure and debug MCP servers for OpenCode, Codex CLI, and Claude Code, including auth headers, scope, and validation checks. Use when MCP tools fail to connect or when adding a new MCP server.

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Configure and debug MCP servers for Claude Code, OpenCode, and Codex CLI, including auth headers, scope, and validation checks. Use when MCP tools fail to connect, when an MCP server returns 401/404/HTML, or when adding a new MCP server to this repo.

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Review Stellar Community Fund (SCF) Build Award applications. Use when evaluating SCF submissions, covering project fit assessment, technical architecture evaluation, team readiness, traction validation, budget analysis, and funding recommendations.

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Pre-PR verification for VenTu — tests, data validation, static build, and e2e for the touched surface. Use before opening any PR. For visual UI checks also load ventu-verify-ui.

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Author and diagnose YAML, prototype schemas, workflows, manifests, and structured configuration with exact validation.

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Build localized client XAML controls with correct lifecycle, culture refresh, resource references, ownership, and validation.

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Implement BUI contracts, server validation, localized client windows, lifecycle cleanup, and state refresh.

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Implement commands and CVar-backed configuration with validation, authority, persistence, localized feedback, and compatibility.

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Validate UI, command, text, numeric, entity, and configuration input with localized feedback and server authority.

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Implement reusable interactions, verbs, in-hand use, actions, and BUI requests with clear validation and mutation.

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Build AI output validation systems with guardrails. TRIGGERS - Use when user needs help with ai-output-validator related tasks.

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Build AI guardrails with input/output validation. TRIGGERS - Use when user needs help with ai-guardrails-system related tasks.

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Create, migrate, improve, or debug detailed vehicle assets for CARLA using Blender and Unreal, including reference-based geometry, materials, wheels, physics, lights, and runtime validation. Use for vehicle asset authoring rather than ordinary traffic spawning or map decoration.

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Expert security auditor specializing in comprehensive security assessments, compliance validation, and risk management. Masters security frameworks, audit methodologies, and compliance standards with focus on identifying vulnerabilities and ensuring regulatory adherence.

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Web API development conventions for Adynato projects. Covers API routes, middleware, authentication, error handling, validation, and response formats for Next.js and Node.js backends. Use when building or modifying API endpoints, server actions, or backend logic.

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Full adversarial quality loop — implement, self-attack, parallel verification, quality gates, final validation. 全品質循環：實現、自攻、並行驗證、質量關卡、最終確認. Use when: implement task with quality, run adversarial review, verify code quality, run quality gates, complete workflow task

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Enhanced architecture guidance for voice-first Brazilian fintech applications. Use when designing voice interfaces, implementing PIX/Boletos, optimizing financial systems, or making technology stack decisions for Brazilian market applications. Integrates with docs/ content, MCP tools for Brazilian market research, enhanced validation scripts, and comprehensive Brazilian compliance patterns.

日本語の概要は準備中です。原文の説明を表示しています。