2,577 件 ・ 関連度順
概要と使いどころ
End-to-end observational epidemiology analysis — from research question (PECO Population/Exposure/Comparator/Outcome) to publication-ready statistical report. Covers cohort/case-control/cross-sectional design, regression with confounders, propensity scoring, sensitivity analysis. Writes Python code for every step. Use for epidemiology study analysis, NHANES/UK-Biobank-style analyses.
日本語の概要は準備中です。原文の説明を表示しています。
Build genome-browser-style multi-track figures with pyGenomeTracks (config-driven), Gviz (R), and IGV batch screenshotting. Covers BigWig coverage tracks, BED/peak overlays, gene-model rendering, Hi-C matrix tracks, BedPE link arcs, spike-in-aware normalization, and the bamCoverage --normalizeUsing trap. Use when producing publication figures of genomic loci with stacked aligned tracks (coverage, peaks, genes, interactions) for ChIP-seq, ATAC-seq, RNA-seq, Hi-C, or generic locus visualization.
日本語の概要は準備中です。原文の説明を表示しています。
Build Sankey, alluvial, river, and CONSORT-style flow diagrams to visualize cohort transitions, cell-state changes, or pipeline filtering using ggalluvial, networkD3, plotly, and consort. Use when showing how entities move between categories across timepoints (cell states, drug response classes, patient flow through a trial) or filtering pipelines (variants filtered through QC stages).
日本語の概要は準備中です。原文の説明を表示しています。
End-to-end alternative splicing analysis from FASTQ to differential splicing results for short-read bulk RNA-seq. Aligns with STAR 2-pass cohort-style, performs junction QC (RSeQC, MaxEntScan, SpliceAI), runs rMATS-turbo and leafcutter for concordant differential analysis, optionally MAJIQ V3 for complex events / heterogeneous cohorts, isoform-switching with NMD/ORF/domain consequences (IsoformSwitchAnalyzeR v2 + DRIMSeq+DEXSeq+stageR DTU), and sashimi visualizations. Use when performing comprehensive splicing analysis from raw bulk RNA-seq data; for variant-driven splice prediction see splice-variant-prediction; for rare-disease single-patient outlier detection see outlier-splicing-detection; for full-isoform PacBio/ONT analysis see long-read-splicing.
日本語の概要は準備中です。原文の説明を表示しています。
Designs covalent inhibitors and warheads targeting cysteine (most common, 98% of covalent drugs), lysine, serine, threonine, tyrosine, and aspartate residues, with explicit handling of warhead reactivity (acrylamide, chloroacetamide, vinyl sulfone, sulfonyl fluoride, fluorosulfate, aldehyde, boronate, nitrile), reversibility (kinact/Ki, t_residence), glutathione (GSH) stability, intrinsic reactivity assays, and covalent docking (DOCKovalent, GOLD, HCovDock). Use when designing covalent inhibitors for targeted covalent inhibition (TCI), KRAS G12C-style approaches, or rationalizing covalent SAR.
日本語の概要は準備中です。原文の説明を表示しています。
Compile your local stellar-build usage traces into sharper skills. Use when the user says "optimize my skills", "optimize-skills", "improve my skills from usage", "learn from my traces", "stellar-loop optimize", or wants the learning loop to refine installed skills based on how they've actually been used. DSPy-style prompt optimization over the local trace store at ~/.stellar-build/traces — fully local, reversible.
日本語の概要は準備中です。原文の説明を表示しています。
Apple's approach to interface design and fluid, physical motion, translated for the web. Use when building or reviewing gesture-driven UI, spring animations, drag/swipe/sheet interactions, momentum and interruptible transitions, translucent materials and depth, typography (optical sizing, tracking, leading), reduced-motion, or the design foundations (feedback, spatial consistency, restraint) behind Apple-style interfaces.
日本語の概要は準備中です。原文の説明を表示しています。
Write repository-consistent C# only after proving symbol access, ownership, and compatibility.
日本語の概要は準備中です。原文の説明を表示しています。
Implement or modify web UI in React, Next.js, or Angular. Use for components, pages, styles, forms, and frontend state or data flows.
日本語の概要は準備中です。原文の説明を表示しています。
Central authority for Claude Agent SDK (TypeScript and Python SDKs). Covers SDK installation, authentication (Anthropic key, Bedrock, Vertex), sessions and resumption, forking sessions, streaming vs single mode, custom tools, permissions (allowedTools, disallowedTools, permissionMode), MCP integration, system prompts (CLAUDE.md, appendSystemPrompt, outputStyle), cost tracking, todo tracking, structured outputs, hosting patterns, plugins, and SDK branding guidelines. Assists with building custom agents, configuring SDK options, and troubleshooting SDK issues. Delegates 100% to docs-management skill for official documentation.
日本語の概要は準備中です。原文の説明を表示しています。
Self-review, audit, or verify CS/AI/ML paper drafts as a critical peer reviewer. Three-round review (evidence→argument→style) with Verification Status and debt tracking. Use when: reviewing a paper draft before submission, checking evidence compliance of claims, simulating peer reviewer feedback, verifying citation closure and evidence debts, performing cross-section consistency checks. Triggers on: 审修, self review, 自查, verification, revise, 修订, check draft, 审稿, evidence compliance, peer review, 论文审查, draft audit, 验证论文, 检查引用, cross-section review.
日本語の概要は準備中です。原文の説明を表示しています。
Create pixelated borders, shadows, and effects for 8-bit retro components. Apply when building 8-bit styled UI components that need authentic pixel art aesthetics.
日本語の概要は準備中です。原文の説明を表示しています。
Accessibility audit for CSS covering focus styles, color contrast, text sizing, screen reader support, and WCAG compliance. Provides actionable fixes. Use when auditing accessibility or fixing a11y issues.
日本語の概要は準備中です。原文の説明を表示しています。
Expert knowledge of academic writing standards for peer-reviewed papers, including citation integrity, style compliance, clarity, and scientific writing best practices. Use when reviewing or editing academic manuscripts, papers, or research documentation.
日本語の概要は準備中です。原文の説明を表示しています。
Creates high-quality content (blog posts, tweets, newsletters, documentation) that matches the user's writing style and voice. Performs web research to find citations and supporting evidence. Use when user requests blog posts, marketing content, newsletters, tweets, or any written content that should sound authentic and be well-researched.
日本語の概要は準備中です。原文の説明を表示しています。
Perform a diff-scoped, behavior-neutral cleanup of AI-generated slop on the current branch before code review. Use for removing trivial comment, defensive-check, type-laundering, redundant-intermediate, compatibility-shim, or local style drift from the branch diff. Do not use for full correctness or safety review, documentation work handled by technical-documentation or docs-refactor, or repo-wide refactors.
日本語の概要は準備中です。原文の説明を表示しています。
Prepare a request to change the terms of a Japanese job offer before accepting it, sorting what the user wants changed (pay components, start date, work style, location, title, probation) by priority, tying each ask to a basis the user can show (the written offer, the job posting, what was said in interviews, their own records), working the timing back from the acceptance deadline, and drafting the message to the employer or recruiting agent. Use when a user has an offer and wants to ask for higher pay, a later start date, more remote days, or other changed terms, or wants to know how to raise it without losing the offer; do not use to predict whether the request will succeed, to set a target figure from market rates, to fabricate a competing offer, to decide whether to accept, or to send anything to the employer.
日本語の概要は準備中です。原文の説明を表示しています。
Detects focal chromatin loops (point interactions / corner-dots) in balanced Hi-C and Micro-C contact maps and aggregates/validates a loop set. Covers de-novo calling with cooltools dots (HiCCUPS-style 4-background local enrichment with lambda-chunked FDR), chromosight (template-correlation), and Mustache (scale-space blob detection); aggregate peak analysis (APA) via cooltools pileup for confirmation; the depth/resolution prerequisite (de-novo needs ~5-10kb resolution = hundreds of millions to billions of valid pairs); consensus across callers and convergent-CTCF support as validation; and differential loops via union anchors plus chromosight quantify. Use when calling chromatin loops or dots from a cooler, deciding whether a map is deep enough to call de-novo vs running APA on known CTCF/cohesin anchors, building an aggregate peak pileup, comparing loops across conditions, or validating loop calls. For HiChIP/PLAC-seq/PCHi-C protein-anchored data use FitHiChIP/MAPS, not dots.
日本語の概要は準備中です。原文の説明を表示しています。
Batch effect correction for CRISPR screens covering ComBat empirical-Bayes, RUV, SVA, control-sgRNA normalization, and the model-based alternative of including batch as a covariate in MAGeCK MLE or Chronos. Covers screen-specific batch sources (passage cohort, library lot, infection day, sequencing run, Cas9 lot, FBS lot), PCA + variance-decomposition diagnostic to decide if correction is needed, when correction harms biology by over-correcting condition into batch, limma removeBatchEffect for visualization-only correction, and relationship to multi-condition design matrices. Use when combining screens for joint analysis, when passage cohort confounds biology, when DepMap-style panels need Chronos with batch covariates, when picking ComBat vs RUV, or when correction harms biology and should be replaced with explicit covariate modeling.
日本語の概要は準備中です。原文の説明を表示しています。
Quality control for pooled CRISPR screens covering library representation, Gini index, log-skew, replicate Pearson and Spearman concordance, essentialome precision-recall AUC against CEGv2 (Hart 2017), Cas9 cut-toxicity diagnostics, copy-number amplicon detection (Aguirre 2016 / Munoz 2016), bottleneck propagation through plasmid pool, infection, selection, and endpoint stages, MOI verification, and DepMap-style screen-quality scoring. Use when assessing screen quality before hit calling, deciding whether to repeat or rescue a screen, diagnosing low-confidence hits, choosing between MAGeCK / BAGEL2 / Chronos based on quality grade, picking a normalization strategy from QC signatures, or evaluating whether an in-vivo screen retained adequate library complexity.
日本語の概要は準備中です。原文の説明を表示しています。
Build Sankey, alluvial, river, and CONSORT-style flow diagrams to visualize cohort transitions, cell-state changes, or pipeline filtering using ggalluvial, networkD3, plotly, and consort. Use when showing how entities move between categories across timepoints (cell states, drug response classes, patient flow through a trial) or filtering pipelines (variants filtered through QC stages).
日本語の概要は準備中です。原文の説明を表示しています。
Build genome-browser-style multi-track figures with pyGenomeTracks (config-driven), Gviz (R), and IGV batch screenshotting. Covers BigWig coverage tracks, BED/peak overlays, gene-model rendering, Hi-C matrix tracks, BedPE link arcs, spike-in-aware normalization, and the bamCoverage --normalizeUsing trap. Use when producing publication figures of genomic loci with stacked aligned tracks (coverage, peaks, genes, interactions) for ChIP-seq, ATAC-seq, RNA-seq, Hi-C, or generic locus visualization.
日本語の概要は準備中です。原文の説明を表示しています。
Build Manhattan, Miami, QQ, and locuszoom-style regional plots from GWAS, TWAS, PWAS, and QTL summary statistics with correct genomic-inflation diagnostics, multi-trait overlays, lead-SNP labeling, and LD-aware regional rendering. Use when visualizing association results across the genome, comparing two traits, computing genomic inflation lambda, or zooming into a locus with LD coloring.
日本語の概要は準備中です。原文の説明を表示しています。
Project gene annotations across genomes using TOGA (Kirilenko 2023 whole-genome-alignment chain-based projection with intactness classification), CESAR 2.0 (Sharma & Hiller 2017 codon-aware exon projection), LiftOff (Shumate & Salzberg 2020 reference-based annotation transfer), Liftover (UCSC), GeMoMa (Keilwagen 2019 evidence-based projection), and Comparative Annotation Toolkit (CAT). Use when transferring annotations from a well-annotated reference to query genome(s), classifying gene-loss vs gene-intact across many genomes at scale, building Zoonomia-style comparative annotations across hundreds of mammals or birds (Kirilenko 2023), detecting pseudogenization, projecting alternative isoforms, or selecting between WGA-anchored (TOGA) vs ortholog-based (LiftOff) annotation transfer strategies.
日本語の概要は準備中です。原文の説明を表示しています。