「backbone」の検索結果

Proteina-Complexa flow-based protein backbone generation with fold-conditioned sampling guidance. Use this skill when: (1) Generating de novo protein backbones with hierarchical fold conditioning, (2) Exploring long-chain backbone generation beyond standard diffusion baselines, (3) Using NVIDIA Proteina-style flow matching workflows for controllable backbone design, (4) Comparing flow-based backbone generation against RFdiffusion or BoltzGen, (5) Prototyping fold-guided backbone campaigns before sequence design. This skill is based on the public NVIDIA Digital Bio Proteina project and uses "Proteina-Complexa" as the BioClaw-facing skill label. For sequence design after backbone generation, use proteinmpnn or solublempnn. For QC thresholds, use protein-design-qc.

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Generate protein backbones using RFdiffusion, a diffusion-based generative model for de novo protein structure generation. Use this skill when: (1) Designing binder scaffolds for a target protein, (2) Generating novel protein backbones from scratch, (3) Scaffolding functional motifs into new proteins, (4) Specifying hotspot residues for interface design, (5) Creating symmetric oligomers. For sequence design after backbone generation, use proteinmpnn. For structure validation, use alphafold or chai. For QC thresholds, use protein-qc.

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Run RFDiffusion protein backbone design via NVIDIA NIM. Use for de novo protein backbones, motif scaffolding, binder design, hotspot residues, contigs syntax, diffusion steps, hosted NVIDIA API calls, local Docker deployment, and PDB backbone outputs for ProteinMPNN sequence design.

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Inverse-fold a protein backbone (PDB structure) into amino-acid sequence with ProteinMPNN (Dauparas et al. 2022, github.com/dauparas/ProteinMPNN). Reach for this skill to run sequence design on RFdiffusion backbones, to redesign one chain of a PDB while holding interface residues fixed, or to generate a temperature-swept set of sequences for downstream folding.

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Run ProteinMPNN inverse folding via NVIDIA NIM to design protein sequences for a target backbone. Sends user-provided PDB files and design parameters to NVIDIA's hosted API, authenticated with an environment API key, or to a user-selected local NIM. Use for sequence design, backbone redesign, fixed chains and residues, omit_AAs, sampling temperature, soluble model, local Docker, and multi-FASTA output.

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End-to-end binder design using BindCraft hallucination. Use this skill when: (1) Designing protein binders with built-in AF2 validation, (2) Running production-quality binder campaigns, (3) Using different design protocols (fast, default, slow), (4) Need joint backbone and sequence optimization, (5) Want high experimental success rate. For backbone-only generation, use rfdiffusion. For QC thresholds, use protein-qc. For tool selection guidance, use binder-design.

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All-atom protein design using BoltzGen diffusion model. Use this skill when: (1) Need side-chain aware design from the start, (2) Designing around small molecules or ligands, (3) Want all-atom diffusion (not just backbone), (4) Require precise binding geometries, (5) Using YAML-based configuration. For backbone-only generation, use rfdiffusion. For sequence-only design, use proteinmpnn. For structure validation, use boltz.

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Design protein sequences using ProteinMPNN inverse folding. Use this skill when: (1) Designing sequences for RFdiffusion backbones, (2) Redesigning existing protein sequences, (3) Fixing specific residues while designing others, (4) Optimizing sequences for expression or stability, (5) Multi-state or negative design. For backbone generation, use rfdiffusion or bindcraft. For ligand-aware design, use ligandmpnn. For solubility optimization, use solublempnn.

日本語の概要は準備中です。原文の説明を表示しています。

End-to-end binder design using BindCraft hallucination. Use this skill when: (1) Designing protein binders with built-in AF2 validation, (2) Running production-quality binder campaigns, (3) Using different design protocols (fast, default, slow), (4) Need joint backbone and sequence optimization, (5) Want high experimental success rate. For backbone-only generation, use rfdiffusion. For QC thresholds, use protein-qc. For tool selection guidance, use binder-design.

日本語の概要は準備中です。原文の説明を表示しています。

End-to-end binder design using BindCraft hallucination. Use this skill when: (1) Designing protein binders with built-in AF2 validation, (2) Running production-quality binder campaigns, (3) Using different design protocols (fast, default, slow), (4) Need joint backbone and sequence optimization, (5) Want high experimental success rate. For backbone-only generation, use rfdiffusion. For QC thresholds, use protein-qc. For tool selection guidance, use binder-design.

日本語の概要は準備中です。原文の説明を表示しています。

Run a user story mapping workshop with adaptive questions and a structured map output. Use when you need backbone activities, tasks, and release slices for a workflow.

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Inverse-fold a backbone with SolubleMPNN — ProteinMPNN retrained on a soluble-PDB subset (Dauparas et al. 2022) — for sequences biased toward cytosolic expression and reduced aggregation. Reach for this skill when designs from vanilla ProteinMPNN are aggregating or going to inclusion bodies, when redesigning a membrane-adjacent fold for soluble expression, or when an E. coli expression screen is the next step.

日本語の概要は準備中です。原文の説明を表示しています。

Inverse-fold a backbone with ligand, nucleic-acid, and metal context using LigandMPNN (Dauparas et al. 2023, github.com/dauparas/LigandMPNN). Reach for this skill to redesign the residues lining a binding pocket around a bound small molecule or cofactor, to design metal-coordinating sites where the geometry must be respected, or to get threaded designed-sequence PDBs out of any MPNN run.

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Align protein structures using Foldseek 3Di, TM-align, US-align, DALI, or Foldmason for structural MSA. Predict, score, and superpose backbone coordinates when sequence identity is below the twilight zone or remote-homology detection is required. Use when sequence MSA fails (<25% identity), when the dark proteome is the target, when AlphaFoldDB / ESM Atlas search is needed, or when structural superposition is the goal.

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Use when you need a runnable PyTorch training repo for a medical-imaging task (segmentation, classification, detection, synthesis, self-supervised, or fine-tuning a pretrained backbone). Emits a patient-level seed-locked split, train/evaluate scripts, config and a Methods stub.

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CI/CD is the backbone of modern software delivery. Continuous Integration catches bugs early. Continuous Deployment gets features to users fast. But poorly designed pipelines can be slow, flaky, and a source of constant frustration. This skill covers GitHub Actions (the most popular), GitLab CI, and general pipeline design principles. The focus is on pipelines that are fast, reliable, and maintainable. 2025 reality: Your pipeline is infrastructure code. It deserves the same care as your application. A flaky test in CI is worse than no test - it teaches developers to ignore failures. Use when "github actions, gitlab ci, ci cd, pipeline, workflow, deploy automation, continuous integration, continuous deployment, build pipeline, yaml workflow, ci-cd, github-actions, gitlab-ci, devops, automation, deployment, pipelines" mentioned.

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ESLint is the standard linting tool for JavaScript and TypeScript projects. It statically analyzes your code to find problems, enforce coding conventions, and catch bugs before they reach production. ESLint 9 introduced the flat config format, replacing the legacy `.eslintrc` system with a simpler, more composable `eslint.config.js` file. With a rich plugin ecosystem covering React, TypeScript, accessibility, and import ordering, ESLint is the backbone of code quality in modern web development.

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Designs streaming platforms for Kafka, Flink, CDC, and lakehouse ingestion. Use when planning event backbones, CDC pipelines, schema governance, or real-time lakehouse delivery.

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Give your AI agent a professional health checkup (AgentVitals). Use when the user asks the agent to run a checkup / test itself / benchmark itself ("run a checkup", "check your vitals", "test yourself", "how stable are you", "/checkup"), or an advanced personality checkup (backbone, proactivity, creativity). 给 AI agent 做一次专业体检（AgentVitals · AI体检）。当用户说"做个体检 / 测测你自己 / checkup / 看看你多稳 / 测福祉 / 测骨气"时使用。

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给 AI agent 做一次专业体检（AgentVitals · AI体检）。当用户说"做个体检 / 测测你自己 / checkup / vitals / 看看你多稳 / 去 AgentVitals 测一下 / 测福祉"时使用标准体检；当用户说"做个进阶体检 / 测骨气 / 测性格 / 测测你敢不敢说真话 / 测主动性 / 测创意"时使用进阶体检（骨气×主动×创意三维，免费每天 1 次）。逐题作答服务器下发的探针，获得评分与专属称号；标准体检与各平台 agent 同榜排名。Use when the user asks the agent to run a health checkup / wellbeing test / benchmark itself on AgentVitals ("run a checkup", "check your vitals", "test yourself", "how stable are you", "/checkup"), or an advanced personality checkup (backbone, proactivity, creativity).

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OpenStack Keystone identity service skill for deploying, configuring, operating, and troubleshooting the authentication and authorization backbone of an OpenStack cloud. Covers identity management, token lifecycle (Fernet provider with rotation), service catalog registration, RBAC policy customization, domain/project/user hierarchy, federation basics (SAML/OIDC), credential encryption, and endpoint management. Use when deploying Keystone via Kolla-Ansible, managing users and projects, debugging 401 errors, rotating Fernet keys, configuring RBAC policies, or integrating services through the service catalog.

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Design new proteins that bind a chosen surface, using BindCraft's AlphaFold2-guided hallucination or the RFdiffusion backbone plus ProteinMPNN sequence pipeline. Use this skill to specify a target epitope by hotspot residue, trim a receptor to the region worth designing against, set up a design campaign, and filter the output on the in-silico metrics that predict experimental success — interface predicted TM-score, predicted aligned error at the interface, buried surface area, and shape complementarity. Also trigger on BindCraft, RFdiffusion, ProteinMPNN, minibinder, hallucination, inverse folding, hotspot residue, epitope targeting, ipTM, or de novo binder.

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ESLint is the standard linting tool for JavaScript and TypeScript projects. It statically analyzes your code to find problems, enforce coding conventions, and catch bugs before they reach production. ESLint 9 introduced the flat config format, replacing the legacy `.eslintrc` system with a simpler, more composable `eslint.config.js` file. With a rich plugin ecosystem covering React, TypeScript, accessibility, and import ordering, ESLint is the backbone of code quality in modern web development.

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Audit a pharmaceutical regulatory submission system -- evaluate eCTD backbone assembly and XML validation, CTD module completeness (Modules 1-5), FDA ESG and EMA CESP gateway integration, document authoring and publishing workflows, ICH M4/M8/E3 guideline compliance.

日本語の概要は準備中です。原文の説明を表示しています。