Use Intel CHIPSEC to assess platform firmware configuration, SPI flash write protection, BIOS lock, SMM/SMRR, and Secure Boot variable state, dump SPI flash, and triage UEFI variables for firmware-level threats.
日本語の概要は準備中です。原文の説明を表示しています。
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概要と使いどころ
Use Intel CHIPSEC to assess platform firmware configuration, SPI flash write protection, BIOS lock, SMM/SMRR, and Secure Boot variable state, dump SPI flash, and triage UEFI variables for firmware-level threats.
日本語の概要は準備中です。原文の説明を表示しています。
Use Intel CHIPSEC to assess platform firmware configuration, SPI flash write protection, BIOS lock, SMM/SMRR, and Secure Boot variable state, dump SPI flash, and triage UEFI variables for firmware-level threats.
日本語の概要は準備中です。原文の説明を表示しています。
Detect UEFI Secure Boot bypasses and bootkits such as BlackLotus and Bootkitty by verifying Secure Boot state, checking dbx revocation currency, and hashing EFI boot binaries against known-bad sets using mokutil, efi-readvar/dbxtool, CHIPSEC, sbverify/pesign, and Windows Confirm-SecureBootUEFI. Use when auditing fleet dbx rollout after a bootkit advisory or hunting for pre-OS persistence on a suspected-compromised endpoint.
日本語の概要は準備中です。原文の説明を表示しています。
Analyzes UEFI bootkit persistence (SPI flash implants, ESP modifications, Secure Boot bypass, UEFI variable manipulation) using chipsec for firmware integrity verification, detecting known families like BlackLotus, LoJax, and MoonBounce. Use for UEFI malware analysis, firmware persistence investigation, or Secure Boot bypass detection.
日本語の概要は準備中です。原文の説明を表示しています。
Annotate ChIP-seq peaks to genomic features and genes using ChIPseeker. Assign peaks to promoters, exons, introns, and intergenic regions. Find nearest genes and calculate distance to TSS. Generate annotation plots and statistics. Use when annotating ChIP-seq peaks to genomic features.
日本語の概要は準備中です。原文の説明を表示しています。
Visualize ChIP-seq data using deepTools, Gviz, and ChIPseeker. Create heatmaps, profile plots, and genome browser tracks. Visualize signal around peaks, TSS, or custom regions. Use when visualizing ChIP-seq signal and peaks.
日本語の概要は準備中です。原文の説明を表示しています。
Use when an installed DSH Web plugin misbehaves only at runtime in the browser — paste/attachment/composer features that work once then fail, chips or panels showing stale placeholder state, update chips claiming the wrong version — and the fix must be diagnosed against the exact host API semantics rather than guessed from names. Also use when reviewing a plugin's calls into input-machine or facade verbs (insert, consume, remove, subscribe) before a release.
日本語の概要は準備中です。原文の説明を表示しています。
Annotates ChIP-seq peaks to genomic features, nearest genes, ENCODE candidate cis-regulatory elements (cCREs), and regulatory domains. Uses ChIPseeker (R), HOMER annotatePeaks.pl (CLI), pyranges (Python), GREAT/rGREAT (regulatory domain gene-set enrichment), ChIP-Enrich (locus-length-adjusted), ENCODE SCREEN cCRE classification (PLS/pELS/dELS/CA-CTCF/CA-H3K4me3), and ENCODE-rE2G for cell-type-specific enhancer-gene linking. Handles nearest-TSS vs host-gene ambiguity, promoter window definition, and feature priority. Use when assigning genomic context to peaks, linking enhancer peaks to target genes, classifying peaks against ENCODE cCRE registry, or running gene-set enrichment on peak-associated genes.
日本語の概要は準備中です。原文の説明を表示しています。
Visualizes ChIP-seq data using deepTools (computeMatrix, plotHeatmap, plotProfile, bamCoverage, bamCompare), pyGenomeTracks (modern INI-driven track plots), Gviz (R browser-style), EnrichedHeatmap (ComplexHeatmap-based), ChIPseeker tag heatmaps, and IGV batch screenshots. Handles bigWig normalization choices (CPM, BPM, RPGC, spike-in scaled), bamCompare operations (log2 ratio, subtract) with SES scaling, k-means clustering of heatmaps for biological subgrouping, and spike-in-scaled tracks for global-shift experiments. Use when generating publication-quality ChIP-seq signal heatmaps, profile plots, genome-browser tracks, or comparing samples visually.
日本語の概要は準備中です。原文の説明を表示しています。
Normalizes ChIP-seq data using exogenous spike-in (ChIP-Rx with Drosophila chromatin per Orlando 2014 / Egan 2016; E. coli carryover for CUT&RUN/CUT&Tag). Distinguishes RRPM from Rx-Input scaling, integrates with DiffBind / DESeq2 / edgeR / csaw via sizeFactors and DiffBind library-size vectors, applies the Patel et al 2024 *Nat Biotechnol* failure-mode framework, and validates that normalization is applied at the read level (not peak counts). Use when global signal shifts are expected (HDACi, BETi, EZH2i, dosage, target knockdown), when ChIPseqSpikeInFree detects post-hoc shifts, or when validating internal-control regions before publication.
日本語の概要は準備中です。原文の説明を表示しています。
Static analysis of UEFI/BIOS firmware dumps using Intel's chipsec framework. Decode firmware structure, detect known malware and rootkits (LoJax, ThinkPwn, HackingTeam, MosaicRegressor), generate EFI executable inventories with hashes, extract NVRAM variables, and parse SPI flash descriptors. Use when analyzing firmware .bin/.rom/.fd/.cap files offline without requiring hardware access.
日本語の概要は準備中です。原文の説明を表示しています。
ChIPseeker is a Bioconductor package for annotating ChIP-seq data analysis. Peak Annotation is performed by the annotatePeak function. The position and strand information of nearest genes are reported, in addition to the distance from the p
日本語の概要は準備中です。原文の説明を表示しています。
Visualizes ChIP-seq data using deepTools (computeMatrix, plotHeatmap, plotProfile, bamCoverage, bamCompare), pyGenomeTracks (modern INI-driven track plots), Gviz (R browser-style), EnrichedHeatmap (ComplexHeatmap-based), ChIPseeker tag heatmaps, and IGV batch screenshots. Handles bigWig normalization choices (CPM, BPM, RPGC, spike-in scaled), bamCompare operations (log2 ratio, subtract, SES), k-means clustering of heatmaps for biological subgrouping, and spike-in-scaled tracks for global-shift experiments. Use when generating publication-quality ChIP-seq signal heatmaps, profile plots, genome-browser tracks, or comparing samples visually.
日本語の概要は準備中です。原文の説明を表示しています。
End-to-end ChIP-seq workflow from FASTQ files to annotated peaks. Covers QC, alignment, peak calling with MACS3 (or HOMER), and peak annotation with ChIPseeker. Use when processing ChIP-seq data from alignment through peak annotation.
日本語の概要は準備中です。原文の説明を表示しています。
Security hygiene for GSD's self-modifying skill and agent system. Use this skill whenever: creating, editing, or deleting skill files (.claude/skills/, .claude/commands/), modifying agent definitions (.claude/agents/), working with YAML configuration or chipset files, handling JSONL observation data (.planning/patterns/), processing community-contributed skills or chipsets, any file path operations that could involve user input, or when installing/updating project-claude configuration. Also activates for discussions about skill-creator security, trust models, or content hygiene.
日本語の概要は準備中です。原文の説明を表示しています。
Guide for annotating ENCODE peaks with genomic features using ChIPseeker and GREAT. Use when users need to assign peaks to genes, determine genomic feature distribution (promoter, intron, intergenic), or perform gene ontology enrichment of peak-associated genes. Trigger on: peak annotation, ChIPseeker, GREAT, peak to gene, genomic feature, promoter enrichment, gene ontology, peak distribution, TSS distance, nearest gene.
日本語の概要は準備中です。原文の説明を表示しています。
Visualizes ChIP-seq data using deepTools (computeMatrix, plotHeatmap, plotProfile, bamCoverage, bamCompare), pyGenomeTracks (modern INI-driven track plots), Gviz (R browser-style), EnrichedHeatmap (ComplexHeatmap-based), ChIPseeker tag heatmaps, and IGV batch screenshots. Handles bigWig normalization choices (CPM, BPM, RPGC, spike-in scaled), bamCompare operations (log2 ratio, subtract) with SES scaling, k-means clustering of heatmaps for biological subgrouping, and spike-in-scaled tracks for global-shift experiments. Use when generating publication-quality ChIP-seq signal heatmaps, profile plots, genome-browser tracks, or comparing samples visually.
日本語の概要は準備中です。原文の説明を表示しています。
Normalizes ChIP-seq data using exogenous spike-in (ChIP-Rx with Drosophila chromatin per Orlando 2014 / Egan 2016; E. coli carryover for CUT&RUN/CUT&Tag). Distinguishes RRPM from Rx-Input scaling, integrates with DiffBind / DESeq2 / edgeR / csaw via sizeFactors and DiffBind library-size vectors, applies the Patel et al 2024 *Nat Biotechnol* failure-mode framework, and validates that normalization is applied at the read level (not peak counts). Use when global signal shifts are expected (HDACi, BETi, EZH2i, dosage, target knockdown), when ChIPseqSpikeInFree detects post-hoc shifts, or when validating internal-control regions before publication.
日本語の概要は準備中です。原文の説明を表示しています。
Annotates ChIP-seq peaks to genomic features, nearest genes, ENCODE candidate cis-regulatory elements (cCREs), and regulatory domains. Uses ChIPseeker (R), HOMER annotatePeaks.pl (CLI), pyranges (Python), GREAT/rGREAT (regulatory domain gene-set enrichment), ChIP-Enrich (locus-length-adjusted), ENCODE SCREEN cCRE classification (PLS/pELS/dELS/CA-CTCF/CA-H3K4me3), and ENCODE-rE2G for cell-type-specific enhancer-gene linking. Handles nearest-TSS vs host-gene ambiguity, promoter window definition, and feature priority. Use when assigning genomic context to peaks, linking enhancer peaks to target genes, classifying peaks against ENCODE cCRE registry, or running gene-set enrichment on peak-associated genes.
日本語の概要は準備中です。原文の説明を表示しています。
Analyzes UEFI bootkit persistence mechanisms including firmware implants in SPI flash, EFI System Partition (ESP) modifications, Secure Boot bypass techniques, and UEFI variable manipulation. Covers detection of known bootkit families (BlackLotus, LoJax, MosaicRegressor, MoonBounce, CosmicStrand), ESP partition forensic inspection, chipsec-based firmware integrity verification, and Secure Boot configuration auditing. Activates for requests involving UEFI malware analysis, firmware persistence investigation, boot chain integrity verification, or Secure Boot bypass detection.
日本語の概要は準備中です。原文の説明を表示しています。
Analyzes UEFI bootkit persistence mechanisms including firmware implants in SPI flash, EFI System Partition (ESP) modifications, Secure Boot bypass techniques, and UEFI variable manipulation. Covers detection of known bootkit families (BlackLotus, LoJax, MosaicRegressor, MoonBounce, CosmicStrand), ESP partition forensic inspection, chipsec-based firmware integrity verification, and Secure Boot configuration auditing. Activates for requests involving UEFI malware analysis, firmware persistence investigation, boot chain integrity verification, or Secure Boot bypass detection.
日本語の概要は準備中です。原文の説明を表示しています。
End-to-end ChIP-seq workflow from FASTQ files to annotated peaks. Covers QC, alignment, peak calling with MACS3 (or HOMER), and peak annotation with ChIPseeker. Use when processing ChIP-seq data from alignment through peak annotation.
日本語の概要は準備中です。原文の説明を表示しています。
Normalizes ChIP-seq data using exogenous spike-in (ChIP-Rx with Drosophila chromatin per Orlando 2014 / Egan 2016; E. coli carryover for CUT&RUN/CUT&Tag). Distinguishes RRPM from Rx-Input scaling, integrates with DiffBind / DESeq2 / edgeR / csaw via sizeFactors and DiffBind library-size vectors, and applies the Patel et al 2024 *Nat Biotechnol* review's failure-mode framework to validate that normalization is correctly applied at the read level (not peak counts). Use when global signal shifts are expected (HDACi, BETi, EZH2i, dosage, target knockdown), when ChIPseqSpikeInFree detects post-hoc shifts, or when validating internal-control regions before publication.
日本語の概要は準備中です。原文の説明を表示しています。
Annotates ChIP-seq peaks to genomic features, nearest genes, ENCODE candidate cis-regulatory elements (cCREs), and regulatory domains. Uses ChIPseeker (R), HOMER annotatePeaks.pl (CLI), pyranges (Python), GREAT/rGREAT (regulatory domain gene-set enrichment), ChIP-Enrich (locus-length-adjusted), ENCODE SCREEN cCRE classification (PLS/pELS/dELS/CTCF-only/DNase-H3K4me3), and ENCODE-rE2G for cell-type-specific enhancer-gene linking. Handles nearest-TSS vs host-gene ambiguity, promoter window definition, and feature priority. Use when assigning genomic context to peaks, linking enhancer peaks to target genes, classifying peaks against ENCODE cCRE registry, or running gene-set enrichment on peak-associated genes.
日本語の概要は準備中です。原文の説明を表示しています。