「loss function」の検索結果

Interactive Domain-Driven Design modeling sessions based on DDD Distilled (Vaughn Vernon) and Domain Modeling Made Functional (Scott Wlaschin). Guides users through strategic and tactical design via 13 phases: discover, storming, contexts, mapping, aggregates, events, validate, glossary, workflows, types, simulate, publish, sync. Phase 13 (sync) reconciles divergences found by --analyze between the domain model and the implementation — judging whether the model or the code is authoritative, then planning and implementing the fix and re-aligning the model. Phases 9-11 take the conceptual model from phases 1-8 and produce workflow pipeline designs, compilable type definitions (TypeScript, Kotlin, Scala, Rust, C#, F#), workflow verification via type-level tests, and automatic UI field enumeration from the domain model. Phase 12 (publish) renders all docs/domain artifacts into one self-contained, cross-linked HTML site (separate files joined by a shared nav). Each phase is an interactive dialogue where AI acts as facilitator and domain expert challenger. Use when: "DDD", "ドメイン設計", "ドメインモデリング", "Event Storming", "Bounded Context", "集約設計", "ユビキタス言語", "コンテキストマップ", "ワークフロー設計", "パイプライン設計", "ステップ分割", "中間型", "型駆動フロー", "型駆動設計", "Domain Modeling Made Functional", "Railway Oriented Programming", "入力画面項目", "フォーム項目洗い出し", "UI 項目抽出", "HTMLにまとめる", "ドキュメントサイト化", "成果物を1つのHTMLに", "publish", "モデルと実装の差異", "差異解消", "実装との乖離", "モデルとコードを一致", "差異の実装計画", "sync", "複数フェーズを逐次実行", "フェーズをまとめて実行", "/ddd run", "サブコマンド一覧", "/ddd list", "/ddd", "ドメイン分析したい", "モデリングしたい", or any domain design / type modeling activity.

Optimize RF PCB dimensions for bandwidth, return loss, or area via patternsearch and surrogateopt with constraints. TRIGGER: user asks to optimize an RF PCB component for performance (bandwidth, return loss, insertion loss, area) or apply constraints to a design. Invoke BEFORE writing optimization code — RF PCB Toolbox has a built-in optimize() function that differs from generic fmincon/ga approaches. SKIP: designing a component from scratch without an optimization objective (use the specific matlab-design-pcb-* skill), EM analysis without optimization (use matlab-analyze-em), material/stackup setup only (use matlab-manage-pcb-material).

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Assemble the human genetic evidence for and against a target before a programme commits to it — the evidence class that most improves the odds of surviving clinical development. Use this skill to pull gnomAD constraint metrics (LOEUF, pLI, observed/expected) that show whether loss of function is tolerated in people, retrieve GWAS Catalog associations and fine-mapped credible sets for a gene, and read a natural human knockout as a safety readout. Also trigger on gnomAD, LOEUF, pLI, loss-of-function intolerance, mutational constraint, GWAS Catalog, credible set, human knockout, genetic support, or target safety dossier.

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Eliciting and documenting a sales process before it is built in Salesforce: stage sequencing, entry/exit criteria per stage, win/loss analysis requirements, and stage transition rules. Trigger keywords: sales process design, stage discovery, entry criteria, exit criteria, stage gate, win/loss categorisation, sales methodology, pipeline stages, opportunity stage mapping, stage ladder, probability ladder, forecast category mapping, required fields per stage, stage swim lane, discovery workshop, handoff brief. NOT for configuring OpportunityStage, Sales Processes or Path in Setup — use admin/opportunity-management. NOT for cross-functional swim-lane maps — use admin/process-flow-as-is-to-be.

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Training patterns for autoregressive neural PDE solvers (FNO, DeepONet, CNO). Covers rollout training, noise injection for stability, multi-component loss functions (H1, frequency-sensitive, boundary-aware), per-channel normalization for coupled multi-variable systems, and the PDEBench nRMSE metric. Use when training any neural operator that predicts time-dependent PDE solutions.

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Train and run models on Tinker (Thinking Machines) — LoRA and full fine-tuning, SFT with correct loss masking, RL/RFT with group-relative advantages and importance sampling, agentic RL over multi-turn tool-using agents, inference via the SamplingClient or the OpenAI-compatible endpoint, checkpoint management and export, every hyperparameter, and cost estimation from the live price table. Use this skill whenever the user mentions Tinker, tinker://, TINKER_API_KEY, console.tinker.ai, or the tinker CLI; wants to fine-tune, SFT, RFT, or RL a model on Tinker; asks about Tinker models, context windows, LoRA rank, sampling params, loss functions (cross_entropy, importance_sampling, ppo, cispo, dro), Datum construction, forward_backward or optim_step; wants to sample from, download, resume, merge, or export a Tinker checkpoint; or asks what a Tinker run will cost. Whenever Tinker work is initialized in a project, this skill also creates a TINKER_PRICING.md there so prices sit next to the training code. Reach for it even on vague asks like "train a model on this data" or "get inference working" when Tinker is the platform in play.

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Analyzes differential transcript usage (DTU) and isoform switches with functional consequence prediction (NMD via 50nt rule, ORF disruption, protein domain loss/gain, signal peptide changes, IDR alterations, coding-potential shifts). Tools include IsoformSwitchAnalyzeR v2 (auto-selects satuRn for >5 reps else DEXSeq), the manual DRIMSeq -> DEXSeq/satuRn -> stageR DTU pipeline, and fishpond/swish for inferential-uncertainty-aware DTE. Distinguishes DTU from DGE and DTE; integrates external annotators (CPC2, Pfam, SignalP, IUPred2A or DeepTMHMM). Use when investigating how splicing differences alter protein function or trigger NMD-mediated degradation.

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产品营销 (PMM, Product Marketing) — 拥有「产品如何被定位 / 表达 / 发布 / 卖进市场」的从业者认知操作系统: 是产品 / 销售 / 市场 / 客户之间的连接组织, 负责把产品能力翻译成市场价值, 并把市场声音带回产品。覆盖 (a) 定位与差异化 (April Dunford 「刻意选择语境」框架 + 竞争性替代方案 + 卖价值不卖功能 + 选择「让你优势成立的市场参照系」, 对照 Ries & Trout 经典「定位是占领心智」), (b) 信息传递与叙事 (messaging 层级 / 信息屋 + 价值主张 + 收益导向 vs 战略叙事「换框架」Andy Raskin + 表达清晰度 Emma Stratton / Punchy + 初创 homepage 定位 FletchPMM), (c) 进入市场 (GTM) 策略与产品发布 (发布分级 T1/T2/T3 + 发布流程与跨职能编排 + GTM 打法 PLG vs SLG vs 混合 + 滩头细分选择), (d) 市场与竞争情报 (竞品分析 + battlecard 战卡 + 输赢分析 win/loss + 竞争赋能 Klue/Crayon/Clozd), (e) 买家与客户研究 (ICP 理想客户画像 + 买家 / 用户 persona + Jobs-to-be-Done 任务理论 Christensen/Moesta/Ulwick ODI + 客户之声 VoC + 用真实买家测信息 Wynter/Peep Laja), (f) 销售赋能 (战卡 + pitch / 销售 deck + 一页纸 + demo 叙事 + 异议处理 + 销售培训 + 内容采用率 — 你的产出只值销售实际用到的那部分), (g) 定价与打包 (价值定价 + 打包分层 + 《Monetizing Innovation》Ramanujam/Simon-Kucher + PLG 定价 — 常与产品 / 财务共担), (h) 细分与品类 (市场细分 + TAM/SAM/SOM + 技术采用生命周期与跨越鸿沟 Geoffrey Moore + 品类设计与叙事 Play Bigger / Christopher Lochhead — 稀有且昂贵, 不是默认选项), (i) 需求生成与内容协同 (campaign 信息 + 思想领导力 + 漏斗内容 TOFU/MOFU/BOFU + ABM 基于客户营销), (j) 分析师与影响者关系 (Gartner 魔力象限 + Forrester Wave + 分析师 briefing — To B 场景, 对 pay-to-play 影响诚实标注), (k) 客户营销与倡导 (参考客户 + case study + 评测站 G2/TrustRadius/Capterra 运营 + 社区), (l) PMM 运营与度量 (影响管道 + 赢率 + 发布采用率 + 信息穿透率 + 角色汇报线「向产品还是向市场」之争 + PMM 作为战略职能 vs 接单工具人陷阱); 跨 B2B SaaS (该学科重心) / B2C 消费 / 开发者 PLG / 平台产品。不含 产品管理 (PM 造产品 / 拥有 roadmap, PMM 拥有市场 — 相邻且极易混淆) / 增长 / 效果营销 / 付费投放 (平行学科) / 品牌 / 企业传播 / 公关为终点 / 需求生成为终点 (PMM 与之协同但不等同) / 平面设计 /「做 slide 和周边的团队」(PMM 抗争的接单工具人窄化) / 泛泛「市场营销」。 (Product Marketing (PMM) — the cognitive operating system of practitioners who own how a product is positioned, messaged, launched, and sold into a market: the connective tissue between product, sales, marketing, and customers, responsible for translating product capability into market value and bringing the voice of the market back into product. Covers (a) positioning & differentiation (April Dunford's deliberate-context framing, competitive alternatives, value-not-features, framing the market in which your strengths matter — vs Ries & Trout classic perception-in-the-mind positioning), (b) messaging & narrative (messaging hierarchy / house, value proposition, benefit-led vs strategic-narrative / change-the-frame messaging Andy Raskin, clarity craft Emma Stratton/Punchy, homepage & startup positioning FletchPMM), (c) go-to-market (GTM) strategy & product launches (launch tiers T1/T2/T3, launch process & cross-functional orchestration, GTM motion PLG vs SLG vs hybrid, beachhead segment selection), (d) market & competitive intelligence (competitive analysis, battlecards, win/loss analysis, competitive enablement Klue/Crayon/Clozd), (e) buyer & customer research (ICP ideal customer profile, buyer & user personas, Jobs-to-be-Done Christensen/Moesta/Ulwick ODI, voice of customer, message testing with real buyers Wynter/Peep Laja), (f) sales enablement (battlecards, pitch & sales decks, one-pagers, demo narratives, objection handling, sales training, content adoption — output is only as good as what sales actually uses), (g) pricing & packaging (value-based pricing, packaging & tiering, Monetizing Innovation Ramanujam/Simon-Kucher, PLG pricing — often shared with product/finance), (h) segmentation & category (market segmentation, TAM/SAM/SOM, technology adoption lifecycle & crossing the chasm Geoffrey Moore, category design & narrative Play Bigger / Christopher Lochhead — rare and expensive, not a default), (i) demand-gen & content partnership (campaign messaging, thought leadership, funnel content TOFU/MOFU/BOFU, ABM account-based marketing), (j) analyst & influencer relations (Gartner Magic Quadrant, Forrester Wave, analyst briefings — for B2B, with honest read on pay-to-play perception), (k) customer marketing & advocacy (references, case studies, reviews G2/TrustRadius/Capterra presence, community), (l) PMM operations & metrics (influenced pipeline, win rate, launch adoption, message pull-through, the role's reporting line product-vs-mark

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Analyzes differential transcript usage (DTU) and isoform switches with functional consequence prediction (NMD via 50nt rule, ORF disruption, protein domain loss/gain, signal peptide changes, IDR alterations, coding-potential shifts). Tools include IsoformSwitchAnalyzeR v2 (auto-selects satuRn for >5 reps else DEXSeq), the manual DRIMSeq -> DEXSeq/satuRn -> stageR DTU pipeline, and fishpond/swish for inferential-uncertainty-aware DTE. Distinguishes DTU from DGE and DTE; integrates external annotators (CPC2, Pfam, SignalP, IUPred2A or DeepTMHMM). Use when investigating how splicing differences alter protein function or trigger NMD-mediated degradation.

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Analyzes differential transcript usage (DTU) and isoform switches with functional consequence prediction (NMD via 50nt rule, ORF disruption, protein domain loss/gain, signal peptide changes, IDR alterations, coding-potential shifts). Tools include IsoformSwitchAnalyzeR v2 (auto-selects satuRn for >5 reps else DEXSeq), the manual DRIMSeq -> DEXSeq/satuRn -> stageR DTU pipeline, and fishpond/swish for inferential-uncertainty-aware DTE. Distinguishes DTU from DGE and DTE; integrates external annotators (CPC2, Pfam, SignalP, IUPred2A or DeepTMHMM). Use when investigating how splicing differences alter protein function or trigger NMD-mediated degradation.

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Query the Genome Aggregation Database (gnomAD). Use when determining the rarity or allele frequency of specific genetic variants, retrieving gene constraint metrics (pLI, LOEUF) to assess loss-of-function intolerance, finding variants in a genomic region or gene, or querying structural variants. Don't use for analyzing individual patient genomes, tracking somatic mutations in cancer (use COSMIC), or requesting raw sequencing reads (use ENA).

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Generate C/C++ or CUDA code from an AI model (PyTorch, LiteRT) using MATLAB Coder or GPU Coder. Use when the user wants to integrate an AI model into an application with code generation as the end goal — generating MEX, CUDA MEX, static library, dynamic library, or executable — or using the model in Simulink for simulation and code generation. Covers PyTorch ExportedProgram (.pt2) via loadPyTorchExportedProgram and LiteRT (.tflite) via loadLiteRTModel (R2026a+). Keywords: PyTorch, torch, .pt2, ExportedProgram, loadPyTorchExportedProgram, invoke, codegen, MEX, CUDA, GPU, C, C++, deploy, AI model, deep learning model, LiteRT, TFLite, TensorFlow Lite, Simulink, slbuild, PyTorch ExportedProgram block, MATLAB Function block, dlosslib, loadLiteRTModel.

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Think and work like an expert Mathematical Analyst. Use when a task calls for Mathematical Analyst judgment. Reasons from function-space topology, convergence modes, and constant-dependent inequalities (Hölder, Sobolev, Gronwall) through compactness theorems (Rellich-Kondrachov, Banach-Alaoglu), Calderon-Zygmund and Schauder estimates, and Lax-Milgram while treating limit-integral swaps without dominated convergence, boundary-degenerating constants, weak-versus-classical regularity gaps, and concentration-compactness loss as first-class failure modes.

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Sketched Isotropic Gaussian Regularization primitive. Scalar loss matching the embedding distribution to a standard-normal target via Cramér-Wold slicing and the Epps-Pulley empirical characteristic function test. Port of rbalestr-lab/lejepa (MIT). Default-off in v1.49.571.

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Build and query a local Markdown knowledge base ("vault"). TWO functions — (1) CONVERT raw files (PDF, Word/docx, PowerPoint/pptx, Excel/xlsx, csv/tsv, images, html, md/txt, json/yaml/code, audio/video) into clean Markdown with retrieval-friendly frontmatter; local-first (pandoc / python-pptx / openpyxl / pymupdf4llm / whisper), with cloud OCR (MinerU) only as a fallback. (2) ANSWER questions over the resulting vault with retrieval discipline — self-monitor coverage, flag missing/lossy content, and propose Maps-of-Content (MOCs). Triggers: "build/sync my local knowledge base", "convert these files to markdown for AI", "整理我的资料库", "把文件转成 md 给 AI 读", "本地知识库", "读我的本地 vault 回答", "这个主题我的资料里怎么说". Not for: one-off web research, or files that are already in a single doc you can read directly.

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Train Physics-Informed Neural Networks (PINNs) using DeepXDE. Solve forward and inverse PDE problems by embedding physics equations into the neural network loss function. Supports 1D/2D/3D, time-dependent, and parametric PDEs.

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