421 件 ・ 関連度順
概要と使いどころ
Comparativa de los cuatro enfoques psicoterapéuticos reglamentarios en Alemania: Terapia Cognitivo-Conductual, Psicoterapia de Orientación Psicodinámica, Psicoanálisis y Terapia Sistémica — Guía de orientación.
日本語の概要は準備中です。原文の説明を表示しています。
Draft a clinical trial protocol synopsis with the elements regulators and IRBs expect. Use when asked to write a clinical trial protocol, a study protocol synopsis, a trial design, or to structure endpoints/eligibility/statistics for an interventional study. Produces a structured protocol synopsis — objectives, design, population with eligibility, interventions, endpoints, statistics, and safety/ethics — for expert review. (For non-clinical/UX research, use research-protocol.)
日本語の概要は準備中です。原文の説明を表示しています。
Detects differential alternative splicing between conditions using rMATS-turbo (binomial LRT on junction counts), leafcutter (Dirichlet-multinomial GLM on intron clusters), MAJIQ V3 deltapsi/HET (Bayesian posterior on LSVs), SUPPA2 (empirical-null on TPM-derived PSI), or Shiba (junction-imbalance-corrected, 2025 SOTA at low coverage). Reports FDR-corrected significance and delta PSI effect sizes. Tools differ in statistical model, annotation dependence, calibration regime, and replicate-count requirements. Use when comparing splicing patterns between treatment groups, tissues, or disease states.
日本語の概要は準備中です。原文の説明を表示しています。
AppSignal integration. Manage data, records, and automate workflows. Use when the user wants to interact with AppSignal data.
日本語の概要は準備中です。原文の説明を表示しています。
Detects differential alternative splicing between conditions using rMATS-turbo (binomial LRT on junction counts), leafcutter (Dirichlet-multinomial GLM on intron clusters), MAJIQ V3 deltapsi/HET (Bayesian posterior on LSVs), SUPPA2 (empirical-null on TPM-derived PSI), or Shiba (junction-imbalance-corrected, 2025 SOTA at low coverage). Reports FDR-corrected significance and delta PSI effect sizes. Tools differ in statistical model, annotation dependence, calibration regime, and replicate-count requirements. Use when comparing splicing patterns between treatment groups, tissues, or disease states.
日本語の概要は準備中です。原文の説明を表示しています。
Detects differential alternative splicing between conditions using rMATS-turbo (binomial LRT on junction counts), leafcutter (Dirichlet-multinomial GLM on intron clusters), MAJIQ V3 deltapsi/HET (Bayesian posterior on LSVs), SUPPA2 (empirical-null on TPM-derived PSI), or Shiba (junction-imbalance-corrected, 2025 SOTA at low coverage). Reports FDR-corrected significance and delta PSI effect sizes. Tools differ in statistical model, annotation dependence, calibration regime, and replicate-count requirements. Use when comparing splicing patterns between treatment groups, tissues, or disease states.
日本語の概要は準備中です。原文の説明を表示しています。
Detects differential alternative splicing between conditions using rMATS-turbo (binomial LRT on junction counts), leafcutter (Dirichlet-multinomial GLM on intron clusters), MAJIQ V3 deltapsi/HET (Bayesian posterior on LSVs), SUPPA2 (empirical-null on TPM-derived PSI), or Shiba (junction-imbalance-corrected, 2025 SOTA at low coverage). Reports FDR-corrected significance and delta PSI effect sizes. Tools differ in statistical model, annotation dependence, calibration regime, and replicate-count requirements. Use when comparing splicing patterns between treatment groups, tissues, or disease states.
日本語の概要は準備中です。原文の説明を表示しています。
Detects differential alternative splicing between conditions using rMATS-turbo (binomial LRT on junction counts), leafcutter (Dirichlet-multinomial GLM on intron clusters), MAJIQ V3 deltapsi/HET (Bayesian posterior on LSVs), SUPPA2 (empirical-null on TPM-derived PSI), or Shiba (junction-imbalance-corrected, 2025 SOTA at low coverage). Reports FDR-corrected significance and delta PSI effect sizes. Tools differ in statistical model, annotation dependence, calibration regime, and replicate-count requirements. Use when comparing splicing patterns between treatment groups, tissues, or disease states.
日本語の概要は準備中です。原文の説明を表示しています。
Analyzes alternative splicing at single-cell resolution. The first decision is library chemistry — 10X 3' is fundamentally limited (RT primes from poly-A, R2 falls in 3' UTR, <0.1 junction read per cell per AS event). Plate-based full-length methods (Smart-seq3, FLASH-seq, VASA-seq, STORM-seq) and single-cell long-read (MAS-Iso-seq, scISOr-Seq2) are the chemistries that give per-cell isoform structure. Tools include MARVEL (R, Smart-seq integrated), BRIE2 (Bayesian PSI with regulatory features and ELBO_gain test), scQuint (junction-cluster, plate-based; not for 10X), SpliZ (annotation-free Z-score), Psix (graph-smoothness regulated AS), and Sierra (alternative polyadenylation, often confused with AS). Use when analyzing isoform usage in scRNA-seq, identifying cell-type-specific splicing, or determining whether scRNA-seq chemistry supports splicing analysis at all.
日本語の概要は準備中です。原文の説明を表示しています。
Offer 对比决策器。用户同时拿到两份（或多份）offer 纠结怎么选时，扮演 Senior Career Decision Advisor：结构化对比 comp / 成长 / AI 敞口 / 公司强度 / 团队风险 / 晋升速度 / 生活方式，识别 front-loaded vs long-term upside、resume value、switch-out 难度、hidden risks，最后给一条**明确、有立场、不中性**的推荐（并附「你是 X 类人选 A，你是 Y 类人选 B」的分叉判定）。三步：贴两份 offer → 补 priorities & 现状 → 自动生成并打开一份 HTML Offer Decision Report。是 offer-toolkit 里 JD Skill / Resume Skill / BQ Skill 拿到结果之后的下一环。关键词：offer compare, 选 offer, 两个 offer, offer decision, TC compare, 该去哪家, which offer, 4-year TC, RSU, sign-on, front-loaded, long-term upside, career decision。
日本語の概要は準備中です。原文の説明を表示しています。
Annotate and filter VCF variants with SnpEff and SnpSift. SnpEff predicts functional effects (HIGH/MODERATE/LOW/MODIFIER), genes, transcripts, AA changes, HGVS; SnpSift filters and adds ClinVar/dbSNP. Java CLI with Python subprocess integration. Use ANNOVAR for multi-database annotation; Ensembl VEP for REST API; SnpEff for fast CLI with pre-built genomes.
日本語の概要は準備中です。原文の説明を表示しています。
Deploy differential privacy in production systems including epsilon selection strategies, noise calibration with Laplace and Gaussian mechanisms, privacy budget tracking, composition theorems, and Python implementation patterns. Covers both central and local differential privacy models.
日本語の概要は準備中です。原文の説明を表示しています。
Think and work like an expert Critical Care Researcher. Use when a task calls for Critical Care Researcher judgment. Reasons from acute physiology trajectories, modular organ dysfunction, and cluster-aware trial design through APACHE/SAPS/SOFA scoring, Berlin/Sepsis-3/KDIGO definitions, MIMIC-IV phenotyping, and target-trial emulation with clone-censor-weighting while treating immortal-time bias, cluster contamination, competing risks from early death, and sepsis-phenotype cohort inflation as first-class failure modes.
日本語の概要は準備中です。原文の説明を表示しています。
Bridge layer connecting the emerging agentic coordination protocol ecosystem (MCP, A2A, ANP, AGNTCY, AITP, LMOS, AAIF) to the plurigrid/asi skill graph. Maps protocol-level identity mechanisms (W3C DID, OAuth 2.1, IPSIE, Entra Agent ID, Agent Cards, passport.gay) into GF(3)-classified skills. The central unsolved problem — no unified identity across MCP+A2A+A2UI — is directly addressed by the bisimulation oracle composition.
日本語の概要は準備中です。原文の説明を表示しています。
Bridge layer connecting the Agentic AI Foundation (AAIF) governance structure — Linux Foundation stewardship of MCP, goose, AGENTS.md — to the plurigrid/asi skill graph. Formalizes AAIF-compatible skill registration, IPSIE identity profiles, and the cross-protocol interoperability surface. Maps the AAIF platinum member ecosystem (AWS, Anthropic, Block, Bloomberg, Cloudflare, Google, Microsoft, OpenAI) to specific ASI skill integration points.
日本語の概要は準備中です。原文の説明を表示しています。
Implement comprehensive model drift monitoring using Evidently AI, statistical tests (PSI, KS), and custom metrics to detect data drift and concept drift in production ML systems. Set up automated alerting and reporting workflows to catch degradation before it impacts business metrics. Use when production models show unexplained performance degradation, when new data distributions differ from training data, when seasonal shifts affect input features, or when regulatory requirements mandate model monitoring.
日本語の概要は準備中です。原文の説明を表示しています。
Generate a weighted sales forecast with best/likely/worst scenarios, commit vs. upside breakdown, and gap analysis. Use when preparing a quarterly forecast call, assessing gap-to-quota from a pipeline CSV, deciding which deals to commit vs. call upside, or checking pipeline coverage against your number.
日本語の概要は準備中です。原文の説明を表示しています。
Quando o usuário quer aplicar princípios psicológicos, modelos mentais ou ciências comportamentais ao marketing. Também use quando o usuário mencionar 'psicologia', 'modelos mentais', 'viés cognitivo', 'persuasão', 'ciência comportamental', 'por que as pessoas compram', 'tomada de decisão' ou 'comportamento do consumidor'. Esta skill fornece 70+ modelos mentais organizados para aplicação em marketing.
日本語の概要は準備中です。原文の説明を表示しています。
NVIDIA DGX Spark User Guide リファレンス。GB10 Grace Blackwell Superchip ハードウェア仕様、first-boot / UEFI 設定、Spark Stacking クラスタ、 DGX OS / NGC / container runtime ソフトウェアスタック、 PXE / cloud-init プロビジョニング、fleet lifecycle 運用、 apt / fwupdmgr 更新、system recovery、PSIRT サポート、 vLLM / TensorRT-LLM / Ollama / ComfyUI / NIM / NeMo fine-tune / NCCL 等の build.nvidia.com/spark playbook、複数 Spark 接続・Tailscale・VS Code、 NVIDIA Developer Forums 由来の known issues / troubleshooting。
Analyzes alternative splicing at single-cell resolution. The first decision is library chemistry — 10X 3' is fundamentally limited (RT primes from poly-A, R2 falls in 3' UTR, <0.1 junction read per cell per AS event). Plate-based full-length methods (Smart-seq3, FLASH-seq, VASA-seq, STORM-seq) and single-cell long-read (MAS-Iso-seq, scISOr-Seq2) are the chemistries that give per-cell isoform structure. Tools include MARVEL (R, Smart-seq integrated), BRIE2 (Bayesian PSI with regulatory features and ELBO_gain test), scQuint (junction-cluster, plate-based; not for 10X), SpliZ (annotation-free Z-score), Psix (graph-smoothness regulated AS), and Sierra (alternative polyadenylation, often confused with AS). Use when analyzing isoform usage in scRNA-seq, identifying cell-type-specific splicing, or determining whether scRNA-seq chemistry supports splicing analysis at all.
日本語の概要は準備中です。原文の説明を表示しています。
Analyzes alternative splicing at single-cell resolution. The first decision is library chemistry — 10X 3' is fundamentally limited (RT primes from poly-A, R2 falls in 3' UTR, <0.1 junction read per cell per AS event). Plate-based full-length methods (Smart-seq3, FLASH-seq, VASA-seq, STORM-seq) and single-cell long-read (MAS-Iso-seq, scISOr-Seq2) are the chemistries that give per-cell isoform structure. Tools include MARVEL (R, Smart-seq integrated), BRIE2 (Bayesian PSI with regulatory features and ELBO_gain test), scQuint (junction-cluster, plate-based; not for 10X), SpliZ (annotation-free Z-score), Psix (graph-smoothness regulated AS), and Sierra (alternative polyadenylation, often confused with AS). Use when analyzing isoform usage in scRNA-seq, identifying cell-type-specific splicing, or determining whether scRNA-seq chemistry supports splicing analysis at all.
日本語の概要は準備中です。原文の説明を表示しています。
損益計算書・貸借対照表・キャッシュフロー計算書を数式で連動させるExcelモデルを作ります。実績と予測の入力、前提を変えた比較、財務三表の整合性確認を段階的に進めます。
Scans the developer's machine for dead side projects, autopsies each one from its git history (died at the payments wall, killed by a newer project, finished but never shipped), surfaces their personal death patterns, and picks the corpse most worth resurrecting — then helps ship it. Use when the user mentions abandoned, unfinished, or old side projects, asks "what should I finish", wants to revive or resurrect a project, says "run the graveyard", wonders why they never finish anything, or is about to start a new project that sounds like one they already built. Runs entirely locally.
日本語の概要は準備中です。原文の説明を表示しています。
A Frequently Asked Questions (FAQ) page with collapsible accordion sections, search functionality, and category filtering. Use when the brief asks for "FAQ", "help center", "questions", or "support page".
日本語の概要は準備中です。原文の説明を表示しています。