编码规范、框架、重构、代码审查（1.5万 个）
Extract and analyze mutational signatures from somatic variants using SigProfiler or MutationalPatterns to characterize mutagenic processes. Use when identifying DNA damage mechanisms or etiology in cancer genomes.
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Query BindingDB for measured drug-target binding affinities (Ki, Kd, IC50, EC50). Search by target (UniProt ID), compound (SMILES/name), or pathogen. Essential for drug discovery, lead optimization, polypharmacology analysis, and structure-activity relationship (SAR) studies.
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Query gnomAD for population allele frequencies to assess variant rarity. Use when filtering variants by population frequency for rare disease analysis or determining if a variant is common in the general population.
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Calculate polygenic risk scores using PRSice-2, LDpred2, or PRS-CS from GWAS summary statistics. Use when predicting disease risk from genome-wide genetic variants.
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Process multiple sequence files in batch using Biopython. Use when working with many files, merging/splitting sequences, or automating file operations across directories.
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Perform pairwise sequence alignment using Biopython Bio.Align.PairwiseAligner. Use when comparing two sequences, finding optimal alignments, scoring similarity, and identifying local or global matches between DNA, RNA, or protein sequences.
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Query myvariant.info API for aggregated variant annotations from multiple databases (ClinVar, gnomAD, dbSNP, COSMIC, etc.) in a single request. Use when annotating variants with clinical and population data from multiple sources simultaneously.
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Query PharmGKB and CPIC for drug-gene interactions, pharmacogenomic annotations, and dosing guidelines. Use when predicting drug response from genetic variants or implementing clinical pharmacogenomics.
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Access AlphaFold's 200M+ AI-predicted protein structures. Retrieve structures by UniProt ID, download PDB/mmCIF files, analyze confidence metrics (pLDDT, PAE), for drug discovery and structural biology.
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Read, write, and convert multiple sequence alignment files using Biopython Bio.AlignIO. Supports Clustal, PHYLIP, Stockholm, FASTA, Nexus, and other alignment formats for phylogenetics and conservation analysis. Use when reading, writing, or converting alignment file formats.
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Predicts ADMET properties using ADMETlab 3.0 API or DeepChem models. Estimates bioavailability, CYP inhibition, hERG liability, and 119 toxicity endpoints with uncertainty quantification. Filters for PAINS and other structural alerts. Use when filtering compounds for drug-likeness or prioritizing leads by predicted safety.
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Query dbSNP for rsID lookups, variant annotations, and cross-references to other databases. Use when mapping between rsIDs and genomic coordinates or retrieving basic variant information.
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Query ClinVar for variant pathogenicity classifications, review status, and disease associations via REST API or local VCF. Use when determining clinical significance of variants for diagnostic or research purposes.
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Call HLA alleles from NGS data using OptiType, HLA-HD, or arcasHLA for immunogenomics applications. Use when determining HLA genotype for transplant matching, neoantigen prediction, or pharmacogenomic screening.
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Apply Michael Feathers-inspired legacy-code rules when changing hard-to-test code safely with characterization tests, seams, sprout methods, or wrap methods.
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Apply Martin Fowler-inspired refactoring rules when improving existing code structure while preserving observable behavior.
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Apply Refactoring.Guru-inspired rules when diagnosing code smells, choosing refactoring techniques, and stopping cleanup before uncontrolled redesign.
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Apply Steve McConnell-inspired construction rules when implementing routines, variables, classes, control flow, defensive code, or tests.
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Apply Robert C. Martin-inspired clean code rules when improving readability, naming, function design, responsibilities, or testable everyday code.
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Apply Hunt and Thomas-inspired pragmatic programming rules when improving engineering judgment, feedback loops, DRY knowledge, orthogonality, automation, or adaptability.
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AI 电影/短剧解说视频自动生成（AI 解说大师 CLI Skill）。当用户需要创建电影解说视频、短剧解说、影视二创、AI 配音旁白视频、film commentary、video narration、drama dubbing、movie narration 时触发。内置电影素材库、BGM、多语种配音、解说模板。通过 narrator-ai-cli 命令行实现：搜片→选模板→选 BGM→选配音→生成文案→合成视频的全流程自动化。CLI client for Narrator AI video narration API.
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Generate a weekly performance summary from closed trader-memory-core theses — win rate, expectancy, profit factor, R-multiple, MAE/MFE, and win/loss pattern analysis by source skill, exit reason, thesis type, sector, and mechanism. No API required; pure local calculation.
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Mine Claude Code session logs for skill idea candidates. Use when running the weekly skill generation pipeline to extract, score, and backlog new skill ideas from recent coding sessions.
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Screen US stocks for high-quality dividend opportunities combining value characteristics (P/E ratio under 20, P/B ratio under 2), attractive yields (3% or higher), and consistent growth (dividend/revenue/EPS trending up over 3 years). Supports two-stage screening using FINVIZ Elite API for efficient pre-filtering followed by FMP API for detailed analysis. Use when user requests dividend stock screening, income portfolio ideas, or quality value stocks with strong fundamentals.
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