其他技能

Medicinal chemistry filters for compound triage. Apply drug-likeness rules (Lipinski rule of five, Veber, Oprea, CNS, lead-like, rule of three), structural alert catalogs (PAINS a/b/c, NIBR screening-deck severity, Brenk, BMS, Glaxo, Dundee, ChEMBL common alerts), ZINC-15 percentile complexity metrics (Bertz, SAscore, QED, Whitlock, Barone), chemical-group detection, Lilly demerits, and the medchem query language (MATCHRULE, HASALERT, HASPROP, HASGROUP) for filtering a library at scale. Also trigger on medchem, `import medchem as mc`, RuleFilters, NIBRFilters, CommonAlertsFilters, NamedCatalogs, QueryFilter, PAINS filtering, or structural alerts.

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Compute relative and absolute binding free energies with the Open Free Energy toolkit — the rigorous alchemical alternative to docking scores when a congeneric series needs reliable potency ranking. Use this skill to plan a perturbation network over a ligand set, choose atom mappings, run hybrid-topology or separated-topology protocols, and analyse the result — per-edge ΔΔG with uncertainty, cycle-closure error, and mean unsigned error against measured affinities. Also trigger on OpenFE, alchemical transformation, thermodynamic cycle, RBFE, ABFE, SepTop, lambda window, MBAR, cycle closure, or perturbation map.

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Work on bifunctional degraders and molecular glues, where potency comes from a ternary complex rather than occupancy. Use this skill to apply the property rules that govern this beyond-rule-of-five space, reason about linker length, attachment vector and E3 ligase choice, prepare inputs for ternary complex structure prediction, and interpret degradation readouts — DC50, Dmax, cooperativity, and the hook effect that makes a dose-response curve turn over. Also trigger on PROTAC, molecular glue, targeted protein degradation, E3 ligase, cereblon, VHL, ternary complex, DC50, Dmax, hook effect, cooperativity, or PROTAC-DB.

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Navigate make-on-demand catalogues — ZINC-22 through CartBlanche and Enamine REAL Space — to find compounds that can actually be ordered. Use this skill to look substances up by ZINC identifier or structure, understand tranche partitioning by heavy-atom count and logP, and choose between screening an enumerated subset and searching a combinatorial synthon space with a fragment-growing method such as V-SYNTHES. Also trigger on ZINC22, CartBlanche, Enamine REAL, make-on-demand, tangible library, synthon, tranche, giga-scale enumeration, or ultra-large virtual screening.

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Cofold protein-ligand, protein-protein, and nucleic-acid complexes with Boltz-2, and predict binding affinity with its trained affinity head. Use this skill to build Boltz input YAML, run structure prediction with MSAs, pocket constraints, templates, and modified residues, screen compound libraries by cofolding, and interpret confidence scores (pLDDT, pTM, ipTM, PDE) and affinity output (binder probability and log10 IC50). Also trigger on Boltz, Boltz-1, Boltz-2, cofolding, boltz predict, affinity_pred_value, affinity_probability_binary, ipTM, or open-weights AlphaFold3 alternatives.

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Use for module boundaries and dependencies. Triggers: circular import, coupling, barrel, re-export, validation placement, 모듈 경계, 순환 참조.

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Use for Telegram/Discord bridge setup. Triggers: remote, messenger, pairing, tokens, webhooks, 텔레그램 연결, 디스코드 연결, 메신저 연결, 봇 연결, 원격, 페어링.

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Use for PABCD completion loops. Triggers: cxc-loop, continue until done, HOTL, repeated PABCD, 루프 돌려, 끝까지 해줘, docs-first.

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Deprecated alias. Use cxc-dev.

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Use for requirements interviews. Triggers: interview, ambiguity, contradiction scan, ask me questions, I phase, 인터뷰.

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Deprecated alias. Use cxc-pabcd.

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Use for past-session context recovery. Triggers: recall, last time, previous session, chat search, memory search, 그때, 지난번, 저번 세션, 예전에 했던, 기억나?, 리콜, 지난 세션, 이전 작업, 뭐였지, 어떻게 했었지.

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Deprecated alias. Use cxc-loop.

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Deprecated alias. Use cxc-dev-visualizer.

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Strategic compaction skill: suggests context compression at logical breakpoints. Use to suggest compaction at logical intervals during development sessions.

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Native app development strategies including iOS/macOS (Apple platforms), Tauri desktop apps. Use when developing native mobile or desktop applications.

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Break a failed implementation loop by tracing attempts, identifying the real blocker, and proposing a materially different direction before further changes. Use when repeated fixes or investigations are not converging.

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Turn one user criticism into a principle-level fix: find the violated principle, every similar occurrence, and fix the shared cause. Use only when the user explicitly invokes expand, $expand, /up:expand, or /skill:expand.

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Zod 4 schema validation patterns. Trigger: When using Zod for validation - breaking changes from v3.

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Astro framework patterns and best practices for content-focused sites. Trigger: When working with .astro files, content collections, or Astro routing.

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Post to Reddit using AppleScript Chrome control. Use when user wants to post to Reddit, share on subreddits, or promote open source projects on Reddit. Triggers on "post to reddit", "share on reddit", "reddit post", "submit to subreddit", or any Reddit posting request.

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Reddit account cultivation for indie developers. Uses AppleScript to control real Chrome — undetectable by anti-bot systems. Checks karma, finds rising posts, drafts comments, and posts directly. Triggers on "/reddit-cultivate", "check my reddit", "reddit maintenance", "find reddit opportunities", "build reddit karma".

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Create, update, or validate a PRD. Use when the user wants help producing, editing, or validating a PRD

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Use when the user wants to contribute a fix or roadmap item back to the Hedgehog project itself (skyf0xx/hedgehog) rather than their own project. Triggers on "let's fix that in Hedgehog", "I want to contribute", "let's pick up a roadmap item", or when `tweaker` offers this at the end of a build and the user says yes. Covers forking/branching, making the change under Hedgehog's own repo rules, committing with Conventional Commits, and opening the PR.

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