调研与学习技能

Use Biopython tools to examine sequence motifs, restriction enzyme sites, codon usage, and related bioinformatics data. The skill helps produce structured analysis results and supports genomic feature visualization with GenomeDiagram.

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• Summarizing motifs across aligned sequences
• Finding restriction enzyme cut sites in DNA
• Calculating codon frequencies and basic sequence statistics

Checks Mendelian randomization results for horizontal pleiotropy, where genetic instruments affect outcomes through other pathways. It applies MR-PRESSO, MR-Egger, and Steiger filtering to examine outliers, directional bias, and causal direction, then supports sensitivity analysis and reporting.

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• Checking MR findings for horizontal pleiotropy
• Testing whether genetic instruments have directional bias
• Filtering variants with uncertain causal direction

Review a paper or thesis before submission or internal evaluation. The skill assesses novelty, methods, evidence, reproducibility, and clarity, separates major concerns from minor edits, and turns findings into concrete revision suggestions and a reasoned recommendation.

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• Reviewing a manuscript before journal submission
• Assessing a thesis before committee review
• Checking methods and conclusions for evidence alignment

Draft or revise a research paper’s Methods section with the details readers need to understand and reproduce the study. Organize it around IMRAD conventions, reporting checklists, statistical choices, ethics, and journal requirements.

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• Drafting a reproducible Methods section
• Checking a manuscript against CONSORT, STROBE, or PRISMA
• Addressing reviewer requests for methodological detail

Plan and carry out a systematic review using PRISMA 2020, a reporting guideline for evidence reviews. Organize database searches, study screening, data extraction, quality assessment, meta-analysis, and final review reporting.

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• Planning a systematic review or meta-analysis
• Searching and screening studies across databases
• Extracting study details and assessing bias

Turn informal invention notes into a structured patent disclosure, identify missing technical details, and prepare or analyze related-patent searches. It compares key features and offers a preliminary novelty assessment and drafting directions.

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• Structuring an invention description for a patent disclosure
• Preparing keywords and IPC suggestions for a patent search
• Comparing related patents with an invention’s key features

Drafts a meta-analysis results section describing risk of bias from supplied assessment tables and summary statistics. It reports the overall ratings, reviews each assessment domain with specific numbers, and formats the text with a figure citation and caption in Chinese or English.

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• Drafting the risk of bias results for a meta-analysis
• Summarizing overall ratings across assessed studies
• Describing domain-level findings using supplied statistics

Prepare for presentations by generating challenging questions about methods, statistics, interpretation, limitations, and future work. It provides response frameworks and key points to address, based on an abstract or research topic and a specified audience.

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• Preparing answers to likely questions about a research abstract
• Rehearsing a presentation for an expert or general audience
• Identifying questions about methods, statistics, or study limitations

Estimate required sample sizes and statistical power for study designs including t-tests, survival analysis, clustered designs, and multiple comparisons. Given inputs such as effect size and significance level, the skill can also provide power curves, sensitivity analysis, and dropout-adjusted sample estimates.

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• Estimating sample size for a survival study
• Planning a clustered or non-inferiority trial
• Comparing power across effect size assumptions

Create a formatted meta-analysis results section from a funnel plot image, statistics, an analysis title, and a requested language. The report includes a plot description, figure legend, and Markdown tables for Egger's test, Begg's test, and the Trim and Fill method.

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• Formatting funnel plot results for a meta-analysis
• Preparing Egger's, Begg's, and Trim and Fill tables
• Drafting an English or Chinese figure legend and results text

Create a baseline characteristics section for a meta-analysis from supplied study data. The skill produces a descriptive paragraph and a formatted Markdown table in Chinese or English, then combines them into a consistent results section with a table reference.

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• Draft a baseline characteristics section from meta-analysis data
• Create the accompanying Markdown table in Chinese or English
• Format the paragraph and table into a consistent results section

Draft a structured Methods section for a meta-analysis using the supplied PICOS, eligibility criteria, risk-of-bias tool, and language. It covers the search strategy, screening, quality assessment, data extraction, and statistical analysis.

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• Drafting a meta-analysis Methods section from PICOS and eligibility criteria
• Describing planned screening and risk-of-bias assessment
• Preparing a structured manuscript section in English or Chinese

Interpret scientific charts by identifying statistical measures, trends, uncertainty, and possible visual pitfalls. Create clear explanations for researchers, clinicians, patients, or public audiences, and draft figure captions for papers, posters, or presentations.

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• Explaining a clinical research graph to an audience
• Drafting a publication figure caption
• Interpreting effect sizes and confidence intervals

Plan and conduct a systematic or scoping literature review across academic databases, screen and synthesize studies by theme, assess evidence quality, and verify citations. Produce a documented Markdown review and, when dependencies are available, a formatted PDF.

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• Prepare a systematic review on a research question
• Synthesize findings and research gaps across studies
• Write a thesis literature review with checked citations

Create structured literature reviews of medical imaging AI, covering areas such as segmentation, detection, and classification. Organize methods, datasets, metrics, limitations, and applications into a review manuscript with comparison tables and evidence-backed claims.

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• Surveying AI methods for CT or MRI imaging
• Comparing segmentation and detection approaches
• Organizing datasets and evaluation metrics

Helps researchers prepare IRB submissions by checking protocols for missing or noncompliant sections, drafting informed consent documents, generating application forms, and validating submission packages against required fields and documents.

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• Drafting an informed consent form from study details
• Checking a protocol for IRB requirements
• Generating initial or continuing review forms

Build a long-form medical review through staged work: outline the topic, gather PubMed literature, write and verify chapters, then format citations and assemble the final files. The workflow keeps intermediate documents and checks claims against references.

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• Planning a detailed medical review outline
• Gathering PubMed references for each chapter
• Writing and verifying a review chapter by chapter

Create population-level clinical decision support documents for research and pharmaceutical work. The skill structures biomarker-stratified cohort analyses and evidence-graded treatment recommendations, with statistical outcome comparisons and decision algorithms in LaTeX or PDF format.

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• Comparing outcomes across biomarker groups
• Drafting evidence-graded treatment guidelines
• Preparing trial subgroup analyses

Draft and review biomedical grant proposal sections, including aims, methods, and budget justifications. It helps organize an application for agencies such as NIH or NSF, connect the research aims with the proposed methods, and assess clarity with review checklists.

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• Drafting a Specific Aims page
• Creating a grant section template for NIH or NSF
• Preparing personnel or equipment budget justifications

Stress-test a biomedical grant proposal with a structured simulation of NIH peer review. It scores five review criteria, identifies strengths and weaknesses, drafts a summary statement, and suggests prioritized revisions; scores are simulated and may differ from real reviewers.

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• Reviewing a biomedical grant before submission
• Finding weaknesses in specific aims or research approach
• Comparing an original and revised proposal

Turn a medical research abstract into a plain-language summary for patients, the public, or media audiences. Replace jargon, adjust the reading level, and extract key takeaways in a structured result with a configurable word limit.

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• Explain a medical abstract to patients in plain language
• Create a short public-facing summary of research findings
• Adapt an abstract summary for a media audience

Turns biomedical keywords, findings, or a proposal title with background into a structured outline for a review, discussion, or thesis proposal. It supplies stable section headings and actionable subpoints while keeping claims within the information provided.

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• Plan chapters for a biomedical review article
• Organize results into a discussion outline
• Structure a thesis or research proposal

Format manuscript references and bibliographies for academic writing, convert between styles such as APA, MLA, Vancouver, and Chicago, and check whether reference entries contain required details. The package documents batch processing and journal-oriented formatting workflows.

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• Formatting a bibliography for a journal submission
• Converting references from APA to Vancouver style
• Checking reference entries for missing fields

Drafts an IACUC animal research application with a structured justification of the 3Rs: replacement, reduction, and refinement. It produces editable text from supplied protocol details, with standard, minimal, or detailed templates and text, Markdown, or DOCX output.

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• Draft an animal study application from protocol details
• Explain why live animals are needed instead of alternatives
• Document sample size reasoning and ways to reduce animal numbers