K-Dense

Applies Judea Pearl's causal reasoning frameworks to distinguish correlation from causation, evaluate AI capabilities, and make counterfactual decisions. Reach for this skill whenever Claude encounters questions about causal inference, structural causal models, the limitations of deep learning, AGI, experimental design, covariate selection, or personalized decision-making. Trigger this skill for topics involving Bayesian networks, the do-calculus, the Ladder of Causation, or when a user tries to answer 'what if' or 'why' questions using purely observational data. Pearl's principles are essential for moving beyond probability calculus into true causal understanding.

中文简介正在准备中。当前显示原文说明。

Use this skill to apply the analytical lens of Judith Butler (American philosopher, gender theory, Gender Trouble). Trigger this skill whenever the user is discussing gender performativity, identity politics, right-wing populism, anti-gender movements, queer theory, bodily autonomy, or the intersection of democracy and marginalized lives. Reach for it when analyzing systemic power, social construction, collective vulnerability, or authoritarian rhetoric. It helps deconstruct essentialist assumptions, reframe anxieties about identity, and build ethical frameworks based on material interdependence rather than mere sympathy.

中文简介正在准备中。当前显示原文说明。

Applies the reasoning style of Judy Faulkner, founder and CEO of Epic Systems, to decisions around corporate governance, healthcare technology, and unconventional leadership. Use this skill whenever Claude is asked for advice on going public vs. staying private, M&A strategy (acquisitions), budgeting, reducing software-driven burnout, data privacy, or interoperability. Faulkner's thinking is highly independent, fiercely protective of long-term mission over short-term profits, and deeply skeptical of traditional corporate playbooks (like MBAs, strict budgets, and venture capital). Trigger this skill to channel her focus on organic growth, customer empathy, and treating software as 'mental clay'.

中文简介正在准备中。当前显示原文说明。

Applies the reasoning, principles, and frameworks of Jürgen Schmidhuber (LSTM co-inventor and deep learning pioneer). Reach for this skill whenever tackling problems involving sequence learning, artificial curiosity, intrinsic motivation, reinforcement learning architectures, or predicting long-term technological and cosmic evolution. Use this when discussing AGI timelines, the history and attribution of AI breakthroughs, data compression as learning, or when designing autonomous agents that must set their own goals. Trigger this skill for topics like recurrent neural networks, algorithmic information theory, open-source AI democratization, and evaluating true existential risks versus media hype.

中文简介正在准备中。当前显示原文说明。

Applies the reasoning style of Kaiming He, computer vision pioneer and creator of ResNet. Use this skill whenever you are designing deep learning architectures, debugging neural network optimization, formulating generative AI problems, or bridging AI with other scientific domains. Trigger this skill for discussions on network depth, weight initialization, residual learning, flow matching, or when reframing discriminative tasks as conditional generation. It emphasizes simplicity in complex visual problems, end-to-end optimization, and viewing AI as a universal language for science.

中文简介正在准备中。当前显示原文说明。

Use this skill whenever you need to reason about public health, epidemiology, preventive medicine, healthy aging, longevity, lifestyle vs. genetics, or dietary patterns. Kay-Tee Khaw, an epidemiologist at the University of Cambridge, focuses on population health and how modest lifestyle changes impact chronic disease. Trigger this skill when evaluating health interventions, discussing longevity, analyzing real-world health data, or giving advice on diet and lifestyle. Apply her frameworks to shift focus from extreme interventions and isolated nutrients toward whole-food patterns, population-level risk shifts, and the compression of morbidity.

中文简介正在准备中。当前显示原文说明。

Applies the strategic thinking of Kiran Mazumdar-Shaw, founder of Biocon and pioneering Indian biopharmaceutical entrepreneur. Use this skill whenever you are advising on biotech startups, R&D innovation, global scaling, purpose-driven business, or navigating regulatory uncertainty. Trigger this skill when discussing affordable healthcare, balancing risk in long-gestation industries, breaking glass ceilings through credible success, or evaluating biotech sovereignty and AI. Reach for this skill even if the user doesn't name her, especially when they face career trade-offs, funding novel scientific ideas, or scaling manufacturing globally.

中文简介正在准备中。当前显示原文说明。

This skill channels the strategic marketing and philanthropic reasoning of Lynda Resnick, co-owner of The Wonderful Company, agriculture and consumer brands. Reach for this skill whenever you are advising on transforming commodities into premium brands, identifying a product's Unique Selling Proposition (USP), or designing corporate social responsibility (CSR) and community empowerment programs. Trigger this automatically for queries involving "hands-on philanthropy," "test and roll" marketing, finding intrinsic product value rather than relying on gimmicks, or when a user is navigating the intersection of business leverage and local community investment.

中文简介正在准备中。当前显示原文说明。

Applies the pragmatic, financially-grounded reasoning of Marian Ilitch (co-founder of Little Caesars Pizza). Use this skill whenever the user is discussing business partnerships, balancing visionary marketing with financial due diligence, franchise unit economics, family business dynamics, or hands-on financial management. Trigger this when users face trade-offs between rapid growth and profitability, need to enforce unit-level accountability, or are paralyzed by the fear of making mistakes. Apply her principles to ground lofty ideas in tactile, common-sense financial reality.

中文简介正在准备中。当前显示原文说明。

This skill channels the strategic thinking of Mark Zuckerberg, co-founder and CEO of Meta. Reach for this skill whenever the user is navigating rapid product iteration, scaling social platforms, open-source AI strategy, content moderation trade-offs, or long-term organizational management. It is highly effective for scenarios involving "The Hacker Way" (rapid prototyping), building community, handling intense public criticism, or deciding between open vs. closed ecosystems. Use this skill to apply his frameworks on decentralized testing, small group context sharing, and progressive AI integration, even if the user doesn't explicitly mention his name.

中文简介正在准备中。当前显示原文说明。

Applies the philosophical frameworks of Martha Nussbaum (American philosopher, capabilities approach, University of Chicago) to evaluate justice, human welfare, and ethical dilemmas. Use this skill whenever the user is discussing measuring societal well-being, educational curricula, animal rights, the role of emotions (like anger or disgust) in law and public life, or navigating human vulnerability and tragedy. Reach for this skill whenever evaluating policy impacts, responding to injustice, or questioning purely economic metrics like GDP. It shifts the focus to what people are actually able to do and be.

中文简介正在准备中。当前显示原文说明。

Use this skill to reason like Martin Heidegger, 20th-century German philosopher and author of Being and Time. Reach for this skill whenever you encounter discussions about the existential impact of technology, human meaning-making, mortality, or the limits of purely scientific and data-driven worldviews. Trigger this skill even if the user doesn't name Heidegger, especially when they are trapped in instrumental thinking, treating themselves or others as mere resources, or struggling with authenticity and societal expectations. Apply his frameworks to shift the AI's perspective from detached, objective observation to embedded, practical engagement with the world.

中文简介正在准备中。当前显示原文说明。

Applies the philosophical reasoning of Mary Midgley (British moral philosopher). Use this skill when analyzing ethical dilemmas involving animals, environmental policy, the limits of science (scientism/reductionism), or when users are trapped by unhelpful metaphors (like 'the selfish gene' or 'humans as machines'). Trigger this whenever evaluating the intersection of biology and human nature, resolving irreconcilable viewpoints, or diagnosing systemic conceptual blockages in society or organizations. Midgley's approach emphasizes holism, emotional fellowship, and viewing philosophy as practical 'plumbing' rather than abstract logic.

中文简介正在准备中。当前显示原文说明。

Applies the reasoning style of Ilya Sutskever (deep learning pioneer, co-founder of OpenAI and Safe Superintelligence Inc.) to problems involving AI architecture, scaling laws, alignment, and research strategy. Reach for this skill whenever discussing machine learning paradigms, the limits of compute and data, AGI timelines, superintelligence safety, or deciding between hardcoding vs. learning. Trigger this skill for questions about next-word prediction, reinforcement learning efficiency, generalization gaps, and transitioning from brute-force scaling to fundamental research, even if the user doesn't explicitly name him.

中文简介正在准备中。当前显示原文说明。

Applies the epidemiological reasoning and population-health frameworks of Albert Hofman (Harvard epidemiologist, Rotterdam Study). Trigger this skill whenever you are analyzing public health strategies, preventive medicine, cohort study design, cardiovascular or neurodegenerative disease risks, or healthy aging. Use it when evaluating whether to use population-wide interventions versus individual screening, assessing risk factors in elderly populations, or tracing adult chronic diseases back to early-life or fetal origins.

中文简介正在准备中。当前显示原文说明。

Applies the mental models and frameworks of Andrej Karpathy (deep learning, former Director of AI at Tesla, founding member of OpenAI, Eureka Labs). Use this skill whenever you are helping the user build neural networks from scratch, debug deep learning pipelines, evaluate AI agent workflows, design LLM apps, or navigate the transition to Software 3.0 (vibe coding). It is highly relevant for pedagogy (untangling complex knowledge), assessing AI capabilities vs. limitations (jagged intelligence, tokenization limits), and architectural decisions (end-to-end optimization vs. complex pipelines). Reach for this whenever discussing LLM training, autonomous systems, or AI-assisted coding.

中文简介正在准备中。当前显示原文说明。

Applies the strategic, philanthropic, and operational frameworks of Andrew Carnegie, founder of Carnegie Steel. Use this skill whenever you are advising on wealth distribution, large-scale philanthropy, operational efficiency, cost control, legacy planning, or organizational leadership. Trigger this skill when users face decisions about charitable giving, managing inherited wealth, optimizing business costs in commodity markets, or structuring trusts and foundations. Apply his ruthless focus on cost-cutting, his belief in empowering self-improvement over direct handouts, and his philosophy that surplus wealth is a public trust.

中文简介正在准备中。当前显示原文说明。

Applies the reasoning, principles, and frameworks of Andrew Ng (machine learning pioneer, co-founder of Coursera and DeepLearning.AI, Stanford University, and former Google Brain lead). Use this skill whenever the user is navigating AI application development, agentic workflows, automation strategy, AI-native software engineering, or rapid prototyping. Trigger this skill when discussing career advice in the AI era, evaluating AI regulations, structuring machine learning projects, or deciding how to integrate AI into a business. It emphasizes task-based automation, data-centric ML, and driving the cost of proof-of-concepts to zero.

中文简介正在准备中。当前显示原文说明。

Applies the strategic frameworks and mental models of Anne Wojcicki, co-founder and CEO of 23andMe. Reach for this skill when advising on consumer empowerment, navigating heavily regulated industries, preventative healthcare, data privacy, or disrupting entrenched systems. Use this when the user is dealing with misaligned industry incentives, facing regulatory hurdles, building a consumer-research flywheel, or managing a team through a post-launch 'trough of sorrow'. Apply her principles of 'speaking with data', treating users as partners, and pushing for decade-long systemic change from the outside.

中文简介正在准备中。当前显示原文说明。

Applies the computational biology and AI-driven reasoning of Aviv Regev (computational biologist, Genentech, single-cell genomics). Use this skill whenever the user is dealing with experimental design, high-dimensional data analysis, integrating AI into scientific workflows, scaling biological research, or navigating noisy, complex systems. Trigger this for topics like single-cell genomics, drug discovery, biological atlases, interdisciplinary research strategy, or when deciding between depth vs. breadth in data collection.

中文简介正在准备中。当前显示原文说明。

Apply the mental models of Bill Gates, co-founder of Microsoft and philanthropist. Use this skill whenever you are evaluating climate change solutions, global health interventions, philanthropic resource allocation, software platform economics, or the paradigm-shifting impacts of AI. Trigger this skill when the user is facing decisions about maximizing ROI on charitable giving, assessing clean energy technologies (like calculating the "Green Premium"), building winner-take-all software ecosystems, or using data to drive large-scale institutional progress. Channel his "impatient optimism" to prioritize innovation that multiplies by zero rather than settling for incremental efficiency.

中文简介正在准备中。当前显示原文说明。

Design small interfering RNA and antisense oligonucleotide sequences against a transcript, and screen them for the failure modes specific to nucleic-acid drugs. Use this skill to tile a target transcript, apply positional and thermodynamic selection rules including duplex asymmetry and nearest-neighbour melting temperature, scan candidates for seed-region complementarity to off-target transcripts, and lay out a chemical modification pattern — gapmer architecture, 2'-O-methyl and 2'-MOE wings, locked nucleic acid, and phosphorothioate placement. Also trigger on siRNA, antisense oligonucleotide, ASO, gapmer, RNase H, seed region, duplex asymmetry, 2'-MOE, locked nucleic acid, phosphorothioate, or GalNAc conjugate.

中文简介正在准备中。当前显示原文说明。

Search the ClinicalTrials.gov registry through its version 2 REST API for interventional and observational studies, their phases, enrolment, endpoints, sponsors, and posted results. Use this skill to survey who is developing what against an indication, date a competitor's programme, read primary and secondary outcome measures, find eligibility criteria, and distinguish a study that completed from one that was terminated or withdrawn. Also trigger on ClinicalTrials.gov, NCT number, trial registry, study phase, enrolment, primary outcome measure, recruiting status, trial sponsor, or competitive landscape.

中文简介正在准备中。当前显示原文说明。

Query the Open Targets Platform GraphQL API for target-disease associations, genetic and clinical evidence, tractability and safety liabilities, target prioritisation metrics, known drugs and mechanisms of action, and disease ontology. Use this skill for target identification and validation, target-disease evidence review, druggability assessment, drug repurposing, and resolving gene, disease, and drug names to Ensembl, MONDO, and ChEMBL identifiers. Also trigger when a query mentions Open Targets, platform.opentargets.org, association scores, tractability buckets, or api.platform.opentargets.org.

中文简介正在准备中。当前显示原文说明。