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cccskills

“duplication”的搜索结果

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Assembles genomes de novo from noisy long reads (Oxford Nanopore R9/R10/Dorado, PacBio CLR) with Flye (repeat graph), Canu (correct-trim-assemble OLC), NextDenovo, Shasta, Raven, wtdbg2, or miniasm, and reconciles bacterial assemblies into a consensus with Trycycler/Autocycler. Covers matching the input flag to the basecaller era (--nano-hq vs --nano-raw), why a raw long-read assembly is contiguous but low-QV and not finished until polished, haplotig false-duplication and purge_dups, coverage and read-N50 as non-substitutable inputs, and mid-read adapter de-chimerization. Use when assembling a bacterial or eukaryotic genome from ONT or PacBio noisy reads, choosing a long-read assembler, or diagnosing an over-collapsed or duplicated assembly. For PacBio HiFi use hifi-assembly instead.

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peacezha/HPClaw32026年10月11日 更新

Evaluates genome assembly quality across the three orthogonal axes - contiguity (QUAST auN/NG50/NGx, not bare N50), completeness (BUSCO/compleasm gene-space plus Merqury k-mer completeness), and correctness (reference-free Merqury QV, Inspector/CRAQ structural errors, asmgene false-duplication/collapse). Covers why N50 is the most-gamed metric, why QV measured on the polishing reads is circular, distinguishing uncollapsed haplotigs from real WGD, and the EBP/VGP 6.C.Q40 standard. Use when judging whether an assembly is good enough to annotate or publish, comparing assemblers, diagnosing a fragmented or duplicated assembly, or assessing a phased diploid assembly.

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peacezha/HPClaw32026年10月11日 更新

Prepare high-quality datasets for LLM fine-tuning with filtering, deduplication, augmentation, and RLHF data formatting. Activate on: fine-tuning data, training data curation, RLHF dataset, data quality filtering, SFT dataset. NOT for: model training infrastructure (ai-engineer), prompt engineering without fine-tuning (prompt-engineer).

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curiositech/port-daddy32026年10月19日 更新

Secures webhook receivers with signature verification, retry handling, deduplication, idempotency keys, and error responses. Provides verification code, dedupe storage strategy, runbook for incidents. Use when implementing "webhooks", "webhook security", "event receivers", or "third-party integrations".

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sathishssj3/Stereix-Engine22026年10月4日 更新

Converts documents into clean, chunked datasets suitable for embeddings and vector search. Produces chunked JSONL files with metadata, deduplication logic, and quality checks. Use when preparing "training data", "vector datasets", "document processing", or "embedding data".

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sathishssj3/Stereix-Engine22026年10月4日 更新

Week 2 of the exploit development curriculum. Covers fuzzing methodology: target selection, corpus generation, coverage-guided fuzzing with AFL++/libFuzzer, structured fuzzing, and triage/deduplication. Use when setting up fuzz campaigns, selecting harness strategies, or triaging fuzzer output.

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ajtazer/heckit22026年10月7日 更新