“alignment”的搜索结果

群众路线：从持有真实情况的多方（用户、使用者、代码库、日志、运行结果）收集分散意见，系统化为方案，再带回去对齐与检验，循环改进。当多方意见分歧、需要汇总零散反馈、方案要拿回给真实使用者确认、或你发觉自己在闭门造车时触发；信息源单一且完整、处于执行阶段时不触发。 English: Mass line. Collect scattered input from everyone who holds ground truth (users, operators, codebase, logs, runtime results), synthesize it into a coherent plan, take it back for alignment and validation, and iterate. Trigger when inputs conflict, feedback must be consolidated, a plan needs sign-off from real users, or you sense you are designing in isolation; skip when there is a single complete source and the work is pure execution.

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Design engineering principles for making interfaces feel polished. Use when building UI components, reviewing frontend code, implementing animations, hover states, shadows, borders, typography, icons, micro-interactions, enter/exit animations, or any visual detail work. Supports quick and full review modes. Triggers on UI polish, design details, "make it feel better", "feels off", stagger animations, border radius, optical alignment, font smoothing, tabular numbers, image outlines, box shadows, icons, icon stroke weight, icon states, motion restraint.

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Biological data toolkit. Sequence analysis, alignments, phylogenetic trees, diversity metrics (alpha/beta, UniFrac), ordination (PCoA), PERMANOVA, FASTA/Newick I/O, for microbiome analysis.

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Primary retained Python toolkit for molecular biology sequence work. Preferred for sequence manipulation, FASTA/FASTQ/GenBank parsing, Bio.Entrez, BLAST workflows, alignments, structures, and phylogenetics. For biological database evidence lookup, use bio-database-evidence. For single-cell workflows use scanpy. For direct literature REST API, use pubmed-database.

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Use when the user wants to orchestrate defect image generation with NVIDIA Cosmos AnomalyGen (Cosmos-Predict2-derived) on OSMO for PCBA, metal surface, and glass inspection. The Day 0 path handles cold-start with USD-to-ROI, image-edit augmentation, and AnomalyGen to create initial PCBA datasets. The Day 1 path performs inference and labeling on real images. This skill helps with first-time asset setup, creation of finetuning checkpoints, and configuring deployment. Trigger keywords: defect image generation, dig workflow, dig pipeline, defect image detection workflow, aoi pipeline, aoi anomalygen, usd2roi anomalygen, day 0 pcba, day 1 pcba, day 1 real-photo alignment, day 1 manual roi, metal surface anomaly, glass defect, anomalygen finetune, setup_pcb, setup_metal, setup_glass, setup_pretrained, dig setup, dig datasets, dig pretrained checkpoint, dig image-edit endpoint, cosmos defect generation, cosmos-predict2 defect, cosmos-anomalygen, cosmos predict2 finetune.

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Plan, configure, and chain repo-native Nemotron customization steps into single-step or multi-step pipelines: curation, translation, SFT/PEFT (AutoModel or Megatron-Bridge), pretraining/CPT, RL alignment (DPO/RLVR/GRPO/RLHF), BYOB/MCQ benchmarks, checkpoint conversion, ModelOpt optimization, env profiles, and evaluation of trained checkpoints or existing/hosted endpoints. Use when a request names a Nemotron step or workflow, or asks to clean, translate, train, fine-tune, align, convert, optimize, evaluate, or compose these into a pipeline. Do NOT use for frontend/dashboard/visualization work, generic ML advice, billing/access, or non-Nemotron coding tasks.

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WARNING: guides IRREVERSIBLE BlueField-4 hardware operations (PLDM firmware burns, ISO reflashes, power cycles, BMC factory resets); every mutating step is governed by doca-hardware-safety (window, rollback). BlueField-4 only: BlueField-3 bring-up is doca-bf3-deployment. Use this skill for BlueField-4 (BF4) day-1 platform bring-up from the BMC: installing the BlueField/DOCA bundle ISO onto the DPU (Grace, the Arm complex) over UEFI HTTP Boot, PXE, or Redfish Virtual Media; the PLDM firmware-update flow (BMC, NIC firmware, SBIOS, ERoT) via the Redfish UpdateService and pldmtool; and a Grace Ubuntu image with optional cloud-init. Trigger on BlueField-4/BF4 bring-up phrasings even without "BF4": {bring up my new BlueField-4}, {the BlueField ISO will not boot over HTTP from the BMC}, {attach BF4 virtual media via Redfish}, {BF4 firmware Task stuck at Running}, {prepare a BlueField-4 host: platform support, version alignment, safest first smoke test}. Application launch and library APIs belong to other skills.

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Modern, clean UI/UX guidance + review skill. Use when you need actionable UX/UI recommendations, design principles, or a design review checklist for new features or existing systems (web/app). Focus on CRAP (Contrast/Repetition/Alignment/Proximity) plus task-first UX, information architecture, feedback & system status, consistency, affordances, error prevention/recovery, and cognitive load. Enforce a modern minimal style (clean, spacious, typography-led), reduce unnecessary copy, forbid emoji as icons, and recommend intuitive refined icons from a consistent icon set.

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Query TradingView market data through the bundled tradingview MCP server without a desktop app or login. Use whenever the user wants a technical analysis readout (RSI, MACD, Bollinger rating, BUY/SELL summary), multi-timeframe alignment (weekly→daily→4h→1h→15m), exchange-wide scans (Bollinger squeeze, volume breakout, consecutive candles, smart volume), top gainers/losers by exchange, futures market data (NQ/ES/CL/GC overview, overnight movers, category snapshots), pre-market / after-hours quotes, a quick options chain or unusual options activity (volume/OI by strike), bulk stock prices, a global market snapshot, strategy backtests (Sharpe, drawdown, win rate), or crypto exchange scans. Triggers include "TA on X", "multi-timeframe read", "BB squeeze scan", "futures movers", "NQ overnight", "pre-market price", "unusual options activity", "backtest RSI on AAPL", and "top gainers on NASDAQ". For options greeks, watchlists, alerts, or chart screenshots use tradingview-reader instead.

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Access protein metadata, function, taxonomy, and sequences across UniProtKB, UniParc, and UniRef. Use when searching for proteins, mapping identifiers, or retrieving functional annotations and publications. Don't use for sequence alignment, protein folding, or sequence similarity search (use specialized skills for those tasks).

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Visualize, analyze, and render protein and molecular structures using PyMOL. Use when the user wants to create images of protein structures, perform structural alignments or superposition, measure distances or contacts, highlight binding sites or active site residues, color by B-factor/pLDDT, or analyze protein-ligand interactions. Do not use for docking, molecular dynamics, or sequence-only analysis.

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SUPERSEDED by /claudex-loop (formerly /crucible; its docs-aware mode covers this variant) — prefer that skill unless you explicitly want this one. Two-act plan hardening with living documentation. ACT 1 (you ↔ Claude) — Claude interviews you relentlessly about a plan, one question at a time, challenging it against your project's existing domain model and glossary (CONTEXT.md), sharpening fuzzy terms, stress-testing with concrete scenarios, cross-referencing code, and updating CONTEXT.md + ADRs inline as decisions crystallise. ACT 2 (Claude ↔ Codex) — Claude writes the locked plan to PLAN.md and OpenAI Codex adversarially reviews it in a read-only sandbox (VERDICT:APPROVED/REVISE), Claude revises and re-submits to the SAME Codex session until APPROVED or a MAX_ROUNDS cap, then you sign off before any code. Use when the user says "/grill-with-docs-codex", "grill me against the docs then have codex review", "stress-test this against our domain model then get a second model on it", or is about to build something high-stakes in a project with established terminology/ADRs and wants alignment, documentation, AND a cross-model sanity check. Builds on Matt Pocock's grill-with-docs (MIT). NOT for reviewing already-written code (use /codex:review) and NOT for trivial changes.

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SUPERSEDED by /claudex-loop (formerly /crucible; adds a Phase 0 research/recon pass + rebuilt interview) — prefer that skill unless you explicitly want this one. Two-act plan hardening. ACT 1 (you ↔ Claude) — Claude interviews you relentlessly about a plan or design, one question at a time, recommending an answer for each and exploring the codebase when it can answer itself, until every branch of the decision tree is resolved. ACT 2 (Claude ↔ Codex) — Claude writes the locked plan to PLAN.md and OpenAI Codex adversarially reviews it in a read-only sandbox (VERDICT:APPROVED/REVISE), Claude revises and re-submits to the SAME Codex session until APPROVED or a MAX_ROUNDS cap, then you sign off before any code. Use when the user says "/grill-me-codex", "grill me then have codex review", "grill me and stress-test the plan", "interview me about this plan then get a second model on it", or is about to build something high-stakes (auth, schema, concurrency, migrations, payments) and wants both alignment AND a cross-model sanity check before implementation. Builds on Matt Pocock's grill-me (MIT). For the docs-aware variant use /grill-with-docs-codex; if you already have a plan and want only the Codex review use /codex-review. NOT for reviewing already-written code (use /codex:review) and NOT for trivial changes.

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Architect and provision enterprise Azure infrastructure from workload descriptions. For cloud architects and platform engineers planning networking, identity, security, compliance, and multi-resource topologies with WAF alignment. Generates Bicep or Terraform directly (no azd). WHEN: 'plan Azure infrastructure', 'architect Azure landing zone', 'design hub-spoke network', 'plan multi-region DR topology', 'set up VNets firewalls and private endpoints', 'subscription-scope Bicep deployment', 'Azure Backup for VM workloads'. PREFER azure-prepare FOR app-centric workflows.

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Preprocessing and harmonization of multi-omics data before integration. Covers normalization, batch correction, feature alignment, and missing value handling across data types. Use when preparing multi-omics datasets for integration analysis.

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Remove sequencing adapters from FASTQ files using Cutadapt and Trimmomatic. Supports single-end and paired-end reads, Illumina TruSeq, Nextera, and custom adapter sequences. Use when FastQC shows adapter contamination or before alignment of short reads.

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Preprocess ribosome profiling data including adapter trimming, size selection, rRNA removal, and alignment. Use when preparing Ribo-seq reads for downstream analysis of translation.

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Deep learning-based variant calling from long reads using Clair3 for SNPs and small indels. Use when calling germline variants from ONT or PacBio alignments, particularly when high accuracy is needed for clinical or research applications.

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Quality control for long-read sequencing data using NanoPlot, NanoStat, and chopper. Generate QC reports, filter reads by length and quality, and visualize read characteristics. Use when assessing ONT or PacBio run quality or filtering reads before assembly or alignment.

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XCMS3 workflow for LC-MS/MS metabolomics preprocessing. Covers peak detection, retention time alignment, correspondence (grouping), and gap filling. Use when processing raw LC-MS data into a feature table for untargeted metabolomics.

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Align long reads using minimap2 for Oxford Nanopore and PacBio data. Supports various presets for different read types and applications. Use when aligning ONT or PacBio reads to a reference genome for variant calling, SV detection, or coverage analysis.

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MS-DIAL-based metabolomics preprocessing as alternative to XCMS. Covers peak detection, alignment, annotation, and export for downstream analysis. Use when processing MS-DIAL output files for R/Python analysis or when preferring GUI-based preprocessing.

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Detect structural variants from long-read alignments using Sniffles, cuteSV, and SVIM. Use when detecting deletions, insertions, inversions, translocations, or complex rearrangements from ONT or PacBio data, especially those missed by short-read methods.

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Process Hi-C read pairs using pairtools. Parse alignments, filter duplicates, classify pairs, and generate contact statistics from Hi-C sequencing data. Use when processing raw Hi-C read pairs.

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