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Query the Cancer Dependency Map (DepMap) for cancer cell line gene dependency scores (CRISPR Chronos), RNAi DEMETER2 scores, PRISM compound sensitivity, and gene effect profiles across the cell-line panel. Use for identifying cancer-selective vulnerabilities, separating pan-essential genes from selective ones, finding synthetic lethal interactions, correlating dependency with mutation, expression and copy number, and validating oncology drug targets. Also trigger on DepMap, Chronos gene effect, CRISPRGeneEffect.csv, DEMETER2, PRISM repurposing, co-essentiality, pan-essential, or ACH- cell line identifiers.

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State management decision tree for React SPAs: useState/useReducer, Context API, Zustand, Jotai, Redux Toolkit, TanStack Query, SWR. Detect what's installed and apply matching patterns. Use this skill to: - Pick the right state tool for the data shape (local / shared UI / server / form). - Use Context correctly (and know when to switch to Zustand/Jotai). - Implement a Zustand or Jotai store. - Set up TanStack Query for server state with caching, pagination, mutations. - Avoid common mistakes (overusing Redux, prop drilling, forgetting query invalidation). Do NOT use this skill for: - General hook conventions (see react-conventions). - Form state specifically (see react-forms). - Routing state (see react-routing). - Testing stores/queries (see react-testing).

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Vue 3 form patterns: native v-model, vee-validate + zod (most common), VueUse helpers, defineModel for custom inputs, controlled vs uncontrolled, field arrays, multi-step wizards. Use this skill to: - Wire vee-validate with a validation schema (zod / yup). - Build custom form components with defineModel (Vue 3.4+). - Implement multi-step forms. - Handle async validation. - Integrate forms with TanStack Query mutations or Pinia actions. Do NOT use this skill for: - General SFC conventions (see vue-conventions). - State management (see vue-state-management). - Routing (see vue-routing). - Testing forms (see vue-testing).

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Form patterns for React: react-hook-form (most common), Formik (legacy/stable), TanStack Form (newer). Validation via zod / yup / valibot. Controlled vs uncontrolled inputs, field arrays, multi-step wizards. Use this skill to: - Wire react-hook-form with a validation schema. - Pick between controlled and uncontrolled patterns. - Build multi-step forms with state preservation. - Handle async validation (e.g., username availability). - Integrate forms with TanStack Query mutations. Do NOT use this skill for: - General state management (see react-state-management). - Routing (see react-routing). - Component conventions (see react-conventions). - Testing forms (see react-testing).

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Data fetching, caching, and revalidation patterns in Next.js App Router. Covers native fetch caching, ISR/SSG/SSR per-route choice, generateStaticParams, unstable_cache, revalidatePath/revalidateTag, Route Handlers, dynamic vs static rendering. Use this skill to: - Pick the right rendering mode (SSG / ISR / SSR / streaming) per route. - Use native fetch caching options correctly. - Build Route Handlers that match REST conventions. - Invalidate cached data after mutations. - Use generateStaticParams for dynamic SSG. Do NOT use this skill for: - RSC vs Client boundaries (see server-component-patterns). - Routing primitives (see nextjs-routing). - General conventions (see nextjs-conventions).

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Hunt reflected, stored, and DOM-based Cross-Site Scripting (XSS) including CSP bypass, polyglot payloads, mutation XSS (mXSS), markdown XSS, and template XSS. Use when the user has identified a parameter or input that reflects to the page, or wants to test for XSS in a specific input.

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Hunt GraphQL-specific vulns — introspection abuse, field-level authorization (IDOR), batched queries for brute force, alias-based rate limit bypass, deep query DoS, mutation injection, schema disclosure, suggestion leakage, CSRF via GET, and CSRF via POST without preflight. Use when a GraphQL endpoint is present.

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Drive a GitHub Copilot (or any bot reviewer) pull-request review to a clean pass without babysitting it: fix each finding in its own commit, reply to the review thread with the fix sha, resolve the thread, re-request the bot, and poll for the async re-review. Covers the thread node-id (PRRT_...) vs comment databaseId distinction, the resolveReviewThread GraphQL mutation, the copilot-pull-request-reviewer[bot] slug, and how to read the bot's verdict (COMMENTED plus a "human review recommended" banner is not a blocking finding). Use when Copilot has left review comments on your PR, when bot review threads must be closed out with an auditable fix-reply-resolve trail before merge, or when you need to verify that a re-review actually landed on the new HEAD rather than the old one.

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Canon TDD for humans and AI agents. Use for production code changes by writing tests first, proving RED, implementing minimal GREEN, and refactoring safely. 2026 edition adds TDP, flakiness gate, ralph-loop integration, memory-search in Step 0, PBT as Step 5.5, mutation testing gate in Step 4, and CJS LSP warning.

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Living catalogue of 7 known hazard entries (SE-01 through SE-07) specific to agent-studio: Windows backslash paths, prototype pollution, hook exit codes, async swallowing, ReDoS in glob-to-regex, DST arithmetic, array mutation during iteration. Each entry: symptom, root cause, fix, test assertion.

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Use when asked to mine prior chats on a scheduled or watcher tick and maintain project memory. Not for remote, credential, publish, deploy, or irreversible mutation.

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Use when the user asks to rank deployment platforms and stacks against their product with quantitative trade-offs. Not for source or remote mutation.

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Use when a scheduled or watcher tick requests a repository-health pass. Not for source, label, merge, or close mutation.

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Post one already selected Proto UI work-item claim as a reversible GitHub metadata mutation. Use after pui-select produced a current proposal and the exact claim has authorization, live permission, current readiness, and an idempotent write boundary. Do not select work, decide readiness, release claims, or widen the authorized wording.

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Release one current Proto UI work-item claim when it expired, became invalid, or the contributor stopped. Use only for the contributor's own recorded claim and only when the exact reversible GitHub mutation is authorized. Do not select replacement work, change readiness, or release another contributor's claim.

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Design and build reactive, type-safe, production-grade backends on Convex. Covers schema, queries/mutations/actions, indexes, auth, file storage, scheduling, real-time multiplayer, mobile backends, and LLM/agent workflows on Convex's one-platform stack.

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RED-GREEN-MUTATE-KILL MUTANTS-REFACTOR workflow for writing production code. Use before ANY production code change - new features, bug fixes, or behavior changes. Triggers on starting implementation work of any kind. Covers the cycle itself - failing test first, minimum code to pass, mutation verification, refactor assessment. For how to write good tests, see testing. For the refactoring step in detail, see refactoring. TDD is non-negotiable.

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Set up or refine open-source .NET code-quality gates for CI: formatting, `.editorconfig`, SDK analyzers, third-party analyzers, coverage, mutation testing, architecture tests, and security scanning. Use when a .NET repo needs an explicit quality stack in `AGENTS.md`, docs, or pipeline YAML.

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Use this skill when applying VCSDD to Rust projects. Provides Kani proof harness patterns, proptest strategies, cargo-fuzz integration, and cargo-mutants mutation testing guidance.

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Use this skill when applying VCSDD to Python projects. Provides hypothesis property testing patterns, mutmut mutation testing, and pytest integration for the VCSDD pipeline.

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Use this skill when applying VCSDD to TypeScript/JavaScript projects. Provides fast-check property testing patterns, Stryker mutation testing, and vitest/jest integration for the VCSDD pipeline.

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Next.js App Router patterns (15-16) - file-based routing, Server/Client Components, streaming, Suspense, metadata API, parallel routes, Server Actions, mutations, revalidation, Cache Components

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URQL GraphQL client patterns — the exchange pipeline, document and normalized caching, queries, mutations, subscriptions, and authentication

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Apollo Client GraphQL patterns — normalized cache and type policies, queries, mutations with optimistic updates, pagination, fragments, subscriptions, and Suspense hooks

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