“stability”的搜索结果

Query the Ensembl REST API for gene/transcript/protein lookup, sequence retrieval, comparative genomics (Compara), variant effect prediction (VEP), regulatory features, and cross-species ortholog/paralog calls. Use when pulling Ensembl-native data (Ensembl Gene IDs, version-pinned releases, archive endpoints for reproducibility), gene/transcript/exon structure with stable IDs, or VEP for variant annotation. Encodes the 15 req/sec rate limit, archive (e110.rest.ensembl.org) for reproducibility, Ensembl divisions (vertebrates / plants / fungi / metazoa / bacteria), and the symbol-vs-ID stability problem.

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Quantify homologous recombination deficiency (HRD) from tumor copy number using the three genomic-scar metrics — loss of heterozygosity (LOH), large-scale state transitions (LST), and telomeric allelic imbalance (TAI) — with scarHRD, and via the whole-genome HRDetect and CHORD models. Covers the genomic instability score, the PARP-inhibitor clinical context, whole-genome-doubling correction, and the scar-versus-state distinction. Use when computing an HRD score for PARP-inhibitor eligibility, deriving LOH/LST/TAI scars from allele-specific copy number, deciding between scar-based and mutational-signature HRD methods, or interpreting an HRD result in a BRCA-reverted or low-purity tumor.

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Calls microsatellite instability from WES/WGS/targeted-panel with MSIsensor, MSIsensor-pro, MSIsensor-ct (panel-aware), MSIngs, MANTIS, MSIPanel, MSIDetect, and ngsMSI for FDA pembrolizumab MSI-H pan-tumor / Lynch syndrome / dMMR ICI biomarker. Use when stratifying ICI eligibility (Le 2015), pairing MSI with TMB-H (Sha 2020 / Salem 2018), screening Lynch syndrome (universal IHC + MSI), or distinguishing MSI-H tumors from POLE-exo hypermutator with overlapping signatures.

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Designs PROTACs, molecular glues, and bivalent degraders with explicit handling of E3 ligase choice (VHL, CRBN, IAP, MDM2, KEAP1), linker design (length, composition, rigidity), ternary complex prediction (PRosettaC, DeepTernary, AlphaFold3 with constraints), cooperativity (alpha), DC50 / Dmax characterization, hook effect, and prediction-experiment reconciliation. Use when designing targeted protein degraders, planning linker SAR, predicting ternary complex stability, or building generative degrader workflows.

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Designs covalent inhibitors and warheads targeting cysteine (most common, 98% of covalent drugs), lysine, serine, threonine, tyrosine, and aspartate residues, with explicit handling of warhead reactivity (acrylamide, chloroacetamide, vinyl sulfone, sulfonyl fluoride, fluorosulfate, aldehyde, boronate, nitrile), reversibility (kinact/Ki, t_residence), glutathione (GSH) stability, intrinsic reactivity assays, and covalent docking (DOCKovalent, GOLD, HCovDock). Use when designing covalent inhibitors for targeted covalent inhibition (TCI), KRAS G12C-style approaches, or rationalizing covalent SAR.

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Expert in ALL computational collage composition: photo mosaics, grid layouts, scrapbook/journal styles, magazine editorial, vision boards, mood boards, social media collages, memory walls, abstract/generative arrangements, and art-historical techniques (Hockney joiners, Dadaist photomontage, Surrealist assemblage, Rauschenberg combines). Masters edge-based assembly, Poisson blending, optimal transport color harmonization, and aesthetic optimization. Activate on 'collage', 'photo mosaic', 'grid layout', 'scrapbook', 'vision board', 'mood board', 'photo wall', 'magazine layout', 'Hockney', 'joiner', 'photomontage'. NOT for simple image editing (use native-app-designer), generating new images (use Stability AI), single photo enhancement (use photo-composition-critic), or basic image similarity search (use clip-aware-embeddings).

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Detects test antipatterns and code smells in PHP test suites. Identifies 15 smells (Logic in Test, Mock Overuse, Fragile Tests, Mystery Guest, etc.) with fix recommendations and refactoring patterns for testability.

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Analyzes coupling and cohesion metrics in PHP codebases. Calculates Afferent/Efferent coupling (Ca/Ce), LCOM metrics, instability index, and abstractness. Identifies highly coupled modules and low cohesion classes.

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Expert security auditor for AI Skills and Bundles. Performs non-intrusive static analysis to identify malicious patterns, data leaks, system stability risks, and obfuscated payloads across Windows, macOS, Linux/Unix, and Mobile (Android/iOS).

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Google SRE (Site Reliability Engineering) practices distilled from the SRE book series and real Google Brain/Meta/ByteDance production experience. Covers SLI/SLO/Error Budget design, incident response, capacity planning, toil automation, monitoring golden signals, and chaos engineering principles. USE WHEN: designing reliability targets, setting up monitoring/alerting, planning capacity, reducing operational load, building incident response runbooks, implementing chaos engineering, defining error budgets, or establishing reliability culture that balances velocity with stability.

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Self-healing stability monitor for AI agents - 5 core checks + 15 extended checks, auto-recovery, health scoring

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Surface architectural friction and propose deepening opportunities that improve testability and AI-navigability. Use when the user wants to improve architecture, find refactoring opportunities, consolidate tightly-coupled modules, or make a codebase easier for agents to navigate.

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Complete guide for .NET Aspire Testing integration testing framework. Use when testing .NET Aspire distributed applications, configuring AppHost tests, or migrating from Testcontainers to Aspire testing. Covers DistributedApplicationTestingBuilder, container lifecycle management, multi-service orchestration, Respawn configuration, and time testability design. Keywords: aspire testing, .NET Aspire, DistributedApplicationTestingBuilder, AppHost testing, distributed testing, AspireAppFixture, IAsyncLifetime, ContainerLifetime.Session, cloud-native testing, multi-service integration, Aspire.Hosting.Testing, Respawn

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Generate or materially revise a repository-local test plan, QA plan, acceptance matrix, or regression checklist on explicit request or when one concrete testability gap blocks formal DEFINE; do not trigger for ordinary implementation, test execution, TDD, review, or completion claims.

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Refactors route handlers into service layer with clean boundaries, dependency injection, testability, and separation of concerns. Provides service interfaces, folder structure, testing strategy, and migration plan. Use when refactoring "fat controllers", "business logic", "service layer", or "architecture cleanup".

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Compares old vs new prompts across test cases with diff summaries, stability metrics, breakage analysis, and fix suggestions. Use for "prompt testing", "A/B testing prompts", "prompt versioning", or "quality regression".

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Diagnoses and fixes flaky tests by identifying root causes (timing issues, shared state, randomness, network dependencies) and provides stabilization strategies. Use for "flaky tests", "test stability", "intermittent failures", or "test debugging".

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