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Use when writing Python tests with pytest - fixtures, parametrization, markers, conftest layout, pytest-asyncio, pytest-django, coverage with pytest-cov, mocking with pytest-mock, parallel runs with xdist, mutation testing with mutmut, or CI integration
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Use when testing Django applications with pytest - TDD workflow, pytest-django setup, factory_boy and model-bakery fixtures, DRF API testing, mocking and patching, integration tests, mutation testing with mutmut, or coverage
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Use when testing APIs and web frameworks for mass assignment vulnerabilities where user-controlled request body fields are bound directly to model attributes without a field allowlist. Trigger on: ORM update/create endpoints, REST APIs accepting JSON body, Rails strong parameters, Django model forms, Laravel fillable/guarded, Node.js Mongoose/Sequelize, PUT/PATCH requests, registration endpoints, profile update endpoints, GraphQL mutations. Detects privilege escalation via role/admin/isAdmin fields, plan upgrades via subscription fields, and horizontal access via ownerId/userId injection.
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Exploit exposed GraphQL introspection endpoints to map the entire API schema. This skill details how to extract available queries, mutations, types, and fields, which significantly aids in identifying hidden endpoints, Broken Object Level Authorization (BOLA/IDOR), and mass assignment vulnerabilities.
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Discovery-only Gaia curation for one manually selected source page. Fetches and normalizes up to five real SKILL.md candidates, deduplicates and maps them for human L4 review, then stops without evidence scoring or registry mutation.
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Discovery-only global trending extension for Gaia. Snapshots configured external skill sources, prioritizes five-candidate pages for L4 review, and stops before trust, evidence, intake, or registry mutation.
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Curate Gaia bot crawler branches into real-skill catalog entries and clean up processed bot/* branches. Use when the user says: "process bot branches", "curate the crawl output", "clean up bot proposals", "run bot curation", "merge the crawler results", "review bot/* branches", "ingest crawler data", or explicitly types /gaia-bot-curate. Also triggers when the user asks to review pending `bot/*` branches, turn crawler JSON proposals into registry nodes, decide which crawled skills to accept vs reject, or batch-add skills from an automated crawl run. This skill handles the full pipeline: fetch remote bot branches, triage proposals, run `gaia dev` mutations, validate, open a PR, and delete consumed bot branches.
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Search, inspect, plan, apply, remove, pack, and scaffold local Pulp package manifests. Use for Pulp-native source/UI/template kits and for untrusted or semi-trusted manifest-bearing artifacts that must be reviewed before project mutation.
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Use when the user asks to query Volcengine CloudTrail audit logs, investigate login or resource operations, or manage CloudTrail trails and backfill delivery tasks. Trigger on 操作审计, 审计日志, CloudTrail, cloud_trail, trail, 跟踪, 历史补投, or backfill in a Volcengine context. Audit queries are read-only; trail and backfill mutations require an explicit preview and confirmation.
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用于实现或审查前端服务端状态流程：类型化查询、请求缓存、失效、mutation、乐观更新、无限查询、预取、SSR hydration 或 API 层整合。不要用于本地 UI 状态或 Service Worker 缓存；中文触发词包括 数据获取、缓存、乐观更新。
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Use when implementing or reviewing frontend server-state flows: typed queries, request caching, invalidation, mutations, optimistic updates, infinite queries, prefetch, SSR hydration, or API-layer integration. Do not use for local UI state or Service Worker caching; Chinese triggers include data fetch, cache, optimistic updates.
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Inspect Caveman Cloud's eval-gated experiment lifecycle and block unsafe execution. Use when the user asks to start, approve, cancel, promote, or roll back a Caveman experiment, or asks what action an experiment's evidence supports. Read evidence first; do not execute lifecycle mutations until server-authoritative transition and evidence gates ship.
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Deep codebase exploration, architectural research, and solution discovery. Use when investigating problems, understanding complex flows, or evaluating technical approaches without jumping straight into code mutation or TDD.
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Detect and use the official Obsidian command-line interface for read-only vault access; use for wiki-cli, Obsidian CLI, Obsidian read, Obsidian search, vault transport, which transport, transport detection, backlinks, tags, or Obsidian command line. Mutations always go through the claude-obsidian transaction core.
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Set up a paid-media client, account, data-source, privacy, and mutation-guardrail profile for Claude Ads. Use for onboarding, initial configuration, API tokens or credential profiles, environment-variable or keychain setup, connecting exports or read adapters, safe native or verified-local installation, curl-pipe-bash install requests, declaring KPIs, or preparing a new advertising project.
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Turn a one-line objective into a step-by-step construction plan for multi-session, multi-agent engineering projects. Each step has a self-contained context brief so a fresh agent can execute it cold. Includes adversarial review gate, dependency graph, parallel step detection, anti-pattern catalog, and plan mutation protocol. TRIGGER when: user requests a plan, blueprint, or roadmap for a complex multi-PR task, or describes work that needs multiple sessions. DO NOT TRIGGER when: task is completable in a single PR or fewer than 3 tool calls, or user says "just do it".
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TanStack Query (React Query) best practices for data fetching, caching, mutations, and server state management. Activate when building data-driven React applications with server state.
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Implement randomization methods for RCTs. Use when user mentions: random assignment, treatment allocation, stratification, blocking, permutation randomization, cluster randomization, randomization balance, misfit handling, re-randomization.
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Assigns pathogen lineages (SARS-CoV-2 Pangolin UShER mode; Nextclade clade + QC; pango-designation alias resolution) and tracks variant frequencies over time using Nextstrain (Augur + Auspice), wastewater deconvolution (Freyja, COJAC, alcov, lineagespot), lineage-fitness modelling (multinomial logistic), and recombinant detection (3SEQ, RDP4, Bolotie). Covers Pangolin pangolin-data and Nextclade dataset version pinning (mandatory; lineage-defining mutations change with dataset), Freyja barcode forward-only date constraint, ARTIC primer scheme churn (V3/V4/V4.1/V5.3.2/Midnight) with dropout regions, and recombinant X-prefix designation lag. Use when assigning Pango lineages and Nextclade clades to viral consensus sequences, building Nextstrain Augur surveillance pipelines, deconvolving wastewater into lineage frequencies with Freyja, tracking lineage frequencies over time, handling ARTIC primer dropouts, or running surveillance for SARS-CoV-2/influenza/Mpox/RSV/H5N1/measles.
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Analyzes single-cell pooled CRISPR screens (Perturb-seq, CROP-seq, Perturb-CITE-seq, ECCITE-seq, multiome) where each cell carries an sgRNA and a scRNA-seq / surface-protein / chromatin readout. Covers experimental design (direct-capture Perturb-seq Dixit 2016 vs CROP-seq 3'UTR-barcoded Datlinger 2017 vs ECCITE-seq vs Multiome), MOI for sgRNA assignment, escaper-cell filtering (Mixscape, Papalexi 2021), SCEPTRE NB GLM + permutation for low-MOI (Barry 2024 Genome Biol 25:124), the Pertpy framework, factor decomposition, genome-scale Perturb-seq (Replogle 2022 Cell, 2.5M cells), and per-perturbation single-cell DE. Use when running a single-cell CRISPR screen, choosing direct-capture vs CROP-seq architecture, filtering escaper cells, performing single-cell DE, integrating Perturb-seq with pathway analysis, scaling to GW CRISPRi via Replogle protocol, or analyzing multi-omics screens.
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Build whole-genome alignments using Progressive Cactus (Armstrong 2020 reference-free clade-level WGA), Minigraph-Cactus (Hickey 2024 pangenome-aware), LASTZ chain/net (UCSC pipeline), MUMmer4 (Marçais 2018 pairwise), minimap2 -x asm5/10/20 (Li 2018 fast pairwise), AnchorWave (Song 2022 WGD-aware), and Mauve / progressiveMauve (bacterial). Operates the HAL toolkit (Hickey 2013) for downstream extraction including halSynteny, halLiftover, halBranchMutations, and hal2maf. Use when constructing multi-species alignments for comparative-annotation projection (TOGA), synteny detection, conservation analyses (phyloP / PhastCons), or pangenome graph construction; selecting between reference-free (Cactus) and reference-anchored (LASTZ chains/nets) approaches; tuning sensitivity for closely vs distantly related genomes; or producing HAL files for genome-wide downstream tools.
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Detect single-nucleotide crosslink (CL) sites in CLIP-seq data using truncation patterns (iCLIP/eCLIP CITS), crosslink-induced mutations (HITS-CLIP CIMS deletions, PAR-CLIP T-to-C), or HMM/kernel-density methods (PureCLIP, PARalyzer, CTK). Use when single-nucleotide resolution is required for motif registration (mCross), allele-specific binding (BEAPR), variant-effect prediction, or comparing crosslink chemistry across CLIP variants.
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Quantify homologous recombination deficiency (HRD) from tumor copy number using the three genomic-scar metrics — loss of heterozygosity (LOH), large-scale state transitions (LST), and telomeric allelic imbalance (TAI) — with scarHRD, and via the whole-genome HRDetect and CHORD models. Covers the genomic instability score, the PARP-inhibitor clinical context, whole-genome-doubling correction, and the scar-versus-state distinction. Use when computing an HRD score for PARP-inhibitor eligibility, deriving LOH/LST/TAI scars from allele-specific copy number, deciding between scar-based and mutational-signature HRD methods, or interpreting an HRD result in a BRCA-reverted or low-purity tumor.
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Resolve subclonal copy number, whole-genome doubling, and copy-number tumor evolution from bulk sequencing with Battenberg, TITAN, and MEDICC2. Covers clonal versus subclonal copy-number states, haplotype phasing for subclonal resolution, cancer cell fraction, whole-genome-doubling detection and timing relative to mutations, mirrored subclonal allelic imbalance, and copy-number phylogenies. Use when a tumor is heterogeneous and bulk data shows non-integer copy number, when calling subclonal CNAs, detecting or timing whole-genome doubling, reconstructing copy-number evolution, or deciding between Battenberg and TITAN.
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