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Calls HLA class I and class II alleles at 2/4/6/8-field resolution from WGS/WES/RNA-seq/long-read data using OptiType, HLA-LA, T1K, Polysolver, HLA-HD, arcasHLA, StarPhase, or HIBAG imputation. Use when typing for HSCT, solid-organ transplant, neoantigen prediction, PGx screening (B*57:01, B*15:02, etc.), or disease-association studies, with reconciliation across tools and IPD-IMGT/HLA version mismatch handling.
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Map N6-methyladenosine (m6A) RNA modifications at single-nucleotide resolution using miCLIP (Linder 2015), miCLIP2 + m6Aboost machine learning (Kortel 2021), GLORI (Liu 2023, antibody-free chemical conversion), DART-seq (Meyer 2019, APOBEC1-YTH fusion), m6Anet (nanopore direct RNA), or MeRIP-seq with calibration. Use when distinguishing antibody-based from antibody-free m6A detection methods, applying the DRACH motif constraint, reconciling cross-method disagreements (DART 44% in DRACH vs GLORI), or detecting m6Am at the cap.
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Detect syntenic blocks and structural rearrangements between genomes using MCScanX (Wang 2012), JCVI/MCScan (Tang 2008 Python), GENESPACE (Lovell 2022) for orthology-anchored riparian visualization, SyRI for structural variation, AnchorWave for sequence-level synteny, i-ADHoRe 3.0 for highly diverged species, SynNet for synteny networks, and ntSynt for multi-genome macrosynteny. Use when identifying collinear gene blocks across species, distinguishing macrosynteny from microsynteny, detecting inversions/translocations/duplications, anchoring orthology in WGD lineages, producing publication riparian plots, computing synteny block age via Ks (cross-references whole-genome-duplication), or running synteny-aware ortholog inference in polyploids.
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The CI cost rules ($100/week of real money, all CI). Use when editing .github/workflows, adding a schedule or cron, dispatching a workflow, publishing a package version, hitting a billing block, or seeing a CI SPEND OFF TRACK line, ci-breaker issue or spend alert.
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Use when generating REST controllers, response wrappers, DTOs, error handlers, or any HTTP-facing code. Defines response envelope, HTTP status mapping, pagination, and versioning.
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Use when creating database migrations, schema changes, seed data, or any SQL that modifies database structure. Covers Flyway naming conventions, versioning, and safe migration patterns.
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Azure API Center SDK for .NET. Centralized API inventory management with governance, versioning, and discovery.
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API design principles and decision-making. REST vs GraphQL vs tRPC selection, response formats, versioning, pagination.
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Master AngularJS to Angular migration, including hybrid apps, component conversion, dependency injection changes, and routing migration.
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Migration guide for Swift and iOS. Use when migrating ObservableObject to @Observable (iOS 17), enabling Swift 6/6.2 Strict Concurrency, fixing @MainActor/Sendable warnings, adopting Approachable Concurrency (Swift 6.2), or handling iPadOS 26 windowing system changes (UIRequiresFullScreen deprecation). Covers breaking changes and version upgrade tasks.
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SwiftUI UI component catalog. Use when implementing NavigationStack, Swift Charts, PhotosPicker, TipKit, ScrollView enhancements, animations, layouts, WebView, Liquid Glass and other UI components. Organized by feature category with OS version compatibility info. Reference for discovering available components and implementation patterns.
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Restore a thesis, sector, or macro note from a snapshot in _Archive/Snapshots/. Use when user says "rollback", "restore", "revert", "undo sync", or "go back to the previous version".
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Generate a concise 1-page investment brief from a thesis — the elevator pitch version. Use when user says "brief", "summarise thesis", "pitch me [TICKER]", "one-pager", or "investment memo".
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Download NASA GES DISC NLDAS_FORA0125_H version 2.0 primary hourly forcing data for a point location. Use when Codex needs to retrieve NLDAS File A meteorological forcing from the GES DISC API or HTTPS archive for a longitude/latitude pair, including Earthdata username/password authentication, hourly URL generation, nearest-grid-point extraction, CSV output, or EcoSIM climate-forcing preprocessing.
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Production pipeline for ASCII art video — any format. Converts video/audio/images/generative input into colored ASCII character video output (MP4, GIF, image sequence). Covers: video-to-ASCII conversion, audio-reactive music visualizers, generative ASCII art animations, hybrid video+audio reactive, text/lyrics overlays, real-time terminal rendering. Use when users request: ASCII video, text art video, terminal-style video, character art animation, retro text visualization, audio visualizer in ASCII, converting video to ASCII art, matrix-style effects, or any animated ASCII output.
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Set up a modded Minecraft server from a CurseForge/Modrinth server pack zip. Covers NeoForge/Forge install, Java version, JVM tuning, firewall, LAN config, backups, and launch scripts.
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Verify a released archon binary works end-to-end via a specific install path. Use when: cutting a new release, reproducing a user bug report on the released version, or validating that a hotfix binary actually works after a re-tag. Triggers: "test the release", "test 0.3.1 via brew", "verify the curl install", "smoke test the binary", "did the release binary work", "run /test-release", "verify the release". NOT for: testing dev work (use bun link directly), testing unreleased changes (build locally via scripts/build-binaries.sh first), or running the full validate suite (bun run validate is separate).
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Create a release from dev branch. Generates changelog entries from commits, bumps version, and creates a PR to main. TRIGGERS - Use this skill when user says: - "/release" - create a patch release (default) - "/release minor" - create a minor release - "/release major" - create a major release - "make a release", "cut a release", "ship it", "release to main"
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Comprehensive GitHub release orchestration with AI swarm coordination for automated versioning, testing, deployment, and rollback management
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Quantum-resistant, self-learning version control for AI agents with ReasoningBank intelligence and multi-agent coordination
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Conversion-focused design that removes friction and guides users toward action through clarity, trust, and speed.
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Step through versioning, tagging, and verification
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Review or refactor an existing SKILL.md and its bundled resources — a smaller always-loaded core, conditional references, preserved behavior, lean/guided consumer profiles, and an A/B protocol to compare a candidate with the previous version. Use when a skill repeats itself, loads references on every run, triggers too broadly or misses legitimate requests, or needs its efficiency measured across models. Do NOT use for writing a new skill from scratch, refactoring application code, translating a skill verbatim, or performing the target skill's own task.
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Use when the user wants to change an existing PRD — 'refinar o PRD', 'adicionar requisito', 'atualizar escopo do PRD', 'update the PRD' — through targeted questions, bumping the version and re-opening approval. Do NOT use to create a PRD (prd-create).
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