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Tests associations between categorical variables in clinical data using chi-square, Fisher's exact, Boschloo, Cochran-Mantel-Haenszel, and modern McNemar variants with calibrated confidence intervals (Wilson, Newcombe, Miettinen-Nurminen). Use when analyzing categorical outcomes, paired binary endpoints, or testing treatment-outcome independence in confirmatory or exploratory clinical trials.
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Implements multiplicity control for confirmatory clinical trials using graphical procedures (Bretz-Maurer-Hommel), gatekeeping (parallel, serial, mixed), Hochberg/Hommel/Holm with PRDS, and the closed-testing principle (Marcus-Peritz-Gabriel; Goeman 2021 admissibility). Covers FDA Multiple Endpoints Final Guidance (October 2022), graphical procedures via R gMCP, primary + key-secondary + subgroup hierarchies, and FWER vs FDR distinction. Use when designing the multiplicity strategy for confirmatory trials with multiple primary or key secondary endpoints.
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Decompose total effects into direct and indirect paths through mediators using mediation, CMAverse 4-way, HIMA/HIMA2 high-dimensional, BAMA, two-step / MVMR mediation, or double-ML medDML. Use when testing whether a molecular phenotype (expression, methylation, protein) mediates a treatment-outcome relationship, decomposing exposure-mediator interaction via VanderWeele 4-way, screening high-dimensional EWAS mediators, or running MR-based mediation when sequential ignorability is implausible.
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Estimate causal effects of an exposure on an outcome from GWAS summary statistics using genetic instruments. Implements IVW (fixed/random), MR-Egger, weighted median/mode, MR-RAPS, CAUSE, GSMR-HEIDI, MR-PRESSO, MVMR, MR-Clust, LCV, and LHC-MR via TwoSampleMR, MendelianRandomization, MR-PRESSO, cause, and lhcMR. Use when testing causal direction between traits, evaluating drug-target effects via cis-pQTL/cis-eQTL, performing multivariable mediation MR, distinguishing causation from correlated horizontal pleiotropy, or producing STROBE-MR-compliant sensitivity batteries.
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Use when a driver has been involved in a crash — regardless of preventability or injury — and the carrier needs to handle the immediate, post-investigation, and return-to-work phases. Covers trauma response, post-accident testing under 49 CFR 382.303, paid time off, retraining, light duty, and re-entry planning.
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Use this skill when selecting a Consortium/Third-Party Administrator (C/TPA) for drug + alcohol testing program management. Covers what services they provide, what to look for, and red flags.
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Use this skill when selecting an MRO for drug testing program oversight. Covers MRO qualifications under Part 40, what the MRO does, and how to evaluate MRO services.
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Use this skill when the user asks about onboarding a new CDL driver — pre-hire process, day-zero requirements, application + DQF setup, road test, drug & alcohol pre-employment, Clearinghouse Full query, MVR initial pull, PSP report, ELDT verification, sequence of activities + timing, and what NOT to do (handing keys before testing complete). Cite 49 CFR 391, 382.
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Use this skill when hiring a driver who has a recent valid pre-employment test from a prior employer. Covers the conditions under § 382.301(c) that allow accepting it instead of testing again.
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Use this skill when an owner-operator (single CDL driver, single operating authority) needs to comply with random testing. Covers consortium membership, pool size requirements, and self-employed driver rules.
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Use this skill when referring a driver to SAP after a positive test or refusal. Covers SAP selection, the evaluation/treatment cycle, return-to-duty test, and follow-up testing schedule.
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Use this skill when the user asks about accident registers, DOT-recordable accident definitions, what counts as a "reportable accident" under 49 CFR 390.5 + 390.15, accident register retention, post-accident testing trigger logic, FMCSA accident reporting (no longer required to FMCSA directly for non-fatal accidents), insurance reporting timelines, and what to do after a CMV crash. Cite 49 CFR 390.5 + 390.15.
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Refute-before-prove research discipline: automated counterexample sweeps before any formalization, meter-integrity audits for information-bound experiments, mutation-tested model checkers, pre-registered commit-or-cut gates for speculative directions, wrong-turn reporting, and numeric-claim provenance. Use when validating any new theorem, bound, equilibrium, or security claim; when building or trusting a checker, simulator, or experiment; or when deciding whether a speculative research direction lives or dies. NOT for exploratory brainstorming, product prioritization, writing style, or literature review.
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Create and review Cloudflare Durable Objects. Use when building stateful coordination (chat rooms, multiplayer games, booking systems), implementing RPC methods, SQLite storage, alarms, WebSockets, or reviewing DO code for best practices. Covers Workers integration, wrangler config, and testing with Vitest. Biases towards retrieval from Cloudflare docs over pre-trained knowledge.
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Rigorous benchmarking of multi-agent coordination systems: experiment design, statistical analysis, human evaluation protocols, and reproducible reporting. NOT FOR ML model evaluation (use llm-evaluation-harness), A/B testing for web products, survey design, or general data science.
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dbt Core/Cloud data transformations, testing, documentation, and CI/CD. Activate on: dbt, data transformation, analytics engineering, ref, source, staging model, mart, dbt test. NOT for: orchestration/scheduling (use airflow-dag-orchestrator), data warehouse tuning (use data-warehouse-optimizer).
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Expert in developer tool documentation as a product. Activate on: docs site, getting started guide, API reference, developer documentation, Docusaurus, Mintlify, Nextra, ReadMe, migration guide, troubleshooting page, docs information architecture, documentation testing, llms.txt. NOT for: marketing copy (use seo-content-blogging), API design itself (use api-architect), general technical writing (use technical-writer).
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Great Expectations, dbt tests, anomaly detection, and data contracts for data quality. Activate on: data quality, data validation, Great Expectations, data contract, anomaly detection, SLA, freshness check, schema validation. NOT for: dbt model structure (use dbt-analytics-engineer), schema evolution (use schema-evolution-manager).
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Design modern, intuitive DAG/workflow visual editors that feel like LEGO, not LabView NOT for runtime DAG admission, graph execution, or claiming usability without user testing.
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App Store and Google Play submission automator with Fastlane, screenshot automation, metadata management, and TestFlight/internal testing. Activate on: app store submission, Fastlane, TestFlight, Google Play Console, screenshot automation, metadata management, app review, code signing, provisioning profiles. NOT for: CI/CD pipeline setup (use github-actions-pipeline-builder), app architecture (use react-native-architect), analytics (use mobile-analytics-crash-reporting-expert).
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Generates OpenAPI 3.0/3.1 specs, TypeScript client types, and curl examples from existing route handler code. Supports Express, Next.js API routes, Fastify, and Hono. Produces complete documentation including auth requirements, rate limits, error codes, and request/response examples. Activate on: 'generate API docs', 'OpenAPI from code', 'document endpoints', 'API reference', 'swagger generation', 'endpoint documentation'. NOT for: API design from scratch (use api-architect), deployment (use devops-automator), testing (use test-automation-expert).
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Implement WCAG 2.2 AA/AAA compliance with automated testing, keyboard navigation, screen reader support, and focus management. Activate on: accessibility audit, WCAG compliance, keyboard navigation, screen reader, aria attributes, axe-core, focus trap. NOT for: design-level accessibility review (use design-accessibility-auditor), color contrast only (use css-in-js-architect).
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Analyze a Coval accent testing report from runs across different speaker accents. Use when a user provides a Coval report URL, report export, run IDs, screenshots, or metric summary and wants evidence-backed next steps such as prompt changes, STT/confirmation adjustments, accent-robust routing, or expanded accent coverage.
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Analyze a Coval audio-quality testing report from runs across different voice, speaking-style, volume, interruption, and background-noise scenarios. Use when a user provides a Coval report URL, report export, run IDs, screenshots, or metric summary and wants evidence-backed next steps such as prompt changes, tool handling fixes, STT/TTS adjustments, trace setup, or expanded audio-scenario coverage.
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