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Analyzes documents and processes against FINRA, SEC, Federal Reserve, and CFPB regulatory frameworks. Identifies compliance gaps, classifies findings by severity, and recommends remediation. Use when performing compliance audits, regulatory reviews, gap analyses, or verifying policy adherence to financial regulations.
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Use when analyzing transcription factor (TF) regulatory networks using Dorothea database. Input gene list, identify regulating transcription factors, generate TF-Target network visualization. For: transcription factor enrichment analysis, gene regulatory network research.
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Build enhancer-driven gene regulatory networks (eGRNs) by integrating single-cell RNA-seq and ATAC-seq using SCENIC+, CellOracle base GRNs, Pando, FigR, DIRECT-NET, TRIPOD, and scMEGA. Covers the accessibility-defines-enhancers principle, peak-to-gene linking and its cell-composition confound, the paired-vs-unpaired decision, and TF-region-gene eRegulon triplets. Use when analyzing 10x multiome or paired/unpaired scRNA+scATAC to infer cis-regulatory GRNs. For RNA-only regulons see scenic-regulons; for in silico TF perturbation see perturbation-simulation.
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Infer gene regulatory networks from bulk or general expression data with mutual-information (ARACNe) and tree-ensemble (GENIE3, GRNBoost2) methods, and infer transcription-factor protein activity from regulons with VIPER and msVIPER. Covers the activity-not-edges paradigm, the undirected-association caveat, the DREAM5 wisdom-of-crowds and method-complementarity result, AUPRC-over-AUROC evaluation, and gold-standard incompleteness. Use when inferring a regulatory network from a bulk expression matrix, finding master regulators, or scoring TF activity from a signature. For single-cell motif-pruned regulons see scenic-regulons; for co-expression modules see coexpression-networks.
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Annotates ChIP-seq peaks to genomic features, nearest genes, ENCODE candidate cis-regulatory elements (cCREs), and regulatory domains. Uses ChIPseeker (R), HOMER annotatePeaks.pl (CLI), pyranges (Python), GREAT/rGREAT (regulatory domain gene-set enrichment), ChIP-Enrich (locus-length-adjusted), ENCODE SCREEN cCRE classification (PLS/pELS/dELS/CA-CTCF/CA-H3K4me3), and ENCODE-rE2G for cell-type-specific enhancer-gene linking. Handles nearest-TSS vs host-gene ambiguity, promoter window definition, and feature priority. Use when assigning genomic context to peaks, linking enhancer peaks to target genes, classifying peaks against ENCODE cCRE registry, or running gene-set enrichment on peak-associated genes.
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Infer cis-regulatory connections (peak-to-peak co-accessibility) from scATAC-seq using Cicero, ArchR getCoAccessibility, or SCENIC+. Use when linking enhancer accessibility to promoter accessibility, identifying enhancer-gene pairs from chromatin alone (without paired RNA), running gene-regulatory inference combining ATAC + RNA, or comparing predicted regulatory contacts against Hi-C/Micro-C ground truth.
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Legal leadership advisor on legal strategy, risk, contract governance, and regulatory tracking. Use when defining a legal strategy, scoring legal risk, auditing the contract portfolio, or building a regulatory calendar.
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Generates standalone interactive HTML "deal cards" that translate complex regulations into negotiation-ready reference tools, systematically distinguishing mandatory obligations from negotiable implementation choices. Use when the user needs an interactive regulatory guide for (1) contract negotiation support, (2) client education or internal training, (3) regulatory briefings for commercial stakeholders, or (4) structured comparison between required and flexible compliance paths. Primary focus on EU digital regulation (Data Act, AI Act, CRA, DORA, NIS2, GDPR) but the structural pattern transfers to any regulation where separating hard obligations from implementation choice is the point. Supports bilingual output where the jurisdiction calls for it.
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Use when an application or system — including one built quickly with AI coding agents — needs a security review with regulatory grounding: a STRIDE threat model, a LINDDUN privacy threat model, a dependency exposure screen against live CVE / CISA-KEV / EPSS data, or a selected, non-exhaustive screen of which EU security obligations (GDPR, NIS2, Cyber Resilience Act, AI Act) may apply and which need determination. Orchestrates the server-enforced threat-modeling workflows of the Ansvar Gateway MCP connector and grounds every regulatory statement in officially published text fetched at answer time — scope, role, and application-date limits stated, never a compliance verdict. Never simulates a workflow and never answers legal questions from model memory.
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An end-to-end method for drafting and finalising a complex, multi-pillar regulated fintech agreement — from intake to signature. Authored from a senior fintech lawyer's manual: a licensed payment-services provider engaging a counterparty across agent cash-in/cash-out, QR payments, wallet e-payments, and a marketplace, each with its own regulatory profile. Runs five phases and fourteen steps: regulatory mapping (activity-to-licence matrix, grey-zone classification gates), architecture (framework-plus-sub-agreement structure, ring-fenced marketplace), the regulatory–commercial balance (what flexes vs what cannot), core drafting (authority, float mechanics, hard-coded regulator caps, liability — all tracking control), execution-blocker triage, and a pre-signature check closing open blockers as conditions precedent. It refuses to invent licence-specific values or draft a representation as true without executed evidence. Use it to structure, draft, negotiate, or review any regulated payments contract.
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Analyzes how multiple regulations interact for a specific product, service, or business model. Identifies where obligations overlap, reinforce, complement, duplicate, or conflict; builds a priority matrix; produces an integrated compliance timeline; and estimates the total compliance burden. Use when (1) scoping a new product or service against the full regulatory landscape before launch, (2) conducting M&A due diligence on a target's multi-regulation exposure, (3) building a strategic compliance roadmap where single-regulation analyses miss the interactions, (4) advising on complex situations where regulations touch the same conduct from different angles, or (5) estimating budget and resourcing for multi-regulation compliance. Primary coverage of EU digital regulation (GDPR, Data Act, AI Act, CRA, NIS2, DORA, DMA, DSA, ePrivacy) and national implementations; the framework extends to any jurisdiction where overlapping regulatory regimes apply to the same activity.
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Query RegulomeDB v2 GET REST API to score variants for regulatory function and retrieve overlapping evidence (TF binding, histone marks, DNase peaks, footprints, motifs, eQTLs, chromatin state). Scores range 1a (strongest) to 7 (none). Use for GWAS hit prioritization, regulatory variant annotation, cis-regulatory discovery. Use clinvar-database for pathogenicity; gwas-database for trait associations.
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ENCODE Portal REST API for regulatory genomics: TF ChIP-seq, ATAC-seq/DNase-seq peaks, histone marks, and RNA-seq across 1000+ cell types. Search experiments by assay/biosample/target; download BED/bigWig; retrieve SCREEN cCREs by region or gene. Use to annotate variants with regulatory tracks, find open chromatin in a cell type, or fetch peak files for ChIP/ATAC analysis. For regulatory variant scoring use regulomedb-database; for GWAS associations use gwas-database.
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Guides privacy law change monitoring and impact assessment for multi-jurisdiction organisations. Covers regulatory tracking sources, change classification, impact scoring methodology, and implementation prioritisation. Keywords: law monitoring, regulatory tracking, change management, impact assessment, implementation priority.
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Guides continuous privacy compliance monitoring implementation including automated control testing, evidence collection automation, real-time compliance dashboards, alert-based remediation workflows, regulatory change integration, and deviation management. Covers GRC platform configuration, control framework mapping, and compliance-as-code approaches. Keywords: continuous compliance, automated monitoring, evidence collection, dashboard, regulatory change, compliance-as-code.
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Compare gene regulatory and co-expression networks between biological conditions to identify rewired regulatory relationships using DiffCorr. Detects gained, lost, and reversed gene-gene correlations between conditions. Use when comparing co-expression networks between disease vs control, treatment conditions, or developmental stages.
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Infer cis-regulatory connections (peak-to-peak co-accessibility) from scATAC-seq using Cicero, ArchR getCoAccessibility, or SCENIC+. Use when linking enhancer accessibility to promoter accessibility, identifying enhancer-gene pairs from chromatin alone (without paired RNA), running gene-regulatory inference combining ATAC + RNA, or comparing predicted regulatory contacts against Hi-C/Micro-C ground truth.
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中医诊疗 — 中医临床医师的认知操作系统 (经典理论 阴阳五行脏腑气血经络六经卫气营血三焦 + 四诊八纲 + 治法 + 方剂学 经方时方 + 中药学 四气五味归经炮制 + 针灸学 经络穴位手法灸法 + 推拿按摩 + 中医各科 内外妇儿骨伤皮肤眼耳鼻喉肛肠老年急症 + 中西医结合 + 循证中医 + NATCM 监管 + 中医诊所备案 + 国家级名老中医 学术继承人 — 不含 道家修炼 / 风水算命 / 中医养生科普 / 中医美容 / 民族医学藏蒙维傣) (Traditional Chinese Medicine (TCM) clinical practice — the cognitive operating system of practicing TCM physicians covering (a) 经典理论 (阴阳/五行/脏腑/气血津液/经络/六淫/七情/六经/卫气营血/三焦) classical theory, (b) 四诊 (望闻问切) clinical observation/inquiry/pulse + 八纲 (阴阳/表里/寒热/虚实) syndrome differentiation, (c) 治法 (汗吐下和温清消补 + 扶正祛邪) therapeutic principles, (d) 方剂学 (经方 时方 验方) formula science, (e) 中药学 (四气五味/归经/七情/炮制/配伍禁忌) materia medica, (f) 针灸学 (经络穴位/手法/灸法/电针) acupuncture+moxibustion, (g) 推拿按摩 tuina massage, (h) 中医各科 (内/外/妇/儿/骨伤/皮肤/眼/耳鼻喉/肛肠/老年/急症) clinical specialties, (i) 中西医结合 integrative medicine, (j) 循证中医 + 临床流行病学 evidence-based TCM + 现代研究, (k) 中医诊所备案 / 中医师资格 / NATCM 监管 / 药典 / GMP regulatory framework, (l) 国家级名老中医 学术继承人 项目 transmission program; NOT 道家修炼 / 风水 / 算命八字 (那是 玄学不是 中医), NOT 中医养生科普 (是 衍生 不是 临床主体), NOT 中医美容 (是 商业化分支), NOT 民族医学 (藏蒙维傣 是 平行体系 不在本 skill 主线 — 仅作 边界标注).) Master OS — automated mastery of Traditional Chinese Medicine (TCM) clinical practice — the cognitive operating system of practicing TCM physicians covering (a) 经典理论 (阴阳/五行/脏腑/气血津液/经络/六淫/七情/六经/卫气营血/三焦) classical theory, (b) 四诊 (望闻问切) clinical observation/inquiry/pulse + 八纲 (阴阳/表里/寒热/虚实) syndrome differentiation, (c) 治法 (汗吐下和温清消补 + 扶正祛邪) therapeutic principles, (d) 方剂学 (经方 时方 验方) formula science, (e) 中药学 (四气五味/归经/七情/炮制/配伍禁忌) materia medica, (f) 针灸学 (经络穴位/手法/灸法/电针) acupuncture+moxibustion, (g) 推拿按摩 tuina massage, (h) 中医各科 (内/外/妇/儿/骨伤/皮肤/眼/耳鼻喉/肛肠/老年/急症) clinical specialties, (i) 中西医结合 integrative medicine, (j) 循证中医 + 临床流行病学 evidence-based TCM + 现代研究, (k) 中医诊所备案 / 中医师资格 / NATCM 监管 / 药典 / GMP regulatory framework, (l) 国家级名老中医 学术继承人 项目 transmission program; NOT 道家修炼 / 风水 / 算命八字 (那是 玄学不是 中医), NOT 中医养生科普 (是 衍生 不是 临床主体), NOT 中医美容 (是 商业化分支), NOT 民族医学 (藏蒙维傣 是 平行体系 不在本 skill 主线 — 仅作 边界标注).: top builders' mental models, tool stack, current workflows, jargon, and where to keep up. Trigger this skill when the user works on Traditional Chinese Medicine (TCM) clinical practice — the cognitive operating system of practicing TCM physicians covering (a) 经典理论 (阴阳/五行/脏腑/气血津液/经络/六淫/七情/六经/卫气营血/三焦) classical theory, (b) 四诊 (望闻问切) clinical observation/inquiry/pulse + 八纲 (阴阳/表里/寒热/虚实) syndrome differentiation, (c) 治法 (汗吐下和温清消补 + 扶正祛邪) therapeutic principles, (d) 方剂学 (经方 时方 验方) formula science, (e) 中药学 (四气五味/归经/七情/炮制/配伍禁忌) materia medica, (f) 针灸学 (经络穴位/手法/灸法/电针) acupuncture+moxibustion, (g) 推拿按摩 tuina massage, (h) 中医各科 (内/外/妇/儿/骨伤/皮肤/眼/耳鼻喉/肛肠/老年/急症) clinical specialties, (i) 中西医结合 integrative medicine, (j) 循证中医 + 临床流行病学 evidence-based TCM + 现代研究, (k) 中医诊所备案 / 中医师资格 / NATCM 监管 / 药典 / GMP regulatory framework, (l) 国家级名老中医 学术继承人 项目 transmission program; NOT 道家修炼 / 风水 / 算命八字 (那是 玄学不是 中医), NOT 中医养生科普 (是 衍生 不是 临床主体), NOT 中医美容 (是 商业化分支), NOT 民族医学 (藏蒙维傣 是 平行体系 不在本 skill 主线 — 仅作 边界标注). problems and wants industry-grade thinking, tool selection, or workflow guidance. 触发词：「中医」「中医学」「中医药」「中医诊疗」「中医临床」
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中国网站备案 与 互联网内容合规 (含 ICP 备案 主体+网站 / 公安备案 / ICP 经营许可证 增值电信 / 域名实名认证 / APP 备案 2024 工信部新规 / 等级保护测评 网安 / 算法推荐 + 深度合成 + 生成式 AI 备案 网信办 / 数据出境 + 个保法 + 数安法 合规联动 / 变更注销转移跨省迁移 — 不含 通用法律咨询 / 海外域名注册 / 网络营销 SEO / 翻墙 VPN) (China ICP filing & internet content compliance — the full regulatory life-cycle for any website / app / mini-program / IT service that publishes content or runs commercial services targeting mainland-China users; covers (a) 主体备案 + 网站备案 (non-commercial ICP record on beian.miit.gov.cn 经接入商 提交), (b) 域名实名认证 (CNNIC 一级域名 / 注册商核验), (c) 公安备案 (网安部门 30 日内补办), (d) ICP经营许可证 (有偿经营 / 增值电信业务 — 申请门槛极高), (e) APP 备案 (2024-03 工信部令), (f) 等级保护测评 (公安部 GB/T 22239), (g) 算法推荐 / 深度合成 / 生成式 AI 备案 (网信办专项), (h) 数据出境 + 个保法 + 数安法 合规联动, (i) 变更 / 注销 / 转移 / 跨省迁移 工作流; NOT 通用法律咨询, NOT 海外域名注册技术, NOT 网络营销 SEO, NOT 翻墙 / VPN 相关.) Master OS — automated mastery of China ICP filing & internet content compliance — the full regulatory life-cycle for any website / app / mini-program / IT service that publishes content or runs commercial services targeting mainland-China users; covers (a) 主体备案 + 网站备案 (non-commercial ICP record on beian.miit.gov.cn 经接入商 提交), (b) 域名实名认证 (CNNIC 一级域名 / 注册商核验), (c) 公安备案 (网安部门 30 日内补办), (d) ICP经营许可证 (有偿经营 / 增值电信业务 — 申请门槛极高), (e) APP 备案 (2024-03 工信部令), (f) 等级保护测评 (公安部 GB/T 22239), (g) 算法推荐 / 深度合成 / 生成式 AI 备案 (网信办专项), (h) 数据出境 + 个保法 + 数安法 合规联动, (i) 变更 / 注销 / 转移 / 跨省迁移 工作流; NOT 通用法律咨询, NOT 海外域名注册技术, NOT 网络营销 SEO, NOT 翻墙 / VPN 相关.: top builders' mental models, tool stack, current workflows, jargon, and where to keep up. Trigger this skill when the user works on China ICP filing & internet content compliance — the full regulatory life-cycle for any website / app / mini-program / IT service that publishes content or runs commercial services targeting mainland-China users; covers (a) 主体备案 + 网站备案 (non-commercial ICP record on beian.miit.gov.cn 经接入商 提交), (b) 域名实名认证 (CNNIC 一级域名 / 注册商核验), (c) 公安备案 (网安部门 30 日内补办), (d) ICP经营许可证 (有偿经营 / 增值电信业务 — 申请门槛极高), (e) APP 备案 (2024-03 工信部令), (f) 等级保护测评 (公安部 GB/T 22239), (g) 算法推荐 / 深度合成 / 生成式 AI 备案 (网信办专项), (h) 数据出境 + 个保法 + 数安法 合规联动, (i) 变更 / 注销 / 转移 / 跨省迁移 工作流; NOT 通用法律咨询, NOT 海外域名注册技术, NOT 网络营销 SEO, NOT 翻墙 / VPN 相关. problems and wants industry-grade thinking, tool selection, or workflow guidance. 触发词：「ICP备案」「icp备案」「icp filing」「icp license」「中国备案」
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CatColab Regulatory Networks - signed graphs for molecular biology modeling gene regulatory networks with positive (activating) and negative (inhibiting) edges.
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Coordinates regulatory and compliance information requests from institutional LPs including FOIA, regulatory filings, and audit support. Use when responding to compliance requests, managing FOIA inquiries, or supporting LP audit processes.
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Structures infrastructure DD with technical assessment, regulatory review, environmental analysis, and community impact evaluation. Use when conducting infra DD, evaluating asset condition, or assessing regulatory risk.
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Prepare an organisation for regulatory inspection by assessing readiness against agency-specific focus areas (FDA, EMA, MHRA). Covers warning letter and 483 theme analysis, mock inspection protocols, document bundle preparation, inspection logistics, and response template creation. Use when a regulatory inspection has been announced or is anticipated, when a periodic self-assessment is due, when new systems have been implemented since the last inspection, or after a significant audit finding that may attract regulatory attention.
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Design a compliance architecture that maps applicable regulations to computerized systems. Covers system inventory, criticality classification (GxP-critical, GxP-supporting, non-GxP), GAMP 5 category assignment, regulatory requirements traceability, and governance structure definition. Use when establishing a new regulated facility, formalising compliance across multiple systems, addressing a regulatory gap analysis, harmonising compliance after mergers or reorganisations, or preparing a site master file that references computerized systems.
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