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Designs and analyzes pooled prime-editor (PE) screens for installing precise genetic variants without bystander confounding. Covers pegRNA design with PRIDICT and PRIDICT2 for predicting per-pegRNA editing efficiency, pegRNA architecture (spacer + scaffold + PBS + RTT), PE2/PE3/PE3b/PEmax variants, MOSAIC in situ saturation mutagenesis, the PRIME pooled-screen methodology (Ren 2023; ~3,699 ClinVar variant screens), chromatin context as a major locus-level determinant of PE efficiency, scaffold-incorporation and indel byproduct quantification with CRISPResso2, and the cross-modal validation strategy of PE + base-editor screens for variant function. Use when designing a pegRNA library for variant installation, choosing between BE and PE for a specific edit, predicting pegRNA efficiency before library synthesis, analyzing PE screen output, distinguishing intended-edit from scaffold-incorporation, or scaling PE screens to thousands of variants.

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Analyzes base-editing screens for variant function. Covers library design (Hanna 2021 ClinVar-scale CBE screen benchmarked on BRCA1/2, Cuella-Martin 2021 DDR saturation), CBE vs ABE chemistry choice (BE3/BE4 vs ABE7.10/ABE8.20/ABE8e), editing-window math (positions 4-8 from PAM-distal end; 4-7 for ABE7.10), bystander-edit quantification and the variant-call ambiguity it creates, sgRNA-efficiency filtering before hit calling, indel byproduct interpretation, the substitution-vs-indel diagnostic, variant annotation against ClinVar / COSMIC, and the Broad be-validation-pipeline. Use when designing a BE variant screen, choosing CBE vs ABE for a specific edit, interpreting bystander-confounded hits, distinguishing functional signal from indel artifact, integrating CRISPResso2 output with screen scoring, or deciding BE vs PE for SNV installation.

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Evaluate and install ecosystem tools (Hermes plugins, skills, integrations) — assess complexity vs. benefit before installation, show examples for visual tools, and avoid "cloned but not configured" states.

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Create production-ready public repos with complete documentation, automated setup, bundled dependencies, and user-friendly installation.

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Use when running verbose CLI commands — wraps them with rtk (Rust Token Killer, third-party Apache-2.0; upstream reports 60-90% token savings). Covers installation, configuration, and usage patterns.

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Use Kanpeki component library in React projects. Activate when user wants to add, use, customize, or compose accessible UI components from Kanpeki (@kanpeki/*). Covers installation, component patterns, forms, theming, and dark mode with React Aria Components + Tailwind CSS 4.1 + CVA.

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Get started with your Open SaaS project — fetches docs, checks Wasp installation, and helps you start your database and app.

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Upgrade or synchronize Agent Skills, or determine a Skill's source and ownership across runtimes and roots. Use only for those lifecycle decisions. Do not use for installation, creation or editing, validation, inventory, usage statistics, general audits, cleanup, packaging, publishing, or ordinary file and package work.

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Helps users discover and install agent skills when they ask questions like "how do I do X", "find a skill for X", "is there a skill that can...", or express interest in extending capabilities. Use it proactively when an existing skill could be a ready-made building block, while keeping installation scoped to the current project unless the user explicitly requests a global install.

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Create, alter, and validate Snowflake semantic views using Snowflake CLI (snow). Use when asked to build or troubleshoot semantic views/semantic layer definitions with CREATE/ALTER SEMANTIC VIEW, to validate semantic-view DDL against Snowflake via CLI, or to guide Snowflake CLI installation and connection setup.

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Deploy and use the Exasol Transformers Extension AI Functions for NLP inference inside Exasol with notebook-connector. Covers initialize_te_extension, model installation, activation SQL, validation, and safe use of large models.

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Deploy and use the Exasol Text AI Extension (TXAIE) with notebook-connector. Covers `deploy_license`, `initialize_text_ai_extension`, the `PYTHON3_TXAIE` language container, the Extraction API classes `StandardExtractor`, `NamedEntityExtractor`, `TopicClassifierExtractor`, `PipelineExtractor`, and `BranchExtractor`, named-entity, zero-shot classification, and feature extraction runs, default-model installation, and result-table querying such as `TXAIE_AUDIT_LOG`.

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Convex backend specialist. Use this agent for any code inside a `convex/` directory — function definitions, schemas, indexes, queries, mutations, actions, HTTP endpoints, cron jobs, file storage, auth wiring, and component installation. Knows the object-form function syntax, validator patterns, resource limits, and component ecosystem that generic Claude routinely gets wrong.

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Convex backend specialist. Use this agent for any code inside a `convex/` directory — function definitions, schemas, indexes, queries, mutations, actions, HTTP endpoints, cron jobs, file storage, auth wiring, and component installation. Knows the object-form function syntax, validator patterns, resource limits, and component ecosystem that generic Claude routinely gets wrong.

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Deploys and configures CrowdStrike Falcon EDR agents across enterprise endpoints to enable real-time threat detection, behavioral analysis, and automated response. Use when onboarding endpoints to EDR coverage, configuring detection policies, or integrating Falcon telemetry with SIEM platforms. Activates for requests involving CrowdStrike deployment, Falcon sensor installation, EDR policy configuration, or endpoint detection and response.

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Parses and analyzes the Windows Amcache.hve registry hive to extract evidence of program execution, application installation, and driver loading for digital forensics investigations. Uses Eric Zimmerman's AmcacheParser and Timeline Explorer for artifact extraction, SHA-1 hash correlation with threat intel, and timeline reconstruction. Activates for requests involving Amcache forensics, program execution evidence, Windows artifact analysis, or application compatibility cache investigation.

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Full SolanaOS operator skill — install the runtime, query Solana blockchain data via SolanaTracker RPC, manage wallets, run OODA trading loops, configure multi-venue strategies (spot + Hyperliquid + Aster perps), control BitAxe mining fleets, pair Seeker devices, and interact with the SolanaOS Hub. Use when asked about SolanaOS installation, Solana wallet balances, token research, trading strategy, OODA loops, gateway setup, Telegram bot configuration, mining fleet management, or any SolanaOS runtime operation.

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Reconstructed reference notes on US FAA approval guidance for airborne software and airborne electronic hardware, built from four public-domain sources (FAA Order 8110.49A, AC 20-115D, AC 20-152A, AC 00-69; documents dated 2017-07-21 to 2022-10-07, pinned 2026-10-12). Use for how FAA certification staff plan and conduct software reviews (certification liaison, desk versus on-site review, review planning agreements), how the level of FAA involvement (LOI) is picked and scored with the Appendix A worksheets, how software conformity inspection works (software part and installation conformity, ASE and ASI tasks, Form 8120-10), what AC 20-115D recognizes and how DO-178B processes and tool qualification transition to DO-178C/DO-330 (supplements, FLS, UMS, legacy software changes), and what AC 20-152A adds for airborne electronic hardware (simple versus complex custom devices, robustness and HDL code coverage, tool assessment, previously developed hardware, COTS IP, COTS devices, circuit board assemblies), and what AC 00-69 adds as best practices for change impact analysis, data and control coupling, and design-level error handling (best practices, not guidance and not a means of compliance). SCOPE LIMITS: FAA guidance only, and guidance is not regulation (ACs are acceptable means, not the only means); no RTCA DO-178C or DO-254, EUROCAE ED-12C or ED-80, supplement, or SAE ARP text, which are copyrighted and named only (see the avionics-signpost pack); no AC 00-72 (named, not packed); no DO-178C software-level objective tables; no EASA AMC 20-115D or AMC 20-152A content (use easa-rules); reflects the pinned source dates, not later FAA actions; synthesized reference notes, not legal advice and not a substitute for the source documents. LICENCE: Public Domain (US Government work, 17 U.S.C. 105).

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Knowledge base from MIL-HDBK-516C (Airworthiness Certification Criteria). Use for DoD air-system airworthiness planning: tailoring a certification basis, systems engineering criteria, and domain clusters for structures, flight technology, propulsion/installation, avionics/electrical/E3/diagnostics, computer systems/software, and crew systems (including applicable UAS control-station elements). Qualitative guidance handbook — not raw contractual requirements. Does not replace service airworthiness authority policy, civil FAA certification rules as authorities, or detailed JSSG/MIL performance specs.

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Anbieterneutrales Onboarding-Protokoll für einen neuen, neu aufgesetzten oder ausgetauschten Arbeitsplatzrechner. Es richtet Betriebssystemvoraussetzungen, Agentenlaufzeiten, gemeinsame Regelflächen, portable Skills, verifizierte Konfiguration und Nachweise nach der Installation ein, ohne Zugangsdaten, private Prompts oder host-spezifische Konfiguration in ein Repository zu kopieren.

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Structured code review through the shared OpenClaw agent-skills installation.

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Discover and execute specialized skills from a curated marketplace catalog on GitHub, fetched on-demand and run ephemerally (no permanent installation). The catalog covers a broad and growing range — document generation (PDF/Word/Excel/PowerPoint), visual design, presentations, web app testing, animated GIFs, dev tooling (MCP scaffolding, frontend components), creative outputs (algorithmic art), technical documentation lookup (library/API/framework references), and more. Consult this skill whenever the user asks for a capability that could plausibly be covered by a community skill — the catalog is the source of truth, not this description.

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Read MIKE+ .res1d results via the mike-plus MCP server — list contents, summarize peaks, extract a single time series, or check which nodes flood (peak water level vs ground level). Use when an agent needs to inspect or pull numbers from MIKE+ network results (node water levels, link/reach discharge, velocities, flooding). No MIKE+ license or installation required.

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Use when adding CopilotKit to an existing project or bootstrapping a new CopilotKit project from scratch. Covers framework detection, package installation, runtime wiring, provider setup, and first working chat integration.

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