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Framework for building LLM-powered applications with agents, chains, and RAG. Supports multiple providers (OpenAI, Anthropic, Google), 500+ integrations, ReAct agents, tool calling, memory management, and vector store retrieval. Use for building chatbots, question-answering systems, autonomous agents, or RAG applications. Best for rapid prototyping and production deployments.
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Serves LLMs with high throughput using vLLM's PagedAttention and continuous batching. Use when deploying production LLM APIs, optimizing inference latency/throughput, or serving models with limited GPU memory. Supports OpenAI-compatible endpoints, quantization (GPTQ/AWQ/FP8), and tensor parallelism.
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Simplest distributed training API. 4 lines to add distributed support to any PyTorch script. Unified API for DeepSpeed/FSDP/Megatron/DDP. Automatic device placement, mixed precision (FP16/BF16/FP8). Interactive config, single launch command. HuggingFace ecosystem standard.
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Python library for working with geospatial vector data including shapefiles, GeoJSON, and GeoPackage files. Use when working with geographic data for spatial analysis, geometric operations, coordinate transformations, spatial joins, overlay operations, choropleth mapping, or any task involving reading/writing/analyzing vector geographic data. Supports PostGIS databases, interactive maps, and integration with matplotlib/folium/cartopy. Use for tasks like buffer analysis, spatial joins between datasets, dissolving boundaries, clipping data, calculating areas/distances, reprojecting coordinate systems, creating maps, or converting between spatial file formats.
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End-to-end Ribo-seq analysis from FASTQ through periodicity QC, P-site calibration, ORF detection, translation efficiency, and stalling. Use when orchestrating a full ribosome profiling pipeline and deciding harvest/dedup/alignment options and which downstream analyses the library can support.
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Runs LLM inference on CPU, Apple Silicon, and consumer GPUs without NVIDIA hardware. Use for edge deployment, M1/M2/M3 Macs, AMD/Intel GPUs, or when CUDA is unavailable. Supports GGUF quantization (1.5-8 bit) for reduced memory and 4-10× speedup vs PyTorch on CPU.
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End-to-end Hi-C analysis workflow from FASTQ to compartments, TADs, and loops, with the decision of WHICH features the sequencing depth can support. Covers pairtools read-pair processing and library QC, cooler matrices, ICE balancing and distance-decay expected, A/B compartments, TAD boundaries, loop calling, and the routing of HiChIP/PLAC-seq/Capture Hi-C to protein-directed loop callers. Use when processing Hi-C data end to end, deciding a resolution for a given depth, or choosing between bulk-Hi-C and protein-directed loop calling.
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End-to-end gene regulatory network inference pipeline from processed single-cell data to regulon discovery and perturbation simulation. Supports RNA-only (pySCENIC) and multiome (SCENIC+) paths. Use when building gene regulatory networks from single-cell transcriptomic or multiome data.
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Transform GWAS signals into drug targets and repurposing opportunities. Connects GWAS-significant loci to causal genes via fine-mapping/eQTL, then to druggable proteins via DGIdb/OpenTargets, then to existing drugs via ChEMBL. Use for GWAS-to-target hypothesis generation, druggable-fraction analysis of disease loci, and human-genetics-validated drug-repurposing prioritization.
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Infer gene regulatory networks (GRNs) from gene expression data using scalable algorithms (GRNBoost2, GENIE3). Use when analyzing transcriptomics data (bulk RNA-seq, single-cell RNA-seq) to identify transcription factor-target gene relationships and regulatory interactions. Supports distributed computation for large-scale datasets.
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Create new scientific tools for ToolUniverse framework with proper structure, validation, and testing. Use when users need to add tools to ToolUniverse, implement new API integrations, create tool wrappers for scientific databases/services, expand ToolUniverse capabilities, or follow ToolUniverse contribution guidelines. Supports creating tool classes, JSON configurations, validation, error handling, and test examples.
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Assess drug-drug interactions — CYP metabolic interactions (substrate/inhibitor/inducer), transporter (P-gp, BCRP, OATP) effects, pharmacodynamic synergy/antagonism, clinical significance scoring, and management recommendations. Use for polypharmacy review, prescribing decision support, and safety analysis when adding or switching drugs.
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Complete mass spectrometry analysis platform. Use for proteomics workflows feature detection, peptide identification, protein quantification, and complex LC-MS/MS pipelines. Supports extensive file formats and algorithms. Best for proteomics, comprehensive MS data processing. For simple spectral comparison and metabolite ID use matchms.
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Turns untargeted LC-MS/MS features (m/z, RT, MS/MS) into confidence-stratified metabolite annotations using spectral-library matching (matchms), in-silico tools (SIRIUS/CSI:FingerID, MetFrag) and molecular networking, and assigns a defensible MSI/Schymanski confidence level to each. Use when naming detected features, scoring MS/MS against a reference library, running SIRIUS, or deciding what confidence level an evidence set actually supports. For upstream feature extraction see metabolomics/xcms-preprocessing and metabolomics/msdial-preprocessing; for downstream enrichment that must respect these levels see metabolomics/pathway-mapping; for lipid-specific structural annotation see metabolomics/lipidomics.
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Improve interface resilience through better error handling, i18n support, text overflow handling, and edge case management, making interfaces robust and production-ready. Use when the user asks to harden, make production-ready, handle edge cases, add error states, or fix overflow and i18n issues.
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Improve how interfaces use photos, screenshots, icons, illustrations, and user-uploaded media so visuals support clarity instead of undermining it. Use when the user mentions images, screenshots, background photos, hero images, icon sizing, user-uploaded media, crops, overlays, or image readability.
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Plan, implement, or improve an internationalization and localization strategy for UI content, formatting, and regional adaptation. Use when the user asks to add i18n, localize, translate, support multiple languages, handle regional formats, manage locale switching, or build a multilingual product.
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Review and rank an entire SCF round end-to-end from a CSV export. Supports Open Track, Integration Track, and RFP Track with track-specific scoring dimensions. Reads submission data directly from an Airtable CSV, auto-detects columns, categorizes, runs parallel batch reviews, cross-batch calibration, and final ranking. All output is markdown. Use when you have a CSV export of an SCF Build Award round and need to review, score, and rank every submission.
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Tells you what CARLA on UE 5.5 (branch ue5-dev) cannot do that UE 5.8 (ue58-dev) can, so you do not attempt an unsupported workflow there — no Autoware integration, no ROS 2 middleware choice (FastDDS only), no DLSS or ray-traced-lens camera, no OFPA large-map mount so Town12/13/15 load black, and a few missing World/Actor methods. Also states what is identical, so the ue58 skills can be used directly for everything else. Use when working against a 5.5 checkout, when a ue58 skill's step has no counterpart, or when deciding whether a feature request is possible on 5.5 at all.
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Runs a single ScenarioRunner Python scenario (or a whole group) against a running CARLA server — FollowLeadingVehicle, ControlLoss, DynamicObjectCrossing, SignalizedJunctionLeftTurn and the rest of srunner/examples — in sync or async mode, with result output, recording and manual/agent control of the ego. Lists what is runnable on the checked-out branch and on the loaded map. Use when the user asks to "run a scenario", "test FollowLeadingVehicle", "list scenarios", "run a CARLA traffic scenario", or reports a scenario that is "not supported".
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Builds CARLA (branch ue4-dev, Unreal Engine 4.26) from source on Linux end-to-end — UE4 fork, the Carla server (editor C++ modules), the LibCarla Python client wheel, and content — then verifies them against a from-source server. Optionally builds the native ROS 2 interface in (ROS2=1 → --ros2, Fast-DDS/CycloneDDS/Zenoh), which is compile-time only and cannot be enabled later. Use when the user asks to "build CARLA from source", "compile CARLA ue4-dev", "set up CARLA on Ubuntu (incl. 24.04)", "build CARLA with ROS2 support", or "produce a CARLA server + client wheel". Cooking a distributable Dist/ package is a separate skill (package-carla-ue4); running the build is run-carla-server.
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Adds a new ROS 2 message type to CARLA's native ROS 2 interface — the hand-written POD struct under LibCarla/source/carla/ros2/types/msg, its Fast-CDR serialize/deserialize pair, the RIHS01 type hash computed in Docker, the CdrTopicInfo registration and the type-hash test. Use when the user asks to "add a ROS message type", "support sensor_msgs/X in CARLA", "add a carla_msgs type", "why is my type hash warning appearing", or needs a message CARLA does not publish yet. There is no IDL codegen — every step is manual.
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Book reservations through Google Maps using browser automation. Searches for businesses, checks availability, and completes bookings via "Reserve with Google" or 3rd-party providers (OpenTable, Resy, Vagaro). Supports restaurants (primary), salons, fitness, healthcare. Use when user wants to book, reserve, or schedule at a business found on Google Maps.
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Hermes Agent (Nous Research の AI CLI エージェント)。インストール、 CLI コマンド (chat, model, gateway, config, cron, webhook, mcp, skills, profile, hermes pm)、 Configuration (Terminal Backends, Memory, TTS / STT, Auxiliary Models, Compression, Display, Local Models llama.cpp, Egress / Secrets)、 Features (Tools, Skills, Hooks, Delegation, Kanban, Cron, Voice Mode, Personality, Context Files)、 Messaging Gateway (Platform Support, Bot Mode, Connectors)、Security、Architecture、 Hermes Desktop、Plugin Catalog、Profiles、Developer Guide、Nous Portal (Tool Gateway)。
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